Michiaki Nagai, Takeshi Fujiwara, Kazuomi Kario
No abstract text is available yet for this article.
July 30, 2021: Journal of Clinical Hypertension
Asirvatham Alwin Robert, Abdulghani Al Saeed, Mohamed Abdulaziz Al Dawish
BACKGROUND AND AIM: This review aims to report the current status of COVID-19 among people with diabetes, newly diagnosed diabetes, diabetic ketoacidosis, and programmatic efforts including vaccinations. METHODS: We conducted a literature search using PubMed, Google, and Scopus until July 15, 2021. RESULTS: In Saudi Arabia, most studies have reported diabetes as one of the highly prevalent comorbidities among patients with COVID-19. Currently, there are limited studies from Saudi Arabia on the newly diagnosed diabetes and diabetic ketoacidosis caused by COVID-19...
July 24, 2021: Diabetes & Metabolic Syndrome
Jothydev Kesavadev, Anjana Basanth, Gopika Krishnan, Rebecca Vitale, Hari Parameswaran, Sajna Shijin, Sreelakshmi R, Sumesh Raj, Asha Ashik, Arun Shankar, Sameer Badarudeen, A V Raveendran, Indu Rajalakshmy, Geethu Sanal, Akhila Manoj, Remya Jose, Yaseen Unes, Sunitha Jothydev
AIM: Amidst COVID-19 pandemic, the health care delivery in India faces major challenges owing to the overwhelming hospitals, exhausted healthcare workers, and shortage of crucial medical supplies such as ventilators and oxygen. The study aims to propose a novel successful interventional home care model, the Virtual COVID In-Patient (VCIP) care for effective COVID management. METHODS: The Covid-19 positive patients enrolled in VCIP were chosen for the study. A 24/7 active multidisciplinary WhatsApp group was created for each patient, for remote monitoring of temperature, blood pressure, blood glucose, respiratory and pulse rate along with the symptoms...
July 23, 2021: Diabetes & Metabolic Syndrome
Albert Serra-Compte, Susana González, Marina Arnaldos, Sabrina Berlendis, Sophie Courtois, Jean Francois Loret, Olivier Schlosser, Adela M Yáñez, Elena Soria-Soria, Mariana Fittipaldi, Gemma Saucedo, Anna Pinar-Méndez, Miquel Paraira, Belén Galofré, Juan M Lema, Sabela Balboa, Miguel Mauricio-Iglesias, Albert Bosch, Rosa M Pintó, Isabelle Bertrand, Christophe Gantzer, Carlos Montero, Xavier Litrico
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is shed in the feces of infected people. As a consequence, genomic RNA of the virus can be detected in wastewater. Although the presence of viral RNA does not inform on the infectivity of the virus, this presence of genetic material raised the question of the effectiveness of treatment processes in reducing the virus in wastewater and sludge. In this work, treatment lines of 16 wastewater treatment plants were monitored to evaluate the removal of SARS-CoV-2 RNA in raw, processed waters and sludge, from March to May 2020...
July 15, 2021: Water Research
A J Khan, K Nishimi, P Tripp, D Maven, A Jiha, E Woodward, S Inslicht, A Richards, T C Neylan, S Maguen, A O'Donovan
BACKGROUND: The coronavirus-2019 (COVID-19) pandemic is associated with increased potential for morally injurious events, during which individuals may experience, witness, or learn about situations that violate deeply held moral beliefs. However, it is unknown how pandemic risk and resilience factors are associated with COVID-related moral injury. METHODS: Individuals residing in the U.S. (N = 839; Mage  = 37.09, SD = 11.06; 78% women; 63% White; 33% PTSD) participating in an online survey reported on COVID-19 related moral injury (modified Moral Injury Events Scale), perceived current and future threat of pandemic on life domains (social, financial, health), and COVID-19 risky and protective behaviors...
July 22, 2021: Journal of Psychiatric Research
Duduzile Ndwandwe, Charles S Wiysonge
COVID-19 is a pandemic of unprecedented proportions in recent human history. Less than 18 months since the onset of the pandemic, there are close to two hundred million confirmed cases and four million deaths worldwide. There have also been massive efforts geared towards finding safe and effective vaccines. By July 2021 there were 184 COVID-19 vaccine candidates in pre-clinical development, 105 in clinical development, and 18 vaccines approved for emergency use by at least one regulatory authority. These vaccines include whole virus live attenuated or inactivated, protein-based, viral vector, and nucleic acid vaccines...
July 12, 2021: Current Opinion in Immunology
Amine Bouachba, Fabienne Allias, Beatrice Nadaud, Jerome Massardier, Yahia Mekki, Maude Bouscambert Duchamp, Benoit De LA Fourniere, Cyril Huissoud, Alexis Trecourt, Sophie Collardeau-Frachon
INTRODUCTION: Pregnant women with covid-19 are more likely to experience preterm birth. The virus seems to be associated with a wide range of placental lesions, none of them specific. METHOD: We collected cases of Covid-19 maternal infection during pregnancy associated with poor pregnancy outcomes, for which we received the placenta. We studied clinical data and described pathological findings of placenta and post-mortem examination of fetuses. We performed an immunohistochemical study and RT-PCR of SARS-Cov-2 on placenta samples...
July 15, 2021: Placenta
Amanda Culp-Roche, Fran Hardin-Fanning, Todd Tartavoulle, Debra Hampton, Angie Hensley, Jessica L Wilson, Amanda Thaxton Wiggins
BACKGROUND: COVID-19 forced many colleges and schools of nursing to abruptly pivot face-to-face learning to online formats. Online teaching is not new, but some faculty have not taught in a virtual environment and rapidly transitioning courses online was challenging. It is not known if teacher self-efficacy was impacted by these circumstances. OBJECTIVES: We aimed to assess online teacher self-efficacy of nursing faculty who transitioned at least one-face-to face course to an online format...
July 22, 2021: Nurse Education Today
Vahid Babaahmadi, Hooman Amid, Mohammadreza Naeimirad, Seeram Ramakrishna
Providing the greater public with the current coronavirus (SARS-CoV-2) vaccines is time-consuming and research-intensive; intermediately, some essential ways to reduce the transmission include social distancing, personal hygiene, testing, contact tracing, and universal masking. The data suggests that universal masking, especially using multilayer surgical face masks, offers a powerful efficacy for indoor places. These layers have different functions including antiviral/antibacterial, fluid barrier, particulate and bacterial filtration, and fit and comfort...
July 24, 2021: Science of the Total Environment
Dongren Sun, Hengshu Chen, Yeqing Xiao, Weiye Xu, Fan Liu, Shihang Luo, Fafa Tian
No abstract text is available yet for this article.
July 24, 2021: Clinical Imaging
Om Prakash Singh, Marta Vallejo, Ismail M El-Badawy, Ali Aysha, Jagannathan Madhanagopal, Ahmad Athif Mohd Faudzi
Due to the continued evolution of the SARS-CoV-2 pandemic, researchers worldwide are working to mitigate, suppress its spread, and better understand it by deploying digital signal processing (DSP) and machine learning approaches. This study presents an alignment-free approach to classify the SARS-CoV-2 using complementary DNA, which is DNA synthesized from the single-stranded RNA virus. Herein, a total of 1582 samples, with different lengths of genome sequences from different regions, were collected from various data sources and divided into a SARS-CoV-2 and a non-SARS-CoV-2 group...
July 21, 2021: Computers in Biology and Medicine
Selvakumar Murugesan, Sanjay Kottekad, Inchara Crasta, Sivakumar Sreevathsan, Dandamudi Usharani, Madan Kumar Perumal, Sandeep Narayan Mudliar
Coronavirus Disease-2019 (COVID-19), a viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a global pandemic by WHO in 2020. In this scenario, SARS-CoV-2 main protease (COVID-19 Mpro ), an enzyme mainly involved in viral replication and transcription is identified as a crucial target for drug discovery. Traditionally used medicinal plants contain a large amount of bioactives and pave a new path to develop drugs and medications for COVID-19. The present study was aimed to examine the potential of Emblica officinalis (amla), Phyllanthus niruri Linn...
July 24, 2021: Computers in Biology and Medicine
Yeong-Geun Lee, Kyung Won Kang, Woojae Hong, Yeon Hwa Kim, Jen Taek Oh, Dae Won Park, Minsung Ko, Yun-Feng Bai, Young-Jin Seo, Sang-Myeong Lee, Hyunggun Kim, Se Chan Kang
Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B...
July 23, 2021: Bioorganic & Medicinal Chemistry
Narges Karimi, Ali Asghar Okhovat, Bentolhoda Ziaadini, Bahram Haghi Ashtiani, Shahriar Nafissi, Farzad Fatehi
Several neurological presentations have been reported following coronavirus 2019 (COVID-19) infection. This case report describes three myasthenia gravis (MG) patients presented following COVID-19 infection. We report three adult patients with myasthenic Gravis and COVID-19 infection. The patients are between 38 and 61 years old. Case 1 is a 61-year-old woman with progressive dysphagia, nasal speech, ocular ptosis, diplopia, and proximal muscle weakness for 10 days. She had a COVID-19 infection 6 weeks ago...
July 23, 2021: Clinical Neurology and Neurosurgery
Yair Daykan, Rina Tamir Yaniv, Yael Yagur, Meir Pomerantz, Nissim Arbib, Zvi Klein, Ron Schonman
OBJECTIVE: COVID-19 pandemic caused a dramatic decline in the gynecology emergency department (ED) visits. The Israeli government took a determined step of quarantine to suppress and control the spread. This study evaluates the effect of the COVID -19 quarantine on gynecology emergency department (ED) visits compared to the previous year. MATERIALS AND METHODS: A retrospective case-control study was conducted during the first half-year of the COVID-19 pandemic and focused on the quarantine during April...
July 27, 2021: Journal of Gynecology Obstetrics and Human Reproduction
Dora Buonfrate, Chiara Piubelli, Federico Gobbi, Davide Martini, Giulia Bertoli, Tamara Ursini, Lucia Moro, Niccolò Ronzoni, Andrea Angheben, Paola Rodari, Chiara Cardellino, Francesca Tamarozzi, Stefano Tais, Eleonora Rizzi, Monica Degani, Michela Deiana, Marco Prato, Ronaldo Silva, Zeno Bisoffi
OBJECTIVES: We assessed the antibody response to BNT162b2 mRNA COVID-19 vaccine in a cohort of health care workers (HCW), comparing subjects with previous SARS-CoV-2 infection and naïve subjects. METHODS: HCW were tested at T0 (day of first dose), T1 (day of second dose), and T2 (2-3 weeks after) for IgG anti nucleocapside protein, IgM anti spike protein and IgG anti receptor binding domain (IgG-RBD-S). The antibody response was compared between 4 main groups: A) Subjects with previous infection and positive antibodies at baseline; B) subjects with same history but negative antibodies; C) subjects with no infection history but positive antibodies; D) naïve subjects...
July 27, 2021: Clinical Microbiology and Infection
Sarah Erem, Mohammed S Razzaque
This review examines the beneficial effects of ultraviolet radiation on systemic autoimmune diseases, including multiple sclerosis and type I diabetes, where the epidemiological evidence for the vitamin D-independent effects of sunlight is most apparent. Ultraviolet radiation, in addition to its role in the synthesis of vitamin D, stimulates anti-inflammatory pathways, alters the composition of dendritic cells, T cells, and T regulatory cells, and induces nitric oxide synthase and heme oxygenase metabolic pathways, which may directly or indirectly mitigate disease progression and susceptibility...
July 27, 2021: Journal of Steroid Biochemistry and Molecular Biology
Juan Zhao, Ling Wang, Madison Schank, Xindi Dang, Zeyuan Lu, Dechao Cao, Sushant Khanal, Lam N Nguyen, Lam N T Nguyen, Jinyu Zhang, Yi Zhang, James L Adkins, Evan M Baird, Xiao Y Wu, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
The COVID-19 pandemic caused by SARS-CoV-2 infection poses a serious threat to public health. An explicit investigation of COVID-19 immune responses, particularly the host immunity in recovered subjects, will lay a foundation for the rational design of therapeutics and/or vaccines against future coronaviral outbreaks. Here, we examined virus-specific T cell responses and identified T cell epitopes using peptides spanning SARS-CoV-2 structural proteins. These peptides were used to stimulate peripheral blood mononuclear cells (PBMCs) derived from COVID-19-recovered subjects, followed by an analysis of IFN-γ-secreting T cells by enzyme-linked immunosorbent spot (ELISpot)...
July 27, 2021: Virus Research
Hui Ma, Arabelle Cassedy, Richard O'Kennedy
Cardiovascular disease has remained the world's biggest killer for 30 years. To aid in the diagnosis and prognosis of patients suffering cardiovascular-related disease accurate detection methods are essential. For over 20 years, the cardiac-specific troponins, I (cTnI) and T (cTnT), have acted as sensitive and specific biomarkers to assist in the diagnosis of various types of heart diseases. Various cardiovascular complications were commonly detected in patients with COVID-19, where cTn elevation is detectable, which suggested potential great prognostic value of cTn in COVID-19-infected patients...
July 27, 2021: Journal of Immunological Methods
Elena Moizo, Alberto Zangrillo, Sergio Colombo, Carlo Leggieri, Milena Mucci, Paolo Beccaria, Nicola Pasculli, Giovanni Borghi, Valentina Paola Plumari, Alessia La Bruna, Roberto Dossi, Martina Baiardo Redaelli, Anna Tornaghi, Gaetano Lombardi, Giovanni Landoni, Antonio Dell'Acqua, Francesca Guzzo, Giacomo Monti
BACKGROUND: Percutaneous dilation tracheostomy is an aerosol-generating procedure carrying a documented infectious risk during respiratory virus pandemics. For this reason, during the COVID-19 outbreak, surgical tracheostomy was preferred to the percutaneous one, despite the technique related complications increased risk. METHODS: We describe a new sequence for percutaneous dilation tracheostomy procedure that could be considered safe both for patients and healthcare personnel...
July 27, 2021: Brazilian Journal of Anesthesiology
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