Eliza Stalley, Matthew J Verheyden, Elizabeth Eykman, Leticia Deveza
No abstract text is available yet for this article.
September 29, 2023: Rheumatology
Feifei Si, Yaheng Lu, Yizhou Wen, Tingting Chen, Yingzi Zhang, Yanfeng Yang
BACKGROUND: Kawasaki disease (KD) is a type of vasculitis with an unidentified etiology. Cathelicidin (LL-37) may be involved in the development of the KD process; therefore, further research to investigate the molecular mechanism of LL-37 involvement in KD is warranted. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, NLRP3, and LL-37 in the sera of healthy subjects, children with KD, and children with pneumonia...
September 2023: Immunity, Inflammation and Disease
Toshiki Ariyoshi, Madoka Hoshide, Takahiro Motonaga, Yuno Korenaga, Yoshihiro Azuma, Takuya Ichimura, Takeshi Matsushige, Shunji Hasegawa
Childhood primary angiitis of the central nervous system (cPACNS) is a vasculitis of unknown etiology that is confined to the central nervous system (CNS) and can lead to repeated cerebral infarctions if left untreated. Several cases of cPACNS after COVID-19 have been reported. Herein, we present a case of post-vaccination cPACNS. A 9-year-old healthy boy presented with persistent headache and fever after receiving the second COVID-19 vaccine (BNT162b2/Pfizer-BioNtech) dose. Brain magnetic resonance angiography (MRA) performed on the sixth day of symptom onset after vaccination revealed stenosis of the left middle cerebral artery; the patient was referred to our department on the 12th day of symptom onset...
August 2023: Human Vaccines & Immunotherapeutics
Aseel Abuhammad, Osama N Dukmak, Diya Asad, Izzeddin A Bakri, Saed I Y Attawna
Different types of vasculitis have been reported after various vaccine administrations. Recently, the coronavirus disease 2019 (COVID-19) vaccine was one of the most common vaccine-induced vasculitis. Herein, we describe a 56-year-old male patient with chronic hepatitis B who presented with abdominal pain for 2 days, which was associated with vomiting and bloody diarrhea. He had a history of petechial rash for 25 days, multiple joint pain and lower limb weakness after the second dose of the COVID-19 vaccine...
September 2023: Oxford Medical Case Reports
D Bontempo, A M Frydrych, O Kujan, D Gebauer, M Fallon, P K Panegyres
We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral mucosal involvement. A 35-year-old African Zambian man presented with headache and bleeding swollen gingiva. He was myeloperoxidase (MPO) antibody positive with cytoplasmic staining. His MRI showed stable small callosal, periventricular and subcortical white matter non-enhancing lesions, without change over 15 months-compatible with vasculitis...
September 2023: Oxford Medical Case Reports
Nestor Oliva-Damaso, Andrew S Bomback
No abstract text is available yet for this article.
September 1, 2023: Kidney360
Martin Russwurm, Birgit Kortus-Goetze, Tanja Maier-Giebing, Hermann-Josef Groene, Joachim Hoyer
BACKGROUND: ANCA-associated vasculitis is an organ and life-threatening disease with the highest incidence in elderly patients. However, few studies have focussed on characteristics and treatment outcomes in a direct comparison of elderly and younger patients. METHODS: In a retrospective, single-centre, renal biopsy-cohort, patients were dichotomized by age ≥ 65 years to analyse baseline clinical, histological, laboratory and immunological characteristics and outcome differences in elderly and younger patients as regard to mortality, renal recovery from dialysis and eGFR after two years...
September 28, 2023: Journal of Nephrology
Dong Wang, Zunjing Liu, Huailian Guo, Li Yang, Xinhua Zhang, Li Peng, Min Cheng, Hong Jiang
Giant cell arteritis (GCA) is a kind of systemic vasculitis affecting individuals over 50 years old and is often the cause of new-onset headaches in older adults. Patients with GCA sometimes have rheumatic polymyalgia (PMR). The diagnosis of GCA generally depends on clinical manifestation, elevated erythrocyte sedimentation rate (ESR) or C-reactive protein, and positive imaging findings commonly obtained by ultrasound or temporal artery biopsy. In this study, we report a case of an 83-year-old woman with a new-onset headache and an elevated ESR...
2023: Frontiers in Neurology
N Ashok Kumar, Manoharan Dhanaraj, Shreya Srinivasan, Raksha Raja Narendra
Nodular lesions can be seen in a wide range of conditions such as infections, granulomatous conditions, neutrophilic disorders, vasculitis, benign tumours and malignant conditions. These numerous aetiologies behind the occurrence of nodular lesions signify the importance of thorough work-up of the patient to diagnose the underlying reason behind the clinical condition. Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation, the diagnosis of which can be challenging. Extracutaneous signs such as arthralgias, oral and penile ulcers, involvement of the eye and neuropathy have all been linked to it...
August 2023: Journal of Family Medicine and Primary Care
Muhammad Hamza Mushtaq, Osama Ali Khan, Hasnat Khan, Muhammad Tabish Ikram, Muhammad Danyal Tariq
Behcet syndrome is a systemic vasculitic syndrome. Vascular involvement in Behcet syndrome affects both arterial and venous vascular systems, contributing to significant morbidity and mortality. However, diagnosing vascular lesions can be challenging due to their resemblance to common vascular diseases, leading to potential misdiagnoses. This case report emphasizes the importance of recognizing atypical manifestations of this disease to ensure a prompt and accurate diagnosis. This case report describes a unique presentation of Behcet syndrome in a 23-year-old male patient who presented with per rectal bleeding, abdominal distension, right quadrant abdominal pain, pleuritic chest pain, and fever...
August 2023: Curēus
Sataroopa Mishra, Saurabh Kumar Gupta, Sivasubramanian Ramakrishnan, Shyam Sunder Kothari, Anita Saxena, Sanjeev Kumar
Organ-specific vasculitis is an uncommon, delayed complication of COVID-19 infection. It is usually seen in mildly symptomatic or asymptomatic patients. Underlying endothelitis is the most likely pathophysiological mechanism for such a manifestation. We report two infants with renal artery stenosis, most likely consequent to COVID-19 infection.
2023: Annals of Pediatric Cardiology
Michela Amatruda, Nicolina Stefania Carucci, Roberto Chimenz, Giovanni Conti
The clinical spectrum of immunoglobulin A vasculitis nephritis (IgAVN) ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome, rapidly progressive glomerulonephritis, or even renal failure. Clinical and experimental studies have shown a multifactor pathogenesis: Infection triggers, impaired glycosylation of IgA1, complement activation, Toll-like-receptor activation and B cell proliferation. This knowledge can identify IgAVN patients at a greater risk for adverse outcome and increase the evidence for treatment recommendations...
September 25, 2023: World Journal of Nephrology
Ionuț Isaia Jeican, Dan Gheban, Alexandra Mariș, Silviu Albu, Maria Aluaș, Costel Vasile Siserman, Bogdan Alexandru Gheban
COVID-19-associated coinfections increase the patient's risk of developing a severe form of the disease and, consequently, the risk of death. The term "flurona" was proposed to describe the coinfection of the influenza virus and SARS-CoV-2. This report is about a case of a 7-month-old female infant who died due to flurona coinfection. A histopathological exam showed activation of microglia (becoming CD45 positive), bronchial inflammation, diffuse alveolar damage in proliferative phase with vasculitis, a peribronchial infiltrate that was predominantly CD20-positive, and a vascular wall infiltrate that was predominantly CD3-positive...
September 7, 2023: Medicina
Maria Carmela Padula, Angela Anna Padula, Salvatore D'Angelo, Nancy Lascaro, Rosa Paola Radice, Giuseppe Martelli, Pietro Leccese
Tumor Necrosis Factor-alpha ( TNFα ) rs1800629 (-308G>A) is a single nucleotide polymorphism (SNP) related to variable responses to anti- TNFα therapy. This therapy is efficient in severe and refractory manifestation of Behçet syndrome (BS), an auto-inflammatory systemic vasculitis. We investigated (1) the association between rs1800629 genotypes and responses to therapy and (2) the correlation between SNP and clinical patterns in a cohort of 74 BS Italian patients receiving anti- TNFα therapy with a follow-up of at least 12 months...
August 31, 2023: Journal of Personalized Medicine
Ryu Watanabe, Motomu Hashimoto
Eosinophilic granulomatosis with polyangiitis (EGPA) causes necrotizing vasculitis and eosinophil-rich granulomatous inflammation in small- to medium-sized vessels, resulting in multiple organ damage. EGPA is classified as an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with myeloperoxidase-ANCA detected in approximately one-third of the patients. Conventional treatment of EGPA relies on systemic glucocorticoids (GCs) in combination with cyclophosphamide when poor prognostic factors are present; however, the dilemma between disease control and drug-related adverse effects has long been a challenge...
September 15, 2023: Journal of Clinical Medicine
Syed Hasan, Nabeel Khatri, Zainab N Rahman, Amanda A Menezes, Joud Martini, Faheem Shehjar, Numa Mujeeb, Zahoor A Shah
Flavonoids are a large subgroup of polyphenols known to be sourced from over 6000 natural products, including fruits, vegetables, bark, and herbs. Due to their antioxidant properties, flavonoids have been implicated as a therapy source for many diseases and conditions, including inflammation, vasculitis, venous insufficiency, and hemorrhoids. Currently, some flavonoids are being researched for their antioxidant ability concerning neuroprotection. These flavonoids can penetrate the blood-brain barrier and, depending on the specific flavonoid, retain adequate bioavailability in certain brain regions...
August 29, 2023: Brain Sciences
Monica Singh, Baani Singh, Kirti Sharma, Nitin Kumar, Sarabjit Mastana, Puneetpal Singh
Avascular necrosis of the femoral head (ANFH) is a painful disorder characterized by the cessation of blood supply to the femoral head, leading to its death and subsequent joint collapse. Influenced by several risk factors, including corticosteroid use, excessive alcohol intake, hypercholesterolemia, smoking and some inflammatory disorders, along with cancer, its clinical consequences are thrombus formation due to underlying inflammation and endothelial dysfunction, which collaborates with coagulopathy and impaired angiogenesis...
September 14, 2023: Cells
Mai A Salem, Olfat A Mahdy, Mohamed Shaalan, Reem M Ramadan
Cattle Egret (Bubulcus ibis) is one of the most well-known herons in Egypt. It is called the friend of the farmer because it benefits farmers and helps them get rid of insects and worms. It acts as a reservoir for many diseases. Few researchers have discussed the significance of parasitic diseases that affect this wild bird and may lead to mortalities among the population especially the importance of vital organs such as kidneys. Therefore, this study aimed to spotlight parasitic infection-affected herons in Egypt and consider the risks to this beneficial bird...
September 27, 2023: Scientific Reports
Deepti Vibha, Rajesh Kumar Singh, Ajay Garg, Manjari Tripathi
Primary angiitis of the central nervous system (PACNS) is an autoimmune disease with myriad presentations in the form of headache, focal neurological deficits, seizures and rapid cognitive decline. Predilection or isolated and recurrent involvement of one hemisphere is rarely described in literature. This leads to low clinical suspicion and often delayed diagnosis of PACNS, if clinical and radiological involvement is focal. We describe the case of a young man presenting with new-onset focal seizures with imaging suggestive of focal involvement and the brain biopsy clinched an early diagnosis...
September 27, 2023: BMJ Case Reports
Jens Rathmann, Mårten Segelmark, Aladdin J Mohammad
OBJECTIVE: To evaluate the ACR/EULAR 2022 criteria for AAV classification and compare it to the EMA algorithm and to classification based only on ANCA serology. METHODS: In the analysis, 374 cases (47% female) were classified according to EMA algorithm, ANCA serology, and ACR/EULAR criteria. The agreement rate was calculated using the kappa (κ) statistic. RESULTS: Under EMA, 192 patients were classified as GPA, 159 as MPA, and 23 as EGPA...
September 27, 2023: Rheumatology
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