Qian-Rong Huang, Qian Jiang, Ju-Yuan Tan, Ren-Bao Nong, Jun Yan, Xia-Wei Yang, Li-Gen Mo, Guo-Yuan Ling, Teng Deng, Yi-Zhen Gong
Background: Previous studies have shown that MCM3 plays a key role in initiating DNA replication. However, the mechanism of MCM3 function in most cancers is still unknown. The aim of our study was to explore the expression, prognostic role, and immunological characteristics of MCM3 across cancers. Methods: We explored the expression pattern of MCM3 across cancers. We subsequently explored the prognostic value of MCM3 expression by using univariate Cox regression analysis. Spearman correlation analysis was performed to determine the correlations between MCM3 and immune-related characteristics, mismatching repair (MMR) signatures, RNA modulator genes, cancer stemness, programmed cell death (PCD) gene expression, tumour mutation burden (TMB), microsatellite instability (MSI), and neoantigen levels...
2024: Frontiers in Pharmacology