keyword
https://read.qxmd.com/read/38490257/characteristics-of-carcinoembryonic-antigen-related-cell-adhesion-molecules-and-their-relationship-to-cancer
#21
JOURNAL ARTICLE
Ru-Xue Ma, Yan-Wei Hu, Jian-Rui Wei
Carcinoembryonic antigen related cell adhesion molecules (CEACAMs), such as carcinoembryonic antigen (CEA) and the oncofetal glycoprotein family, are tumor markers. The CEACAMs consist of 12 different human CEACAMs and 5 different murine CEACAMs. The CEACAM family of proteins participates in multiple biological processes that include the immune response, angiogenesis, and cancer. CEACAMs play a significant role in cancer initiation and development. Increasing evidence suggests that family members may be new cancer biomarkers and targets in that CEACEAMs tend to be aberrantly expressed and therefore may have potential diagnostic and therapeutic importance...
March 16, 2024: Molecular Cancer Therapeutics
https://read.qxmd.com/read/38490170/bioorthogonal-in-situ-polymerization-of-dendritic-agents-for-hijacking-lysosomes-and-enhancing-antigen-presentation-in-cancer-cells
#22
JOURNAL ARTICLE
Dan Zhong, Xingyu Hou, Dayi Pan, Zhiqian Li, Qiyong Gong, Kui Luo
A low generation lysine dendrimer, SPr-G2, responds to intracellular glutathione to initiate bioorthogonal in situ polymerization, resulting in the formation of large assemblies in mouse breast cancer cells. The intracellular large assemblies of SPr-G2 can interact with lysosomes to induce lysosome expansion and enhance lysosomal membrane permeabilization (LMP), leading to major histocompatibility complex class I (MHC-I) upregulation on tumor cell surfaces and ultimately tumor cell death. Moreover, the use of the SPr-G2 dendrimer to conjugate the chemotherapeutic drug, camptothecin (CPT), can boost the therapeutic potency of CPT...
March 15, 2024: Advanced Materials
https://read.qxmd.com/read/38490092/considerations-for-selecting-second-line-treatment-in-patients-with-progressive-small-cell-lung-cancer-and-the-use-of-lurbinectedin-in-this-setting
#23
REVIEW
Firas Badin
Small cell lung cancer (SCLC) is characterized by high initial responses to platinum-based chemotherapy plus immune checkpoint inhibitors; however, most patients quickly relapse and require subsequent treatment. Second-line treatment options in SCLC remain limited, and treatment algorithms are not completely consistent across the available guidelines in this setting. This review highlights key considerations regarding selection of second-line treatment for patients with relapsed SCLC. In particular, the role of lurbinectedin, which was first approved in 2020, representing the first significant addition to treatment algorithms in this setting for decades, is summarized...
February 29, 2024: Cancer Treatment and Research Communications
https://read.qxmd.com/read/38489959/atomic-force-microscopy-correlates-mechanical-and-electrical-properties-of-hepg2-cells-with-curcumin-concentration
#24
JOURNAL ARTICLE
Zeling Guo, Yu Meng, Shang Zhou, Jiangting Li, Xinyu Li, Rongrong Feng, Yulan Zou, Wenchao Liao, Weiting Wu, Mingjing Xu, Xiangfu Zeng, Weidong Zhao, Haijian Zhong
Hepatocellular carcinoma (HCC) is a highly prevalent cancer with a significant impact on human health. Curcumin, a natural compound, induces cytoskeletal changes in liver cancer cells and modifies the distribution of lipids, proteins, and polysaccharides on plasma membranes, affecting their mechanical and electrical properties. In this study, we used nanomechanical indentation techniques and Kelvin probe force microscopy (KPFM) based on atomic force microscopy (AFM) to investigate the changes in surface nanomechanical and electrical properties of nuclear and cytoplasmic regions of HepG2 cells in response to increasing curcumin concentrations...
March 13, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38489894/arctigenin-from-arctium-lappa-l-inhibits-chikungunya-virus-by-affecting-its-entry-and-replication
#25
JOURNAL ARTICLE
Shridhar Shukla, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar
BACKGROUND: Dengue and chikungunya, caused by dengue virus (DENV) and chikungunya virus (CHIKV) respectively, are the most common arthropod-borne viral diseases worldwide, for which there are no FDA-approved antivirals or effective vaccines. Arctigenin, a phenylpropanoid lignan from the seeds of Arctium lappa L. is known for its anti-inflammatory, anti-cancer, antibacterial, and immunomodulatory properties. Arctigenin's antimicrobial and immunomodulatory capabilities make it a promising candidate for investigating its potential as an anti-DENV and anti-CHIKV agent...
February 27, 2024: Phytomedicine
https://read.qxmd.com/read/38489077/critical-examination-of-modeling-approaches-used-in-economic-evaluations-of-first-line-treatments-for-locally-advanced-or-metastatic-non-small-cell-lung-cancer-harboring-epidermal-growth-factor-receptor-mutations-a-systematic-literature-review
#26
Angie Raad, Maria Rizzo, Katherine Appiah, Isabella Kearns, Luis Hernandez
BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with up to 32% of patients with NSCLC harboring an epidermal growth factor receptor (EGFR) mutation. NSCLC harboring an EGFR mutation has a dedicated treatment pathway, with EGFR tyrosine kinase inhibitors and platinum-based chemotherapy often being the therapy of choice. OBJECTIVE: The aim of this study was to systemically review and summarize economic models of first-line treatments used for locally advanced or metastatic NSCLC harboring EGFR mutations, as well as to identify areas for improvement for future models...
March 15, 2024: PharmacoEconomics
https://read.qxmd.com/read/38489072/psoralen-a-narrative-review-of-current-and-future-therapeutic-uses
#27
REVIEW
Panagis Galiatsatos, Daniella D Maydan, Elle Macalpine, Beatrice Schleupner, Alexandra Hunter Aitchison, Andrew D Lerner, Benjamin Levy, Aditya Halthore, William Eward
Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves. Psoralens penetrate the phospholipid cellular membranes and insert themselves between the pyrimidines of deoxyribonucleic acid (DNA). Psoralens are initially biologically inert and acquire photoreactivity when exposed to certain classes of electromagnetic radiation, such as ultraviolet light. Once activated, psoralens form mono- and di-adducts with DNA, leading to marked cell apoptosis...
March 15, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38488813/integrative-molecular-analyses-of-the-md-anderson-prostate-cancer-patient-derived-xenograft-mda-pca-pdx-series
#28
JOURNAL ARTICLE
Nicolas Anselmino, Estefania Labanca, Peter D A Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy J Lee, Nikolaus Schultz, Jianhua Zhang, John C Araujo, Ana M Aparicio, Sumit K Subudhi, Paul G Corn, Louis L Pisters, John F Ward, John W Davis, Elba S Vazquez, Geraldine Gueron, Christopher J Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M Navone
PURPOSE: Develop and deploy a robust discovery platform that encompasses heterogeneity, clinical annotation, and molecular characterization and overcomes the limited availability of prostate cancer (PCa) models. This initiative builds on the rich MD Anderson (MDA) PCa patient-derived xenograft (PDX) resource to complement existing publicly available databases by addressing gaps in clinically annotated models reflecting the heterogeneity of potentially lethal and lethal PCa. EXPERIMENTAL DESIGN: We performed whole-genome, targeted, and RNA sequencing in representative samples of the same tumor from 44 PDXs derived from 38 patients linked to donor tumor metadata and corresponding organoids...
March 15, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38488036/doxorubicin%C3%A2-induced-cardiomyopathy-is-mitigated-by-empagliflozin-via-the-modulation-of-endoplasmic-reticulum-stress-pathways
#29
JOURNAL ARTICLE
Akshi Malik, Ashim K Bagchi, Davinder S Jassal, Pawan K Singal
Doxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation of cardiomyocyte apoptosis...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488001/zmynd8-protects-breast-cancer-stem-cells-against-oxidative-stress-and-ferroptosis-through-activation-of-nrf2
#30
JOURNAL ARTICLE
Maowu Luo, Lei Bao, Yuanyuan Xue, Ming Zhu, Ashwani Kumar, Chao Xing, Jennifer E Wang, Yingfei Wang, Weibo Luo
Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase-high (ALDHhi) BCSCs, leading to BCSC expansion and tumor initiation in mice. The underlying mechanism involved a two-fold posttranslational regulation of nuclear factor erythroid 2-related factor 2 (NRF2)...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38487917/outcomes-for-pembrolizumab-stratified-by-pemetrexed-maintenance-post-pembrolizumab-platinum-pemetrexed-induction-in-metastatic-non-small-cell-lung-cancer
#31
JOURNAL ARTICLE
Jerome H Goldschmidt, Srinivas Annavarapu, Divea Venkatasetty, Yunfei Wang, Melissa L Santorelli, Thomas Burke, Nathan A Pennell
Aim: We assessed treatment patterns and outcomes in patients with metastatic nonsquamous non-small-cell lung cancer (mNSCLC) who initiated first-line pembrolizumab-platinum-pemetrexed (induction) in US community oncology settings. Methods: Patients initiating induction were retrospectively identified. Patients continuing pembrolizumab afterward underwent chart review. Clinical outcomes were described by maintenance pemetrexed exposure after inverse probability of treatment weighting (IPTW). Results: Median induction pembrolizumab and pemetrexed durations were 5...
March 15, 2024: Immunotherapy
https://read.qxmd.com/read/38487624/humoral-complementomics-exploration-of-noninvasive-complement-biomarkers-as-predictors-of-renal-cancer-progression
#32
JOURNAL ARTICLE
Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T Roumenina, Marie-Agnes Dragon-Durey
Despite the progress of anti-cancer treatment, the prognosis of many patients with solid tumors is still dismal. Reliable noninvasive biomarkers are needed to predict patient survival and therapy response. Here, we propose a Humoral Complementomics approach: a work-up of assays to comprehensively evaluate complement proteins, activation fragments, and autoantibodies targeting complement proteins in plasma, which we correlated with the intratumoral complement activation, and/or local production, focusing on localized and metastatic clear cell renal cell carcinoma (ccRCC)...
2024: Oncoimmunology
https://read.qxmd.com/read/38487542/directing-the-migration-of-serum-free-ex-vivo-expanded-v%C3%AE-9v%C3%AE-2-t-cells
#33
JOURNAL ARTICLE
Kiran K Parwani, Gianna M Branella, Rebecca E Burnham, Andre J Burnham, Austre Y Schiaffino Bustamante, Elisabetta Manuela Foppiani, Kristopher A Knight, Brian G Petrich, Edwin M Horwitz, Christopher B Doering, H Trent Spencer
Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing practice (GMP)-compliant, serum-free conditions are not tested easily in most mouse models, mainly because they lack the ability to migrate from the blood to tissues or tumors. We demonstrate that these T cells do not migrate from the circulation to the mouse bone marrow (BM), the site of many malignancies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487014/glioblastoma-stem-cell-derived-exosomal-mir-374b-3p-promotes-tumor-angiogenesis-and-progression-through-inducing-m2-macrophages-polarization
#34
JOURNAL ARTICLE
Shilu Huang, Peng Zhang, Nanheng Yin, Zhipeng Xu, Xinglei Liu, Anyi Wu, Xiaopei Zhang, Zengyang Li, Zhicheng Zhang, Tao Zhong, Liang Liu, Yan Shi, Jun Dong
Glioblastoma stem cells (GSCs) reside in hypoxic periarteriolar niches of glioblastoma micro-environment, however, the crosstalk of GSCs with macrophages on regulating tumor angiogenesis and progression are not fully elucidated. GSCs-derived exosomes (GSCs-exos) are essential mediators during tumor immune-microenvironment remodeling initiated by GSCs, resulting in M2 polarization of tumor-associated macrophages (TAMs) as we reported previously. Our data disclosed aberrant upregulation of miR-374b-3p in both clinical glioblastoma specimens and human cell lines of GSCs...
March 15, 2024: IScience
https://read.qxmd.com/read/38486999/ehmt2-promotes-tumorigenesis-in-gnaq-11-mutant-uveal-melanoma-via-arhgap29-mediated-rhoa-pathway
#35
JOURNAL ARTICLE
Yongyun Li, Tianyu Zhu, Jie Yang, Qianqian Zhang, Shiqiong Xu, Shengfang Ge, Renbing Jia, Jianming Zhang, Xianqun Fan
Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma (UM). Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular functions. In search of genetic vulnerability for UM, we found that inhibition of euchromatic histone lysine methyltransferase 2 (EHMT2) expression or activity significantly reduced the proliferation and migration capacity of cancer cells. Notably, elevated expression of EHMT2 had been validated in UM samples. Furthermore, Kaplan-Meier survival analysis indicated high EHMT2 protein level was related to poor recurrence-free survival and a more advanced T stage...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38486826/a-nursing-pre-transplant-intervention-to-reduce-patients-uncertainty-about-allogeneic-hematopoietic-stem-cell-transplantation
#36
JOURNAL ARTICLE
Kimiko Nakano, Shiro Fujii, Ayame Fujioka, Kumi Kimura, Yoshiki Abe, Masahiro Abe, Sena Yamamoto, Harue Arao
Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) procedures often experience high levels of uncertainty. In this study, we developed and implemented a nursing intervention program to help patients recognize and reduce pre-transplant uncertainty. This study used a pretest-posttest single-group design without a control group. Eighteen patients undergoing HSCT participated in the intervention program-which included informational support, confirmation that the patients understood the information provided, and emotional support...
February 25, 2024: Blood Cell Ther
https://read.qxmd.com/read/38486479/a-nomogram-based-on-clinical-characteristics-and-nutritional-indicators-for-relative-and-absolute-weight-loss-during-radiotherapy-in-initially-inoperable-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Yuan He, Wen-Jun Liao, An-Qi Hu, Xiao-Yang Li, Jian-Guo Wang, Dong Qian
OBJECTIVE: Radiation for locally advanced esophageal squamous cell carcinoma often is accompanied by radiation esophagitis, which interferes with oral intake. We aimed to develop a nomogram model to identify initially inoperable patients with relative and absolute weight loss who need prophylactic nutritional supplementation. METHODS: A total of 365 initially inoperable patients with locally advanced esophageal squamous cell carcinoma receiving radiotherapy between January 2018 and December 2022 were included in the study, which was divided into discovery and validation cohorts...
January 2024: Nutrition
https://read.qxmd.com/read/38486394/structural-insights-into-non-hotspot-kras-mutations-and-their-potential-as-targets-for-effective-cancer-therapies
#38
JOURNAL ARTICLE
Cong Ding, Gaoyuan Wang, Wenqing Zou, Yanping Mao, Jun Ma
Kirsten rat sarcoma virus protein (KRAS) is a protein that plays a central role in signal transduction using extracellular signal regulated kinase (ERK) and mitogen activated protein kinase (MAPK) cellular signaling pathway. KRAS is a frequently mutated oncogene and plays a pivotal role in tumor initiation and progression. Hotspot mutations on codon 12, 13 and 61 in KRAS are well-known for their role in drug resistance and non-hotspot mutations also play a significant part in contributing to resistance mechanisms...
March 14, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38486392/comprehensive-pan-cancer-analysis-of-cmpk2-as-biomarker-and-prognostic-indicator-for-immunotherapy
#39
JOURNAL ARTICLE
Jingyuan Luo, Qianyue Zhang, Shutong Wang, Luojie Zheng, Jie Liu, Yuchen Zhang, Yingchen Wang, Ranran Wang, Zhigang Xiao, Zheng Li
INTRODUCTION: UMP-CMP kinase 2 (CMPK2) is involved in mitochondrial DNA synthesis which can be oxidized and released into the cytoplasm in innate immunity. It initiates the assembly of NLRP3 inflammasomes and mediates various pathological processes such as human immunodeficiency virus infection and systemic lupus erythematosus. However the role of CMPK2 in tumor progression and tumor immunity remains unclear. METHOD: In this study we conducted a systematical analysis of CMPK2 across 33 different cancers based on datasets such as Genotype Tissue-Expression (GTEx) The Cancer Genome Atlas (TCGA) the Cancer Cell Line Encyclopedia (CCLE) and Tumor Immune Syngeneic Mouse (TISMO)...
March 13, 2024: Current Cancer Drug Targets
https://read.qxmd.com/read/38486364/cytoreductive-nephrectomy-in-the-era-of-immune-checkpoint-inhibitors-a-u-s-fda-pooled-analysis
#40
JOURNAL ARTICLE
Jaleh Fallah, Haley Gittleman, Chana Weinstock, Elaine Chang, Sundeep Agrawal, Shenghui Tang, Richard Pazdur, Paul G Kluetz, Daniel L Suzman, Laleh Amiri-Kordestani
BACKGROUND: This pooled analysis of patient-level data from trials evaluated the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) with or without cytoreductive nephrectomy (CN) prior to a combination of immune checkpoint inhibitor (ICI) and anti-angiogenic therapy. METHODS: Five trials of ICI plus anti-angiogenic therapy were pooled. Only patients with stage 4 at initial diagnosis were included to ensure that nephrectomy was done for cytoreductive purposes and not to previously treat an earlier stage of disease...
March 14, 2024: Journal of the National Cancer Institute
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