Price Obot, Antonio Cibelli, Jian Pan, Libor Velíšek, Jana Velíšková, Eliana Scemes
There is a high co-morbidity between childhood epilepsy and autism spectrum disorder (ASD), with age of seizure onset being a critical determinant of behavioral outcomes. The interplay between these comorbidities has been investigated in animal models with results showing that the induction of seizures at early post-natal ages leads to learning and memory deficits and to autistic-like behavior in adulthood. Modifications of the excitation/inhibition (glutamate/GABA, ATP/adenosine) balance that follows early-life seizures (ELS) are thought to be the physiological events that underlie neuropsychiatric and neurodevelopmental disorders...
2024: ASN Neuro
Amy E Kalkbrenner, Cheng Zheng, Justin Yu, Tara E Jenson, Thomas Kuhlwein, Christine Ladd-Acosta, Jakob Grove, Diana Schendel
BACKGROUND: Testing etiologic heterogeneity - whether a disorder subtype is more or less impacted by a risk factor, is important for understanding causal pathways and optimizing statistical power. The study of mental health disorders especially benefits from strategic sub-categorization because these disorders are heterogenous and frequently co-occur. Existing methods to quantify etiologic heterogeneity are not appropriate for non-competing events in an open cohort of variable-length follow-up...
July 18, 2024: Epidemiology
Catherine Friel, Alastair H Leyland, Jana J Anderson, Alexandra Havdahl, Anne Lise Brantsæter, Ruth Dundas
IMPORTANCE: Prenatal diet may be causally related to autism; however, findings are inconsistent, with a limited body of research based on small sample sizes and retrospective study designs. OBJECTIVE: To investigate the associations of prenatal dietary patterns with autism diagnosis and autism-associated traits in 2 large prospective cohorts, the Norwegian Mother, Father, and Child Cohort Study (MoBa), and the Avon Longitudinal Study of Parents and Children (ALSPAC)...
July 1, 2024: JAMA Network Open
Mackenzie Robeson, Katey Hayes, Kristina Rossetti, Erica Ahlich, Kimberly Zlomke
OBJECTIVE: The purpose of this study was to investigate the relationship between sleep quality and quality of life (QOL), or overall level of well-being, in caregivers of children with autism spectrum disorder (ASD) on the daily level. METHOD: This study utilizes mobile ecological momentary assessment (mEMA) to capture daily experiences of caregivers of children with ASD over a period of 14 days. Utilizing mEMA, this study examines relations between sleep quality and QOL and the role of mood and physical health as mediators on the daily level, specifically for caregivers of children with ASD (n = 51)...
July 18, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
Stephanie Castelin, Josselyn Okorodudu, Teresa Smith
OBJECTIVE: Black children with autism and their families face disparities within clinical care and services, leading to inequitable health outcomes. However, there is limited research centering the voices of the Black autism community in understanding how to address these inequities. In this study, researchers explored the perspectives of caregivers of Black children with autism regarding barriers to equitable care and recommendations for improved services. METHODS: Community leaders from an autism advocacy group and researchers from a large academic medical center partnered to conduct a Group Level Assessment with 31 Black families of children with autism...
July 17, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
Ann Marie Martin, Brandon Keehn, Angela Paxton, Mary R Ciccarelli, Rebecca McNally Keehn
OBJECTIVE: Despite long-standing racial and ethnic disparities in autism spectrum (AS) diagnosis, recent research suggests that overall, greater numbers of Black and Latine children are now diagnosed with AS as compared with non-Latine White (NLW) children in some US regions. However, gaps remain in the equitable detection of Black and Latine children with AS without significant developmental impairment. The objective of this study was to determine whether the clinical profiles of young children evaluated for AS across a statewide system of early autism diagnosis in Indiana vary by race and ethnicity...
July 17, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
Angela Yarnell Bonino, Deborah Mood, Mary S Dietrich
We aim to determine the accessibility of gold-standard hearing assessments - audiogram or auditory brainstem response (ABR) - during the first 3 months of hearing health care for children with and without developmental disabilities. Electronic health records were examined from children (0-18 years) who received hearing health care at three hospitals. Children with developmental disabilities had a diagnosis of autism, cerebral palsy, Down syndrome, or intellectual disability. Assessments from the first 3 months were reviewed to determine if ≥ 1 audiogram or ABR threshold was recorded...
July 18, 2024: Journal of Autism and Developmental Disorders
Blaise Di Mento, James Rufus John, Antonio Mendoza Diaz, Ping-I Lin, Anne Masi, Rachel Grove, Valsamma Eapen
Examining sub-threshold autistic traits in non-autistic first-degree relatives of individuals on the autism spectrum, known as the Broad Autism Phenotype (BAP), could provide new insights into the associations and familial aggregation of autistic traits. This study was a retrospective cross-sectional study of parents (n = 1008), probands with autism (n = 613), and unaffected siblings (n = 221) of probands with autism. BAP traits were examined by the BAP Questionnaire and Communication Checklist-Adult in parents, Autism Developmental Observation Scale-Second edition in probands, and Social Responsiveness Scale in siblings...
July 18, 2024: Journal of Autism and Developmental Disorders
Yingxin Wang, Wenzhu Liu, Yichang Jiao, Yitong Yang, Didi Shan, Xinbo Ji, Rui Zhang, Zexin Zhan, Yao Tang, Dandan Guo, Chuanzhu Yan, Fuchen Liu
The cerebellum has historically been primarily associated with the regulation of precise motor functions. However, recent findings suggest that it also plays a pivotal role in the development of advanced cognitive functions, including learning, memory, and emotion regulation. Pathological changes in the cerebellum, whether congenital hereditary or acquired degenerative, can result in a diverse spectrum of disorders, ranging from genetic spinocerebellar ataxias to psychiatric conditions such as autism, and schizophrenia...
July 18, 2024: Stem cell reviews and reports
Quentin Moreau, Florence Brun, Anaël Ayrolles, Jacqueline Nadel, Guillaume Dumas
Autism Spectrum Disorder (ASD) is defined by distinctive socio-cognitive behaviors that deviate from typical patterns. Notably, social imitation skills appear to be particularly impacted, manifesting early on in development. This paper compared the behavior and inter-brain dynamics of dyads made up of two typically developing (TD) participants with mixed dyads made up of ASD and TD participants during social imitation tasks. By combining kinematics and EEG-hyperscanning, we show that individuals with ASD exhibited a preference for the follower rather than the lead role in imitating scenarios...
July 18, 2024: Social Neuroscience
Greta Ryan, Valerie Watchorn, Sherryn Evans
INTRODUCTION: Autistic children commonly receive simultaneous services from various health-care and other professionals, including occupational therapy, throughout their journey of diagnosis and consequent therapeutic support. Current best practice guidelines for supporting autistic youth emphasise the importance of interprofessional collaboration. Despite this, collaboration among health-care professionals does not always occur, and little is understood about clinicians' experiences of collaborative care...
July 18, 2024: Australian Occupational Therapy Journal
Demet Öztürk, Sena Aydoğan, İbrahim Kök, Işık Akın Bülbül, Selda Özdemir, Suat Özdemir, Diyar Akay
Diagnosing autism spectrum disorder (ASD) in children poses significant challenges due to its complex nature and impact on social communication development. While numerous data analytics techniques have been proposed for ASD evaluation, the process remains time-consuming and lacks clarity. Eye tracking (ET) data has emerged as a valuable resource for ASD risk assessment, yet existing literature predominantly focuses on predictive methods rather than descriptive techniques that offer human-friendly insights...
December 2024: Health Information Science and Systems
Amber M Angell, Elinor E Taylor, Joana Nana Serwaa Akrofi, Elaine D Carreon, Marshae D Franklin, Julie Miller, Catherine Crowley, Shona Orfirer Maher
This qualitative study examined participants' experiences of transitioning to telehealth-delivered pediatric occupational therapy for autistic children during the COVID-19 pandemic. We interviewed three clinic administrators, four occupational therapists, and six parents of autistic children ( n =13) from three Los Angeles area clinics over a 7-month period. Our narrative and thematic analyses yielded three overarching themes: Transformative Experiences , Reimagining Therapy , and Going Forward . Overall, we found that the transition to telehealth shifted participants' preconceptions about themselves, their relationships, and the nature of occupational therapy...
2024: International Journal of Telerehabilitation
Shu-Yuan Bai, De-Yang Zeng, Ming Ouyang, Yan Zeng, Wei Tan, Lang Xu
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a monogenic cause of autism spectrum disorders. Deficiencies in the fragile X messenger ribonucleoprotein, encoded by the FMR1 gene, lead to various anatomical and pathophysiological abnormalities and behavioral deficits, such as spine dysmorphogenesis and learning and memory impairments. Synaptic cell adhesion molecules (CAMs) play crucial roles in synapse formation and neural signal transmission by promoting the formation of new synaptic contacts, accurately organizing presynaptic and postsynaptic protein complexes, and ensuring the accuracy of signal transmission...
2024: Frontiers in Cellular Neuroscience
Dingmei Deng, Bo Tao, Yizhi Yuan, Yongsheng Ao, Lihua Qiu
The clinical manifestations of adult-acquired cerebellar diseases often surpass those of congenital cerebellar diseases, suggesting the significant role of the cerebellum in the developing brain. Moreover, emerging evidence from structural and functional magnetic resonance imaging indicates that the cerebellum is implicated not only in motor functions but also in non-motor domains such as cognition, emotion, and language. However, delineating the specific extent of cerebellar development required to prevent deficits in either motor or non-motor functions remains challenging...
2024: Psychoradiology
Fahad Almuqhim, Fahad Saeed
Autism Spectrum Disorder (ASD) is a heterogeneous disorder in children, and the current clinical diagnosis is accomplished using behavioral, cognitive, developmental, and language metrics. These clinical metrics can be imperfect measures as they are subject to high test-retest variability, and are influenced by assessment factors such as environment, social structure, or comorbid disorders. Advances in neuroimaging coupled with machine-learning provides an opportunity to develop methods that are more quantifiable, and reliable than existing clinical techniques...
December 2023: Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine
Jennifer Whipple, Edward Todd Schwartzberg
Scientific integrity is fundamental to evidence-based practice (EBP) and essential in music therapy (MT) research and clinical practice. Researchers conducted an integrative review of approaches and interventions employed by music therapists (MTs) with individuals on the autism spectrum in the context of how studies are analyzed by the National Autism Center (NAC) and National Clearinghouse on Autism Evidence and Practice (NCAEP). Researchers identified 880 database records meeting initial search criteria (i...
July 17, 2024: Journal of Music Therapy
Victoria Lindblad, Rasmus L Ravn, Pernille S Gaardsted, Line E M Hansen, Fie F Lauritzen, Dorte Melgaard
INTRODUCTION: In the fields of labor market and education research, there is a vast interest in mental health factors affecting unsuccessful school-to-work transitions, dropout from school and labor market disconnections for young people. Young people who are not in employment, education or training are conceived of as NEET. AIM: To get an overview we conducted a systematic review of the present literature on the influence of mental health on the likelihood of becoming NEET in Europe...
July 17, 2024: Journal of Adolescence
Jessica Hill, Jodie Copley, Sophie Donovan, Jill Ashburner, Jennifer Taylor, Natasha Bobir
INTRODUCTION: Increasingly, autistic adolescents and adults are accessing occupational therapy. However, limited evidence exists on the type of supports that are important to them. Examining the patterns of supports valued by autistic adolescents and adults will inform the design of occupational therapy services. Therefore, this study aimed to identify what supports autistic adolescents and adults believed to be the most important. METHODS: This study involved two anonymous online surveys...
July 17, 2024: Australian Occupational Therapy Journal
Feifan Pang, Lan Yang, Choi Yeung Tse, Kuen Fung Sin
This study examined the associations between teachers' beliefs and behaviors related to inclusive education (IE) and their evaluations of social and academic competences in students with Autism Spectrum Disorder (ASD) - important indicators of IE. Utilizing the Theory of Planned Behavior (TPB), the research investigated how teachers' intentions to implement IE and their supportive practices affected the social and academic competences of students with ASD. The study involved 267 teachers from 78 mainstream secondary schools in Hong Kong...
July 17, 2024: Journal of Autism and Developmental Disorders
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