Zeshan A Chisty, Deana D Li, Melia Haile, Hollis Houston, Juliana DaSilva, Rahsaan Overton, Amy J Schuh, Jenn Haynie, Jacob Clemente, Alicia G Branch, Melissa M Arons, Clarisse A Tsang, Gerald J Pellegrini, Julia Bugrysheva, Justina Ilutsik, Romy Mohelsky, Patricia Comer, Solomon B Hundia, Hyungseok Oh, Matthew J Stuckey, Caitlin D Bohannon, Mohammed Ata Ur Rasheed, Monica Epperson, Natalie J Thornburg, L Clifford McDonald, Allison C Brown, Preeta K Kutty
BACKGROUND: Understanding the immune response kinetics to SARS-CoV-2 infection and COVID-19 vaccination is important in nursing home (NH) residents, a high-risk population. METHODS: An observational longitudinal evaluation of 37 consenting vaccinated NH residents with/without SARS-CoV-2 infection from October 2020 to July 2022 was conducted to characterize the immune response to spike protein due to infection and/or mRNA COVID-19 vaccine. Antibodies (IgG) to SARS-CoV-2 full-length spike, nucleocapsid, and receptor binding domain protein antigens were measured, and surrogate virus neutralization capacity was assessed using Meso Scale Discovery immunoassays...
2024: PloS One