Charlotte Reichardt, Sabine Brandt, Anja Bernhardt, Anna Krause, Jonathan A Lindquist, Sönke Weinert, Robert Geffers, Tobias Franz, Sascha Kahlfuss, Anne Dudeck, Akash Mathew, Rajiv Rana, Berend Isermann, Peter R Mertens
DNA-binding protein-A (DbpA; gene: Ybx3) belongs to the cold shock protein family with known functions in cell cycling, transcription, translation, and tight junction communication. In chronic nephritis, DbpA is upregulated. However, its activities in acute injury models, such as kidney ischemia/reperfusion injury (IRI), are unclear. To study this, mice harboring Ybx3+/+ , Ybx3+/- or the Ybx3-/ - genotype were characterized over 24 months and following experimental kidney IRI. Mitochondrial function, number and integrity were analyzed by mitochondrial stress tests, MitoTracker staining and electron microscopy...
May 29, 2024: Kidney International