Stomach cancer

Tsutomu Hayashi, Takaki Yoshikawa, Ayako Kamiya, Keichi Date, Takayuki Wada, Sho Otsuki, Yukinori Yamagata, Hitoshi Katai, Toshirou Nishida
BACKGROUND: Splenectomy for dissecting splenic hilar lymph nodes (#10) should be avoided for most gastric cancer, considering the high morbidity and lack of any survival benefit, but it is often selected for scirrhous gastric cancer because this type frequently invades the whole stomach and lymph nodes. Splenectomy is necessary for dissecting #10; however, the survival benefit of dissecting #10 is unclear. METHODS: Patients who had scirrhous gastric cancer and underwent D2 total gastrectomy with splenectomy at National Cancer Center Hospital, Japan, between 2000 and 2011 were retrospectively analyzed...
March 24, 2020: Gastric Cancer
Alexey Moisseev, Eugene Albert, Dan Lubarsky, David Schroeder, Jeffrey Clark
Gastric cancer is globally the fifth leading cause of cancer death. We present a case report describing the unique genomic characteristics of an Epstein-Barr virus-negative gastric cancer with esophageal invasion and regional lymph node metastasis. Genomic tests were performed first with the stomach biopsy using platforms FoundationOne, OncoDNA, and Oncopanel at Dana Farber Institute. Following neoadjuvant chemotherapy, residual tumor was resected and the stomach and esophageal residual tumor samples were compared with the initial biopsy by whole exome sequencing and molecular pathway analysis platform Oncobox...
March 23, 2020: Biomedicines
Akihiro Fujimoto, Masashi Fujita, Takanori Hasegawa, Jing Hao Wong, Kazuhiro Maejima, Aya Oku-Sasaki, Kaoru Nakano, Yuichi Shiraishi, Satoru Miyano, Go Yamamoto, Kiwamu Akagi, Seiya Imoto, Hidewaki Nakagawa
Microsatellites are repeats of 1- to 6-bp units, and approximately 10 million microsatellites have been identified across the human genome. Microsatellites are vulnerable to DNA mismatch errors and have thus been used to detect cancers with mismatch repair deficiency. To reveal the mutational landscape of microsatellite repeat regions at the genome level, we analyzed approximately 20.1 billion microsatellites in 2717 whole genomes of pan-cancer samples across 21 tissue types. First, we developed a new insertion and deletion caller (MIMcall) that takes into consideration the error patterns of different types of microsatellites...
March 24, 2020: Genome Research
Tyson A Moore, Yahya Al-Habbal, Julian M Choi
Intussusception is defined as the invagination of one part of the gastrointestinal tract into another. Jejunogastric intussusception is a rare phenomenon following major upper abdominal surgery, where its aetiology is not well understood. We describe a 68-year-old woman who presented with abdominal pain and haematemesis on the background of a previous pancreaticoduodenectomy (Whipple procedure) for pancreatic cancer. Gastroscopy demonstrated retrograde jejunogastric intussusception, where part of the efferent jejunal limb had prolapsed into the remnant stomach...
March 24, 2020: BMJ Case Reports
Hui Zhao, Jianhua Chen
BACKGROUND: Lymphoepithelioma-like carcinoma, an uncommon epithelial tumor, is mostly originated form the nasopharynx and also occurs in foregut-derived organs, such as lung, stomach, salivary gland, and thymus. Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype accounting for around 0.9% of non-small cell lung cancer (NSCLC). We aimed to evaluate clinicopathological features, treatment modalities, and prognosis of PPLELC. METHODS: In the current study, a retrospective analysis on 8 patients diagnosed with PPLELC at Hunan Cancer Hospital between October 2013 and June 2016 was conducted with respect to their clinical characteristics and outcomes, in order to deeply investigate this rare subtype of lung cancer...
March 20, 2020: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Y Kano, M Ohashi, S Ida, K Kumagai, T Sano, N Hiki, S Nunobe
BACKGROUND: Laparoscopic proximal gastrectomy with double-flap technique (LPG-DFT) and laparoscopic subtotal gastrectomy (LSTG) may replace laparoscopic total gastrectomy (LTG) for proximal early gastric cancer. The aim of this study was to evaluate short- and long-term outcomes after LPG-DFT and LSTG. METHODS: Patients who underwent LPG-DFT or LSTG at the Cancer Institute Hospital in Tokyo between January 2006 and April 2015 were included in this retrospective study...
April 2020: BJS Open
Jesse J Balic, Mohamed I Saad, Ruby Dawson, Alice J West, Louise McLeod, Alison C West, Kimberley D'Costa, Virginie Deswaerte, Anouk Dev, William Sievert, Daniel J Gough, Prithi S Bhathal, Richard L Ferrero, Brendan J Jenkins
Gastric cancer is associated with chronic inflammation (gastritis) triggered by infection with the Helicobacter pylori (H. pylori) bacterium. Elevated tyrosine phosphorylation (pY) of the latent transcription factor STAT3 is a feature of gastric cancer, including H. pylori-infected tissues, and is aligned to nuclear transcriptional activity. By contrast, the transcriptional role of STAT3 serine phosphorylation (pS), which promotes STAT3-driven mitochondrial activities, is unclear. Here, by coupling pS-STAT3-deficient Stat3SA/SA mice with chronic H...
March 19, 2020: American Journal of Pathology
Hisashi Doyama, Hiroyoshi Nakanishi, Kenshi Yao
In recent years, the technological innovation and progress of endoscopic equipment have been remarkable, and various endoscopic observation techniques have been developed. Among them, representative techniques are magnified observation and narrow-band imaging. Magnifying endoscopy with narrow-band imaging (M-NBI) can visualize superficial microanatomies in the stomach. The normal morphology of the microanatomy visualized using M-NBI differs according to the part of the stomach. The vessel plus surface (VS) classification system has been developed as a diagnostic criterion for early gastric cancer using M-NBI, and its usefulness has been proven...
March 25, 2020: Gut and Liver
Shuanghua Xie, Shaoming Wang, Liyan Xue, Daniel R S Middleton, Chentao Guan, Changqing Hao, Jinwu Wang, Bianyun Li, Ru Chen, Xinqing Li, Wenqiang Wei
Background: Helicobacter pylori (H. pylori) is widely accepted to be the most important cause of gastric non-cardia adenocarcinoma (GNCA), while its role in the development of gastric cardia adenocarcinoma (GCA) is not well-defined. We aimed to investigate current H. pylori infection in relation to the severity of both precancerous and cancerous lesions of the gastric cardia in an Asian population at high risk of GCA. Methods: A population-based cross-sectional study was conducted in Linzhou County, Henan Province, China...
2020: Frontiers in Oncology
Andreea D Stuparu, Catherine A L Meyer, Susan L Evans-Axelsson, Katharina Lückerath, Liu H Wei, Woosuk Kim, Soumya Poddar, Christine E Mona, Magnus Dahlbom, Mark D Girgis, Caius G Radu, Johannes Czernin, Roger Slavik
225 Ac-PSMA-617 targeted-therapy has demonstrated efficacy in 75-85% of patients; however, responses are not durable. We aimed to establish translatable mouse models of disseminated prostate cancer (PCa) to evaluate effectiveness of 225 Ac-PSMA-617 at various disease stages. Methods : C4-2, C4-2B, or 22Rv1 cells were injected into the left ventricle of male NSG mice. Disease progression was monitored using bioluminescence imaging (BLI). For treatment, mice were injected with 40 kBq 225 Ac-PSMA-617 at one (early treatment cohort) or three weeks (late treatment cohort) post-inoculation...
2020: Theranostics
Gil Chun Park, Shin Hwang, Chul Soo Ahn, Ki Hun Kim, Deok Bog Moon, Tae Yong Ha, Gi Won Song, Dong Hwan Jung, Young In Yoon, Hui Dong Cho, Jae Hyun Kwon, Yong Kyu Chung, Sang Hyun Kang, Jin Uk Choi, I Ji Jung, Sung Gyu Lee
BACKGROUND: Hepatocellular carcinoma (HCC) recurrence and development of de novo malignancy (DNM) after liver transplantation (LT) are the major causes of late recipient death. METHODS: We analyzed the incidence of extrahepatic DNM following living donor LT according to the status of pretransplant hepatic malignancy. We selected 2,076 adult patients who underwent primary LDLT during 7 years from January 2010 to December 2016. RESULTS: The pretransplant hepatic malignancy group (n = 1,012) showed 45 cases (4...
March 23, 2020: Journal of Korean Medical Science
Jumpei Shibata, Motoi Yoshihara, Takehito Kato
BACKGROUND: Distal gastrectomy with lymph node dissection, a standard operative technique for gastric cancer treatment, is safely performed because the stomach has a rich vascular supply. Gastric remnant necrosis caused by cholesterol crystal embolization following distal gastrectomy has not been described previously. We report a case of gastric remnant necrosis in a patient with cholesterol crystal embolization. CASE PRESENTATION: A 70-year-old man with a history of cholesterol crystal embolization presented to our surgery department with complaints of anorexia and dysphasia...
March 19, 2020: BMC Surgery
Young Ae Kim, Ye-Rin Lee, Jeongjoo Park, In-Hwan Oh, Hoseob Kim, Seok-Jun Yoon, Keeho Park
Purpose: Though the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to gender and age. Materials and Methods: A prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients...
March 18, 2020: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Motoki Nishimura, Nagara Tamaki, Shigenori Matsushima, Maki Kiba, Tomoya Kotani, Chisa Bamba, Yasunori Nakamura, Kei Yamada
PURPOSE: Serial assessment of visual change in 18 F-FDG uptake on whole-body 18 F-FDG PET imaging was performed to differentiate pathological uptake from physiological uptake in the urinary and gastrointestinal tracts. METHODS: In 88 suspected cancer patients, serial 3-min dynamic whole-body PET imaging was performed four times, from 60 min after 18 F-FDG administration. In dynamic image evaluation, high 18 F-FDG uptake was evaluated by two nuclear medicine physicians and classified as "changed" or "unchanged" based on change in uptake shape over time...
March 18, 2020: European Journal of Nuclear Medicine and Molecular Imaging
Fangmei Chen, Xiaoying Yin, Yanqing Wang, Yixin Lv, Si Sheng, Sheng Ouyang, Youquan Zhong
Cytisine N-methylene-(5,7-dihydroxy-4'-methoxy)-isoflavone (CNF2) is a new compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary pharmacodynamic studies demonstrated its activity in inhibiting breast cancer cell metastasis. This study examined the pharmacokinetics, absolute bioavailability, and tissue distribution of CNF2 in rats, and combined computer-aided technology to predict the druggability of CNF2. The binding site of CNF2 and the breast cancer target HER2 were examined with molecular docking technology...
March 19, 2020: Biological & Pharmaceutical Bulletin
B S Jiang, P T Yao, Y B Ge, M Yang, X Sun, J S Ren, W Q Chen, M Dai, J Li, N Li
Objective: To systematically evaluate the quality of gastric cancer screening guidelines/recommendations, and provide a reference for the update of gastric cancer screening guidelines/recommendations in China. Methods: "guidelines/consensus/specifications/standards" , "stomach/gastric tumors" , "screening/diagnosis" , "guideline/recommendation" , "gastric cancer/gastric tumor," "early detection of cancer/screening" were searched as keywords in PubMed, Embase, Web of knowledge, China Knowledge Network, Wanfang, China Biomedical Literature Database, and Cochrane Library, as well as the US Preventive Services Working Group, the American Cancer Society, the International Agency for Research on Cancer, the Australia Cancer Council and the International Guide Collaboration Network at the end of July 2018...
March 6, 2020: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
J F Shi, A Y Mao, Y N Bai, G X Liu, C C Liu, H Wang, M M Cao, H Feng, L Wang, F Z Bai, H Y Huang, H J Bai, J Zhu, X X Yan, J Zhang, J S Ren, N Li, M Dai, W Q Chen
Objective: The existed economic evaluations of cancer screening in Chinese population are almost all single-cancer focused, evidence on parallel comparison among multiple cancers is lacking. Thus, the aim of this study was, from a priority setting perspective, to compare the cost-effectiveness of six common cancers(colorectal cancer, breast cancer, liver cancer, lung cancer, esophageal cancer and stomach cancer) to facilitate policy making in future scaled-up screening in populations in China. Methods: Partially based on our previous single-cancer systematic reviews (colorectal cancer, breast cancer, liver cancer, and lung cancer), evidence of economic evaluations of cancer screening in populations in mainland China were systematically updated and integrated...
March 6, 2020: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Xin Deng, Xingqiu Liang, Xiaoxiao Zhou, Manjun Jiang, Xiaofang Zhao, Lei Fu, Mingkun Liang, Xinyuan Wang, Jian Liang
OBJECTIVE: To investigate the protective effect and molecular mechanisms of Weining granule on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer in rats. METHODS: A total of sixty healthy male wistar rats were randomly divided into five groups, including control group (CG), gastric cancer model group (MG), low-dose Weining granule treated group (LWT), medium-dose Weining granule treated group (MWT), and high-dose Weining granule treated group (HWT)...
June 2019: Journal of Traditional Chinese Medicine
Min Dai, Ting Ma, Ying Niu, Mengmeng Zhang, Zhiwu Zhu, Shaomin Wang, Hongmin Liu
GC/MS coupled metabolomics analysis, using a simplified and much less expensive silylation process with trimethylsilyl cyanide (TMSCN), was conducted to investigate metabolic abnormalities in stomach cancer cells. Under optimized conditions for derivatization by TMSCN and methanol extraction, 228 metabolites were detected using GC/MS spectrometry analysis, and 89 metabolites were identified using standard compounds and the NIST database. Ten metabolite levels were found to be lower in stomach cancer cells relative to normal cells...
March 18, 2020: Analytical and Bioanalytical Chemistry
Junya Aoyama, Shinichi Sakuramoto, Yutaka Miyawaki, Misato Ito, Sunao Ito, Kenji Watanabe, Shuichiro Oya, Naoto Fujiwara, Hirofumi Sugita, Kouichi Nonaka, Hiroshi Sato, Masanori Yasuda, Shigeki Yamaguchi
BACKGROUND: Additional surgery is recommended for patients with noncurative resection after endoscopic submucosal dissection (ESD) for early gastric cancer. Additional resection requires the excision of an area larger than that of the resected mucosa in ESD, which is larger than the lesion, with convergence of the gastric mucosa due to scarring. Thus, the selection of the surgical procedure for lesion removal in specific areas can be affected by ESD. This study therefore aimed to evaluate the impact of ESD on the selection of additional gastrectomy in patients with early gastric cancer in the boundary area between the upper third and middle third of the stomach (UM boundary region)...
March 16, 2020: Gastric Cancer
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