Amanda D Tran, Alice E White, Michelle R Torok, Rachel H Jervis, Bernadette A Albanese, Elaine J Scallan Walter
BACKGROUND: Sequential mixed-mode surveys using both web-based surveys and telephone interviews are increasingly being used in observational studies and have been shown to have many benefits; however, the application of this survey design has not been evaluated in the context of epidemiological case-control studies. OBJECTIVE: In this paper, we discuss the challenges, benefits, and limitations of using a sequential mixed-mode survey design for a case-control study assessing risk factors during the COVID-19 pandemic...
May 27, 2024: JMIR Formative Research
Joshua A Hill, Michael J Martens, Jo-Anne H Young, Kavita Bhavsar, Jianqun Kou, Min Chen, Lik Wee Lee, Aliyah Baluch, Madhav V Dhodapkar, Ryotaro Nakamura, Kristin Peyton, Dianna S Howard, Uroosa Ibrahim, Zainab Shahid, Paul Armistead, Peter Westervelt, John McCarty, Joseph McGuirk, Mehdi Hamadani, Susan DeWolf, Kinga Hosszu, Elad Sharon, Ashley Spahn, Amir A Toor, Stephanie Waldvogel, Lee M Greenberger, Jeffery J Auletta, Mary M Horowitz, Marcie L Riches, Miguel-Angel Perales
BACKGROUND: The optimal timing of vaccination with SARS-CoV-2 vaccines after cellular therapy is incompletely understood. The objectives of this study are to determine whether humoral and cellular responses after SARS-CoV-2 vaccination differ if initiated <4 months versus 4-12 months after cellular therapy. METHODS: We conducted a multicenter prospective observational study at 30 cancer centers in the United States. SARS-CoV-2 vaccination was administered as part of routine care...
May 27, 2024: Clinical Infectious Diseases
Femi Qudus Arogundade, Syeda Azra, Myron Pulier, Limegreen Ram, Daniela Saderi, Magdalena Tomaskova
No abstract text is available yet for this article.
May 27, 2024: JMIRx med
Barbara W K Son, Otioli W Wambalaba, Wamukota Francis Wambalaba
Monkeypox has been endemic in Congo and Nigeria for at least five decades. Since early May 2022, there have been numerous unprecedented outbreaks throughout the world in places without any previously reported cases. While a majority of the diagnosed cases have been within Europe and the Americas, several cases have occurred in non-endemic African countries. As of December 2022, 82,999 cases had been reported globally, prompting concern among the World Health Organization (WHO) members. While the WHO has not labeled this epidemic a Global Health Emergency, member states have begun to put forward plans to consolidate their emergency vaccine stockpiles and share the limited number of vaccines made by the single FDA-approved manufacturer, Bavarian Nordic...
2024: Advances in Experimental Medicine and Biology
Ann-Charlotte E Granholm, Elisabet Englund, Anah Gilmore, Elizabeth Head, William H Yong, Sylvia E Perez, Samuel J Guzman, Eric D Hamlett, Elliott J Mufson
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality risk for people with Alzheimer's disease (AD) and/or Down syndrome (DS). However, few studies have evaluated the neuropathological and inflammatory sequelae in postmortem brain tissue obtained from AD and people with DS with severe SARS-CoV-2 infections. We examined tau, beta-amyloid (Aβ), inflammatory markers and SARS-CoV-2 nucleoprotein in DS, AD, and healthy non-demented controls with COVID-19 and compared with non-infected brain tissue from each disease group (total n = 24)...
May 27, 2024: Acta Neuropathologica
Haitham Al-Madhagi, Adeela Kanawati, Zaher Tahan
The current era we experience is full with pandemic infectious agents that no longer threatens the major local source but the whole globe. Almost the most emerging infectious agents are severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), followed by monkeypox virus (MPXV). Since no approved antiviral drugs nor licensed active vaccines are yet available, we aimed to utilize immunoinformatics approach to design chimeric vaccine against the two mentioned viruses. This is the first study to deal with design divalent vaccine against SARS-CoV-2 and MPXV...
May 2024: Journal of Cellular and Molecular Medicine
Vivianne Torres, Felipe Olivares, Catherine Fernández, Mario Calvo, Claudio Orellana, Maritza Navarrete, Blaz Lesina, Mónica Fuentes, Eileen Blackburn, Gerardo Velásquez, Alejandra Vera, Alejandro Rojas-Fernández, Johanna Himelreichs
INTRODUCTION: COVID-19 claimed millions of lives, mainly in the pre-vaccine era. Preliminary studies showed promising efficacy of convalescent plasma against SARS-CoV-2 (CP). OBJECTIVE: To evaluate the efficacy of CP in patients hospitalized for COVID-19 with moderate severity. METHODS: Retrospective, bicentric study including adults hospitalized for moderate (non-critical) COVID-19 who required oxygen therapy. CP donated by survivors of mild cases (600 cc) were searched for IgG anti-SARS-CoV-2...
June 2023: Revista Médica de Chile
Luis Peña Bustos, Claudia Oviedo Sarmiento, Maria Carolina Rivacoba, Maria Jesús Arriagada Mora, Felipe Veloso Stiiven, Pedro Zambrano Ostaiza
UNLABELLED: In pediatrics, a process called Pediatric Inflammatory Multisystem Syndrome (PIMS) associated with recent infection by SARS-CoV-2 virus has been observed. One of its variants presents similarities with Kawasaki disease (KD). OBJECTIVE: to compare the clinical presentation, laboratory testing, and evolution of KD with PIMS Kawasaki phenotype (PIMS-KD) in patients hospitalized before the pandemic, compared with the pandemic period. PATIENTS AND METHOD: Cross-sectional study in two groups of patients at the Hospital Exequiel González Cortés: typical KD (group 1) and PIMS-KD (group 2)...
April 2024: Andes pediatrica: revista Chilena de pediatría
Lingsheng Li, Jasmine Kang, Brian Nguyen, Maxwell Ho, Andrew T Li, Jonathan J Shih, Ashwin Kotwal, Jarmin Yeh, Leah Karliner, Russell Jeung, Alexander Smith
BACKGROUND: Since the beginning of the COVID-19 pandemic, older Asians have experienced a rise in racism and discrimination based on their race and ethnicity. This study examines how anti-Asian hate impacts older Asians' mental, social, and physical health. METHODS: From March 18, 2022 to January 24, 2023, we conducted a cross-sectional survey study of community-dwelling Asian/Asian American adults aged ≥50 years from the San Francisco Bay Area. Measures included perceptions of anti-Asian hate; direct encounters with hate incidents; indirect experiences with hate incidents (e...
May 27, 2024: Journal of the American Geriatrics Society
Katriona Harrison, Patrick Carlos, Sven Ullrich, Anupriya Aggarwal, Jason Johansen-Leete, Vishnu Mini Sasi, Isabel Barter, Joshua Maxwell, Max Bedding, Mark Larance, Stuart Turville, Colin Jackson, Alexander Norman, Christoph Nitsche, Richard J Payne
The development of novel antivirals is crucial not only for managing current COVID-19 infections but for addressing potential future zoonotic outbreaks. SARS-CoV-2 main protease (Mpro) is vital for viral replication and viability and therefore serves as an attractive target for antiviral intervention. Herein, we report the optimization of a cyclic peptide inhibitor that emerged from an mRNA display selection against the SARS-CoV-2 Mpro to enhance its cell permeability and in vitro antiviral activity. By identifying mutation-tolerant amino acid residues within the peptide sequence, we describe the development of a second-generation Mpro inhibitor bearing five cyclohexylalanine residues...
May 27, 2024: Chemistry: a European Journal
Olivia A Harmon, Tricia S Howe, Jacqualine D Schaeffer, Ramot Adeboyejo, Laura P Eichelberger
OBJECTIVES: More than 3300 rural Alaska Native homes lack piped water, impeding hand hygiene. During the COVID-19 pandemic, the Alaska Native Tribal Health Consortium and the Centers for Disease Control and Prevention partnered with 10 Tribal communities and regional Tribal health organizations to install a low-cost, intermediate-technology water and sanitation system, the Miniature Portable Alternative Sanitation System (Mini-PASS). We assessed the impact of the Mini-PASS handwashing station on handwashing, other water-related uses, and problems encountered over time...
May 27, 2024: Public Health Reports
Pietro Guacci, Claudia Ballabio, Alice Folegatti, Laura Giancotti, Alessia Scordo, Licia Pensabene, Barbara Parma, Angelo Selicorni, Chiara Luini, Massimo Agosti, Silvia Salvatore
AIM: We aimed to evaluate the impact of Coronavirus Disease-19 (COVID-19) pandemic on the incidence and clinical presentation of celiac disease (CD) in children. METHODS: The diagnoses of CD were compared between the COVID-19 pandemic (from April 2020 to March 2022) and the pre-pandemic period (from April 2018 to March 2020) in three Italian Paediatric Gastroenterology centres (Varese, Como, Catanzaro). Electronic patient records were reviewed and additional information were collected through parental interview...
May 27, 2024: Acta Paediatrica
Brian T Wessman, Julianne Yeary, Helen Newland, Randy Jotte
INTRODUCTION: Coronavirus 2019 (COVID-19) inequitably impacted minority populations and regions with limited access to healthcare resources. The Barnes-Jewish Emergency Department in St. Louis, MO, serves such a population. The COVID-19 vaccine is an available defense to help achieve community immunity. The emergency department (ED) is a potential societal resource to provide access to a vaccination intervention. Our objective in this study was to describe and evaluate a novel ED COVID-19 vaccine program, including its impact on the local surrounding underserved community...
May 2024: Western Journal of Emergency Medicine
Yu-Shiuan Lin, Chih-Cheng Lai, Yu-Chang Liu, Shu-Chun Kuo, Shih-Bin Su
INTRODUCTION: Photokeratoconjunctivitis (PKC) is primarily caused by welding. However, inappropriate use of germicidal lamps, which have been widely used following the COVID-19 outbreak, can also cause PKC. Our goal in this study was to investigate the incidence of and changes in the causes of PKC during the coronavirus 2019 (COVID-19) pandemic. METHODS: We conducted a single-center, retrospective observational study. The health records of patients who visited the emergency department in a tertiary care hospital from January 1, 2018-December 31, 2021 and were diagnosed with PKC, were reviewed...
May 2024: Western Journal of Emergency Medicine
Gary Zhang, Michael J Burla, Benjamin B Caesar, Carolyne R Falank, Peter Kyros, Victoria C Zucco, Aneta Strumilowska, Daniel C Cullinane, Forest R Sheppard
BACKGROUND: Patients with coronavirus 2019 (COVID-19) are at high risk for respiratory dysfunction. The pulse oximetry/fraction of inspired oxygen (SpO2 /FiO2 ) ratio is a non-invasive assessment of respiratory dysfunction substituted for the PaO2 :FiO2 ratio in Sequential Organ Failure Assessment scoring. We hypothesized that emergency department (ED) SpO2 /FiO2 ratios correlate with requirement for mechanical ventilation in COVID-19 patients. Our objective was to identify COVID-19 patients at greatest risk of requiring mechanical ventilation, using SpO2 /FiO2 ratios...
May 2024: Western Journal of Emergency Medicine
Andrés Calvache-Mateo, Gregory Reychler, Alejandro Heredia-Ciuró, Javier Martín-Núñez, Araceli Ortiz-Rubio, Alba Navas-Otero, Marie Carmen Valenza
INTRODUCTION: To date, it is unknown whether respiratory training interventions can benefit Long COVID-19 patients. The main objective was to analyze the effects of respiratory training on patients with Long COVID-19, concretely on respiratory muscle strength, lung function, dyspnea, and functional capacity. METHODS: We performed a systematic review following PRISMA statement using PubMed, Scopus, and PEDro (last search November 2023). The risk of bias was assessed using the Cochrane tool...
May 27, 2024: Expert Review of Respiratory Medicine
Sara Ebling, Sverre Urnes Johnson, Asle Hoffart, Ståle Pallesen, Omid V Ebrahimi
The behavioral restrictions disrupting daily life during the COVID-19 pandemic have profoundly impacted well-being, and health behaviors have been advocated to prevent decline. To understand how processes related to fluctuation in well-being unfold within individuals, analyses on the within-person level are required. In this preregistered intensive longitudinal study, 1,709 individuals from the Norwegian adult population provided data daily over 40 consecutive days during the pandemic. The responses were modeled in a multilevel vector autoregressive model to estimate within-person networks, across and within-day, and a between-person network...
May 27, 2024: Applied Psychology. Health and Well-being
Irina Poleva, Eszter Szomolai, Beata Hegedus, Olga Zhukova
BACKGROUND: Coronavirus disease 2019 (COVID-19) vaccination programs in Europe began in December 2020, and as the number of vaccinated people increased, more information emerged about the possible side effects of vaccines. Recently, some reports appeared around the association of adverse reactions following soft-tissue filler injections and the COVID-19 vaccines. This fact raised the concerns of esthetic practitioners regarding the possibility of the association of the COVID-19 vaccine and adverse effects in other esthetic treatments...
2024: Journal of Cutaneous and Aesthetic Surgery
Alasdair D Henderson, Ben Fc Butler-Cole, John Tazare, Laurie A Tomlinson, Michael Marks, Mark Jit, Andrew Briggs, Liang-Yu Lin, Oliver Carlile, Chris Bates, John Parry, Sebastian Cj Bacon, Iain Dillingham, William A Dennison, Ruth E Costello, Yinghui Wei, Alex J Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M Eggo
BACKGROUND: Long COVID is the patient-coined term for the persistent symptoms of COVID-19 illness for weeks, months or years following the acute infection. There is a large burden of long COVID globally from self-reported data, but the epidemiology, causes and treatments remain poorly understood. Primary care is used to help identify and treat patients with long COVID and therefore Electronic Health Records (EHRs) of past COVID-19 patients could be used to help fill these knowledge gaps...
June 2024: EClinicalMedicine
Ge Liu, Jiapeng Xu, Yuanyuan Huang, Wei Ye, Jieyu Li, Ran Yan, Qiting Luo, Xinrui Zhou, Yingna Cai, Hanfang Jiang, Xiujing Lu, Kai Zheng, Zhendan He, Qinchang Zhu
INTRODUCTION: Rapid identification of infected individuals through viral RNA or antigen detection followed by effective personal isolation is usually the most effective way to prevent the spread of a newly emerging virus. Large-scale detection involves mass specimen collection and transportation. For biosafety reasons, denaturing viral transport medium has been extensively used during the SARS-CoV-2 pandemic. However, the high concentrations of guanidinium isothiocyanate (GITC) in such media have raised issues around sufficient GITC supply and laboratory safety...
2024: Frontiers in Microbiology
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