Christopher A Rajkumar, Michael J Foley, Fiyyaz Ahmed-Jushuf, Florentina A Simader, Muhammad Mohsin, Sashiananthan Ganesananthan, Alexandra N Nowbar, Shayna Chotai, Sayan Sen, Ricardo Petraco, Sukhjinder S Nijjer, Joban Sehmi, Neil Ruparelia, Jason N Dungu, Alamgir Kabir, Kare Tang, Reto Gamma, John R Davies, Tushar Kotecha, Graham D Cole, James P Howard, Thomas R Keeble, Gerald Clesham, Peter D O'Kane, Frank E Harrell, Darrel P Francis, Matthew J Shun-Shin, Rasha K Al-Lamee
BACKGROUND: In stable coronary artery disease, 30% to 60% of patients remain symptomatic despite successful revascularization. Perhaps not all symptoms reported by a patient with myocardial ischemia are, in fact, angina. OBJECTIVES: This study sought to determine whether independent symptom verification using a placebo-controlled ischemic stimulus could distinguish which patients achieve greatest symptom relief from percutaneous coronary intervention (PCI). METHODS: ORBITA-STAR was a multicenter, n-of-1, placebo-controlled study in patients undergoing single-vessel PCI for stable symptoms...
May 8, 2024: Journal of the American College of Cardiology