Abigail B Abrahams, Amy C Beckenstrom, Michael Browning, Rebecca Dias, Guy M Goodwin, Philip Gorwood, Jonathan Kingslake, Richard Morriss, Andreas Reif, Henricus G Ruhé, Judit Simon, Gerard R Dawson
Data from the UK suggests 13-55 % of depression patients experience some level of treatment resistance. However, little is known about how physicians manage inadequate response to antidepressants in primary care. This study aimed to explore the incidence of inadequate response to antidepressants in UK primary care. One-hundred-eighty-four medication-free patients with low mood initiated antidepressant treatment and monitored severity of depression symptoms, using the QIDS-SR16, for 48 weeks. Medication changes, visits to healthcare providers, and health-related quality of life were also recorded...
April 27, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology