Vincent Avecilla, Mayur Doke, Madhumita Das, Oscar Alcazar, Sandeep Appunni, Arthur Rech Tondin, Brandon Watts, Venkataraghavan Ramamoorthy, Muni Rubens, Jayanta Kumar Das
Vascular diseases, including peripheral arterial disease (PAD), pulmonary arterial hypertension, and atherosclerosis, significantly impact global health due to their intricate relationship with vascular remodeling. This process, characterized by structural alterations in resistance vessels, is a hallmark of heightened vascular resistance seen in these disorders. The influence of environmental estrogenic endocrine disruptors (EEDs) on the vasculature suggests a potential exacerbation of these alterations. Our study employs an integrative approach, combining data mining with bioinformatics, to unravel the interactions between EEDs and vascular remodeling genes in the context of PAD...
April 19, 2024: International Journal of Molecular Sciences