Katelyn F Romm, Amy M Cohn, Laura A Beebe, Carla J Berg
Little research has examined mechanisms driving cannabis use disparities among sexual minority (SM; versus heterosexual) young adults (YAs). Participants were US YA women (N = 1345; 24.8% bisexual, 6.1% lesbian) and men (N = 998: 8.9% bisexual, 13.8% gay). Bivariate analyses examined associations between sexual orientation (heterosexual, gay/lesbian, bisexual) and cannabis use outcomes (past 30-day [current] use, use frequency, cannabis-tobacco dual use, use intentions), perceived risks (harm, addictiveness) and social norms (social acceptability, peer use)...
September 26, 2023: Health Education Research
S Sikkes, E Blaauw
BACKGROUND: Patients with a substance use disorder often experience self-stigma. Support of the environment seems to decrease self-stigma, but little is known about the relationship with experienced and desired social support. AIMS: To gain insight in the relationships between experienced social support, desired social support and self-stigma, and to examine whether the severity of the substance use disorder plays a role in these relationships. METHOD: 83 outpatients with a substance use disorder completed the Social Support List and the Internalized Stigma of Mental Illness scale...
2023: Tijdschrift Voor Psychiatrie
Saskia Schawo, Renske Hoefman, Vivian Reckers-Droog, Liesbet Lawerman-van de Wetering, Yifrah Kaminer, Werner Brouwer, Leona Hakkaart-van Roijen
BACKGROUND: Systemic family interventions for adolescents with problems of substance use and/or delinquency are increasingly focused subject of economic evaluations. Treatment effects go beyond improvements in commonly measured health-related quality of life (HRQOL). The Teen-Addiction Severity Index (T-ASI) was identified as capable of capturing these broad outcomes. However, it lacks preference-based scores. An abbreviated self-completion version (ASC T-ASI) was created and validated, covering the T-ASI domains substance use, school, work, family, social relationships, justice, and mental health...
September 27, 2023: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Martin Leurent, Déborah Ducasse, Philippe Courtet, Emilie Olié
This paper offers a systematic review of quantitative and qualitative studies on the main twelve-step mutual-help (TSMH) groups (excluding Alcoholics Anonymous) and four meta-analyses exploring the correlation between (i) duration or involvement in TSMH groups and; (ii) severity of symptoms or quality of life. Systematic review was conducted following PRISMA guidelines. Searches of databases (MEDLINE, PsychInfo), a register (ClinicalTrials) and citations were conducted, from inception through November 01 2022...
September 27, 2023: European Archives of Psychiatry and Clinical Neuroscience
Ronny Bruffaerts, William G Axinn, Dirgha J Ghimire, Corina Benjet, Stephanie Chardoul, Kate M Scott, Ronald C Kessler, Paul Schulz, Jordan W Smoller
AIMS: To measure the independent consequences of community-level armed conflict beatings on alcohol use disorders (AUD) among males in Nepal during and after the 2000-2006 conflict. DESIGN: A population-representative panel study from Nepal, with precise measures of community-level violent events and subsequent individual-level AUD in males. Females were not included because of low AUD prevalence. SETTING: Chitwan, Nepal. PARTICIPANTS: Four thousand eight hundred seventy-six males from 151 neighborhoods, systematically selected and representative of Western Chitwan...
September 27, 2023: Addiction
Pilar Montesó-Curto, Loren Toussaint, Angela Kueny, Ilga Ruschak, Shannon Lunn, Lluís Rosselló, Carme Campoy, Stephanie Clark, Connie Luedtke, Alessandra Queiroga Gonçalves, Carina Aguilar Martín, Ann Vincent, Arya B Mohabbat
Physical exercise is an indispensable element in the multidisciplinary treatment of fibromyalgia syndrome (FMS). The present study examined if men diagnosed with FMS engaged in any type of physical activity or exercise, the perceived effects from exercise, and who specifically recommended exercise. A qualitative cross-cultural study was performed in fibromyalgia clinical units in Spain and the United States. A total of 17 participants, 10 men from Spain and 7 men from the US, were included. In Spain, a focus group was completed in two parts, one month apart in 2018...
September 7, 2023: International Journal of Environmental Research and Public Health
Kavitha Kamalasekaran, Vasanth Magesh, Raji Atchudan, Sandeep Arya, Ashok K Sundramoorthy
Nicotine is the one of the major addictive substances; the overdose of nicotine (NIC) consumption causes increasing heart rate, blood pressure, stroke, lung cancer, and respiratory illnesses. In this study, we have developed a precise and sensitive electrochemical sensor for nicotine detection in saliva samples. It was built on a glassy carbon electrode (GCE) modified with graphene (Gr), iron (III) phthalocyanine-4,4',4″,4'''-tetrasulfonic acid (Fe(III)Pc), and gold nanoparticles (AuNPs/Fe(III)Pc/Gr/GCE)...
August 23, 2023: Biosensors
Fatma Gerez Taşgın, Adnan Taşgın
In this study, we aimed to examine pre-service teachers' attitudes toward reading books and their technology addictions. We used a correlational survey model. The sample of this study consisted of a Turkish pre-service teachers group studying at the Department of Turkish Education in the education faculty of a state university in Turkey. Our research used the "Attitude Scale Towards Reading" and "Technology Addiction Scale" as data collection tools. As a result of the study, we determined that the attitudes towards reading of pre-service teachers were positive...
September 16, 2023: Behavioral Sciences
Xiaofan Yang, Hang Ma, Ling Zhang, Jinyang Xue, Ping Hu
OBJECTIVE: The primary objective of this study is to investigate the relationships between perceived social support and mobile phone addiction, as well as the mediating effect of depressive symptoms and the moderating effect of self-compassion. METHODS: A total of 874 college students completed questionnaires, including the perceived social support scale, depression-anxiety-stress scale, mobile phone addiction index, and the short form of the self-compassion scale...
September 14, 2023: Behavioral Sciences
Shihao Huang, Cuijie Shi, Fanglin Liu, Yue Si, Dan Shen, Liping Yang, Yujun Gao, Yiwei Liao
The susceptibility to drug cravings evoked by stimuli poses a formidable hurdle in the treatment of addiction and the prevention of relapse. Pharmacological interventions targeting drug-associated memories hold promise for curbing relapse by impeding the process of memory reconsolidation, predominantly governed by cAMP signalling. Exchange Protein Activated by cAMP (Epac) serves as a distinctive mediator of cAMP signalling, which has been implicated in reinforcing the effects of cocaine and facilitating the acquisition...
October 2023: Addiction Biology
Yihao Guo, Xiaoling Xu, Tiansheng Li, Huijuan Chen, Xiaoyi Wang, Weiyuan Huang, Tao Liu, Qingle Kong, Feng Chen
The temporal variability of the dynamic functional connectivity (dFC) has been suggested as a useful metric for studying abnormal cognitive function. This study aimed to explore the associations between the temporal properties of dFC and memory performance in betel quid dependence (BQD). Sixty-four BQD individuals and 47 gender- and age-matched healthy controls (HCs) underwent functional magnetic resonance imaging and a series of neuropsychological assessments. The dFC was constructed by calculating the Pearson correlation coefficients within a sliding window and was clustered into three functional connectivity states using k-means clustering...
October 2023: Addiction Biology
Kanako Matsumura, Amélia Nicot, In Bae Choi, Meera Asokan, Nathan N Le, Luis A Natividad, Lauren K Dobbs
Cocaine predictive cues and contexts exert powerful control over behaviour and can incite cocaine seeking and taking. This type of conditioned behaviour is encoded within striatal circuits, and these circuits and behaviours are, in part, regulated by opioid peptides and receptors expressed in striatal medium spiny neurons. We previously showed that augmenting levels of the opioid peptide enkephalin in the striatum facilitates acquisition of cocaine conditioned place preference (CPP), while opioid receptor antagonists attenuate expression of cocaine CPP...
October 2023: Addiction Biology
Hussein Kadhem Al-Hakeim, Mazin Fadhil Altufaili, Amer Fadhil Alhaideri, Abbas F Almulla, Shatha Rouf Moustafa, Michael Maes
Methamphetamine (MA)-induced psychosis (MIP) is associated with increased oxidative toxicity (especially lipid peroxidation) and lowered antioxidant defences. Advanced glycation end products (AGEs) cause oxidative stress upon ligand binding to AGE receptors (RAGEs). There is no data on whether MA use may cause AGE-RAGE stress or whether the latter is associated with MIP. This case-control study recruited 60 patients with MA use disorder and 30 normal controls and measured serum levels of oxidative stress toxicity (OSTOX, lipid peroxidation), antioxidant defences (ANTIOX), magnesium, copper, atherogenicity, AGE and soluble RAGE (sRAGE) and computed a composite reflecting AGE-RAGE axis activity...
October 2023: Addiction Biology
Yunting Liu, Pei Zhang, Hongmei Sheng, Ding Xu, Daixi Li, Lizhe An
Over the past few years, there has been increasing evidence highlighting the strong connection between gut microbiota and overall well-being of the host. This has led to a renewed emphasis on studying and addressing substance use disorder from the perspective of brain-gut axis. Previous studies have suggested that alcohol, food, and cigarette addictions are strongly linked to gut microbiota and faecal microbiota transplantation or the use of probiotics achieved significant efficacy. Unfortunately, little is known about the relationship between drug abuse and gut microbiota...
October 2023: Addiction Biology
Suchan Chang, Hyung Kyu Kim, Yeonhee Ryu, Han Byeol Jang, DanBi Ahn, Bong Hyo Lee, Dong-Ho Youn, Bae Hwan Lee, Hee Young Kim
The medial prefrontal cortex (mPFC) and the lateral habenula (LHb) play roles in drug addiction and cognitive functions. Our previous studies have suggested that acupuncture at Shenmen (HT7) points modulates mesolimbic reward system in order to suppress drug-induced addiction behaviours. To explore whether an mPFC-LHb circuit mediates the inhibitory effects of acupuncture on addictive behaviours, we examined the projection from mPFC to LHb, excitation of mPFC neurons during acupuncture stimulation, the effects of optogenetic modulation of mPFC-LHb on HT7 inhibition of cocaine-induced locomotion and the effect of mPFC lesion on HT7 inhibition of nucleus accumbens (NAc) dopamine release...
October 2023: Addiction Biology
Yihong Zhao, Xuewei Han, Zhi-Liang Zheng
Substance use disorder (SUD) arises from the initiation to subsequent regular, irregular and harmful use of substances such as alcohol, tobacco/nicotine and cannabis. While thousands of genetic variants have been identified from recent large-scale genome-wide association studies (GWAS), understanding their functions in substance involvement and investigating the mechanisms by which they act in the addiction circuits remains challenging. In this study, we re-analysed the brain regional transcriptome data from the most comprehensive postmortem transcriptomic study, with a focus on up- or down-regulation of substance-associated protein-coding genes in the addiction circuit-related brain regions (AddictRegions), including six cortical and 11 subcortical regions...
October 2023: Addiction Biology
Annakarina Mundorf, Annabelle Siebert, John E Desmond, Jutta Peterburs
Recent studies increasingly highlight involvement of the cerebellum in drug craving and addiction. However, its exact role, that is, whether the cerebellum is a critical component of a brain network underlying addictive behaviour, or whether it rather is a facilitator or mediator, is still unclear. Findings concerning the newly recognized internet gaming disorder (IGD) suggest that changes in cerebellar connectivity and functioning are associated with behavioural/non-substance addiction. Here, we systematically review the literature on IGD and cerebellar involvement following the PRISMA guidelines...
October 2023: Addiction Biology
Erin L Martin, Nathaniel L Baker, Cristina Sempio, Uwe Christians, Jost Klawitter, Aimee L McRae-Clark
Cannabis use disorder (CUD) presents differently in men and women, particularly in symptoms of cannabis withdrawal. Novel pharmacotherapeutic interventions for CUD, such as those that target the endocannabinoid (eCB) system, must be developed in a manner consistent with these sex differences. The present pilot study sought to prospectively assess sex differences in cannabis withdrawal in a small sample of adults with moderate-to-severe CUD and to determine if withdrawal was associated with peripheral eCB and eCB congener tone...
October 2023: Addiction Biology
Adedayo Olaniran, Rachel D Altshuler, Megan A M Burke, Hongyu Lin, Julia Firlie, Ilan Linshitz, Xuan Li
Relapse to oxycodone seeking progressively increases after abstinence in rats, a phenomenon termed incubation of oxycodone craving. We have previously shown that the orbitofrontal cortex (OFC) plays a critical role in incubation of oxycodone craving in male rats. Here, we examined the effect of oestrous cycle on incubated oxycodone seeking in female rats, and whether the critical role of OFC in incubated oxycodone seeking generalizes to female rats. We first assessed oxycodone self-administration and incubated oxycodone seeking on abstinence day 15 across the oestrous cycle...
October 2023: Addiction Biology
Dustin R Todaro, Xinyi Li, Laís S Pereira-Rufino, Peter Manza, Ilya M Nasrallah, Sandhitsu Das, Anna Rose Childress, Henry R Kranzler, Nora D Volkow, Daniel D Langleben, Zhenhao Shi, Corinde E Wiers
Incidence of opioid-related overdoses in the United States has increased dramatically over the past two decades. Despite public emphasis on overdose fatalities, most overdose cases are not fatal. Although there are case reports of amnestic syndromes and acute injury to the hippocampus following non-fatal opioid overdose, the effects of such overdoses on brain structure are poorly understood. Here, we investigated the neuroanatomical correlates of non-fatal opioid overdoses by comparing hippocampal volume in opioid use disorder (OUD) patients who had experienced an opioid overdose (OD; N = 17) with those who had not (NOD; N = 32)...
October 2023: Addiction Biology
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