Gustavo de Oliveira Canedo, Laura María Palomino Pérez, Laura Andrea Puerta Macfarland, David Ruano Dominguez, Elvira Cañedo-Villaroya, Beatriz Garcia Alcolea, Luis Madero López, Consuelo Pedrón-Giner
BACKGROUND & AIMS: Different nutritional screening tools have been proposed in childhood cancer, but none has shown convincing predictive capacity so far. The "nutrition screening tool for childhood cancer (SCAN)" has been specifically designed for this population and provides an easy-to-use, promising approach to identify patients at risk of malnutrition. We aim to: 1. Validate the SCAN tool prospectively in identifying malnourished patients or those who required nutritional support 2...
July 2, 2024: Clinical Nutrition ESPEN
Eva Albinsson, Astrid Bergentz Grönlund, Mattias Paulsson, Sverre Wikström, Fredrik Ahlsson
AIM: Extremely premature infants receive nutrition and medication through nasogastric tubes. Breastmilk given accordingly is subject to fat loss. This study aimed to investigate whether this could also apply to vitamin D. METHODS: A questionnaire investigated vitamin D administration at a level III neonatal intensive care unit in Sweden in 2021. Feeding simulations with breastmilk and various vitamin D mixtures were done accordingly. After administration, vitamin D3 concentration was analysed using chromatography with mass spectrometry, followed by repeated simulations with vitamin D mixtures without breastmilk in 2023...
July 7, 2024: Acta Paediatrica
J Jara, C Alba, R Del Campo, L Fernández, M Sáenz de Pipaón, J M Rodríguez, B Orgaz
INTRODUCTION: Preterm birth is a growing problem worldwide. Staying at a neonatal intensive care unit (NICU) after birth is critical for the survival of preterm infants whose feeding often requires the use of nasogastric enteral feeding tubes (NEFT). These can be colonized by hospital-associated pathobionts that can access the gut of the preterm infants through this route. Since the gut microbiota is the most impactful factor on maturation of the immune system, any disturbance in this may condition their health...
2024: Frontiers in Pediatrics
Samantha Goh, Jennifer M Siu, Justine Philteos, Adrian L James, Olivia Ostrow, Nicole K McKinnon, Tobias Everett, Mark Levine, Hilary Whyte, Christopher Z Lam, Evan J Propst, Nikolaus E Wolter
OBJECTIVE: Evaluate implementation of an institutional protocol to reduce the time to removal of esophageal button battery (BB) and increase use of mitigation strategies. METHODS: We developed a protocol for esophageal BB management [Zakai's Protocol (ZP)]. All cases of esophageal BB impaction managed at a tertiary care center before and after implementation from 2011 to 2023 were reviewed. Time to BB removal, adherence to critical steps, and use of mitigation strategies (honey/sucralfate, acetic acid) were evaluated...
June 27, 2024: Laryngoscope
Vidya M Saravagol, Anand Alladi, B Mamatha
AIMS: To study the safety and feasibility of enhanced recovery after surgery (ERAS) protocol in pediatric colostomy closure. MATERIALS AND METHODS: Retrospective observational study of children who underwent colostomy closure. Data were collected from the electronic medical records and telephonic follow-up calls of patients from October 2013 to October 2023, in the Department of Pediatric Surgery of a Tertiary level Medical College. The parameters obtained were age, gender, type of stoma, primary diagnosis, discrepancy in luminal diameters, time to reach full feeds, postoperative hospital stay, and complications...
2024: Journal of Indian Association of Pediatric Surgeons
Nina Standaert, Elke Loos, Nicolas Verhaert, Liesbeth Royackers, Sam Denys, Christian Desloovere
OBJECTIVES: Increased neonatal referral rate of conductive hearing loss (CHL) related to otitis media with effusion (OME) following universal neonatal hearing screening (UNHS) may cause an unnecessary clinical, emotional, and financial burden. This study analyzes the long-term, audiological, and medical characteristics of CHL associated with OME in neonates in order to establish a standardized protocol following technology-driven improvements in detection and referral rates in UNHS. METHODS: A retrospective study of all neonates with OME-related CHL referred to the University Hospital of Leuven (Belgium) after failing UNHS with the MAICO devices between January 1, 2013 and December 31, 2021 was performed...
June 19, 2024: International Journal of Pediatric Otorhinolaryngology
Pilar Ortiz Pérez, Inés Valero-Arredondo, Encarnación Torcuato-Rubio, Marta Herrador-López, Rafael Martín-Masot, Víctor Manuel Navas-López
(1) Background: Pediatric dysphagia presents significant nutritional challenges, often impacting growth and development due to reduced oral intake, increased nutritional needs, and gastrointestinal complications; (2) Methods: This prospective quasi-experimental study assessed 117 children under 14 years old (20 patients were under 1 year old, 80 were aged 1-7 years, and 17 were older than 7 years), diagnosed with swallowing disorders, to analyze their caloric, macro-, and micronutrient intake and identify potential deficiencies...
May 23, 2024: Nutrients
Nicholas Beam, Allison Long, Adam Nicholson, Lauren Jary, Rebecca Veele, Nicole Kalinowski, Matthew Phad, Andrea Hadley
INTRODUCTION: Recent studies have identified enteral feeding as a safe alternative to intravenous fluid hydration for inpatients with bronchiolitis receiving respiratory support. Specifically, it can improve vital signs, shorten time on high-flow nasal cannula, and is associated with reduced length of stay. We aimed to increase the percentage of patients receiving enteral feeding on admission with mild-to-moderate bronchiolitis, including those on high-flow nasal cannula, from 83% to 95% within 6 months...
2024: Pediatric Quality & Safety
Fatma Tuğba Çetin, Ümmühan Çay, Murat Polat, Fatma Kılınç, Asena Ünal, Nisa Nur Tapaç, Özlem Özgür Gündeşlioğlu, Derya Alabaz, Sevcan Bilen, Filiz Kibar, Nazlı Totik
UNLABELLED: In recent years, the incidence and drug resistance of Candida parapsilosis have increased. Our study aimed to determine the antifungal sensitivity of C. parapsilosis and the clinical and demographic characteristics of children with candidemia. Two hundred pediatric patients with C. parapsilosis candidemia were included in the study between 1 January 2010 and 1 August 2023. Clinical samples were evaluated on a BACTEC-FX-40 automatic blood culture device (Becton Dickinson, USA)...
June 12, 2024: Microbiology Spectrum
Gal Barak, Gail Demmler-Harrison, Linda Rossetti, Venée N Tubman, Ameya S Walimbe, Rathi Asaithambi
A 4-month-old full-term female presented with growth faltering associated with progressive feeding difficulty, rash, abdominal distension, and developmental delays. She was found to have disconjugate gaze, abnormal visual tracking, mixed tone, bruising, and splenomegaly on examination. Initial workup was notable for thrombocytopenia and positive cytomegalovirus (CMV) immunoglobulin G and immunoglobulin M antibodies. She initially presented to the infectious diseases CMV clinic, where she was noted to have severe malnutrition, prompting referral to the emergency department for hospital admission to optimize nutrition with nasogastric tube feeding and facilitate additional evaluation...
June 12, 2024: Pediatrics
Nadine Lysyk Funk, Patricija Januskaite, Ruy Carlos Ruver Beck, Abdul W Basit, Alvaro Goyanes
Enteral feeding tubes (EFTs) can be placed in children diagnosed with HIV which need nutritional support due to malnutrition. EFTs are the main route for medication administration in these patients, bringing up concerns about off label use of medicines, dose inaccuracy and tube clogging. Here we report for the first time the use of selective laser sintering (SLS) 3D printing to develop efavirenz (EFZ) dispersible printlets for patients with HIV that require EFT administration. Water soluble polymers Parteck® MXP and Kollidon® VA64 were used to obtain both 500 mg (P500 and K500) and 1000 mg printlets (P1000 and K1000) containing 200 mg of EFZ each...
June 2, 2024: International Journal of Pharmaceutics
Cheryl Hersh, Mollie Warren, Nora Horick, Jessica Sorbo, Kevin Callans, Shannon Fracchia, Marcela Radano, Christopher Hartnick
OBJECTIVE: To design and validate an age and condition-specific health status instrument to best reflect the parental experience caring for these children with complex needs and home Nasogastric Tube (NGT) placement. STUDY DESIGN: Combined Qualitative and Quantitative design, testing and implementation for item production and reduction, followed by formal validation by evaluating validity, reliability, and establishing a clinically meaningful change score. SETTINGS: Tertiary care, multi-disciplinary aerodigestive center...
May 24, 2024: International Journal of Pediatric Otorhinolaryngology
Samantha Mekhuri, Anam Shahil-Feroz, Natalie Pitch, Munazzah Ambreen, Stephanie Chu, Krista Keilty, Naomi Dussah, Nathalie Major, Julia Orkin, Reshma Amin
BACKGROUND: Nasogastric tube (NGT) feeding is used for children unable to tolerate adequate nutrition orally to sustain growth and development. This vulnerable population is at risk of gaps in care because they often lack a medical home due to the transitional nature of the technology. This study explores perspectives and challenges of family caregivers (FCs) of children requiring NGTs transitioning from hospital to home. METHODS: Semi-structured qualitative interviews were conducted with FCs at the Hospital for Sick Children and Children's Hospital of Eastern Ontario...
May 15, 2024: Pediatric Research
Anna Tuiskula, Alexey S Pospelov, Päivi Nevalainen, Saeed Montazeri, Marjo Metsäranta, Leena Haataja, Nathan Stevenson, Anton Tokariev, Sampsa Vanhatalo
OBJECTIVE: To assess whether computational electroencephalogram (EEG) measures during the first day of life correlate to clinical outcomes in infants with perinatal asphyxia with or without hypoxic-ischemic encephalopathy (HIE). METHODS: We analyzed four-channel EEG monitoring data from 91 newborn infants after perinatal asphyxia. Altogether 42 automatically computed amplitude- and synchrony-related EEG features were extracted as 2-hourly average at very early (6 h) and early (24 h) postnatal age; they were correlated to the severity of HIE in all infants, and to four clinical outcomes available in a subcohort of 40 newborns: time to full oral feeding (nasogastric tube NGT), neonatal brain MRI, Hammersmith Infant Neurological Examination (HINE) at three months, and Griffiths Scales at two years...
May 14, 2024: Pediatric Research
Annie Vu, Subah Nanda, Todd Chassee
Neonatal hypotonia presents with low muscle tone and an array of symptoms that vary depending on the etiology. The differential diagnosis for this condition is complex. It is crucial to exclude life-threatening causes before following a diagnostic algorithm and performing additional tests. Given the wide range of clinical symptoms and etiologies for neonatal hypotonia, rapid genetic testing has the potential to expedite diagnosis, reduce invasive testing such as muscle biopsy, reduce hospital stays, and guide condition management...
March 2024: Curēus
Nisreen Khambati, Rinn Song, Jonathan P Smith, Else Margreet Bijker, Kimberly McCarthy, Eleanor S Click, Walter Mchembere, Albert Okumu, Susan Musau, Elisha Okeyo, Carlos M Perez-Velez, Kevin Cain
For microbiological confirmation of pediatric pulmonary tuberculosis (PTB), gastric aspirates (GA) are often operationally unfeasible without hospitalization, and the encapsulated orogastric string test is not easily swallowed in young children. The Combined-NasoGastric-Tube-and-String-Test (CNGTST) enables dual collection of GA and string specimens. In a prospective cohort study in Kenya, we examined its feasibility in children under five with presumptive PTB and compared the bacteriological yield of string to GA...
April 18, 2024: Diagnostic Microbiology and Infectious Disease
Abdullah Alhelal, Ali M Assiri, Anas A Alqarni, Abdulrazak Tamim, Yazeed M Mohammad
Cerebral palsy (CP) is a neurodevelopmental disorder that affects motor function and is often accompanied by secondary musculoskeletal issues. Severe scoliosis, a lateral curvature of the spine over 40 degrees, poses a significant challenge for individuals with CP, impacting their mobility and overall well-being. While the association between scoliosis and gastrointestinal complications is acknowledged, the occurrence of colonic volvulus with necrosis in the context of CP and severe scoliosis is rare and complex...
March 2024: Curēus
Sarah Fuller, Emerie Sheridan, Lee D Hudson, Dasha Nicholls
OBJECTIVE: To estimate the number of patients on paediatric wards in England who received nasogastric tube (NGT) feeding under physical restraint from April 2022 to March 2023, identify the demographics and clinical characteristics of these patients, and which personnel facilitated the restraint. DESIGN: Audit and anonymous case series SETTING: Paediatric wards in England. PATIENTS: Children and young people receiving this intervention in a 1-year period...
April 22, 2024: Archives of Disease in Childhood
Christina Wolfe, Amy Jnah
Tracheoesophageal fistula (TEF) with or without esophageal atresia (EA) results from maldevelopment of the trachea and esophagus during maturation of the primitive foregut. EA/TEF commonly presents shortly after birth because of increased oral secretions and the inability to advance a nasogastric or orogastric tube to the proper depth. Given that prenatal diagnosis is uncommon and early intervention is important to reduce morbidity and mortality risk, early recognition and diagnosis are imperative. We present a case series of two neonates diagnosed with EA/TEF, type "C" and type "E," born at low-acuity centers, who required transport to a tertiary center for surgical support...
April 1, 2024: Neonatal Network: NN
Jessina Thomas, Chirajyoti Deb, Khaled Bittar, Jeffrey Bornstein, Devendra Mehta, Yamen Smadi
BACKGROUND: Recurrent upper endoscopies are essential for monitoring therapy response and disease activity in patients with eosinophilic esophagitis (EoE), leading to increased costs, procedural complications, and anesthesia exposure. The aim of this study was to examine an office-based model using serial sedation-free blind esophageal epithelial brushing (BEEB) to monitor therapy response through eosinophil-derived neurotoxin (EDN) levels and guide therapy plans in pediatric EoE patients...
April 2024: Journal of Pediatric Gastroenterology and Nutrition
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