Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Carlos A Pardo
OBJECTIVE: This article describes an integrative strategy to evaluate patients with suspected myelopathy, provides advice on diagnostic approach, and outlines the framework for the etiologic diagnosis of myelopathies. LATEST DEVELOPMENTS: Advances in diagnostic neuroimaging techniques of the spinal cord and improved understanding of the immune pathogenic mechanisms associated with spinal cord disorders have expanded the knowledge of inflammatory and noninflammatory myelopathies...
February 1, 2024: Continuum: Lifelong Learning in Neurology
#22
JOURNAL ARTICLE
Vicenç Ruiz de Porras, Adrià Bernat-Peguera, Clara Alcon, Fernando Laguia, Maria Fernández-Saorin, Natalia Jiménez, Ana Senan-Salinas, Carme Solé-Blanch, Andrea Feu, Mercedes Marín-Aguilera, Juan Carlos Pardo, Maria Ochoa-de-Olza, Joan Montero, Begoña Mellado, Albert Font
Background: Docetaxel remains the standard treatment for metastatic castration-resistant prostate cancer (mCRPC). However, resistance frequently emerges as a result of hyperactivation of the PI3K/AKT and the MEK/ERK pathways. Therefore, the inhibition of these pathways presents a potential therapeutic approach. In this study, we evaluated the efficacy of simultaneous inhibition of the PI3K/AKT and MEK/ERK pathways in docetaxel-resistant mCRPC, both in vitro and in vivo . Methods: Docetaxel-sensitive and docetaxel-resistant mCRPC cells were treated with selumetinib (MEK1/2 inhibitor), AZD8186 (PI3Kβ/δ inhibitor) and capivasertib (pan-AKT inhibitor) alone and in combination...
2024: Frontiers in Pharmacology
#23
JOURNAL ARTICLE
Manuel García-Ruiz, Pablo Mayo Rodríguez, Luca Palliotti, Clara Lastras, María Romeral-Jiménez, Irene García Morales, Cándido Pardo Rey, Marc Rodrigo-Gisbert, Daniel Campos-Fernández, Estevo Santamarina, Beatriz Parejo Carbonell
PURPOSE: There is insufficient evidence on the management of refractory status epilepticus (RSE) and super-RSE (SRSE). Ketamine is a N-methyl-d-aspartate receptor antagonist in the treatment of these entities. Our objectives were to study the effectiveness and safety of ketamine in the treatment of adult patients with RSE and SRSE, to determine the factors that can influence the response to ketamine, and to explore its use in patients without mechanical ventilation. METHODS: Adult patients who had received intravenous ketamine for the treatment of RSE or SRSE at Hospital Universitario Clínico San Carlos (Madrid, Spain) or Hospital Universitari Vall d'Hebron (Barcelona, Spain) from 2017 to 2023 were retrospectively analysed...
January 22, 2024: Seizure: the Journal of the British Epilepsy Association
#24
JOURNAL ARTICLE
Adela Rojas-Holguín, Constantino Fondevila-Campo, Alfonso Sanjuanbenito, Joan Fabregat-Prous, Luís Secanella-Medayo, Fernando Rotellar-Sastre, Fernando Pardo-Sánchez, Mikel Prieto-Calvo, Héctor Marín-Ortega, Santiago Sánchez-Cabús, Luis Diez-Valladares, Óscar Alonso-Casado, Carmen González-Serrano, Juan Carlos Rodríguez-Sanjuan, Gabriel García-Plaza, Isabel Jaén-Torrejimeno, Miguel Ángel Suárez-Muñoz, Antonio Becerra-Massare, Paula Senra-Del Rio, Elizabeth Pando, Rafael López-Andújar, Elena Muñoz-Forner, Mario Rodriguez-López, Fernando Pereira, Alejandro Serrablo-Requejo, Víctor Sánchez Turrión, Manuel Jiménez Garrido, Fernando Burdío, Elena Martín-Pérez, Rafael Estevan-Estevan, Diego López-Guerra, José Castell-Gómez, Javier Salinas-Gómez, José Ángel López-Baena, Santiago López-Ben, Lorena Solar-García, Alejandro J Pérez-Alonso, Luis Alberto Martínez-Insfran, Juan Luis Blas, Marian Cornejo, Alberto Gutierrez-Calvo, Carlos Domingo-Del Pozo, Federico Ochando-Cerdan, Luis Muñoz-Bellvís, José Rebollar-Saenz, Belinda Sánchez, José María Jover, Miguel Ángel Gómez-Bravo, José M Ramia, Gerardo Blanco-Fernández
BACKGROUND AND OBJECTIVES: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival. METHODS: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020...
January 27, 2024: Surgical Oncology
#25
JOURNAL ARTICLE
Paula Punzon-Jimenez, Alba Machado-Lopez, Raul Perez-Moraga, Jaime Llera-Oyola, Daniela Grases, Marta Galvez-Viedma, Mustafa Sibai, Elena Satorres-Perez, Susana Lopez-Agullo, Rafael Badenes, Carolina Ferrer-Gomez, Eduard Porta-Pardo, Beatriz Roson, Carlos Simon, Aymara Mas
Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we have constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopausal and postmenopausal women. We identify 23 myometrial cell subpopulations, including contractile and venous capillary cells as well as immune-modulated fibroblasts...
January 31, 2024: Nature Communications
#26
REVIEW
Jaime Fernandez-Sarmiento, Maria Camila Perez, Juan David Bustos, Lorena Acevedo, Mauricio Sarta-Mantilla, Jennifer Guijarro, Carlos Santacruz, Daniel Felipe Pardo, Daniel Castro, Yinna Villa Rosero, Hernando Mulett
BACKGROUND: In refractory respiratory failure (RF), extracorporeal membrane oxygenation (ECMO) is a salvage therapy that seeks to reduce lung injury induced by mechanical ventilation. The parameters of optimal mechanical ventilation in children during ECMO are not known. Pulmonary ventilatory management during this therapy may impact mortality. The objective of this study was to evaluate the association between ventilatory parameters in children during ECMO therapy and in-hospital mortality...
2024: Frontiers in Pediatrics
#27
JOURNAL ARTICLE
David F Rivas-Sánchez, Carlos H Gantiva-Q, Carolina Pardo-Díaz, Camilo Salazar, Stephen H Montgomery, Richard M Merrill
Vertical gradients in microclimate, resource availability, and interspecific interactions are thought to underly stratification patterns in tropical insect communities. However, only a few studies have explored the adaptive significance of vertical space use during the early stages of reproductive isolation. We analysed flight-height variation across speciation events in Heliconius butterflies, representing parallel colonizations of high-altitude forest. We measured flight-height in wild H. erato venus and H...
January 29, 2024: Journal of Evolutionary Biology
#28
REVIEW
Laura Pardo González, Martín Ruiz-Ortiz, Mónica Delgado, Sara Rodriguez, Rafael Villalba, Carlos Merino, Jaime Casares, Dolores Mesa, José Suarez de Lezo, Manuel Pan
OBJECTIVE: To describe long-term outcomes of the Ross procedure in a single center and retrospective series after 25 years follow-up. METHODS: From 1997-2019 we included all consecutive patients who underwent Ross procedure at our center. Clinical and echocardiographic evaluations were performed at least yearly. Echocardiographic valvular impairment was defined as at least moderate autograft or homograft dysfunction. Reintervention outcomes included surgical and percutaneous approach...
January 22, 2024: Current Problems in Cardiology
#29
JOURNAL ARTICLE
Joxmer Scott-Fras, Ernesto Gonzlez, Mara Jos Pardo, Rubn Torres, Janet Higuti, Sergio Cohuo, Carlos Lpez
Information on the known species diversity of the non-marine ostracods in Venezuela is compiled from the available literature. The review resulted in 34 species and two varieties, belonging to the superfamilies Cypridoidea and Cytheroidea. Of these, the presence of one species should be confirmed for the country. Furthermore, eight taxonomic entities classified with open nomenclature are mentioned. As additional contributions to the annotated list, georeferences of the records are included, as well as amendments in names and information for some localities...
November 13, 2023: Zootaxa
#30
REVIEW
Naira Figueiredo Deana, Yolanda Pardo, Montse Ferrer, Gerardo Espinoza-Espinoza, Olatz Garin, Patricia Muñoz-Millán, Claudia Atala-Acevedo, Àngels Pont, Margarita Cancino, Carlos Zaror
BACKGROUND: Older adults present a variety of oral diseases and conditions, in addition to co-morbidities and limited access to dental care, which significantly impact their oral health-related quality of life (OHRQoL). There are many instruments published to measure OHRQoL. However, it is challenging for clinicians and researchers to choose the best instrument for a given purpose. PURPOSE: To identify OHRQoL instruments available for older adults and summarize the evidence on the conceptual and measurement model, psychometric properties, interpretability, and administration issues of OHRQoL instruments available for older adults through a systematic review...
January 13, 2024: Health and Quality of Life Outcomes
#31
JOURNAL ARTICLE
Elena Zapata-Arriaza, Manuel Medina-Rodríguez, Francisco Moniche Álvarez, Asier de Albóniga-Chindurza, Marta Aguilar-Pérez, Leire Ainz-Gómez, Pablo Baena-Palomino, Aynara Zamora, Blanca Pardo-Galiana, Fernando Delgado-Acosta, Roberto Valverde Moyano, Elvira Jiménez-Gómez, Isabel Bravo Rey, Rafael Oteros Fernández, Irene Escudero-Martínez, Isabel Vielba-Gomez, Lluis Morales Caba, Jose Díaz Pérez, Estefania García Molina, Sonia Mosteiro, María Del Mar Castellanos Rodrigo, Laura Amaya Pascasio, Carlos Hidalgo, María Del Mar Freijo Guerrero, Eva González Díaz, Jose María Ramírez Moreno, Luis Fernández Prudencio, Mikel Terceño Izaga, Saima Bashir Viturro, Miguel Ángel Gamero-García, Silvia Jiménez Jorge, Clara Rosso Fernández, Joan Montaner, Alejandro González García
RATIONALE: In-stent reocclusion after endovascular therapy has a negative impact on outcomes in acute ischemic stroke (AIS) due to tandem lesions (TL). Optimal antiplatelet therapy approach in these patients to avoid in-stent reocclusion is yet to be elucidated. AIMS: To assess efficacy and safety of intravenous tirofiban versus intravenous aspirin in patients undergoing MT plus carotid stenting in the setting of AIS due to TL. SAMPLE SIZE ESTIMATES: Two hundred forty patients will be enrolled, 120 in every treatment arm...
January 9, 2024: Trials
#32
JOURNAL ARTICLE
Michele Simbolo, Giovanni Centonze, Anastasios Gkountakos, Valentina Monti, Patrick Maisonneuve, Stela Golovco, Giovanna Sabella, Alessandro Del Gobbo, Stefano Gobbo, Stefano Ferrero, Alessandra Fabbri, Carlotta Pardo, Giovanna Garzone, Natalie Prinzi, Sara Pusceddu, Adele Testi, Luigi Rolli, Alessandro Mangogna, Luisa Bercich, Mauro Roberto Benvenuti, Emilio Bria, Sara Pilotto, Alfredo Berruti, Ugo Pastorino, Carlo Capella, Maurizio Infante, Michele Milella, Aldo Scarpa, Massimo Milione
Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small cell lung cancer, adenocarcinoma (ADC), or squamous cell carcinoma (SCC). The available molecular information on this rare disease is limited. This study aimed to provide an integrated molecular overview of 16 cases evaluating the mutational asset of 409 genes and the transcriptomic profiles of 20,815 genes. Our data showed that TP53 was the most frequently inactivated gene (15/16; 93...
January 3, 2024: Virchows Archiv: An International Journal of Pathology
#33
JOURNAL ARTICLE
Marjorie R Levinstein, Paulo A De Oliveira, Nil Casajuana-Martin, Cesar Quiroz, Reece C Budinich, Rana Rais, William Rea, Emilya N Ventriglia, Natàlia Llopart, Verònica Casadó-Anguera, Estefanía Moreno, Donna Walther, Grant C Glatfelter, David Weinshenker, Carlos A Zarate, Vicent Casadó, Michael H Baumann, Leonardo Pardo, Sergi Ferré, Michael Michaelides
(R,S)-methadone ((R,S)-MTD) is a µ-opioid receptor (MOR) agonist comprised of (R)-MTD and (S)-MTD enantiomers. (S)-MTD is being developed as an antidepressant and is considered an N-methyl-D-aspartate receptor (NMDAR) antagonist. We compared the pharmacology of (R)-MTD and (S)-MTD and found they bind to MORs, but not NMDARs, and induce full analgesia. Unlike (R)-MTD, (S)-MTD was a weak reinforcer that failed to affect extracellular dopamine or induce locomotor stimulation. Furthermore, (S)-MTD antagonized motor and dopamine releasing effects of (R)-MTD...
December 25, 2023: Molecular Psychiatry
#34
JOURNAL ARTICLE
Carlos Medina-Saldivar, Sergio Cruz-Visalaya, Anzu Zevallos-Arias, Grace V E Pardo, Luis F Pacheco-Otálora
Major depressive disorder is the most common psychiatric disorder worldwide. To understand mechanisms and search for new approaches to treating depression, animal models are crucial. Chronic mild stress (CMS) is the most used animal model of depression. Although CMS is considered a robust model of depression, conflicting results have been reported for emotion-related behaviors, which the intrinsic characteristics of each rodent strain could explain. To further shed light on the impact of genetic background on the relevant parameters commonly addressed in depression, we examined the effect of 4-weeks CMS on anxiety and depression-related behaviors and body weight gain in three strain mice (BALB/c, C57BL/6, and CD1) of both sexes...
December 21, 2023: Behavioural Brain Research
#35
JOURNAL ARTICLE
Sofía Tesolato, Juan Vicente-Valor, Jose-Ramón Jarabo, Joaquín Calatayud, Melchor Sáiz-Pardo, Asunción Nieto, Dolores Álvaro-Álvarez, María-Jesús Linares, Carlos-Alfredo Fraile, Florentino Hernándo, Pilar Iniesta, Ana-María Gómez-Martínez
Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, with idiopathic pulmonary fibrosis (IPF) being one of the most frequent. Telomere length (TL) shortening causes loss of function of the lung parenchyma. However, little is known about its role as a prognostic factor in ILD patients. With the aim of investigating the role of TL and telomerase activity in the prognosis of patients affected by ILDs, we analysed lung tissue samples from 61 patients. We measured relative TL and telomerase activity by conventional procedures...
December 8, 2023: Biomedicines
#36
Juan-Miguel Gil-Jaurena, Carlos Pardo, Ana Pita, Ramón Perez-Caballero
A 14-year-old girl was scheduled for pulmonary valve replacement. A computed tomography scan showed an enlarged cardiac silhouette with an aneurysmal pulmonary artery. A less-invasive approach through the left axilla with peripheral cannulation was selected. The patient was draped in the decubitus position, with a roll under the left shoulder and the left arm over the head. The anatomical landmarks were the left nipple and the tip of the scapula. A 5-cm vertical incision in the mid-axillary line was performed, and the thorax was entered through the fourth intercostal space...
December 18, 2023: Multimedia Manual of Cardiothoracic Surgery: MMCTS
#37
JOURNAL ARTICLE
Cristian E Cadena-Caballero, Nestor Munive-Argüelles, Lina M Vera-Cala, Carlos Barrios-Hernandez, Ruben O Duarte-Bernal, Viviana L Ayus-Ortiz, Luis A Pardo-Díaz, Mayra Agudelo-Rodríguez, Lola X Bautista-Rozo, Laura R Jimenez-Gutierrez, Francisco Martinez-Perez
In the year 2002, DNA loss model (DNA-LM) postulated that neuropeptide genes to emerged through codons loss via the repair of damaged DNA from ancestral gene namely Neuropeptide Precursor Predictive (NPP), which organization correspond two or more neuropeptides precursors evolutive related. The DNA-LM was elaborated according to amino acids homology among LWamide, APGWamide, red pigment-concentrating hormone (RPCH), adipokinetic hormones (AKHs) and in silico APGW/RPCH NPPAPGW/AKH NPP were proposed. With the above principle, it was proposed the evolution of corazonin (CRZ), gonadotropin-releasing hormone (GnRH), AKH, and AKH/CRZ (ACP), but any NPP never was considered...
December 16, 2023: Journal of Molecular Evolution
#38
JOURNAL ARTICLE
Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S Perlmutter, John C Morris, Carlos Cruchaga, Juan A Botia, Laura Ibanez
There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer's disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic blood-based biomarkers composed by a scalable number of transcripts that capture AD pathobiology even in the presymptomatic stages of the disease. Accuracies are in the range of the current CSF and plasma biomarkers, and specificities are high against other neurodegenerative diseases.
December 15, 2023: IScience
#39
JOURNAL ARTICLE
Description of clinical and genetic features of 122 patients included in the Spanish Pompe registry.
Rafael Jenaro Martinez-Marin, David Reyes-Leiva, Andrés Nascimento, Nuria Muelas, C Dominguez-González, Carmen Paradas, Montse Olivé, Mar García-Romero, Samuel Ignacio Pascual-Pascual, Josep Maria Grau, Miguel Angel Barba-Romero, Maria Teresa Gomez-Caravaca, Javier de Las Heras, Pilar Casquero, Maria Dolores Mendoza, Juan Carlos de León, Antonio Gutierrez, Germán Morís, Raquel Blanco-Lago, Alba Ramos-Fransi, Guillem Pintós, Maria José García-Antelo, Maria Rabasa, Yolanda Morgado, Mercedes Usón, Francisco Javier Miralles, Jose Eulalio Bárcena-Llona, Ana Belén Gómez-Belda, Maria Isabel Pedraza-Hueso, Miryam Hortelano, Antoni Colomé, Guillermina Garcia-Martin, Adolfo Lopez de Munain, Ivonne Jericó, Lucía Galán-Dávila, Julio Pardo, Giorgina Salgueiro-Origlia, Jorge Alonso-Pérez, Francesc Pla-Junca, Marianela Schiava, Sonia Segovia-Simón, Jordi Díaz-Manera
Pompe disease is a rare genetic disorder with an estimated prevalence of 1:60.000. The two main phenotypes are Infantile Onset Pompe Disease (IOPD) and Late Onset Pompe Disease (LOPD). There is no published data from Spain regarding the existing number of cases, regional distribution, clinical features or, access and response to the treatment. We created a registry to collect all these data from patients with Pompe in Spain. Here, we report the data of the 122 patients registered including nine IOPD and 113 LOPD patients...
January 2024: Neuromuscular Disorders: NMD
#40
JOURNAL ARTICLE
Anaïs Redruello-Romero, Maria S Benitez-Cantos, David Lopez-Perez, Jesús García-Rubio, Francisco Tamayo, Daniel Pérez-Bartivas, Sara Moreno-SanJuan, Isabel Ruiz-Palmero, Jose D Puentes-Pardo, Jose R Vilchez, Miguel Á López-Nevot, Federico García, Carlos Cano, Josefa León, Ángel Carazo
INTRODUCTION: Cytomegalovirus (CMV) is a common herpesvirus with a high prevalence worldwide. After the acute infection phase, CMV can remain latent in several tissues. CD8 T cells in the lungs and salivary glands mainly control its reactivation control. White adipose tissue (WAT) contains a significant population of memory T cells reactive to viral antigens, but CMV specificity has mainly been studied in mouse WAT. Therefore, we obtained blood, omental WAT (oWAT), subcutaneous WAT (sWAT), and liver samples from 11 obese donors to characterize the human WAT adaptive immune landscape from a phenotypic and immune receptor specificity perspective...
2023: Frontiers in Immunology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
