keyword
https://read.qxmd.com/read/38995287/a-case-of-postcoronavirus-disease-2019-antineutrophil-cytoplasmic-antibody-associated-vasculitis-successfully-treated-with-rituximab
#1
JOURNAL ARTICLE
Mahmoud M Mohamed, Atif Ibrahim, Zareen Razaq, Waleed Hassan
We report a case of a 69-year-old Caucasian male with a history of hypertension, Type 2 diabetes, and Stage IIIa chronic kidney disease (CKD), who presented to the emergency department with positional dizziness, generalized weakness, weight loss, and suppressed appetite. Two months earlier, the patient was diagnosed with coronavirus disease 2019 (COVID-19). The patient had non-oliguric acute kidney injury alongside preexisting CKD. The urinalysis showed hematuria and significant non-nephrotic proteinuria. His serological markers were positive for antineutrophil cytoplasmic antibodies with high titers...
December 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38995284/the-prevalence-and-clinicopathological-spectrum-of-nondiabetic-renal-disease-in-patients-with-diabetes-in-a-tertiary-care-center
#2
JOURNAL ARTICLE
Bharathisezhian Anbuselvam, Senthilkumar Ramaiah Panneerselvam, Balasubramaniyan Thoppalan, Manoj Kumar
Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM), leading to end-stage renal disease. A wide spectrum of nondiabetic renal diseases (NDRDs) is reported in type 2 DM. We retrospectively reviewed the medical records of patients with type 2 DM who underwent a kidney biopsy from September 2019 to November 2021 at our center. Patients were grouped as having isolated DN, isolated NDRD, or mixed NDRD with underlying DN. According to the 379 renal biopsies performed during the study period, 57 patients had DM...
December 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38994741/primary-cns-vasculitis-mimicking-brainstem-encephalitis
#3
JOURNAL ARTICLE
Ayush Agarwal, Venugopalan Y Vishnu, Divyani Garg, Ajay Garg, Meher Chand Sharma, Achal K Srivastava, M V Padma Srivastava
No abstract text is available yet for this article.
July 12, 2024: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/38994728/neuro-beh%C3%A3-et-s-presentation-as-cerebral-venous-thrombosis-a-report-of-two-cases-and-review-of-the-literature
#4
JOURNAL ARTICLE
M Gupta, V B Rao, S Ramakrishnan, G B Kulkarni
Cerebral venous thrombosis (CVT) is a rare stroke with multiple risk factors. One rare risk factor is Behçet's disease (BD). Out of around 3000 cases at our center in the past 10 years, two cases of BD with CVT were seen. Herein, we report on their clinical symptoms, course, and management. Case 1 was a 18-year-old girl with a history of recurrent skin lesions presenting with encephalopathy syndrome due to CVT, requiring decompression. Despite our best efforts, she developed complications and expired due to sepsis...
July 12, 2024: Journal of Postgraduate Medicine
https://read.qxmd.com/read/38994595/influenza-vaccination-associated-cryoglobulinemic-vasculitis
#5
JOURNAL ARTICLE
Estelle Taki, Stephanie Wirtshafter, Abdallah S Geara
Mixed cryoglobulinemia is a small vessel vasculitis associated with viral infections, mainly hepatitis C virus, however, other important causes include lymphoproliferative and autoimmune disorders. Influenza vaccine-induced cryoglobulinemia has been rarely reported. A 68-year-old male presented on three occasions following influenza vaccination with purpuric rash and lower extremities swelling. His lab work showed mixed cryoglobulins. On his most recent presentation, in addition to the purpura, he presented with thrombocytopenia and nephritic syndrome...
July 12, 2024: Clinical Nephrology
https://read.qxmd.com/read/38994194/necrotizing-sarcoid-granulomatosis-with-hepatic-involvement-and-reversible-noncirrhotic-portal-hypertension
#6
JOURNAL ARTICLE
Vivek V Jasti, Adam J Hanje
Necrotizing sarcoid granulomatosis falls within the spectrum of sarcoidosis and is characterized by features of necrosis and granulomatous vasculitis. Like classical sarcoidosis, it can affect numerous organ systems, and there is a wide range of disease activity. Few cases of necrotizing sarcoid granulomatosis have been reported in the liver. We present a case of necrotizing sarcoid granulomatosis associated with noncirrhotic portal hypertension.
July 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38993035/food-effect-and-pharmacokinetic-bridging-of-avacopan-in-caucasian-and-japanese-healthy-participants
#7
JOURNAL ARTICLE
Shichang Miao, Pirow Bekker, Danielle Armas, Mary Lor, Ryuzo Hanada, Shota Okamura, Yuko Umezawa, Ashit Trivedi
Avacopan 30 mg twice daily (BID) is approved for the treatment of severe active antineutrophil cytoplasmic autoantibody-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis). Food effect on avacopan pharmacokinetics (PKs) and PK bridging in Japanese participants were examined through 2 phase 1 studies involving healthy adult participants. In Study 1, an open-label, crossover trial, participants received oral administration of a single 30-mg dose of avacopan under fasted and fed conditions...
July 11, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38993026/effect-of-mild-or-moderate-hepatic-impairment-on-the-pharmacokinetics-of-avacopan-a-small-molecule-complement-c5a-receptor-antagonist-for-the-treatment-of-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis
#8
JOURNAL ARTICLE
Shichang Miao, Pablo Suso, John A Furst, Matthew G Hudson, Ashit Trivedi
Avacopan is currently approved in several regions of the world as an oral treatment in combination with standard therapy, including glucocorticoids, for adult patients with severe active antineutrophil cytoplasmic autoantibody-associated vasculitis. In vitro and clinical studies have established that avacopan is primarily eliminated through cytochrome P450 3A4 metabolism. This Phase 1, open-label, single-dose study (ClinicalTrials.gov identifier: NCT06004934) was conducted to evaluate the effect of mild (n = 8) or moderate (n = 8) hepatic impairment compared with normal hepatic function (n = 8) on the pharmacokinetics, safety, and tolerability of a single oral dose of 30 mg of avacopan in patients without active antineutrophil cytoplasmic autoantibody-associated vasculitis...
July 11, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38990790/surgical-intervention-for-giant-pulmonary-artery-aneurysm-in-behcet-disease-a-case-report
#9
JOURNAL ARTICLE
Emilia Mottola, Massimiliano Bassi, Camilla Poggi, Tiziano De Giacomo
BACKGROUND Pulmonary artery aneurysm (PAA), defined as a pathologic dilatation of the PA greater than 1.5-fold the normal diameter, is a rare complication of Behçet disease. It is due to a weakening of the vessel wall for a great vessels' vasculitis, often asymptomatic and incidentally diagnosed on imaging studies. However, if ignored, it can lead to life-threatening complications such as rupture and massive hemoptysis. We report the case of a giant fast-growing PAA in a young patient with a history of Behçet disease in which an inadequate follow-up and poor patient information could had led to life-threatening complications...
July 11, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38990385/etiology-and-prognosis-of-non-kawasaki-disease-induced-coronary-aneurysms-in-children-a-retrospective-case-series-study
#10
JOURNAL ARTICLE
Yao Lin, Huiru Qi, Yanyan Liu, Haojie Wu, Yaqi Li, Lin Shi
UNLABELLED: While Kawasaki disease (KD) induced coronary artery aneurysms (KD CAAs) in children are well studied, the features and prognosis of non-KD induced CAAs (non-KD CAAs) in the pediatric population are poorly documented. This case series study is to analyze the etiology and prognosis of non-KD CAAs in children and compare the characteristics of non-KD CAAs and KD CAAs. Non-KD CAA and KD CAA cases at our department from January 2022 to December 2023 were retrospectively collected...
July 11, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38990100/update-on-antineutrophil-cytoplasmic-autoantibody-vasculitis-in-children
#11
JOURNAL ARTICLE
Jessica L Bloom, Eveline Y Wu
PURPOSE OF REVIEW: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is often organ- or life-threatening in children and impacts them during important periods of psychosocial and physical development. This review covers recent advances in the pathophysiology, diagnosis, management, and outcomes of AAV in children and highlights the ongoing need for funding and increased research collaboration. RECENT FINDINGS: Recent work has improved our understanding of AAV disease pathogenesis, potentially identifying new biomarkers and therapeutic targets...
July 11, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38989288/long-term-cardiovascular-inflammation-and-fibrosis-in-a-murine-model-of-vasculitis-induced-by-lactobacillus-casei-cell-wall-extract
#12
JOURNAL ARTICLE
Ana Paula Lombardi Pereira, Emily Aubuchon, Debbie P Moreira, Malcolm Lane, Thacyana T Carvalho, Thassio R R Mesquita, Youngho Lee, Timothy R Crother, Rebecca A Porritt, Waldiceu A Verri, Magali Noval Rivas, Moshe Arditi
BACKGROUND: Kawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of coronary artery aneurysms (CAA) in affected children, which may persist for months and even years after the acute phase of the disease. There is an unmet need to characterize the immune and pathological mechanisms of the long-term complications of KD. METHODS: We examined cardiovascular complications in the Lactobacillus casei cell wall extract (LCWE) mouse model of KD-like vasculitis over 4 months...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38989186/primary-central-nervous-system-angiitis-a-case-report
#13
JOURNAL ARTICLE
Zahraa M M Zeer, Yasmin N A Arda, Hasan Abu Salim, Mohammad M Abbas
INTRODUCTION: Primary central nervous system angiitis is a rare idiopathic vasculitis that is limited to the central nervous system. It has a wide range of clinical presentations that can mimic other vasculopathies. CASE PRESENTATION: A 24-year-old female patient presents with various non-specific neurological complaints in a progressive course. After a challenging diagnostic work-up, she was diagnosed by tissue biopsy to have primary central nervous system angiitis...
July 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38988901/a-unique-case-of-goodpasture-s-syndrome-induced-cardiorenal-syndrome
#14
JOURNAL ARTICLE
Chidambaram Chinniah, Alexander Pyronneau, Gauthier Stepman, Rias Ali
Goodpasture's syndrome (GPS) is a rare small vessel vasculitis characterized by circulating antibodies directed against the glomerular and alveolar basement membrane leading to renal and pulmonary manifestations. Here, we discuss a unique case of a 30-year-old Caucasian male smoker initially presenting with hemoptysis and anemia who was found to have biopsy-proven GPS with elevated anti-glomerular basement membrane (anti-GBM) antibodies. Unfortunately, the patient failed four months of standard treatment for GPS leading to end-stage renal disease (ESRD), while uniquely developing cardiorenal syndrome (CRS) with non-ischemic cardiomyopathy resulting in systolic and diastolic heart failure (HF)...
July 2024: Curēus
https://read.qxmd.com/read/38988828/eosinophilic-granulomatosis-with-polyangiitis-developed-during-treatment-with-benralizmab-for-severe-asthma-a-case-report-and-literature-review
#15
JOURNAL ARTICLE
Mitsukuni Sakabe, Kazunori Tobino, Yumi Obata, Shota Sogabe, Kazuki Uchida, Yosuke Murakami
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare autoimmune disorder characterized by necrotizing vasculitis, asthma, and eosinophilia. We report a case of EGPA that developed during benralizumab treatment for severe asthma and provide a literature review. A 79-year-old Japanese male with severe asthma presented with generalized purpura 4 months after initiating benralizumab treatment. He had reduced his oral prednisolone dose from 7.5 to 2 mg/day. Laboratory tests revealed eosinophilia, and skin biopsy showed vasculitis with eosinophilic infiltration...
July 2024: Respirology Case Reports
https://read.qxmd.com/read/38988571/cranial-hypertrophic-pachymeningitis-with-myelodysplastic-syndrome
#16
JOURNAL ARTICLE
Shohei Kikuchi, Tomohiro Hayashi, Honoka Nitta, Yusuke Kamihara, Akinori Wada, Tomoki Minemura, Yoshimi Nabe, Jun Murakami, Yuji Nakatsuji, Tsutomu Sato
Hypertrophic pachymeningitis (HP) is a rare inflammatory disease characterized by thickening of the dura mater. HP develops with several inflammatory diseases. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and IgG4 related disease are reported as 2 major causes. With hematologic diseases, only 3 cases have been reported. We report the case of myelodysplastic syndrome (MDS) developing HP. Our case provides a thought-provoking hypothesis regarding the potential relationship between MDS and HP...
June 30, 2024: Heliyon
https://read.qxmd.com/read/38985960/cerebrovascular-accident-caused-by-coccidioides-immitis-basilar-meningitis-in-a-patient-with-stroke-risk-factors
#17
JOURNAL ARTICLE
Annika van Oosbree, Aaron Berg, Jennifer Hsu
A 57-year-old female with a history of type 2 diabetes mellitus and hypertension presented to the emergency department on multiple occasions with neurologic symptoms due to multiple embolic strokes of unclear etiology. While participating in inpatient rehabilitation, she subsequently developed fever and shaking chills. Infectious disease consultation was obtained, during which the patient reported travel to Mexico two months prior. Further diagnostic testing revealed basilar-predominant leptomeningeal enhancement and serum fungal antibody testing returned positive for Coccidioides immitis...
November 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://read.qxmd.com/read/38984230/a-case-series-of-unusual-iga-vasculitis
#18
JOURNAL ARTICLE
Jared Bradley, Ian Whitaker, Brittany Lyons, Amy Mangla
INTRODUCTION: Immunoglobulin A vasculitis (IgA)is a rare condition characterized by palpable purpura, often involving the skin, gastrointestinal tract, joints, and kidneys. Presentation is usually acute and is more common in children and adolescents of Southeast Asian and European descent. In the adult population, it is less common and therapies are not as well-established. CASE PRESENTATION: Disease prevalence of IgA vasculitis outside Southeast Asian and European populations is not well-documented...
2024: HCA Healthc J Med
https://read.qxmd.com/read/38984186/before-symptomatic-internal-carotid-artery-stenoses-can-be-attributed-to-giant-cell-arteritis-other-causes-must-be-ruled-out
#19
JOURNAL ARTICLE
Josef Finsterer
No abstract text is available yet for this article.
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38984173/hypertrophic-pachymeningitis-associated-with-eosinophilic-granulomatosis-with-polyangiitis-and-anca-negative-serology
#20
JOURNAL ARTICLE
Daniel Arturo Martínez-Piña, Ana Laura Calderón-Garcidueñas, Elizabeth Gama-Lizárraga, Kevin Giuseppe Enríquez-Peregrino, José María Curiel-Zamudio
BACKGROUND: Hypertrophic pachymeningitis (HP) is a disease with diverse aetiologies, including the autoimmune one, either associated with antineutrophil cytoplasmic antibodies or immunoglobulin G4. CASE DESCRIPTION: A 65-year-old woman with a history of systemic arterial hypertension, presented with intense progressive headaches. HP and hemispheric vasogenic oedema were observed by nuclear magnetic resonance (NMR) study. During the six months before the headache, she had developed progressive hearing loss which she attributed to age...
2024: European Journal of Case Reports in Internal Medicine
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