Daniela Wetzel, Zavier A Carter, Marcos P Monteiro, Adrianne N Edwards, Christopher D Scharer, Shonna M McBride
Clostridioides difficile is an anaerobic gastrointestinal pathogen that spreads through the environment as dormant spores. To survive, replicate, and sporulate in the host intestine, C. difficile must adapt to a variety of conditions in its environment, including changes in pH, the availability of metabolites, host immune factors, and a diverse array of other species. Prior studies showed that changes in intestinal conditions, such as pH, can affect C. difficile toxin production, spore formation, and cell survival...
February 12, 2024: Infection and Immunity