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Bipolar

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https://read.qxmd.com/read/31951826/lithium-treatment-mitigates-white-matter-injury-after-intracerebral-hemorrhage-through-brain-derived-neurotrophic-factor-signaling-in-mice
#1
Mingxi Li, Min Xia, Weixiang Chen, Jie Wang, Yi Yin, Chao Guo, Chengcheng Li, Xiaoqin Tang, Hengli Zhao, Qiang Tan, Yujie Chen, Zhengcai Jia, Xin Liu, Hua Feng
Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether it can be used to alleviate WMI after ICH remains to be researched...
December 27, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/31951419/localized-heating-and-switching-in-mote-2-based-resistive-memory-devices
#2
Isha Datye, Miguel Muñoz Rojo, Eilam Yalon, Sanchit Deshmukh, Michal J Mleczko, Eric Pop
Two-dimensional (2D) materials have recently been incorporated into resistive memory devices due to their atomically thin nature, but their switching mechanism is not yet well understood. Here we study bipolar switching in MoTe2 -based resistive memory of varying thickness and electrode area. Using scanning thermal microscopy (SThM), we map the surface temperature of the devices under bias, revealing clear evidence of localized heating at conductive "plugs" formed during switching. The SThM measurements are correlated to electro-thermal simulations, yielding a range of plug diameters (250 to 350 nm) and temperatures at constant bias and during switching...
January 17, 2020: Nano Letters
https://read.qxmd.com/read/31950674/distress-quality-of-life-and-disability-in-treatment-seeking-young-adults-with-social-anxiety-disorder
#3
Shin Ho Park, Yun Ju C Song, Eleni A Demetriou, Karen L Pepper, Ian B Hickie, Nick Glozier, Daniel F Hermens, Elizabeth M Scott, Adam J Guastella
AIM: This study aimed to: (a) examine whether treatment-seeking young adults with social anxiety disorder (SAD) demonstrate similar degrees of distress, quality of life (QoL) and disability to those with other mental disorders; and (b) investigate the impact of comorbidity, specific comorbid conditions and antidepressants use on distress, QoL and disability in treatment-seeking young adults with SAD. METHODS: A cohort of treatment-seeking young adults (aged 16-45) diagnosed with SAD (N = 298) or other mental health disorders (N = 842; including depression, N = 349; bipolar, N = 141; psychosis, N = 173) completed self-report assessments of distress, QoL and disability...
January 16, 2020: Early Intervention in Psychiatry
https://read.qxmd.com/read/31949107/simultaneous-requirements-for-hes1-in-retinal-neurogenesis-and-optic-cup-stalk-boundary-maintenance
#4
Bernadett Bosze, Myung-Soon Moon, Ryoichiro Kageyama, Nadean L Brown
The bHLH transcription factor Hes1 is a key downstream effector for the Notch signaling pathway. During embryogenesis neural progenitors express low levels of Hes1 in an oscillating pattern, whereas glial brain boundary regions (e.g. isthmus) have high, sustained Hes1 levels that suppress neuronal fates. Here, we show that in the embryonic mouse retina, the optic nerve head and stalk express high Hes1, with the ONH constituting a boundary between the neural retina and glial cells that ultimately line the optic stalk...
January 13, 2020: Journal of Neuroscience
https://read.qxmd.com/read/31948489/psychotropic-medication-non-adherence-and-its-associated-factors-among-patients-with-major-psychiatric-disorders-a-systematic-review-and-meta-analysis
#5
Agumasie Semahegn, Kwasi Torpey, Adom Manu, Nega Assefa, Gezahegn Tesfaye, Augustine Ankomah
BACKGROUND: Major psychiatric disorders are growing public health concern that attributed 14% of the global burden of diseases. The management of major psychiatric disorders is challenging mainly due to medication non-adherence. However, there is a paucity of summarized evidence on the prevalence of psychotropic medication non-adherence and associated factors. Therefore, we aimed to summarize existing primary studies' finding to determine the pooled prevalence and factors associated with psychotropic medication non-adherence...
January 16, 2020: Systematic Reviews
https://read.qxmd.com/read/31947912/psychiatric-manifestations-of-coeliac-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Emma Clappison, Marios Hadjivassiliou, Panagiotis Zis
BACKGROUND: Coeliac disease (CD) is increasingly prevalent and is associated with both gastrointestinal (GI) and extra-intestinal manifestations. Psychiatric disorders are amongst extra-intestinal manifestations proposed. The relationship between CD and such psychiatric disorders is not well recognised or understood. AIM: The aim of this systematic review and meta-analysis was to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of CD...
January 4, 2020: Nutrients
https://read.qxmd.com/read/31947201/electroanatomic-mapping-to-determine-scar-regions-in-patients-with-atrial-fibrillation
#7
Jiyue He, Kuk Jin Jang, Katie Walsh, Jackson Liang, Sanjay Dixit, Rahul Mangharam
Left atrial voltage maps are routinely acquired during electroanatomic mapping in patients undergoing catheter ablation for atrial fibrillation (AF). For patients, who have prior catheter ablation when they are in sinus rhythm (SR), the voltage map can be used to identify low voltage areas (LVAs) using a threshold of 0.2 - 0.45 mV. However, such a voltage threshold for maps acquired during AF has not been well established. A prerequisite for defining a voltage threshold is to maximize the topologically matched LVAs between the electroanatomic mapping acquired during AF and SR...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946808/beamforming-inspired-spatial-filtering-technique-for-intracardiac-electrograms
#8
Simanto Saha, Dominik Linz, Prashanthan Sanders, Mathias Baumert
Bipolar electrograms (EGM) are widely used to assess intracardiac electrical activity and to find the atrial fibrillation-related sources. However, the interpretation of bipolar EGM is not straightforward. Variables including bipolar lead (vector) orientation relative to the wave propagation dynamics significantly impact the EGM and EGM-derived measures, which are clinically used to select target sources for catheter ablation. In this study, left atrial unipolar EGM were recorded using a 4 × 4 grid of 16 unipolar electrodes...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946710/an-energy-efficient-implantable-neural-stimulator-system-with-wireless-charging-and-dynamic-voltage-output
#9
Xingyu Fu, Songping Mai, Zhihua Wang
Neural stimulators have become more and more widely used as an effective tool in neural therapies. To address power supply and consumption issues in this application, an energy-efficient Implantable-Neural-Stimulator system composed of a pulse generator and a wireless charger is proposed and implemented in 0.8μm 40V Bipolar-CMOS-DMOS (BCD) process. By adopting a Single Ended Primary Inductor Converter (SEPIC) and optimizing the switching frequency and the gate width of its power MOSFET, the stimulating output voltage range can cover 0~12V with a maximum output ripple of 0...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946690/fabrication-of-a-self-curling-cuff-with-a-soft-ionically-conducting-neural-interface
#10
R Thakur, A R Nair, A Jin, G Y Fridman
Direct current (DC) has the potential not only to excite but also to inhibit neurons. This property of DC stimulus has been used for generating peripheral nerve blocks. One translational challenge of DC-based neuromodulation technologies, especially for pain suppression, is that the commercially available cuff electrodes have metal-tissue interfaces that are incapable of delivering DC safely. Passing DC through any metal-tissue interface generates harmful electrochemical products which can damage the target nerve...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946520/simulation-study-of-intermittent-responses-of-neuronal-populations-to-axonal-high-frequency-stimulation
#11
Lvpiao Zheng, Zhouyan Feng, Zheshan Guo, Lu Huang
Deep brain stimulation (DBS) have shown a promising future for treating various brain disorders. Studies have indicated that the high frequency stimulation (HFS) used in DBS could cause a partial block in axons thereby attenuating the responses of axon fibers to the pulses of HFS. The attenuated response of axons might play a desynchronization role in modulating activity of neuronal populations. To investigate the detail behavior of individual axons under HFS, we created a computational model of neuronal populations including 1250 neurons...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946513/estimation-of-dispersive-properties-of-encapsulation-tissue-surrounding-deep-brain-stimulation-electrodes-in-the-rat
#12
Karthik Sridhar, Judith Evers, Diego Pereira Botelho, Madeleine M Lowery
The aim of this study was to estimate the electrical properties of the encapsulation tissue surrounding chronically implanted electrodes for deep brain stimulation in the rat. The impedance spectrum of a concentric bipolar microelectrode implanted in the rat brain was measured immediately following surgery and after 8 weeks of implantation. The experimental impedance data were used in combination with a finite element model of the rat brain using a parametric sweep method to estimate the electrical properties of the tissue surrounding the electrode in acute and chronic conditions...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946494/a-numerical-study-on-the-no-touch-bipolar-radiofrequency-ablation
#13
Shelley Yap, Jason K K Cheong, Ean H Ooi, Iman Y Liao, Ji J Foo, Shalini R Nair, Ahmad F Mohd Ali
The commonly used radiofrequency ablation (RFA) technique for treating liver cancer is in the monopolar mode. This requires the insertion of the RF electrode directly into the tumor tissue, which increases the risks of tumor track seeding (TTS). One way to overcome TTS is by employing the bipolar RFA, implemented in the no-touch mode. In the no-touch mode, two RF electrodes are inserted into the healthy tissue that surrounds the tumor. The distance between the electrodes and the tumor is defined as the no-touch gap...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946354/recurrence-quantification-analysis-for-investigating-atrial-fibrillation-dynamics-in-a-heterogeneous-simulation-setup
#14
Tiago P Almeida, Laura A Unger, Diogo C Soriano, Xin Li, Olaf Dossel, Takashi Yoneyama, Axel Loewe
The outcomes of ablation targeting either reentry activations or fractionated activity during persistent atrial fibrillation (AF) therapy remain suboptimal due to, among others, the intricate underlying AF dynamics. In the present work, we sought to investigate such AF dynamics in a heterogeneous simulation setup using recurrence quantification analysis (RQA). AF was simulated in a spherical model of the left atrium, from which 412 unipolar atrial electrograms (AEGs) were extracted (2 s duration; 5 mm spacing)...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946323/evaluation-of-epistemic-uncertainties-for-bipolar-deep-brain-stimulation-in-rodent-models
#15
Konstantin Butenko, Christian Bahls, Ursula van Rienen
Rodent models are widely used in research on deep brain stimulation (DBS) for testing hypotheses of the action mechanism. However, differences in anatomy and technology for DBS in humans and rodents might lead to a non-identical effect on the neural activity. Particularly, strong deviations can be introduced by epistemic uncertainties related to the electrode implantation. In this study, the influence of encapsulation layer properties and implantation precision on axonal activation is quantified using polynomial chaos expansion...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946259/magnetomyographic-recordings-of-pelvic-floor-activity-during-pregnancy-and-postpartum-a-novel-non-invasive-approach
#16
Diana Escalona-Vargas, Sallie Oliphant, Hari Eswaran
The levator ani muscles (LAM) are integral to pelvic floor support and injury to this muscle complex has been associated with pelvic floor disorders, but our ability to evaluate their neuromuscular integrity is limited. During pregnancy, gravidas undergo systemic functional and anatomic modifications, including pelvic floor muscular adaptations. Magnetomyography (MMG) is a novel and non-invasive tool to passively measure the magnetic fields generated by depolarization activity of muscles and offers a unique method to evaluate the LAM...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946119/physical-activity-based-classification-of-serious-mental-illness-group-participants-in-the-uk-biobank-using-ensemble-dense-neural-networks
#17
Tahmina Zebin, Niels Peek, Alexander J Casson
Serious Mental Illnesses (SMIs) including schizophrenia and bipolar disorder are long term conditions which place major burdens on health and social care services. Locomotor activity is altered in many cases of SMI, and so in the long term wearable activity trackers could potentially aid in the early detection of SMI relapse, allowing early and targeted intervention. To move towards this goal, in this paper we use accelerometer activity tracking data collected from the UK Biobank to classify people as being either in a self-reported SMI group or an age and gender matched control group...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31946106/wireless-low-cost-bioimpedance-measurement-device-for-lung-capacity-screening
#18
Esteban J Pino, Britam Gomez, Emyrna Monsalve, Pablo Aqueveque
This paper presents the development and implementation at a prototype level of a wireless, low-cost system for the measurement of the electrical bio-impedance of the chest with two channels using the AD5933 in a bipolar electrode configuration to measure lung volume variation. 15 volunteers were measured with the prototype, and the acquired signal presents the phases of the respiratory cycle, useful for the breathing rate calculation and for possible screening applications.
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31945872/early-preclinical-experience-with-a-novel-endobronchial-radiofrequency-ablation-system-for-lung-cancer-treatment
#19
K Y Yoneda, S Li, F Herth, T Spangler, M Gelfand, S Raina, D Panescu
This paper introduces a novel technology for treating early-stage non-small cell lung cancer using an endobronchial approach via a flexible radiofrequency ablation (RFA) catheter. Methods - The RFA system consisted of an ablation catheter, radiofrequency generator, irrigation pump for infusion of hypertonic saline (HS) and a laptop. The catheter carried an occlusion balloon, a 5 mm long RF electrode, with irrigation holes, and a 1 mm long electrode for bipolar impedance measurements. The outer diameter was 1...
July 2019: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/31945448/genetic-variants-associated-with-psychotic-symptoms-across-psychiatric-disorders
#20
Marco Calabrò, Stefano Porcelli, Concetta Crisafulli, Diego Albani, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Vilma Mantovani, Julien Mendlewicz, Stefano Bonassi, Eduard Vieta, Alessandra Frustaci, Giuseppe Ducci, Stefano Landi, Stefania Boccia, Antonello Bellomo, Marco Di Nicola, Luigi Janiri, Roberto Colombo, Francesco Benedetti, Laura Mandelli, Chiara Fabbri, Alessandro Serretti
BACKGROUND: Recent evidence suggests that psychiatric symptoms share a common genetic liability across diagnostic categories. The present study investigated the effects of variants within previously identified relevant genes on specific symptom clusters, independently from the diagnosis. METHODS: 1550 subjects affected by Schizophrenia (SCZ), Major Depressive Disorder or Bipolar Disorder were included. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Depression Rating Scale (HDRS)...
January 13, 2020: Neuroscience Letters
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