Ricardo Augusto de Melo Reis, Alinny Rosendo Isaac, Hércules Rezende Freitas, Mariana Macedo de Almeida, Patricia Fernanda Schuck, Gustavo Costa Ferreira, Belmira Lara da Silveira Andrade-da-Costa, Isis Hara Trevenzoli
The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer's, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders...
2021: Frontiers in Neuroscience