Stomach cancer

Wonwoong Lee, Jinhee Um, Boram Hwang, Yong Chan Lee, Bong Chul Chung, Jongki Hong
Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Moreover, the progression of gastric cancer, could change the gut microbiome, including bacteria spp. that produce secondary BAs. Gastric juice has various metabolites that could indicate gastric cancer-related stomach conditions. Therefore, profiling of HIST, His, and BAs in gastric juice is crucial for understanding the etiological mechanisms of gastric cancer...
November 12, 2019: Journal of Steroid Biochemistry and Molecular Biology
Harmke J Groot, Flora E van Leeuwen, Sjoukje Lubberts, Simon Horenblas, Ronald de Wit, J Alfred Witjes, Gerard Groenewegen, Philip M Poortmans, Maarten C C M Hulshof, Otto W M Meijer, Igle J de Jong, Hetty A van den Berg, Tineke J Smilde, Ben G L Vanneste, Maureen J B Aarts, Katarzyna Jóźwiak, Alexandra W van den Belt-Dusebout, Jourik A Gietema, Michael Schaapveld
BACKGROUND: Although testicular cancer (TC) treatment has been associated with severe late morbidities, including second malignant neoplasms (SMNs) and ischemic heart disease (IHD), cause-specific excess mortality has been rarely studied among patients treated in the platinum era. METHODS: In a large, multicenter cohort including 6042 patients with TC treated between 1976 and 2006, cause-specific mortality was compared with general population mortality rates. Associations with treatment were assessed with proportional hazards analysis...
November 15, 2019: Cancer
Seiichiro Mitani, Shigenori Kadowaki, Isao Oze, Toshiki Masuishi, Yukiya Narita, Hideaki Bando, Sachiyo Oonishi, Yutaka Hirayama, Tsutomu Tanaka, Masahiro Tajika, Yutaro Koide, Takeshi Kodaira, Tetsuya Abe, Kei Muro
BACKGROUND: Esophageal cancer is associated with synchronous or metachronous cancer at other primary sites. However, few studies have evaluated the second malignancies after the treatment of esophageal cancer. The present study aimed to clarify the frequency of and risk factors for the second malignancies after definitive therapy for esophageal cancer. PATIENTS AND METHODS: We included patients with esophageal cancer who received definitive therapy between 2000 and 2010...
November 15, 2019: Cancer Medicine
Jian-Xian Lin, Xiong-Feng Weng, Xin-Sheng Xie, Ning-Zi Lian, Sheng-Liang Qiu, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Si-Jia Liu, Min Hu, Yi-Ke Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie
Background: Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to date. Methods: Immunohistochemistry was used to assess the expression of CDK5RAP3 in GNEC tissues and adjacent non-tumor tissues. Cell lines with stable overexpression or knockdown of CDK5RAP3 were constructed using lentiviral transfection...
2019: Cancer Cell International
Tao Chen, Cangui Zhang, Yingqiao Liu, Yuyun Zhao, Dingyi Lin, Yanfeng Hu, Jiang Yu, Guoxin Li
BACKGROUND: Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other aspects, thus participating in various biological processes such as cell proliferation, differentiation and apoptosis. As a new nova of anti-tumor therapy, immunotherapy has been shown to be effective in many tumors of which PD-1/PD-L1 monoclonal antibodies has been proofed to increase overall survival rate in advanced gastric cancer (GC)...
November 13, 2019: BMC Genomics
Mohammad Shokrzadeh, Abbas Mohammadpour, Nasrin Ghassemi-Barghi, Vahid Hoseini, Saied Abediankenari, Yahya Saleh Tabari
BACKGROUND: Gastric cancer is the fourth most common cause of worldwide cancer. Also in contrast to the huge advances in curing, the chance of living is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. The association between Metallothionein-2A gene polymorphisms and the risk of adenocarcinoma has been widely studied, yet there is only one study on stomach diseases. OBJECTIVE: In this study, we aimed to investigate the association between 2 (MT-2A) polymorphisms and adenocarcinoma...
November 7, 2019: Arquivos de Gastroenterologia
Haruka Oi, Satoshi Yamamoto, Yoshiharu Kono, Yukiyoshi Masaki
Lymphoepithelioma-like carcinoma (LELC) is histologically similar in form to nasopharyngeal carcinoma (NPC) and is an epithelial tumor that is suggested to be involved in infection with Epstein-Barr virus (EBV), but it is rare to occur in the colon. A 35-year-old woman was found to have a rectal wall thickening by follow-up computed tomography (CT) image after sigmoidectomy and left salpingo-oophorectomy. Biopsy under colonoscopy revealed recurrence of ovarian cancer, and she underwent a low anterior resection...
November 2019: Reports of Practical Oncology and Radiotherapy
Łukasz Szoka, Valery Isidorov, Jolanta Nazaruk, Marcin Stocki, Leszek Siergiejczyk
The present study investigated the magnitude and mechanism of the cytotoxic effect on selected cancer cell lines of 3,4- seco -urs-4(23),20(30)-dien-3-oic acid ( 1 ), 3,4- seco -olean-4(24)-en-19-oxo-3-oic acid ( 2 ), and 3,4- seco -urs-4(23),20(30)-dien-19-ol-3-oic acid ( 3 ) isolated from downy birch ( Betula pubescens ) buds by carbon dioxide supercritical fluid extraction and gradient column chromatography. Cell viability in six human cancer lines exposed to these compounds was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
November 9, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zheng Tang, Xue Zou, Qian Luo, Ying Wang, Fu Jin
OBJECTIVES: To quantify the risk of radiogenic second cancer in pediatric patients receiving hippocampal-sparing craniospinal irradiation either with intensity-modulated radiation therapy or tomotherapy due to the development of a solid second cancer after radiotherapy using the concept of excess absolute risk. METHODS: Computed tomography images of 15 pediatric patients who received craniospinal irradiation treatment were selected for this study. For each case, intensity-modulated radiation therapy and tomotherapy plans were computed...
January 2019: Technology in Cancer Research & Treatment
Yoshihito Takahashi, Takashi Fukuyama, Nobue Futawatari, Yoshinobu Ichiki, Haruki Ohmiya, Motohiro Chuman, Tetsuro Yamashita, Naoki Hiki, Yusuke Kumamoto, Hitoshi Yamazaki, Hiroshi Nonoguchi, Yatsushi Nishi, Noritada Kobayashi
BACKGROUND/AIM: Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a known cancer/testis antigen. Our group has previously shown KK-LC-1 gene expression in gastric cancer. However, could not be detected the KK-LC-1 protein due to the lack of an appropriate antibody. Here, we assessed our original monoclonal antibody (Kmab34B3) and, using it, assessed the expression of KK-LC-1 in gastric cancer. PATIENTS AND METHODS: We evaluated an original monoclonal antibody against KK-LC-1 (Kmab34B3), and used this antibody to compare KK-LC-1 protein expression in tumour and non-tumour stomach cells from gastric cancer patients...
November 2019: Anticancer Research
Hiroshi Ohyama, Dai Yoshimura, Yosuke Hirotsu, Kenji Amemiya, Hiroyuki Amano, Yuko Miura, Hiroshi Ashizawa, Keiko Nakagomi, Shinya Takaoka, Kenji Hosoda, Yoji Suzuki, Toshio Oyama, Masao Hada, Yuichiro Kojima, Hitoshi Mochizuki, Masao Omata
BACKGROUND: Studies indicate that gastric cancer (GC) incidence has decreased, whereas signet ring cell carcinoma (SRC) incidence has increased. However, recent trends in GC incidence are unclear. We used our hospital cancer registry to evaluate the changes in the incidence of GC, SRC, and non-SRC (NSRC) over time in comparison to changes in the H. pylori infection rates over time. METHODS: We identified 2532 patients with GC enrolled in our registry between January 2007 and December 2018 and statistically analyzed SRC and NSRC incidence...
November 8, 2019: BMC Gastroenterology
Satoshi Shinozaki, Hiroyuki Osawa, Yoshikazu Hayashi, Alan Kawarai Lefor, Hironori Yamamoto
In routine upper and lower gastrointestinal endoscopy, overlooking neoplastic lesions is inevitable even for well-trained endoscopists. Various methods have been reported to improve the detection of gastrointestinal neoplasms including chromoendoscopy, special endoscopes, and processor and image enhanced technologies. Equipment-based image enhanced endoscopy (e-IEE) using narrow band imaging (NBI) and blue laser imaging (BLI) is useful to characterize known lesions with magnification at a close-up view. However, they are not useful for the early detection of superficial, pale neoplasms, or both because of the weak image at a distant view in a wide lumen such as the stomach or colon...
2019: Therapeutic Advances in Gastroenterology
Nele Brusselaers, Karl Ekwall, Mickael Durand-Dubief
BACKGROUND: The heat-shock transcription factor 1 (HSF1) has been linked to cell proliferation and survival in cancer and has been proposed as a biomarker for poor prognosis. Here, we assessed the role of HSF1 expression in relation to copy number alteration (CNA) and cancer prognosis. METHODS: Using 10,287 cancer genomes from The Cancer Genome Atlas and Cbioportal databases, we assessed the association of HSF1 expression with CNA and cancer prognosis. CNA of 8q24...
November 7, 2019: Human Genomics
Kyeong Seok Kim, Na Yoon Kim, Ji Yeon Son, Jae Hyeon Park, Su Hyun Lee, Hae Ri Kim, Boomin Kim, Yoon Gyoon Kim, Hye Gwang Jeong, Byung Mu Lee, Hyung Sik Kim
Benzo[a]pyrene (BaP) is a well-known carcinogen formed during the cooking process. Although BaP exposure has been implicated as one of the risk factors for lung cancer in animals and humans, there are only limited data on BaP-induced gastrointestinal cancer. Therefore, this study investigated the protective effects of curcumin on BaP-induced DNA damage in rat stomach tissues. BaP (20 mg/kg/day) and curcumin (50, 100, or 200 mg/kg) were administered daily to Sprague-Dawley rats by oral gavage over 30 days. Curcumin was pre-administered before BaP exposure...
November 6, 2019: International Journal of Molecular Sciences
Arnulf H Hölscher, Simon Law
For Siewert type II adenocarcinoma of the esophagogastric junction (AEG II), or similar tumors classified as Nishi EG, E=G, GE, the type of surgical resection and reconstruction should be individualized. Criteria for decision making mainly focus on the oral extent of esophageal infiltration, the cT and cN category and the functional status of the patient. For cT1/cT2 adenocarcinomas, which are non-poorly cohesive, intestinal type of Lauren Grading 1 or 2 without clinical signs of lymph node metastasis at the distal stomach, a limited transhiatal proximal gastrectomy with double tract reconstruction is recommended...
November 6, 2019: Gastric Cancer
Chenfei Zhou, Tao Ma, Min Shi, Wenqi Xi, Junwei Wu, Chen Yang, Zhenggang Zhu, Jun Zhang
PURPOSE: To determine the maximum tolerated dose (MTD) and recommended dose (RD) of modified FLOT regimen (fluorouracil plus leucovorin, oxaliplatin and docetaxel) for treating Chinese patients with metastatic adenocarcinoma of stomach. METHODS: Chinese patients with untreated advanced or metastatic stomach adenocarcinoma were enrolled. Docetaxel (D), oxaliplatin (O) and leucovorin were administrated intravenously on day 1. Fluorouracil (F) was administrated continuous intravenously on day 1 for 48 h...
November 5, 2019: Cancer Chemotherapy and Pharmacology
Roy J Shephard
No abstract text is available yet for this article.
November 2019: Clinical Journal of Sport Medicine
Zhi Zhu, Pei Wu, Nan Du, Kai Li, Baojun Huang, Zhenning Wang, Huimian Xu
Background : Total gastrectomy with D2 lymphadenectomy is indicated for proximal advanced gastric cancer located in the upper one-third of the stomach; however, due to preserved function and clinical benefits of a proximal gastrectomy, the choice of a surgical method for patients with proximal early stage gastric cancer remains controversial. Methods : We conducted a retrospective study involving 649 patients with proximal gastric cancer. The clinical pathological features, characteristics, lymph node metastatic patterns, prognosis, postoperative complications, and recurrence were compared between the patients who underwent proximal and total gastrectomies with different T and N stages...
November 5, 2019: Expert Review of Gastroenterology & Hepatology
Jordan Levy, Vaibhav Gupta, Elmira Amirazodi, Catherine Allen-Ayodabo, Naheed Jivraj, Yunni Jeong, Laura E Davis, Alyson L Mahar, Charles De Mestral, Olli Saarela, Natalie Coburn
OBJECTIVE: To determine the association between gastric cancer surgery case-volume and Textbook Outcome, a new composite quality measurement. BACKGROUND: Textbook Outcome included (a) negative resection margin, (b) greater than 15 lymph nodes sampled, (c) no severe complication, (d) no re-intervention, (e) no unplanned ICU admission, (f) length of stay of 21 days or less, (g) no 30-day readmission and (h) no 30-day mortality following surgery. METHODS: All patients undergoing gastrectomy for non-metastatic gastric adenocarcinoma registered in the Population Registry of Esophageal and Stomach Tumours of Ontario between 2004 and 2015 were included...
November 4, 2019: Gastric Cancer
Yeonjoo Choi, Jin Won Kim, Koung Jin Suh, Yoo-Joo Lim, Ji Yun Lee, Beo-Deul Kang, Ji-Won Kim, Se-Hyun Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee
BACKGROUND: In-hospital cardiopulmonary resuscitation (CPR) is one of undesirable situations. We tried to identify and characterize a potentially avoidable CPR in cancer patients who were hospitalized in hematology and oncology wards. METHODS: A potentially avoidable CPR was determined based on chemotherapy setting, disease status and clinical situation at the time when a cardiopulmonary arrest occurred, by using a consensus-driven medical records review of two physicians...
November 4, 2019: BMC Palliative Care
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