Rohini Sharma, Kumar G Kallur, Jin S Ryu, Ramanathapuram V Parameswaran, Henrik Lindman, Norbert Avril, Fergus V Gleeson, Jong D Lee, Kyung-Han Lee, Michael J O'Doherty, Ashley M Groves, Matthew P Miller, Edward J Somer, Charles R Coombes, Eric O Aboagye
UNLABELLED: Integrins are upregulated on both tumor cells and associated vasculature, where they play an important role in angiogenesis and metastasis. Fluciclatide is an arginine-glycine-aspartic acid peptide with high affinity for αvβ3/αvβ5 integrin, which can be radiolabeled for PET imaging of angiogenesis. Thus, (18)F-fluciclatide is a potential biomarker of therapeutic response to antiangiogenic inhibitors. The aim of this study was to evaluate the reproducibility of (18)F-fluciclatide in multiple solid-tumor types...
December 2015: Journal of Nuclear Medicine