Stomach cancer

Itaru Yasufuku, Manabu Ohashi, Kojiro Eto, Satoshi Ida, Koshi Kumagai, Souya Nunobe, Takeshi Sano, Naoki Hiki
BACKGROUND: The application of laparoscopic subtotal gastrectomy (LsTG) in the management of early gastric cancer located in the upper third of the stomach creates an extremely small remnant stomach (SRS). However, it is unclear whether retaining such an SRS improves patients' postoperative outcomes in a similar manner to a conventional remnant stomach (CRS). METHODS: Four hundred and nine of 878 patients undergoing laparoscopic distal gastrectomy (LDG) between 2006 and 2012 underwent Roux-en-Y reconstruction...
January 16, 2020: Surgical Endoscopy
Stefan Mönig, Katja Ott, Ines Gockel, Dietmar Lorenz, Kaja Ludwig, Helmut Messmann, Markus Moehler, Pompiliu Piso, Arved Weimann, Hans-Joachim Meyer
No abstract text is available yet for this article.
January 16, 2020: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Hiromi Nagata, Takahiro Einama, Mayumi Hoshikawa, Toshimitsu Iwasaki, Yoichi Miyata, Makoto Nishikawa, Akifumi Kimura, Takuji Noro, Sho Ogata, Suefumi Aosasa, Koichi Okamoto, Yoshiki Kajiwara, Eiji Shinto, Yoshihisa Yaguchi, Hironori Tsujimoto, Kazuo Hase, Hideki Ueno, Yoji Kishi, Junji Yamamoto
The Japanese guideline for gastroenteropancreatic neuroendocrine tumor treatment recommends everolimus or sunitinib as first-line treatment for unresectable pancreatic neuroendocrine tumors (PNETs). Streptozocin (STZ) is recommended as an alternative. We encountered a patient with PNET who had multiple liver metastases and who showed a remarkable response to third-line STZ. The patient was a 50-year-old man with a pancreatic head tumor 32 mm in diameter. We planned to perform subtotal stomach-preserving pancreaticoduodenectomy, but abandoned resecting the pancreas during the surgery upon discovering a small liver tumor 3 mm in diameter, examination of frozen sections of which revealed a poorly differentiated adenocarcinoma...
January 2020: International cancer conference journal
Rodney E Wegner, Vivek Verma, Shaakir Hasan, Suzanne Schiffman, Shyam Thakkar, Zachary D Horne, Abhijit Kulkarni, H Kenneth Williams, Dulabh Monga, Gene Finley, Alexander V Kirichenko
Background: The only potentially curative approach for pancreatic cancer is surgical resection, but this technically challenging procedure carries risks for postoperative morbidities and mortality. This study of a large, contemporary national database illustrates incidences of, and risk factors for, post-procedural mortality, prolonged hospital stay, and 30-day readmission. Methods: From the National Cancer Database (NCDB), stage I-III pancreatic adenocarcinomas were identified [2004-2015]...
December 2019: Journal of Gastrointestinal Oncology
Tao Jiang, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou
ARID1A alterations would compromise mismatch repair pathway and increase the number of tumor-infiltrating lymphocytes and PD-L1 expression in some cancers, which would cooperate with immune checkpoint inhibitors (ICIs) treatment. However, a comprehensive analysis of ARID1A alteration frequency and its predictive value for ICI treatment outcome in cancers has not yet been investigated. Hence, we performed this pan-cancer analysis to evaluate the prevalence and predictive value of ARID1A alterations across >40,000 cases in multiple cancer types...
2020: Journal of Cancer
Annie Kanchan Baa, Ramavath Dev Naik, Ilavarasi Vanidassane, Saurabh Arora, Shamim Ahmed Shamim, Saumyaranjan Mallick, Atul Batra
Triple-negative breast cancer (TNBC) accounts for 20%-25% of breast cancer cases. Around 10%-15% of patients with breast cancer present with upfront metastasis. Lymph node, bone, and liver are common sites of metastasis in hormone-positive breast cancer while brain, lungs, and liver in TNBC. Although visceral metastasis is common in TNBC, metastasis to stomach is unusual. Morphological similarity of primary gastric carcinoma and lobular invasive breast carcinoma often leads to misdiagnosis. Meticulous review of histopathology and immunohistochemistry is essential for diagnosis...
January 2020: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Ayako Okuyama, Takahiro Higashi
Valid data are required to monitor and measure the quality of cancer treatment. This study aims to assess the usability of diagnosis procedure combination (DPC) survey discharge summary data. DPC survey data were analyzed by linking them to the hospital-based cancer registries (HBCR) from 231 hospitals. We focused on patients who were aged 20 years or older and diagnosed in 2013 with stomach, colorectal, liver, lung, or breast cancer. We assessed the percentage of unknown/missing values in supplementary data for patients with five common cancers and compared DPC cancer stage information to that of HBCR...
January 14, 2020: International Journal of Environmental Research and Public Health
Aji Resindra Widya, Yusuke Monno, Kosuke Imahori, Masatoshi Okutomi, Sho Suzuki, Takuji Gotoda, Kenji Miki
Gastric endoscopy is a common clinical practice that enables medical doctors to diagnose the stomach inside a body. In order to identify a gastric lesion's location such as early gastric cancer within the stomach, this work addressed to reconstruct the 3D shape of a whole stomach with color texture information generated from a standard monocular endoscope video. Previous works have tried to reconstruct the 3D structures of various organs from endoscope images. However, they are mainly focused on a partial surface...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Chen Huang, Fengrong Yu, Gang Zhao, Xiang Xia
BACKGROUND: This study aimed to investigate the postoperative quality of life (QOL) between laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) and laparoscopy-assisted distal gastrectomy (LADGBI) in middle-third early gastric cancers (EGC) patients. METHODS: Form January 2015 and August 2017, a total 91 EGC patients underwent LAPPG or LADGBI procedure with complete QLQ-C30 and QLQ-STO22 in Ren ji hospital. Not only do surgical and oncological safety as well as clinicopathologic characteristics analyze, but only chronological changes of QOL and nutritional status were compared for the evaluation of functional advantages...
January 16, 2020: Journal of Gastroenterology and Hepatology
Jason Gurney, James Stanley, Chris Jackson, Diana Sarfati
Māori are more likely than non-Māori to get cancer, and once they have cancer they are less likely to survive it. One frequently proposed explanation for this survival disparity is differences between these groups in terms of stage at diagnosis-whereby Māori may be less likely to be diagnosed at an earlier stage, when treatment is more feasible and outcomes are better for the patient. However, this simple explanation ignores the true complexity of the issue of stage at diagnosis as a driver of survival disparities, and makes critical assumptions about the quality of available staging data...
January 17, 2020: New Zealand Medical Journal
Sumiyo Okawa, Takahiro Tabuchi, Toshitaka Morishima, Shihoko Koyama, Yukari Taniyama, Isao Miyashiro
The relationship between hospital volume and patient outcome is globally known; thus, hospital volume is widely used as a quality indicator. In Japan, however, recent studies on this topic are scarce. This study examined whether hospital surgery volume is associated with post-operative 5-year survival among cancer patients. Using the Osaka Cancer Registry, we identified a sample of 86,145 patients who were diagnosed with cancer at either of the five different sites (stomach, colorectum, lung, breast, and uterus) and underwent surgeries between 2007 and 2011 in Osaka...
January 13, 2020: Cancer Science
Mehdi Sohrabi, Amir Hakimi
A novel 'photoneutron (PN) volume dose equivalent' methodology was hypothesized and applied for the first time for estimating PN second primary cancer (PN-SPC) risks in high-energy X-ray medical accelerators. Novel position-sensitive mega-size polycarbonate dosimeters with 10B converter (with or without cadmium covers) were applied for determining fast, epithermal and thermal PN dose equivalents at positions on phantom surface and depths. The methodology was applied to sites of tumors such as brain, stomach and prostate in 47 patients...
January 14, 2020: Radiation Protection Dosimetry
Nami Sato, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Rintaro Mikata, Naoya Kato, Masayuki Ohtsuka
BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has high accuracy and a low complication rate; therefore, it has been widely used as a useful tool for diagnosis of and to determine treatment strategies for pancreatic tumors. Recently, reports of the recurrence of needle tract seeding after EUS-FNA are emerging. CASE PRESENTATION: An 83-year-old woman was referred to our hospital to undergo further examination of her pancreatic tumor. Multidetector computed tomography (MDCT) revealed a 25-mm-diameter mass in the pancreatic body...
January 15, 2020: BMC Gastroenterology
Holly A Martinson, Dominic Mallari, Christine Richter, Tsung-Teh Wu, James Tiesinga, Steven R Alberts, Matthew J Olnes
Gastric cancer is an aggressive and heterogeneous malignancy that often varies in presentation and disease among racial and ethnic groups. The Alaska Native (AN) people have the highest incidence and mortality rates of gastric cancer in North America. This study examines molecular markers in solid tumor samples from eighty-five AN gastric adenocarcinoma patients using next-generation sequencing, immunohistochemistry, and in situ hybridization analysis. AN patients have a low mutation burden with fewer somatic gene mutations in their tumors compared to other populations, with the most common mutation being TP53 ...
January 13, 2020: Cancers
Irshad Sharafutdinov, Steffen Backert, Nicole Tegtmeyer
Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin poses an attractive target for pathogens to manipulate a given host cell to their own benefit. One of the pathogens following this strategy is Helicobacter pylori , which can cause a variety of gastric diseases and has been shown to be the major risk factor for the onset of gastric cancer. During infection of gastric epithelial cells, H...
January 9, 2020: Cancers
Kang Moo Lee, Jae Seok Min, Won Jung Choi, Jin Woo Ahn, Song Woo Yoon, Young-Jin Kim
BACKGROUND: We aimed to improve the tumor localization system using radiofrequency identification (RFID) technology used during laparoscopic surgery for gastric and colorectal cancer. To this end, we developed a detection algorithm and designed improvement for the RFID clip. METHODS: To evaluate the proposed system, a swine-based animal study was conducted, followed by experiments on porcine stomachs and colons using the EASIE-R simulator. The success rates of endoscopic clipping, detection time, and detection accuracy, which is the distance between the detection point and RFID tag, were measured...
January 13, 2020: Surgical Endoscopy
Toshiro Tanioka, Rawat Waratchanont, Ryosuke Fukuyo, Toshifumi Saito, Yuya Umebayashi, Emi Kanemoto, Kenta Kobayashi, Masatoshi Nakagawa, Mikito Inokuchi
BACKGROUND: Laparoscopic proximal gastrectomy (LPG) is regarded as a less invasive surgery than laparoscopic total gastrectomy (LTG) for early gastric cancer located on the proximal side of the stomach. However, whether LPG is more effective than LTG remains unclear. METHODS: A systematic literature search of studies assessing short-term surgical and nutritional outcomes after LPG and LTG was conducted. A meta-analysis of surgical outcomes (operative time, intraoperative estimated blood loss, postoperative complications, and length of hospital stay) and nutritional outcomes (decrease in body weight, albumin, hemoglobin, total protein, and lymphocyte count) was then performed...
January 13, 2020: Surgical Endoscopy
Kou Kou, Paramita Dasgupta, Susanna M Cramb, Xue Qin Yu, Peter D Baade
BACKGROUND: With the improvements in cancer diagnosis and treatment, more cancer patients are surviving for longer periods than before. This study aims to quantify the proportion cured and median survival time for those who are not cured for major cancers in Australia. METHODS: Australian population-based cohort of 2,164,172 cases aged 15-89 years, whose first cancer diagnosis between 1982 and 2014 was one of 22 leading cancers, were followed up to December 2014...
January 13, 2020: Cancer Epidemiology, Biomarkers & Prevention
Xian-Bao Huang, Yan-Qi Chen, Ding-Yi Xie, Ri-Xin Chen
Professor CHEN Ri-xin has explored the causes of the characteristics of TCM syndromes in modern disease spectrum and pointed out that the TCM syndromes are generally characterized by " yang is often insufficient, but yin is often surplus". Based on the clinical experience and the understanding of TCM classics and ancient literature on tumor, professor CHEN has proposed that TCM syndromes of patients with advanced tumor are also generally characterized by " yang is often insufficient, but yin is often surplus"...
January 12, 2020: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Mira Runkel, Norbert Runkel
One Anastomosis Gastric Bypass (OAGB) is a bariatric technique that combines a long tube-like gastric conduit with a wide end-to-side gastro-jejunostomy. It is a non-complex operation with a low frequency of intestinal obstructions and an excellent long-term weight loss, however, there is a fear of esophagogastric cancer. This narrative review explores the risk of cancer development after OAGB. Five gastric cancers were published after loop gastric bypass (an early version of OAGB, n=4) and after modern OAGB (n=1), four of which occurred in the remnant stomach and one in the gastric stump...
November 2019: Chirurgia
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