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JOURNAL ARTICLE
Carolina López-Guzmán, Ana María García, Juan Diego Ramirez, Trinidad Torres Aliaga, Alejandro Fernández-Moya, Ulrike Kemmerling, Ana María Vásquez
BACKGROUND: The sequestration of Plasmodium falciparum infected erythrocytes in the placenta, and the resulting inflammatory response affects maternal and child health. Despite existing information, little is known about the direct impact of P. falciparum on the placental barrier formed by trophoblast and villous stroma. This study aimed to assess placental tissue damage caused by P. falciparum in human placental explants (HPEs). METHODS: HPEs from chorionic villi obtained of human term placentas (n = 9) from normal pregnancies were exposed to P...
May 1, 2024: Malaria Journal
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JOURNAL ARTICLE
Sergey Senkin, Sarah Moody, Marcos Díaz-Gay, Behnoush Abedi-Ardekani, Thomas Cattiaux, Aida Ferreiro-Iglesias, Jingwei Wang, Stephen Fitzgerald, Mariya Kazachkova, Raviteja Vangara, Anh Phuong Le, Erik N Bergstrom, Azhar Khandekar, Burçak Otlu, Saamin Cheema, Calli Latimer, Emily Thomas, Joshua Ronald Atkins, Karl Smith-Byrne, Ricardo Cortez Cardoso Penha, Christine Carreira, Priscilia Chopard, Valérie Gaborieau, Pekka Keski-Rahkonen, David Jones, Jon W Teague, Sophie Ferlicot, Mojgan Asgari, Surasak Sangkhathat, Worapat Attawettayanon, Beata Świątkowska, Sonata Jarmalaite, Rasa Sabaliauskaite, Tatsuhiro Shibata, Akihiko Fukagawa, Dana Mates, Viorel Jinga, Stefan Rascu, Mirjana Mijuskovic, Slavisa Savic, Sasa Milosavljevic, John M S Bartlett, Monique Albert, Larry Phouthavongsy, Patricia Ashton-Prolla, Mariana R Botton, Brasil Silva Neto, Stephania Martins Bezerra, Maria Paula Curado, Stênio de Cássio Zequi, Rui Manuel Reis, Eliney Ferreira Faria, Nei Soares de Menezes, Renata Spagnoli Ferrari, Rosamonde E Banks, Naveen S Vasudev, David Zaridze, Anush Mukeriya, Oxana Shangina, Vsevolod Matveev, Lenka Foretova, Marie Navratilova, Ivana Holcatova, Anna Hornakova, Vladimir Janout, Mark P Purdue, Nathaniel Rothman, Stephen J Chanock, Per Magne Ueland, Mattias Johansson, James McKay, Ghislaine Scelo, Estelle Chanudet, Laura Humphreys, Ana Carolina de Carvalho, Sandra Perdomo, Ludmil B Alexandrov, Michael R Stratton, Paul Brennan
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden1 . In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence2 . Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations...
May 1, 2024: Nature
#43
JOURNAL ARTICLE
Laura Hernández-Lorenzo, Fernando García-Gutiérrez, Ana Solbas-Casajús, Silvia Corrochano, Jordi A Matías-Guiu, Jose L Ayala
Alzheimer's disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient stratification technique based on one of the most significant risk factors for the development of AD: genetics. We addressed this challenge by including network biology concepts, mapping genetic variants data into a brain-specific protein-protein interaction (PPI) network, and obtaining individualized PPI scores that we then used as input for a clustering technique...
April 30, 2024: Scientific Reports
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REVIEW
Ana M Jaramillo, Eszter K Vladar, Fernando Holguin, Burton F Dickey, Christopher M Evans
Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components...
April 30, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
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JOURNAL ARTICLE
Yasutaka Masuda, Ken Morita, Mineo Kurokawa
Objective Polyclonal hypergammaglobulinemia (PHGG) is a classic problem in internal medicine; however, its conditions and diagnostic procedures have not been well studied. We therefore conducted a retrospective study to characterize the PHGG disease spectrum. Methods We included all patients who underwent serum protein electrophoresis (SPEP) at a hematology tertiary referral center during a five-year period. For these patients, globulin clonality was determined and clinical data were extracted from the records...
May 2, 2024: Internal Medicine
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JOURNAL ARTICLE
Ana Paula Dias Moreno, Priscyla Daniely Marcato, Letícia Bueno Silva, Sérgio Luiz de Souza Salvador, Marina Constante Gabriel Del Arco, Juliana Cristina Biazzoto de Moraes, Roberto Santana da Silva, Andiara De Rossi
Epigallocatechin-3-gallate (EGCG), a polyphenol derived from Green Tea, is one of the sources of natural bioactive compounds which are currently being developed as medicinal ingredients. Besides other biological activities, this natural compound exhibits anti-cariogenic effects. However, EGCG has low physical-chemical stability and poor bioavailability. Thus, the purpose of this study was to develop and characterize lipid-chitosan hybrid nanoparticle with EGCG and to evaluate its in vitro activity against cariogenic planktonic microorganisms...
2024: Journal of Oleo Science
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JOURNAL ARTICLE
Alexandra Valencia, Ana María Muñoz, Monica Ramos-Escudero, Keidy Cancino Chavez, Fernando Ramos-Escudero
Sacha inchi seed oil is a food matrix rich in bioactive constituents, mainly polyunsaturated fatty acids. In this study, the characteristics of color, carotenoid content, tocopherols, and volatile aroma compounds in eight sacha inchi seed (Plukenetia volubilis L.) oil accessions were evaluated. Results showed that the oil obtained from the accessions presented a lightness and chroma of 91 to 98 units and 6 to 10 units respectively, while the hue angle ranged between 93 to 97 units. The total carotenoid content in the different accessions ranged from 0...
2024: Journal of Oleo Science
#48
JOURNAL ARTICLE
Jose A Moran-Guerrero, Hector R Martínez, David G Gonzalez-Sanchez, Luis E Perez-Martinez, Rogelio E Flores-Salcido, Ana S Ferrigno, E Caro-Osorio, Misael Salazar-Alejo, Pablo J Avalos-Montes, Jose A Figueroa-Sanchez
OBJECTIVE: To describe a simple variation of burr hole craniostomy for the management of chronic subdural hematoma (CSDH) that uses a frontal drainage system to facilitate timely decompression in the event of tension pneumocephalus and spares the need for additional surgery. METHODS: We conducted a retrospective analysis of 20 patients with CSDH who underwent burr hole craniostomy and 20 patients who underwent the same procedure alongside the placement of a 5fr neonatal feeding tube as a backup drainage for the anterior craniostomy...
April 29, 2024: World Neurosurgery
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JOURNAL ARTICLE
Mariana Azevedo Rosa, Andreia Granja, Cláudia Nunes, Salette Reis, Ana Beatriz Santos da Silva, Ketolly Natanne da Silva Leal, Marco Aurélio Zezzi Arruda, Luiz Fernando Gorup, Mariane Gonçalves Santos, Marcos Vinicios Salles Dias, Eduardo Costa Figueiredo
Carbon nanotubes are promising materials for biomedical applications like delivery systems and tissue scaffolds. In this paper, magnetic carbon nanotubes (M-CNTs) covered with bovine serum albumin (M-CNTs-BSA) or functionalized with hydrophilic monomers (M-CNTs-HL) were synthesized, characterized, and evaluated concerning their interaction with Caco-2 cells. There is no comparison between these two types of functionalization, and this study aimed to verify their influence on the material's interaction with the cells...
April 29, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Francesca Lupini, Molly Basch, Frances Cooke, Jack Vagadori, Ana Gutierrez-Colina, Katherine Patterson Kelly, Randi Streisand, Lauren Shomaker, Eleanor R Mackey
BACKGROUND: Negative affect is prevalent among adolescents with type 1 diabetes (T1D) and may impact diabetes self-management and outcomes through stress-related behaviors such as disordered eating. METHODS: We describe the development of and design for the adaptation of a mindfulness-based intervention (MBI) for adolescents with T1D and negative affect. BREATHE-T1D is an MBI designed to target negative affect that has been tailored to address the unique lived experiences of adolescents with T1D...
April 29, 2024: Contemporary Clinical Trials
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JOURNAL ARTICLE
Cristina Martin-Martin, Beatriz Suarez-Alvarez, Monika González, Irina B Torres, Oriol Bestard, José E Martín, Gwendolyn Barceló-Coblijn, Francesc Moreso, Ana M Aransay, Carlos Lopez-Larrea, Ramon M Rodriguez
In this proof-of-concept study, spatial transcriptomics combined with public single-cell RNA-sequencing data were used to explore the potential of this technology to study kidney allograft rejection. We aimed to map gene expression patterns within diverse pathological states by examining biopsies classified across non-rejection, T cell-mediated acute rejection, and interstitial fibrosis and tubular atrophy (IFTA). Our results revealed distinct immune cell signatures, including those of T and B lymphocytes, monocytes, mast cells, and plasma cells, and their spatial organization within the renal interstitium...
April 29, 2024: American Journal of Transplantation
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RANDOMIZED CONTROLLED TRIAL
Marie Scully, Ana Antun, Spero R Cataland, Paul Coppo, Claire Dossier, Nathalie Biebuyck, Wolf-Achim Hassenpflug, Karim Kentouche, Paul Knöbl, Johanna A Kremer Hovinga, M Fernanda López-Fernández, Masanori Matsumoto, Thomas L Ortel, Jerzy Windyga, Indranil Bhattacharya, Michael Cronin, Hong Li, Björn Mellgård, Munjal Patel, Parth Patwari, Shan Xiao, Pinghai Zhang, Linda T Wang
BACKGROUND: Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived products) administered as routine prophylaxis or on-demand treatment in patients with congenital TTP is not known. METHODS: In this phase 3, open-label, crossover trial, we randomly assigned patients in a 1:1 ratio to two 6-month periods of prophylaxis with recombinant ADAMTS13 (40 IU per kilogram of body weight, administered intravenously) or standard therapy, followed by the alternate treatment; thereafter, all the patients received recombinant ADAMTS13 for an additional 6 months...
May 2, 2024: New England Journal of Medicine
#53
JOURNAL ARTICLE
Idejan P Gross, Ana Luiza Lima, Giselle R Bedogni, Livia Sa-Barreto, Tais Gratieri, Guilherme M Gelfuso, Claudio J Salomon, Marcílio Cunha-Filho
Considering the health relevance of Chagas' disease, recent research efforts have focused on developing more efficient drug delivery systems containing nifurtimox (NFX). This paper comprehensively investigates NFX through conformational analysis and spectroscopic characterization. Using a conformer-rotamer ensemble sampling tool (CREST-xtb), five distinct conformers of NFX were sampled within a 3.0 kcal mol-1 relative energy window. Subsequently, such structures were used as inputs for geometry optimization by density functional theory (DFT) at B3LYP-def2-TZVP level of theory...
April 26, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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JOURNAL ARTICLE
Marian van der Meulen, Katharina M Rischer, Ana María González Roldán, Juan Lorenzo Terrasa, Pedro Montoya, Fernand Anton
Growing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlies the increased transition from acute to chronic pain in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool to examine the neural mechanisms behind these age-related changes in pain modulation. RsFC studies generally observe decreased within-network connectivity due to aging, but its relevance for pain modulation remains unknown. We compared rsFC within a set of brain regions involved in pain modulation between young and older adults and explored the relationship with the efficacy of distraction from pain...
April 25, 2024: Neurobiology of Aging
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JOURNAL ARTICLE
Claus Garbe, Ana-Maria Forsea, Teresa Amaral, Petr Arenberger, Philippe Autier, Marianne Berwick, Brigitta Boonen, Matilda Bylaite, Veronique Del Marmol, Brigitte Dreno, Maria Concetta Fargnoli, Alan C Geller, Adele C Green, Rüdiger Greinert, Axel Hauschild, Catherine A Harwood, Isabelle Hoorens, Lidija Kandolf, Roland Kaufmann, Nicole Kelleners-Smeets, Aimilios Lallas, Celeste Lebbé, Ulrike Leiter, Henry W Lim, Caterina Longo, Joseph Malvehy, David Moreno, Giovanni Pellacani, Ketty Peris, Caroline Robert, Philippe Saiag, Dirk Schadendorf, H Peter Soyer, Eggert Stockfleth, Alex Stratigos, Hisashi Uhara, Ricardo Vieira, Beate Volkmer, Martin A Weinstock, Dagmar Whitaker, Iris Zalaudek, David C Whiteman, Lieve Brochez
Cancers of the skin are the most commonly occurring cancers in humans. In fair-skinned populations, up to 95% of keratinocyte skin cancers and 70-95% of cutaneous melanomas are caused by ultraviolet radiation and are thus theoretically preventable. Currently, however, there is no comprehensive global advice on practical steps to be taken to reduce the toll of skin cancer. To address this gap, an expert working group comprising clinicians and researchers from Africa, America, Asia, Australia, and Europe, together with learned societies (European Association of Dermato-Oncology, Euromelanoma, Euroskin, European Union of Medical Specialists, and the Melanoma World Society) reviewed the extant evidence and issued the following evidence-based recommendations for photoprotection as a strategy to prevent skin cancer...
April 24, 2024: European Journal of Cancer
#56
JOURNAL ARTICLE
Mayra Trujillo, Anne Conan, Ana Cláudia Calchi, Katja Mertens-Scholz, Anna Becker, Christa Gallagher, Alex Mau, Silvia Marchi, Marcus Machado, Marcos Rogério André, Aspinas Chapwanya, Ananda Müller
This study aimed to evaluate the bacterial burden and perform molecular characterization of Coxiella burnetii during shedding in pregnant (vaginal, mucus and feces) and postpartum (vaginal mucus, feces and milk) ewes from Saint Kitts. Positive IS1111 DNA (n=250) for C. burnetii samples from pregnant (n=87) and postpartum (n=74) Barbados Blackbelly ewes in a previous investigation were used for this study. Vaginal mucus (n=118), feces (n=100), and milk (n=32) positive IS1111 C. burnetii-DNA were analysed by real time qPCR (icd gene)...
April 26, 2024: Comparative Immunology, Microbiology and Infectious Diseases
#57
COMPARATIVE STUDY
Paula Simina Petric, Andreea Teodorescu, Ana Aliana Miron, Mihnea Costin Manea, Petru Ifteni
BACKGROUND: Patients with schizophrenia often face challenges related to cognitive function, affecting their daily functioning and overall quality of life. The choice of antipsychotic treatment may play a crucial role in determining cognitive outcomes. STUDY QUESTION: Our study aimed to investigate whether there was a difference in cognitive ability between the patients with schizophrenia receiving oral antipsychotics (OAP) versus long-acting injectable antipsychotics (LAI-APs)...
May 2024: American Journal of Therapeutics
#58
JOURNAL ARTICLE
Felipe Liporaci, Danilo Carlotti, Ana Carlotti
Bloodstream infection (BSI) is associated with increased morbidity and mortality in the pediatric intensive care unit (PICU) and high healthcare costs. Early detection and appropriate treatment of BSI may improve patient's outcome. Data on machine-learning models to predict BSI in pediatric patients are limited and neither study included time series data. We aimed to develop a machine learning model to predict an early diagnosis of BSI in patients admitted to the PICU. This was a retrospective cohort study of patients who had at least one positive blood culture result during stay at a PICU of a tertiary-care university hospital, from January 1st to December 31st 2019...
2024: PloS One
#59
JOURNAL ARTICLE
Bruna Carolina Ulsenheimer, Alexandre Alberto Tonin, Ana Eucares von Laer, Helton Fernandes Dos Santos, Luís Antônio Sangioni, Rafael Fighera, Matheus Yuri Dos Santos, Daniela Isabel Brayer, Sônia de Avila Botton
Leptospira spp. are bacteria responsible for leptospirosis, a zoonotic disease with considerable impacts on the economy, animal health, and public health. This disease has a global distribution and is particularly prevalent in Brazil. Both rural and urban environments are habitats for Leptospira spp., which are primarily transmitted through contact with the urine of infected animals. Consequently, domestic and wild species can harbor these prokaryotes and serve as infection sources for other hosts. In the context of wild animals, there is a dearth of molecular studies elucidating the roles of various animal and bacterial species in the epidemiology of leptospirosis...
April 30, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#60
JOURNAL ARTICLE
Ricardo A M P Gomes, Lidia Catarino, Ana Luisa Santos
Portable X-ray fluorescence is a new tool in the study of human bone. This research aims to investigate if variations in bone elemental concentrations are related with porous skeletal lesions (PSLs). One hundred well-preserved non-adult skeletons aged 0-11 years were selected from the archaeological site Convent of São Domingos, Lisbon (18th-19th century). Measuring a standard reference material and calculating the technical error of measurement assured elemental data reliability. Moreover, measuring soil samples excluded possible contamination of bones with elements from the soil, except for Pb...
May 1, 2024: Biological Trace Element Research
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