Jie Zhang, Minfang Zhang, Wangbin Ouyang, Fang Wang, Shiying Li
PURPOSE: To describe the characteristics seen on multispectral imaging (MSI) in patients with punctate inner choroidopathy (PIC) and choroidal neovascularisation (CNV) and compare the findings with current standard multimodal imaging techniques. METHODS: This is a retrospective observational case series of 10 patients with PIC complicated by CNV that underwent multimodal retinal imaging examinations. RESULTS: Twelve eyes of 10 patients were included...
November 20, 2020: Ocular Immunology and Inflammation
Martin Dominik Leclaire, Christoph R Clemens, Nicole Eter, Nataša Mihailovic
Punctate inner choroidopathy (PIC) is often accompanied by the development of choroidal neovascularization (CNV). The identification of a fresh CNV in the context of PIC is often difficult. We present the case of a 30-year-old female patient with typical morphological features of PIC. A CNV could not be detected with certainty by optical coherence tomography (OCT) or by fluorescein angiography (FAG); however, OCT angiography (OCT-A) revealed a circumscribed CNV. The case suggests that there are a high number of undiagnosed, subclinical secondary CNVs not requiring treatment in PIC patients...
August 7, 2020: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Omer Karti, Sefik Can Ipek, Yesim Ates, Ali Osman Saatci
Inflammatory choroidal neovascularization (iCNV) is an infrequent but an important cause of visual morbidity in patients with non-infectious uveitis and mostly occurs in intermediate or posterior uveitis. Punctate inner choroiditis, Vogt-Koyanagi-Harada disease and multifocal choroiditis are among the leading causes of uveitis entities resulting in iCNVs. The diagnosis and management of iCNVs still remain a challenge. Use of multimodal imaging techniques such as fluorescein angiography, indocyanine green angiography, optical coherence tomography (OCT) and OCT-angiography may be necessary for the diagnosis of iCNVs...
2020: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Chiara Giuffrè, Alessandro Marchese, Giovanni Fogliato, Elisabetta Miserocchi, Giulio Maria Modorati, Riccardo Sacconi, Maria Vittoria Cicinelli, Alexandra Miere, Francesca Amoroso, Vittorio Capuano, Eric Souied, Francesco Bandello, Giuseppe Querques
INTRODUCTION: To investigate choroidal thickness changes related to the clinical activity of inflammatory choroidal neovascularization in punctate inner choroidopathy/multifocal choroiditis as compared to myopic choroidal neovascularization. MATERIALS AND METHODS: Consecutive inflammatory choroidal neovascularization secondary to punctate inner choroidopathy/multifocal choroiditis, and myopic choroidal neovascularization were retrospectively reviewed. By means of enhanced-depth imaging optical coherence tomography, choroidal thickness was assessed at the same location before choroidal neovascularization development, at choroidal neovascularization onset (baseline), and after treatment...
April 28, 2020: European Journal of Ophthalmology
Ian Abban Thompson, Sonny Caplash, Marib Akanda, Osama Sabbagh, Ben Choan, Shuk K Cheng, Chinwenwa Okeagu, Hatice Nida Sen
Purpose : To describe the changes seen on optical coherence tomography angiography [OCTA] in patients with PIC following immunosuppressive therapy. Methods : We reviewed serial OCTA scans from five consecutive PIC patients (5 eyes) with at least 3 months of follow-up, who underwent imaging before and after immunosuppressive therapy. Using ImageJ, superficial and deep retinal vasculature were analyzed for vessel area and foveal avascular zone. Choriocapillaris layer was analyzed for flow signal loss. Results : Five out of five patients received an orbital floor triamcinolone acetonide injection as the initial treatment for periods of activity...
February 14, 2020: Ocular Immunology and Inflammation
Rose M Gilbert, Rachael L Niederer, Michal Kramer, Lazha Sharief, Yael Sharon, Asaf Bar, Sue Lightman, Oren Tomkins-Netzer
PURPOSE: To develop a robust approach to clinical phenotyping of multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC). DESIGN: Cross-sectional and longitudinal observational study. METHODS: This multicenter study included sites in the United Kingdom and Israel. The study population included 343 eyes of 185 subjects with hospital record diagnoses of MFC or PIC. Eyes were observed over a period of 5 years for clinically relevant characteristics, including demographics and multimodal imaging features, by observers masked to the original diagnoses...
May 2020: American Journal of Ophthalmology
Xuan Shi, Yi Cai, Xiangdong Luo, Shuting Liang, Philip J Rosenfeld, Xiaoxin Li
PURPOSE: To compare the characteristics of choroidal transmission in punctate inner choroidopathy (PIC) with or without choroidal neovascularization (CNV) and myopic CNV (mCNV) using spectral domain optical coherence tomography (SD-OCT). METHODS: This retrospective observational case series includes 22 consecutive myopic patients (22 eyes) recruited from April 2016 until April 2018 who complained of acute blurring of vision and showed evidence of hyper-reflective material on SD-OCT imaging...
January 6, 2020: Graefe's Archive for Clinical and Experimental Ophthalmology
San-Ni Chen, Yi-Ling Chen, Benjamin Chi-Lan Yang
Purpose: To report the long-term prognosis of punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) and associated zonal outer retinopathy (ZOR). Method: Retrospective study in patients with PIC/MFC and ZOR with a clinical follow-up of 4 years or longer. Results: There were 14 patients in this study (M: F = 11:3). All patients received systemic steroid therapy. The initial and final median logarithm of minimal angle of resolution of BCVA were 1.00 and 0.22 ( p = .002). Ellipsoid zone recovery was noted in all patients...
January 6, 2020: Ocular Immunology and Inflammation
Dominika Pohlmann, Sibylle Winterhalter, Uwe Pleyer
The white dot syndromes include a group of diseases which are characterized by multiple yellowish-white foci in the outer retina, retinal pigment epithelium, and choroid. For clinicians and researchers alike they present significant diagnostic and therapeutic challenges. White dot syndromes include primary inflammatory choriocapillaropathies, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE)/acute multifocal ischemic choriocapillaropathy (AMIC), multiple evanescent white dot syndrome (MEWDS)/acute idiopathic blind spot enlargement (AIBSE), multifocal choroiditis (MFC), punctate inner choroidopathy (PIC), serpiginous choroiditis (SC), acute zonal occult outer retinopathy (AZOOR), and acute macular neuroretinopathy (AMN)...
December 2019: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Rui Hua, Hong Ning
The present study aimed to investigate whether optical coherence tomography angiography (OCTA) could be used to guide the treatment of pathological myopic patients with submacular hemorrhage. Two pathological myopia patients with submacular hemorrhage were examined. Initially, choroidal neovascularization (CNV) was not observed during fundus angiography in both patients. However, based on OCTA, the first patient was diagnosed with myopic lacquer crack-related macular hemorrhage, and the second with CNV secondary to punctate inner choroidopathy...
August 27, 2019: Photodiagnosis and Photodynamic Therapy
Luis Arrevola, María Almudena Acero, María Jesús Peral
Punctate inner choroidopathy (PIC) is a rare inflammatory chorioretinopathy that predominantly affects young myopic women. Visual prognosis is generally good, but occurrence of choroidal neovascularization (CNV) is common and may be vision threatening. Case reports and short case series support the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) agents (ranibizumab and bevacizumab) for CNV associated with PIC given their anti-angiogenic and anti-inflammatory effects. Evidence concerning aflibercept, a more recent intravitreal anti-VEGF, is limited to a single case report...
January 2019: Case Reports in Ophthalmology
San-Ni Chen, Yi-Ling Chen, Benjamin Chi-Lan Yang
PURPOSE: To evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after intravitreal bevacizumab treatment. METHODS: Retrospective study of consecutive patients of PIC/MFC complicated with active CNV. Outcome measures included best-corrected visual acuity (BCVA), total number of intravitreal injections of bevacizumab and recurrence of CNV. Correlation analysis was performed to find the correlation of various clinical factors and final BCVA...
April 17, 2019: Ocular Immunology and Inflammation
Hidetaka Matsumoto, Ryo Mukai, Masahiro Morimoto, Shunsuke Tokui, Shoji Kishi, Hideo Akiyama
PURPOSE: To evaluate the clinical characteristics of pachydrusen in central serous chorioretinopathy (CSC) and investigate the relationship between choroidal circulation and pachydrusen. METHODS: In a retrospective case series of 302 eyes of 151 patients with treatment-naïve CSC, we assessed the incidence of pachydrusen and their features on indocyanine green angiography (ICGA) and optical coherence tomography (OCT). RESULTS: Pachydrusen were observed in 82 of the 302 eyes (27...
March 9, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Ji Hwan Lee, Sung Chul Lee, Seo Jin Park, Christopher Seungkyu Lee
PURPOSE: To describe the clinical features and outcomes of punctate inner choroidopathy (PIC) in Korean patients Methods: We retrospectively reviewed the medical records of patients with PIC between 2004 and 2015. The main outcome measures included best-corrected visual acuity (BCVA), presence of choroidal neovascularization (CNV), and optical coherence tomography findings. Patients with and without CNV were compared. RESULTS: Forty eyes of 26 patients were included...
December 14, 2018: Ocular Immunology and Inflammation
Dominika Pohlmann, Uwe Pleyer, Antonia M Joussen, Sibylle Winterhalter
PURPOSE: To report the effectiveness of treatment with antivascular endothelial growth factor (VEGF)-inhibitor and/or immunosuppressants in punctate inner choroidopathy (PIC) using standard imaging modalities and optical coherence tomography angiography (OCTA) over a time period of 16 months. METHODS: In this prospective, unmasked, single-centre study, 23 individuals with PIC underwent imaging with spectral domain OCT, fluorescein angiography, indocyanine green angiography and OCTA...
October 18, 2018: British Journal of Ophthalmology
Wei Wu, Shiying Li, Haiwei Xu, Yong Liu, Yi Wang, Timothy Y Y Lai, Zheng Qin Yin
Background: To evaluate the treatment outcomes of patients with punctate inner choroidopathy (PIC) and secondary choroidal neovascularization (CNV). Methods: This is a retrospective study of 24 eyes in 22 patients suffering from PIC with CNV. Patients were treated with intravitreal ranibizumab monotherapy (14 eyes) or combined oral corticosteroid and intravitreal ranibizumab therapy (corticosteroid-ranibizumab group, 10 eyes). Mean follow-up duration was 24.0 months...
2018: BioMed Research International
Aniruddha Agarwal, Alessandro Invernizzi, Rohan Bir Singh, William Foulsham, Kanika Aggarwal, Sabia Handa, Rupesh Agrawal, Carlos Pavesio, Vishali Gupta
Inflammatory choroidal neovascular membranes are challenging to diagnose and manage. A number of uveitic entities may be complicated by the development of choroidal neovascularization leading to a decrease in central visual acuity. In conditions such as punctate inner choroidopathy, development of choroidal neovascularization is extremely common and must be suspected in all cases. On the other hand, in patients with conditions such as serpiginous choroiditis, and multifocal choroiditis, it may be difficult to differentiate between inflammatory choroiditis lesions and choroidal neovascularization...
September 12, 2018: Journal of Ophthalmic Inflammation and Infection
Bing Liu, Xiongze Zhang, Yuting Peng, Lan Mi, Feng Wen
PURPOSE: To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients. METHODS: A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed. RESULTS: Of the 501 patients (537 eyes) with CNV, 58.7% were female, and 7.2% had bilateral CNV. The mean age was 35 years. The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21...
August 28, 2018: Ophthalmologica. Journal International D'ophtalmologie
Konstantinos T Tsaousis, Mohamed Nassr, Bharat Kapoor, Vasileios E Konidaris, Straton Tyradellis, Theo Empeslidis
Introduction: To present a case series of three female patients with punctate inner choroidopathy. We report the outcomes after an essentially long follow-up period of up to 14 years and provide evidence of the effectiveness of intravitreal injections of bevacizumab and dexamethasone 0.7 mg in punctate inner choroidopathy patients with choroidal neovascular membrane formation. Case series presentation: This is a retrospective case series of three female patients with punctate inner choroidopathy who were treated with intravitreal injections anti-vascular endothelial growth factor agent (bevacizumab, 1...
2018: SAGE Open Medical Case Reports
Dominika Pohlmann, Uwe Pleyer, Antonia M Joussen, Sibylle Winterhalter
AIMS: To characterise punctate lesions and choroidal neovascularisation (CNV) in eyes with punctate inner choroidopathy (PIC) using current standard multimodal imaging techniques and optical coherence tomography angiography (OCTA). METHODS: In our prospective, single-centre study, 20 individuals with PIC underwent imaging with spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), indocyanine green angiography, fundus autofluorescence, fundus colour photography and OCTA...
March 26, 2018: British Journal of Ophthalmology
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