Jocelyn Fotso Soh, Ahmad Almadani, Serge Beaulieu, Tarek Rajji, Benoit H Mulsant, Chien-Lin Su, Suzane Renaud, Istvan Mucsi, S Gabriela Torres-Platas, Andrea Levinson, Ayal Schaffer, Annemiek Dols, Pablo Cervantes, Nancy Low, Nathan Herrmann, Outi Mantere, Soham Rej
OBJECTIVES: Statins have recently been linked to having effects on cognition and mood in mood disorders, though results are mixed. In this paper, we use data from a recent randomized controlled trial (RCT) to examine the effect of statins on cognition and mood in patients with Bipolar Disorder (BD) and Major Depressive Disorder (MDD). METHODS: This is a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial (n = 60) originally designed to examine the effect of atorvastatin (n = 27) versus placebo (n = 33) for lithium-induced diabetes insipidus in BD and MDD patients who were using lithium...
November 4, 2019: Journal of Affective Disorders
Laura M Smith, David M Erceg-Hurn, Peter M McEvoy, Louella Lim
BACKGROUND: Successful management of bipolar disorder (BPD) typically involves individuals undertaking a complex array of self-management tasks (e.g., taking medication, monitoring symptoms, following a regular sleep routine). Many people with BPD doubt they can successfully undertake these tasks. This low sense of self-efficacy may lead to the perpetuation of BPD symptoms, poor quality of life, and low adherence to treatment. Research on self-efficacy in BPD has been hampered by the lack of a short, reliable and valid self-report scale that is practical to use in clinical and research settings...
October 21, 2019: Journal of Affective Disorders
Cesare Galimberti, Valentina Caricasole, Monica F Bosi, Caterina A Viganò, Terence A Ketter, Bernardo Dell'Osso
AIM: Up to just over half of bipolar disorder (BD) patients report at least one-lifetime anxiety disorder (AD). In some, anxiety represents the earliest psychiatric manifestation, prior to any mood episode. We sought to investigate prevalence of AD subtypes as first psychiatric manifestations and AD's relations with duration of untreated illness (DUI) and treatment among BD outpatients. METHODS: We recruited patients referred to the Centre for the Treatment of Depressive Disorders in Milan, diagnosed with BD-I, BD-II, BD not otherwise specified (BD-NOS) and cyclothymia according to Diagnostic and Statistical Manual fourth edition-text revision criteria...
November 15, 2019: Early Intervention in Psychiatry
Bashkim Kadriu, Cristan A Farmer, Peixiong Yuan, Lawrence T Park, Zhi-De Deng, Ruin Moaddel, Ioline D Henter, Bridget Shovestul, Elizabeth D Ballard, Cristoph Kraus, Philip W Gold, Rodrigo Machado-Vieira, Carlos A Zarate
Dysfunction in a wide array of systems-including the immune, monoaminergic, and glutamatergic systems-is implicated in the pathophysiology of depression. One potential intersection point for these three systems is the kynurenine (KYN) pathway. This study explored the impact of the prototypic glutamatergic modulator ketamine on the endogenous KYN pathway in individuals with bipolar depression (BD), as well as the relationship between response to ketamine and depression-related behavioral and peripheral inflammatory markers...
November 15, 2019: Molecular Psychiatry
Clément Dondé, Alexis Lepetit, Benjamin Lavigne
CONTEXT: Bipolar disorder (BD) is a severe and recurrent mood disorder. It is characterized by episodic changes in mood and energy/activity levels that are increased during mania/hypomania or decreased during depression. Recurrent mania (RM) is a mood disorder, which would be defined by at least two manic/hypomanic without depressive episodes. Despite a rich body of clinical descriptions, RM is still not integrated into the latest editions of disease classifications and continues to be subsumed under BD in clinical practice...
November 12, 2019: La Presse Médicale
Claudia Carmassi, Carlo Antonio Bertelloni, Valerio Dell'Oste, Claudia Foghi, Elisa Diadema, Annalisa Cordone, Virginia Pedrinelli, Liliana Dell'Osso
BACKGROUND: Increasing evidence suggests Bipolar Disorder (BD) to be frequently associated to a history of traumatic experiences and Post-traumatic Stress Disorder (PTSD), with consequent greater symptoms severity, number of hospitalizations and worsening in quality of life. The aim of the present study was to investigate the lifetime exposure to traumatic events and PTSD rates in-patients with BD and to analyze the relationships between PTSD symptoms, clinical characteristics and severity of the mood disorder...
October 30, 2019: Journal of Affective Disorders
Tony Nguyen, Natalie Seiler, Ellie Brown, Brian O'Donoghue
Clinical Practice Guidelines are succinct evidence-based recommendations and in psychiatry, exist to advise on psychotropic prescribing to effectively treat mental health conditions whilst minimising medication adverse effects. Implementation of psychiatric guidelines have, in the past, demonstrated little and transient impact on clinical practice. How effective prescribing guidelines are in aligning practice with evidence currently is unknown and this systematic review aimed to investigate said efficacy. Literature searches were performed on MEDLINE, EMBASE, and CINAHL up to September 2019 and articles were selected by two reviewers independently with discrepancies resolved by a third reviewer...
November 1, 2019: Psychiatry Research
Shani Stern, Anindita Sarkar, Tchelet Stern, Arianna Mei, Ana P D Mendes, Yam Stern, Gabriela Goldberg, Dekel Galor, Thao Nguyen, Lynne Randolph-Moore, Yongsung Kim, Guy Rouleau, Anne Bang, Martin Alda, Renata Santos, Maria C Marchetto, Fred H Gage
BACKGROUND: Approximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of induced pluripotent stem cell methodology enabled better modeling of this disorder. METHODS: Having previously studied the phenotype of dentate gyrus granule neurons, we turned our attention to studying the phenotype of CA3 hippocampal pyramidal neurons of 6 patients with BD compared with 4 control individuals...
October 1, 2019: Biological Psychiatry
Tracey P Bastrom, Carrie E Bartley, Peter O Newton
STUDY DESIGN: Observational. OBJECTIVE: To examine changes in patient-reported two-year postoperative outcomes via the Scoliosis Research Society (SRS)-24 Outcomes Instrument from 2001 through 2015. SUMMARY OF BACKGROUND DATA: Techniques for correction of adolescent idiopathic scoliosis (AIS) have evolved over the years, but it is unclear how these changes have impacted patient-reported outcomes. METHODS: AIS patients with two-year postoperative follow-up from a prospective multicenter registry were divided into three-year groups based on trends in surgical approach and construct type (2010-2014: 52% anterior, 43% posterior hybrids; 2005-2011: 3% anterior, 5% posterior hybrids; 2012-2015: 0% anterior, 0...
November 2019: Spine Deformity
Alexander Bonanno, Robert C Blake, Parkson Lee-Gau Chong
In this study, we used optical spectroscopy to characterize the physical properties of microvesicles released from the thermoacidophilic archaeon Sulfolobus acidocaldarius (Sa-MVs). The most abundant proteins in Sa-MVs are the S-layer proteins, which self-assemble on the vesicle surface forming an array of crystalline structures. Lipids in Sa-MVs are exclusively bipolar tetraethers. We found that when excited at 275 nm, intrinsic protein fluorescence of Sa-MVs at 23 °C has an emission maximum at 303 nm (or 296 nm measured at 75 °C), which is unusually low for protein samples containing multiple tryptophans and tyrosines...
October 25, 2019: International Journal of Molecular Sciences
Anoop Krishna Gupta, Subodh B N, Abhishek Ghosh, Debasish Basu
OBJECTIVES: Because of high rates of co-occurrence, common familial risk, and phenotypic similarities, we conjectured that substance use and bipolar disorder might have a common substrate of origin in bipolarity and that they might lie on a continuum of bipolarity. Thus it was aimed to investigate the association between bipolarity and substance use through a controlled, clinic based study. METHODS: Cross sectional assessment and comparison of bipolarity as trait in four groups, namely the substance use disorder (SUD), bipolar disorder (BPAD), dual diagnosis (DD), and the healthy control (HC) groups...
October 17, 2019: Asian Journal of Psychiatry
Ewa Jaworska, Agata Michalska, Krzysztof Maksymiuk
Bipolar electrodes working in a self-powered mode are a basis for development of easy to use electrochemical-optical sensors, these systems are very promising due to their simplicity and no need of external polarization. However, the self-powered mode can be used only in cases when the redox potential difference of reactions occurring at opposite poles of the electrode is sufficiently high. To overcome this limitation we propose development of a system working spontaneously, but involving two bipolar electrodes, forming a cascade system...
November 15, 2019: Analytical Chemistry
Hailey Tremain, Kathryn Fletcher, Greg Murray
OBJECTIVES: Number of mood episodes (NoE) may be an important prognostic indicator in bipolar disorder, with implications for treatment. However, NoE has been conceptualised and measured inconsistently throughout the literature. This review examines the construct of NoE in bipolar disorder, with the aim of enhancing its conceptualisation and measurement. METHODS: A critical evaluation of literatures on important correlates of NoE, conceptually and phenomenologically overlapping features, and previous studies considering and measuring this construct was undertaken...
November 15, 2019: Bipolar Disorders
Bin Chen, Junqin Li, Menglan Wu, Lipeng Hu, Fusheng Liu, Weiqin Ao, Yu Li, Heping Xie, Chaohua Zhang
The Bi2Te3-based alloys have been commercialized for the applications of energy harvesting and refrigeration for decades. However, the commercial Bi2Te3-based alloys produced by zone-melting (ZM) method usually show poor mechanical strength and crack problems as well as the sluggish figure of merit ZT, especially for the less-progressed n-type samples. In this work, we have simultaneously enhanced the thermoelectric and mechanical performance of the one-step spark-plasma-sintering (SPS) derived n-type Bi2Te2...
November 15, 2019: ACS Applied Materials & Interfaces
Marc J Weintraub, Christopher D Schneck, David J Miklowitz
OBJECTIVES: Network analyses of psychopathology examine the relationships between individual symptoms in an attempt to establish the causal interactions between symptoms that may give rise to episodes of psychiatric disorders. We conducted a network analysis of mood symptoms in adolescents with or at risk for bipolar spectrum disorders. METHODS: The sample consisted of 272 treatment-seeking adolescents with or at high risk for bipolar disorder who had at least subsyndromal depressive or (hypo)manic symptoms...
November 15, 2019: Bipolar Disorders
Carolina Gubert, Roberta Andrejew, Carlos Eduardo Leite, Cesar Eduardo Jacintho Moritz, Juliete Scholl, Fabricio Figueiro, Flávio Kapczinski, Pedro Vieira da Silva Magalhães, Ana Maria Oliveira Battastini
The pathophysiology of bipolar disorder remains incompletely elucidated. The purinergic receptor, P2X7 (P2X7R), plays a central role in neuroinflammation, the establishment, and maintenance of microglial activation and neuronal damage/death, all characteristics of bipolar disorder pathology. The present study aims to explore the participation of the P2X7R in a preclinical pharmacological model of mania. We analyzed the modulatory effects of the P2X7R antagonist, brilliant blue, on behavior, monoamines, gene expression, serum purine levels, and cell typing in a pharmacological model of mania induced by D-amphetamine (AMPH) in mice...
November 15, 2019: Molecular Neurobiology
Haiteng Jiang, Zhongpeng Dai, Qing Lu, Zhijian Yao
OBJECTIVES: In clinical practice, bipolar depression (BD) and unipolar depression (UD) appear to have similar symptoms, causing BD being frequently misdiagnosed as UD, leading to improper treatment decision and outcome. Therefore, it is in urgent need of distinguishing BD from UD based on clinical objective biomarkers as early as possible. Here, we aimed to integrate brain neuroimaging data and an advanced machine learning technique to predict different types of mood disorder patients at the individual level...
November 14, 2019: Bipolar Disorders
Giovana Bristot, Marco Antônio De Bastiani, Bianca Pfaffenseller, Flávio Kapczinski, Márcia Kauer-Sant'Anna
Despite the strong genetic component of psychiatric disorders, traditional genetic studies have failed to find individual genes of large effect size. Thus, alternative methods, using bioinformatics, have been proposed to solve these biological puzzles. Of these, here we employ systems biology-based approaches to identify potential master regulators (MRs) of bipolar disorder (BD), schizophrenia (SZ), and major depressive disorder (MDD), their association with biological processes and their capacity to differentiate disorders' phenotypes...
November 14, 2019: Molecular Neurobiology
Rui Du, Xu Wang, Ke Shen, Shigang He
We attempted to explore a noninvasive, easily applicable and economically affordable therapy for retinopathy of prematurity (ROP). Rat pups were raised in 80% oxygen from postnatal day 7 to P12, and returned to room air. Travoprost eye drops were administered twice a day for 7 days, to reduce intraocular pressure (IOP) by about 20%. Immunohistochemical staining was performed to visualize vessel endothelial cells, to analyze retinal neurons and cytoarchitecture. Behavioral experiments were carried out to test visual acuity and contrast sensitivity...
November 12, 2019: Science China. Life Sciences
Julia Alcaide, Ramón Guirado, Carlos Crespo, José Miguel Blasco-Ibáñez, Emilio Varea, Julio Sanjuan, Juan Nacher
BACKGROUND: Alterations in the structure and physiology of interneurons in the prefrontal cortex (PFC) are important factors in the etiopathology of different psychiatric disorders. Among the interneuronal subpopulations, parvalbumin (PV) expressing cells appear to be specially affected. Interestingly, during development and adulthood the connectivity of these interneurons is regulated by the presence of perineuronal nets (PNNs), specialized regions of the extracellular matrix, which are frequently surrounding PV expressing neurons...
November 15, 2019: International Journal of Bipolar Disorders
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