Yu Zhang, Bo-Yang Zheng, Qian-Fan Zhang, Ya-Nan Zhao, Qi-Ming Yu, Xin Liu, Si-Ying Ding, Shuang-Shuang Qian, Han Wu, Qian-Yu Wu, Yu-Han Zhang, Lei Zheng, Xin-Hua Zhang, Hao-Feng Zhang, Yi-Ming Hao, Jing-Chao Lu, Lei Wang, Jin-Kun Wen, Bin Zheng
Vascular restenosis following angioplasty continues to pose a significant challenge. The heterocyclic trioxirane compound [1, 3, 5-tris((oxiran-2-yl)methyl)-1, 3, 5-triazinane-2, 4, 6-trione (TGIC)], known for its anticancer activity, was utilized as the parent ring to conjugate with a non-steroidal anti-inflammatory drug, resulting in the creation of the spliced conjugated compound BY1. We found that BY1 induced ferroptosis in VSMCs as well as in neointima hyperplasia. Furthermore, ferroptosis inducers amplified BY1-induced cell death, while inhibitors mitigated it, indicating the contribution of ferroptosis to BY1-induced cell death...
May 14, 2024: Biomaterials