Shoichi Deguchi, Yasuto Akiyama, Koichi Mitsuya, Tomoatsu Ikeya, Chikako Hozumi, Akira Iizuka, Haruo Miyata, Chie Maeda, Tadashi Ashizawa, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Koji Muramatsu, Takashi Sugino, Yasuhisa Ohde, Yasuhiro Tsubosa, Seiichiro Nishimura, Ken Yamaguchi
BACKGROUND/AIM: Brain metastasis, a leading cause of cancer death, is a clinical challenge. Recently, genetic characterization of brain metastatic lesions based on next generation sequencing-based advanced technologies, such as single-cell RNA sequencing, has been performed to develop novel efficient therapies. The present study aimed to investigate brain-metastasis-specific biomarkers as well as relevant prognostic factors. PATIENTS AND METHODS: The genetic profiles and expression levels of immune response-associated genes and 820 cancer-associated genes were compared between primary cancer lesions and metastatic cancer lesions obtained from nine cancer patients at the Shizuoka Cancer Center...
May 2024: Anticancer Research