Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung, Lindsay N Hayes, Rupali Srivastava, Manling Zhang, Taro Kariya, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman Calva, Satoshi Ikemoto, Rana Rais, Barbara S Slusher, Minae Niwa, Atsushi Saito, Toshiaki Saitoh, Eiki Takimoto, Akira Sawa
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks were elicited, the nuclear glyceraldehyde dehydrogenase (N-GAPDH) cascade was activated specifically in microglia in the prelimbic cortex. The cognitive deficits were normalized with a pharmacological intervention with a compound (the RR compound) that selectively blocked the initiation of N-GAPDH cascade without affecting glycolytic activity...
April 13, 2024: Molecular Psychiatry