Paolo Agostinis, Giulia Bontempo, Paola Della Siega, Valentina Gerussi, Alberto Pagotto, Emanuela Barbano, Lucia Mazzoran, Mario Calci, Massimo Sponza, Francesco Sbrana, Stefano Fapranzi, Aldo Baritussio, Carlo Tascini
Coronavirus disease 2019 poses a serious threat to public health. The protocol developed at the Azienda Sanitaria Universitaria Friuli Centrale (Italy) is based on clinical data, laboratory tests, chest echography and HRCT. Several therapeutic options are considered, since patients vary in disease severity, evolution and co-morbidities and because so far there are no clear indications about therapeutic strategy based on randomized clinical trial. In this protocol chest echography has a central role in categorizing patient status, follow-up and decision-making...
December 16, 2020: New Microbiologica
E Dickson, N E Palmateer, J Murray, C Robertson, C Waugh, L A Wallace, L Mathie, K Heatlie, S Mavin, P Gousias, B Von Wissman, D J Goldberg, A McAuley
OBJECTIVES: The impact of the COVID-19 pandemic in Scotland has been amongst the most severe in Europe. Serological surveillance is critical to determine the overall extent of infection across populations and to inform the public health response. This study aimed to estimate the proportion of people who have antibodies to SARS-CoV-2 ('seroprevalence') in the general population of Scotland and to see if this changes over time. STUDY DESIGN/METHODS: Between International Organization for Standardization (ISO) week 17 (i...
November 24, 2020: Public Health
Mor Saban, Anna Reznik, Tal Shachar, Rachel Wilf-Miron, Rotem Sivan-Hoffmann
PURPOSE: To examine the impact of the COVID-19 pandemic on the presentation and care provided to patients with acute ischemic stroke (AIS) at the emergency department (ED). METHOD: A retrospective-archive study was conducted between January-April 2020, compared with the parallel months in 2017-2019, in a comprehensive stroke center. We compared the time from symptoms onset to ED arrival, the number of neurologic consultations completed in the ED, patients diagnosed with AIS, patients receiving acute treatment and hospital mortality...
December 26, 2020: Journal of Critical Care
Kim Eun-Sung, Chung Ji-Bum
The Korean government collects and releases sociodemographic information about people infected with COVID-19, their travel histories, and whether or not the patients wore masks. Korean mothers then upload this information on the boards of online groups called "mom cafes." Based upon a digital ethnography of 15 "mom cafes," we examine how Korean mothers understand the travel histories of virus patients and explore the relationships between morality and materiality in the context of infectious disease surveillance...
January 5, 2021: Social Science & Medicine
Daniel Martin Simadibrata, Julius Calvin, Alya Darin Wijaya, Naufal Arkan Abiyyu Ibrahim
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of severity and mortality in COVID-19 patients. Here, we investigated whether NLR levels on admission could predict the severity and mortality of COVID-19 patients. METHODS: A literature search was conducted on 23 July 2020 to retrieve all published articles, including grey literature and preprints, investigating the association between on-admission NLR values and severity or mortality in COVID-19 patients...
January 9, 2021: American Journal of Emergency Medicine
Howard Stringer, Andrew Molloy, Joanne Craven, John Moorehead, Alasdair Santini, Lyndon Mason
INTRODUCTION AND AIMS: COVID-19 has had a significant impact on orthopaedic surgery globally. This paper aims to evaluate the impact of COVID-19 on foot and ankle trauma in a major trauma centre. METHODS: A retrospective observational study of prospectively collected data was performed. All foot and ankle trauma patients over a 33 week period (1st December 2019-16th July 2020) were analysed. All patients with trauma classified by the AO/OTA as occurring at locations 43 and 81-88 were included...
January 2, 2021: Foot
Colin Reilly, Amy Muggeridge, J Helen Cross
PURPOSE: To garner the views of young people with epilepsy and caregivers regarding the impact of COVID-19 and subsequent restrictions in the UK. MEHODS: An online survey was used to explore the views of young people with epilepsy (n = 71) and caregivers (n = 130) in June 2020. It included questions on the impact of the pandemic and associated restrictions on the child's epilepsy and on child and parental wellbeing. RESULTS: One in three young people and 29 % of caregivers reported that the young person's seizures had increased during the pandemic (only 10 % of young people and 8% of caregivers reported a decrease)...
January 8, 2021: Seizure: the Journal of the British Epilepsy Association
Jude Mary Cénat, Pari-Gole Noorishad, Cyrille Kossigan Kokou-Kpolou, Rose Darly Dalexis, Saba Hajizadeh, Mireille Guerrier, Lewis Ampidu Clorméus, Jacqueline Bukaka, Jean-Pierre Birangui, Kouami Adansikou, Assumpta Ndengeyingoma, Vincent Sezibera, Daniel Derivois, Cécile Rousseau
OBJECTIVES: Currently, there is little data on the mental health consequences of the COVID-19 pandemic in low- and middle-income countries (LMICs). This study aims to examine the pooled and separate prevalence and determinants of depression during the pandemic in samples from four LMICs. METHODS: Participants (N= 1267, 40.9% women) were recruited from the Democratic Republic of the Congo (DRC), Haiti, Rwanda, and Togo. They completed an online cross-sectional survey on sociodemographics, exposure and stigmatization related to COVID-19, the Hopkins Symptom Checklist depression subscale, and the Connor-Davidson Resilience Scale-2...
January 8, 2021: Psychiatry Research
Luca Valenti, Samantha Griffini, Giuseppe Lamorte, Elena Grovetti, Sara Colonia Uceda Renteria, Francesco Malvestiti, Luigia Scudeller, Alessandra Bandera, Flora Peyvandi, Daniele Prati, Pierluigi Meroni, Massimo Cugno
BACKGROUND: Genetic variation at a multigene cluster at chromosome 3p21.31 and the ABO blood group have been associated with the risk of developing severe COVID-19, but the mechanism remains unclear. Complement activation has been associated with COVID-19 severity. OBJECTIVE: The aim of this study was to examine whether chromosome 3p21.31 and the ABO variants are linked to the activation of the complement cascade in COVID-19 patients. METHODS: We considered 72 unrelated European hospitalized patients with genetic data and evaluation of circulating C5a and soluble terminal complement complex C5b-9 (SC5b-9)...
January 9, 2021: Journal of Autoimmunity
Anne-Sophie Michel, Victoire De Logiviere, Aurélie Schnuriger, Mathilde Lefebvre, Emeline Maisonneuve, Gilles Kayem
BACKGROUND: Data about obstetric complications of maternal infection by SARS-CoV-2 remain sparse. CASE: A 40-year-old pregnant woman, gravida 3 para 1 with no previous obstetric complications, presented a late miscarriage at 16 weeks of gestation on day 9 of COVID-19 disease. The results of her nasopharyngeal swab for SARS-CoV-2, tested the same day, were negative, but the placenta was infected by SARS-CoV-2 and serology was positive 11 days later. No other obstetric or infectious cause was found to explain this outcome...
January 13, 2021: Journal of Gynecology Obstetrics and Human Reproduction
Miguel A Ruiz-Barrera, Mariana Agudelo-Arrieta, Rafael Aponte-Caballero, Santiago Gutierrez-Gomez, Miguel Angel Ruiz-Cardozo, Humberto Madrinan-Navia, David Vergara-Garcia, William M Riveros-Castillo, Javier M Saavedra
BACKGROUND: Continuing Medical Education (CME) and Continuing Professional Development (CPD) have been affected by the ongoing COVID-19 pandemic. Accordingly, the authors developed the 2020 International Web-Based Neurosurgery Congress (2020-IWBNC), which became the first successful virtual neurosurgical congress. The current article aims to describe this experience in designing and organizing a web-congress by the 2020-IWBNC method. METHODS: The 2020-IWBNC was organized by the Center for Research and Training in Neurosurgery (CIEN in Spanish) in a record time of four weeks...
January 13, 2021: World Neurosurgery
Louai Razzouk, Michael E Farkouh
No abstract text is available yet for this article.
January 13, 2021: Trends in Cardiovascular Medicine
Alina Daciana Elec, Mihai Oltean, Patricia Goldis, Cristina Cismaru, Mihaela Lupse, Adriana Muntean, Florin Ioan Elec
OBJECTIVES: The lack of effective COVID-19 treatments mandated the repurposing of several drugs, including antiretrovirals (ARV) and remdesivir (RDV). These compounds may induce acute kidney injuries and are not recommended in patients with poor renal function, such as kidney transplant recipients (KTx). METHODS: We reviewed the records of 42 KTx with COVID-19, some of them receiving ARV (n = 10) or RDV (n = 8) as part of the COVID-19 management. Most patients were male (71%) with a median age of 52 years and median GFR 56 mL/min and had mild (36%), moderate (19%), severe (31%), and critical (12%) disease...
January 13, 2021: International Journal of Infectious Diseases: IJID
Yash Gupta, Dawid Maciorowski, Samantha E Zak, Krysten A Jones, Rahul S Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M Pearce, David J Ilc, Hamza Husein, Andrew S Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P Becker, Bryan C Dickinson, John M Dye, Prakasha Kempaiah
SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2'-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1)...
January 13, 2021: Methods: a Companion to Methods in Enzymology
Adnan Azim, Laura Pini, Zeeshan Khakwani, Santosh Kumar, Peter Howarth
No abstract text is available yet for this article.
January 13, 2021: Annals of Allergy, Asthma & Immunology
Kunal Das, Manish Raturi, Nitika Agrawal, Mansi Kala, Anuradha Kusum
The National Blood Transfusion Services under the aegis of the ministry of health and family welfare, India has recently issued guidelines regarding the blood donor selection criteria and the processing of blood. Care has been taken to make the blood transfusions safer. However, COVID-19 has disrupted the organization of the voluntary blood donation drives, whole blood donations [WBD] and restricted the donors' movement to the blood transfusion centres all across the world. While sickness and the need for transfusions are very much in place, the gap of demand against blood collection has widened...
January 13, 2021: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Julian W Tang, William P Bahnfleth, Philomena M Bluyssen, Giorgio Buonanno, Jose L Jimenez, Jarek Kurnitski, Yuguo Li, Shelly Miller, Chandra Sekhar, Lidia Morawska, Linsey C Marr, Arsen Krikor Melikov, William W Nazaroff, Peter V Nielsen, Raymond Tellier, Pawel Wargocki, Stephanie J Dancer
The Covid-19 pandemic has caused untold disruption and enhanced mortality rates around the world. Understanding the mechanisms for transmission of SARS-CoV-2 is key to preventing further spread but there is confusion over the meaning of "airborne" whenever transmission is discussed. Scientific ambivalence originates from evidence published many years ago, which has generated mythological beliefs that obscure current thinking. This article gathers together and explores some of the most commonly held dogmas on airborne transmission in order to stimulate revision of the science in the light of current evidence...
January 13, 2021: Journal of Hospital Infection
J S P Tulloch, R Green, C Tunnah, E Coffey, M Ashton, S Ghebrehewet
BACKGROUND: COVID-19 placed a significant burden on the care home population during the first wave. Care Quality Commission's care quality ratings are given to all English care homes and could be used to identify whether care homes are at risk of COVID-19 outbreaks. METHODS: An audit was performed, April 2020, of Liverpool care homes to identify associations between COVID-19 status and care quality ratings from the Care Quality Commission. Univariable logistic regression was performed to identify whether the Care Quality Commissions ratings were associated with a care home experiencing a COVID-19 outbreak, or a home having asymptomatic cases...
January 13, 2021: Journal of Hospital Infection
R Green, J S P Tulloch, C Tunnah, E Coffey, K Lawrenson, A Fox, J Mason, R Barnett, A Constantine, W Shepherd, M Ashton, M B J Beadsworth, R Vivancos, I Hall, N Walker, S Ghebrehewet
BACKGROUND: COVID-19 care home outbreaks represent a significant proportion of COVID-19 morbidity and mortality in the UK. National testing initially focused on symptomatic care home residents, before extending to asymptomatic cohorts. AIM: The aim was to describe the epidemiology and transmission of COVID-19 in outbreak free care homes. METHODS: A two-point prevalence survey of COVID-19, in 34 Liverpool care homes, was performed in April and May 2020...
January 13, 2021: Journal of Hospital Infection
Cinzia Cecchetto, Marilena Aiello, Claudio Gentili, Silvio Ionta, Sofia Adelaide Osimo
Due to the spread of COVID 2019, the Italian government imposed a lockdown on the national territory. Initially, citizens were required to stay at home and not to mix with others outside of their household (Phase 1); eventually, some of these restrictions were lifted (Phase 2). To investigate the impact of lockdown on emotional and binge eating, an online survey was conducted to compare measures of self-reported physical (BMI), psychological (Alexithymia), affective (anxiety, stress, and depression) and social (income, workload) state during Phase 1 and Phase 2...
January 13, 2021: Appetite
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