William Robert Kwapong, Fei Tang, Peng Liu, Ziyi Zhang, Le Cao, Zijuan Feng, Shiyun Yang, Yang Shu, Heng Xu, Ying Lu, Xinjun Zhao, Baochen Chong, Bo Wu, Ming Liu, Peng Lei, Shuting Zhang
INTRODUCTION: This study addresses the urgent need for non-invasive early-onset Alzheimer's disease (EOAD) prediction. Using optical coherence tomography angiography (OCTA), we present a choriocapillaris model sensitive to EOAD, correlating with serum biomarkers. METHODS: Eighty-four EOAD patients and 73 controls were assigned to swept-source OCTA (SS-OCTA) or the spectral domain OCTA (SD-OCTA) cohorts. Our hypothesis on choriocapillaris predictive potential in EOAD was tested and validated in these two cohorts...
May 15, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association