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JOURNAL ARTICLE
Nicolas A Suarez, Izraelle I McKinnon, Kathleen H Krause, Catherine N Rasberry, Sanjana Pampati, J Michael Underwood
PURPOSE: Transgender youths (those whose gender identity differs from their sex assigned at birth) experience stigma and discrimination that can place them at increased risk for poor health outcomes compared with cisgender youths (those whose gender identity aligns with their sex assigned at birth). Limited population-based data exist on disparities among transgender and cisgender youths. METHODS: We examined differences in experiences of violence, substance use, mental health, suicide, sexual behavior, unstable housing, parental monitoring, and school connectedness among 98,174 transgender and cisgender high school students using data from 18 states that included an item to assess transgender identity on their 2021 Youth Risk Behavior Survey...
May 9, 2024: Annals of Epidemiology
#62
REVIEW
H A García-Perdomo, V Granados-Duque, P E Spiess
INTRODUCTION: The microbiota is defined as the microorganisms in a particular environment. Conversely, the term microbiome is less firmly defined and is used to reference the habitat. OBJECTIVE: To identify the association between the microbiome and the penile cancer EVIDENCE ACQUISITION: We performed this scoping review according to the recommendations of the Joanna Briggs Institute. We found five articles that fulfilled the inclusion criteria. We focused on oncogenesis and factors that alter the penile microbiome...
May 9, 2024: Actas urologicas españolas
#63
JOURNAL ARTICLE
Timothy W Menza, Stephen A Berry, Julia C Dombrowski, Edward Cachay, Heidi M Crane, Kenneth H Mayer
Among 8455 people engaged in HIV care in 4 US cities, 4925 (58%) had treponemal testing at care entry. Of the 4925 tested, 3795 (77%) had a nonreactive result and might benefit from the reverse algorithm for a future incident syphilis diagnosis. Furthermore, low-barrier treponemal testing as a first step in the reverse algorithm may increase syphilis screening and decrease time to treatment.
June 1, 2024: Sexually Transmitted Diseases
#64
EDITORIAL
Jack Sobel
No abstract text is available yet for this article.
June 1, 2024: Sexually Transmitted Diseases
#65
RANDOMIZED CONTROLLED TRIAL
Anke Hemmerling, Michael R Wierzbicki, Eric Armstrong, Craig R Cohen
OBJECTIVES: Live biotherapeutic products (LBPs) containing vaginal Lactobacillus crispatus are promising adjuvant treatments to prevent recurrent bacterial vaginosis (BV) but may depend on the success of initial antibiotic treatment. METHODS: A post hoc analysis of data collected during the phase 2b LACTIN-V randomized control trial (L. crispatus CTV-05) explored the impact of clinical BV cure defined as Amsel criteria 0 of 3 (excluding pH, per 2019 Food and Drug Administration guidance) 2 days after completion of treatment with vaginal metronidazole gel on the effectiveness of an 11-week LACTIN-V dosing regimen to prevent BV recurrence by 12 and 24 weeks...
June 1, 2024: Sexually Transmitted Diseases
#66
JOURNAL ARTICLE
Elliott Welford, Thomas C S Martin, Natasha K Martin, Winston Tilghman, Susan J Little
BACKGROUND: Standard-of-care nucleic acid amplification tests (routine NAATs) for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) can take several days to result and therefore delay treatment. Rapid point-of-care GC/CT NAAT (rapid NAAT) could reduce the time to treatment and therefore onward transmission. This study evaluated the incremental cost per infectious day averted and overall cost of implementation associated with rapid compared with routine NAAT. METHODS: Prospective sexually transmitted infection (STI) treatment data from men who have sex with men and transgender women in San Diego who received rapid NAAT between November 2018 and February 2021 were evaluated...
June 1, 2024: Sexually Transmitted Diseases
#67
JOURNAL ARTICLE
Julie M Buser, Marie Laetitia Ishimwe Bazakare, Gerard Kaberuka, Ella August, Madeleine Mukeshimana, Rachel Gray, Diomede Ntasumbumuyange, Faelan E Jacobson-Davies, Tamrat Endale, Olive Tengera, Yolanda R Smith
BACKGROUND: Addressing the gap between research and practice is crucial for enhancing reproductive healthcare outcomes. In Rwanda and other low- and middle-income countries, bolstering health researchers' implementation science (IS) capacity is essential. We present a pre-post-intervention study assessing the influence of an intensive IS training program on Rwandan reproductive health researchers' perceived IS knowledge and self-efficacy in applying IS in their own research. METHODS: To introduce IS principles, we held a one-day training for a diverse cohort of 25 sexual and reproductive health researchers in Rwanda...
May 7, 2024: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
#68
JOURNAL ARTICLE
Aimee K Huang, Tabor Hoatson, Payal Chakraborty, Sarah McKetta, Kodiak R S Soled, Colleen A Reynolds, Ulrike Boehmer, Alexis R Miranda, Carl G Streed, Shail Maingi, Sebastien Haneuse, Jessica G Young, Jae H Kang, S Bryn Austin, A Heather Eliassen, Brittany M Charlton
INTRODUCTION: Cancer risk factors are more common among sexual minority populations (e.g., lesbian, bisexual) than their heterosexual peers, yet little is known about cancer incidence across sexual orientation groups. METHODS: The 1989-2017 data from the Nurses' Health Study II, a longitudinal cohort of female nurses across the United States, were analyzed (N = 101,543). Sexual orientation-related cancer disparities were quantified by comparing any cancer incidence among four sexual minority groups based on self-disclosure-(1) heterosexual with past same-sex attractions/partners/identity; (2) mostly heterosexual; (3) bisexual; and (4) lesbian women-to completely heterosexual women using age-adjusted incidence rate ratios (aIRR) calculated by the Mantel-Haenszel method...
May 11, 2024: Cancer
#69
JOURNAL ARTICLE
Jakob Klemm, Daniel R Stelzl, Robert J Schulz, Phillip Marks, Shahrokh F Shariat, Margit Fisch, Roland Dahlem, Malte W Vetterlein
OBJECTIVE: To investigate long-term and patient-reported outcomes, including sexual function, in women undergoing urogenital fistula (UGF) repair, addressing the lack of such data in Western countries, where fistulas often result from iatrogenic causes. PATIENTS AND METHODS: We conducted a retrospective analysis at a tertiary referral centre (2010-2023), classifying fistulas based on World Health Organisation criteria and evaluating surgical approaches, aetiology, and characteristics...
May 11, 2024: BJU International
#70
JOURNAL ARTICLE
Carlos Abril-Pérez, Miguel Mansilla-Polo, Begoña Escutia-Muñoz, Onofre Sanmartín, Joan R Garcés, Manuel A Rodríguez-Prieto, Verónica Ruiz-Salas, Esther de Eusebio-Murillo, Román Miñano-Medrano, Beatriz González-Sixto, Juan L Artola-Igarza, Alberto Alfaro-Rubio, Pedro Redondo, Yolanda Delgado-Jiménez, Julia M Sánchez-Schmidt, Irati Allende-Markixana, María L Alonso-Pacheco, Beatriz García-Bracamonte, Pablo de la Cueva-Dobao, Raquel Navarro-Tejedor, Cristina Ciudad-Blanco, Lucía Carnero-González, Hugo Vázquez-Veiga, Natividad Cano-Martínez, Carlos Serra-Guillén, Eva Vilarrasa, Pedro Sánchez-Sambucety, José L López-Estebaranz, Ángeles Flórez-Menéndez, Antonio Martorell-Calatayud, Pilar Gil, Victoriano Morales-Gordillo, Agustí Toll, Izascun Ocerin-Guerra, Matías Mayor-Arenal, Ricardo Suárez-Fernández, Laura Sainz-Gaspar, Miguel A Descalzo, Ignacio Garcia-Doval, Rafael Botella-Estrada
BACKGROUND: Immunosuppressed (IS) patients, particularly solid organ transplant recipients and those on immunosuppressive therapy, face a higher incidence and recurrence of nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Mohs micrographic surgery (MMS) is the preferred treatment for high-risk NMSC due to its high cure rate and margin examination capabilities. However, IS patients may experience more complications, such as surgical site infections, and a greater risk of recurrence, making their outcomes a subject of interest...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#71
REVIEW
Haiyan Shi, Jun Du, Guifang Jin, Huayu Yang, Haiyun Guo, Guojing Yuan, Zhihui Zhu, Wenzhuo Xu, Sainan Wang, Hao Guo, Kele Jiang, Jiahu Hao, Ying Sun, Puyu Su, Zhihua Zhang
BACKGROUND: Human immunodeficiency virus (HIV) infection has become a major contributor to the global burden of disease. Globally, the number of cases of HIV continues to increase. Electronic health (eHealth) interventions have emerged as promising tools to support disease self-management among people living with HIV. The purpose of this umbrella review is to systematically evaluate and summarize the evidence and results of published systematic reviews and meta-analyses on the effectiveness of eHealth interventions for HIV prevention, testing and management...
May 11, 2024: International Journal of STD & AIDS
#72
JOURNAL ARTICLE
Matthias Augustin, Dominik Beier, Jennifer Branner, Dennis Häckl, Regina Hampel, Thomas Kramps, Hjalmar Kurzen, Hannah Lintener, Nima Melzer, Malina Müller, Petra Staubach, Uwe Schwichtenberg, Christian Termeer, Alexander Zink, Petra Nathan, Marcus Maurer
BACKGROUND AND STUDY AIM: Data from the AWARE study (A Worldwide Antihistamine-Refractory chronic urticaria patient Evaluation) illustrate a substantial disease burden in German patients with H1-antihistamine (-H1-AH)-refractory chronic spontaneous urticaria (CSU). Detrimental effects on patients' quality of life, poor disease control and impairment in the ability to work and perform other daily activities are reported. Based on these findings, this study aims to quantify the epidemiological and socio-economic burden of H1-AH-refractory CSU in Germany...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#73
JOURNAL ARTICLE
Alon Scope, Konstantinos Liopyris, Jochen Weber, Raymond L Barnhill, Ralph P Braun, Clara N Curiel-Lewandrowski, David E Elder, Gerardo Ferrara, Jane M Grant-Kels, Thiago Jeunon, Aimilios Lallas, Jennifer Y Lin, Michael A Marchetti, Ashfaq A Marghoob, Cristian Navarrete-Dechent, Giovanni Pellacani, Hans Peter Soyer, Alexander Stratigos, Luc Thomas, Harald Kittler, Veronica Rotemberg, Allan C Halpern
BACKGROUND: A common terminology for diagnosis is critically important for clinical communication, education, research and artificial intelligence. Prevailing lexicons are limited in fully representing skin neoplasms. OBJECTIVES: To achieve expert consensus on diagnostic terms for skin neoplasms and their hierarchical mapping. METHODS: Diagnostic terms were extracted from textbooks, publications and extant diagnostic codes. Terms were hierarchically mapped to super-categories (e...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#74
JOURNAL ARTICLE
Cailin Liu, Jing Yu, Chunguang Chen, Xiaogai Li, Yafei Ye, Yani Dong, Xinxin Ying, Haijun Li, Wanhai Wang
BACKGROUND: Recently, linezolid-resistant staphylococci have become an emerging problem worldwide. Understanding the mechanisms of resistance, molecular epidemiology and transmission of linezolid-resistant CoNS in hospitals is very important. METHODS: The antimicrobial susceptibilities of all isolates were determined by the microdilution method. The resistance mechanisms and molecular characteristics of the strains were determined using whole-genome sequencing and PCR...
May 10, 2024: BMC Infectious Diseases
#75
JOURNAL ARTICLE
Tamizhini Loganathan, John Fletcher, Priya Abraham, Rajesh Kannangai, Chiranjib Chakraborty, Achraf El Allali, Alsamman M Alsamman, Hatem Zayed, George Priya Doss C
BACKGROUND: Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets. METHODS: GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein-protein interaction (PPI) maps were built. The viral gene expression datasets of Monkeypox virus (MPXV) and Vaccinia virus (VACV) were used to identify the significant viral genes and further investigated for their binding to the library of targeting molecules...
May 10, 2024: BMC Infectious Diseases
#76
JOURNAL ARTICLE
Jules Mongane, Erick Hendwa, Dieudonné Sengeyi, Etienne Kajibwami, Freddy Kampara, Serge Chentwali, Claude Kalegamire, Isaac Barhishindi, Yvette Kujirakwinja, Jeanne Beija Maningo, Benjamin Kasago, Guy Mulinganya
BACKGROUND: Tubal factor infertility (TFI) is common in sub-Saharan Africa and often secondary to pelvic inflammatory disease (PID). Anaerobes associated with bacterial vaginosis (BV) are also found in PIDs widely dominated by Chlamydia trachomatis (C. trachomatis), whose role in TFI is better demonstrated than that of BV. OBJECTIVES: To determine the prevalence of BV and C. trachomatis and to investigate the association between BV, C. trachomatis and TFI. METHODS: We included 137 patients treated for infertility between January 2020 and November 2021...
May 10, 2024: BMC Infectious Diseases
#77
JOURNAL ARTICLE
Daniela Neudecker, Nora Fritisch, Thomas Sutter, Lenette Lu, Pei Lu, Marc Tebruegge, Begoña Santiago-Garcia, Nicole Ritz
BACKGROUND: Tuberculosis (TB) poses a major public health challenge, particularly in children. A substantial proportion of children with TB disease remain undetected and unconfirmed. Therefore, there is an urgent need for a highly sensitive point-of-care test. This study aims to assess the performance of serological assays based on various antigen targets and antibody properties in distinguishing children (0-18 years) with TB disease (1) from healthy TB-exposed children, (2) children with non-TB lower respiratory tract infections, and (3) from children with TB infection...
May 10, 2024: BMC Infectious Diseases
#78
JOURNAL ARTICLE
Yuxin Lin, Yifan Chen, Weiyin Lu, Yu Zhang, Rongqian Wu, Zhaoqing Du
BACKGROUND & AIMS: Pyogenic liver abscess (PLA) is a common hepatobiliary infection that has been shown to have an increasing incidence, with biliary surgery being identified as a trigger. Our aim was to investigate the clinical characteristics and treatments of PLA patients with and without a history of biliary surgery (BS). METHODS: The study included a total of 353 patients with PLA who received treatment at our hospital between January 2014 and February 2023...
May 10, 2024: BMC Infectious Diseases
#79
JOURNAL ARTICLE
Lin Wu, Jingshi Wang, Deli Song, Yahong You, Zhao Wang
BACKGROUND: Haemophagocytic lymphohistiocytosis (HLH) is a syndrome that occurs in patients with severe systemic hyperinflammation. GATA binding protein 2 (GATA2) is a transcription factor and key component in haematopoiesis and stem cell biology. CASE PRESENTATION: Three patients with HLH, one with Mycobacterium avium infection, one with Epstein-Barr virus (EBV) infection, and one with Mycobacterium kansasii infection, were all subsequently found to have a defect in the GATA2 gene through genetic testing...
May 10, 2024: BMC Infectious Diseases
#80
JOURNAL ARTICLE
Wei Zhuang, Tao He, Jianyekai Tuerheng, Guang He, Bao-Li Wang, Yi-Heng Yang, Lan Zhang, Xian-Zhe Dong, Sheng-Yan Xi
BACKGROUND: Neurobrucellosis (NB) is a rare and serious complication of brucellosis. Its clinical manifestations vary, with no obvious specificity. At present, there is no clear clinical diagnosis or treatment for reference. In this study, we retrospectively analyzed the clinical data for 21 patients with NB to provide reference data for its further study. METHODS: We analyzed the epidemiological and clinical manifestations, laboratory tests, imaging examinations, cerebrospinal fluid, and treatment plans of 21 patients diagnosed with NB in the Department of Neurology, Xuanwu Hospital, Capital Medical University Beijing, China...
May 10, 2024: BMC Infectious Diseases
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