Changjian Zhu, Ruilin Zheng, Xu Han, Ziwen Tang, Feng Li, Xinrong Hu, Ruoni Lin, Jiani Shen, Qiaoqiao Pei, Rong Wang, Guangyan Wei, Zhenwei Peng, Wei Chen, Zhou Liang, Yi Zhou
Integrin αvβ6 holds promise as a therapeutic target for organ fibrosis, yet targeted therapies are hampered by concerns over inflammatory-related side effects. The role of αvβ6 in renal inflammation remains unknown, and clarifying this issue is crucial for αvβ6-targeted treatment of chronic kidney disease (CKD). Here, we revealed a remarkable positive correlation between overexpressed αvβ6 in proximal tubule cells (PTCs) and renal inflammation in CKD patients and mouse models...
June 6, 2024: Cell Death & Disease