Su Yeon Jang, Jeong Yeon Seon, Baik Lin Eun, Seong Beom Koh, Jin Hong Yoo, Woo Yong Lee, Ho Kee Yum, Seok Jun Yoon, In Hwan Oh, Sang Cheol Bae, Sung Goo Chang
BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread around the globe, and it is important to determine the risk factors of death in the general population. Our study aimed to determine the risk factors of death and severe illness requiring supplemental oxygen therapy based on the demographic and clinical characteristics of COVID-19 patients in Korea. METHODS: In this study, we used data provided by the Korea Disease Control and Prevention Agency (KDCA) and analyzed a total of 5,068 patients with COVID-19, excluding 19 pregnant women and 544 individuals with missing data...
May 10, 2021: Journal of Korean Medical Science
Zaixing Jia, Wenping Gong
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has spread worldwide since it was first identified in Wuhan, China, at the end of 2019. With the global transmission of the virus, a large number of SARS-CoV-2 variants have also appeared, especially, emerging strains that have recently been discovered in the United Kingdom (variant 20I/501Y.V1, lineage B.1.1.7), South Africa (variant 20H/501Y.V2, lineage B.1.351), and Brazil (variant 20 J/501Y...
May 10, 2021: Journal of Korean Medical Science
Luis Fernandez-Luque, Andre W Kushniruk, Andrew Georgiou, Arindam Basu, Carolyn Petersen, Charlene Ronquillo, Chris Paton, Christian Nøhr, Craig E Kuziemsky, Dari Alhuwail, Diane Skiba, Elaine Huesing, Elia Gabarron, Elizabeth M Borycki, Farah Magrabi, Kerstin Denecke, Linda W P Peute, Max Topaz, Najeeb Al-Shorbaji, Paulette Lacroix, Romaric Marcilly, Ronald Cornet, Shashi B Gogia, Shinji Kobayashi, Sriram Iyengar, Thomas M Deserno, Tobias Mettler, Vivian Vimarlund, Xinxin Zhu
BACKGROUND:  As a major public health crisis, the novel coronavirus disease 2019 (COVID-19) pandemic demonstrates the urgent need for safe, effective, and evidence-based implementations of digital health. The urgency stems from the frequent tendency to focus attention on seemingly high promising digital health interventions despite being poorly validated in times of crisis. AIM:  In this paper, we describe a joint call for action to use and leverage evidence-based health informatics as the foundation for the COVID-19 response and public health interventions...
May 11, 2021: Methods of Information in Medicine
Gerd Fabian Volk, Anna-Maria Kuttenreich, Maren Geitner, Orlando Guntinas-Lichius
Although acute facial nerve palsy (Bell's palsy) is explicitly mentioned in the information sheets for vaccines as a possible complication of vaccination against SARS-CoV-2, from our point of view the benefits of the vaccination clearly outweigh the possible risks. At most, if at all, a slightly increased risk can be derived from the previous case reports. In general, the risk of acute facial palsy is described in association with many vaccinations. The risk, if any, does not appear to be a specific risk of SARS-CoV-2 vaccines...
May 11, 2021: Laryngo- Rhino- Otologie
Wolfram Windisch, Bernd Schönhofer, Daniel Sebastian Majorski, Maximilian Wollsching-Strobel, Carl-Peter Criée, Sarah Bettina Schwarz, Michael Westhoff
Non-invasive strategies such as HFOT (high-flow oxygen therapy), CPAP (continuous positive airway pressure) and NIV (non-invasive ventilation) are increasingly being used during the COVID-19 pandemics in order to treat acute hypoxemic respiratory failure related to COVID-19, and this is aimed at avoiding intubation. This review article summarizes the current evidence by also emphasizing its heterogeneity. Importantly, current evidence suggests that these non-invasive strategies can be successfully used even in case of severe respiratory failure and are, thus, indeed capable of avoiding intubation, and consequently, tube-related complications...
May 11, 2021: Pneumologie
Sajid Hameed, Mohammad Wasay, Bashir A Soomro, Ossama Mansour, Foad Abd-Allah, Tianming Tu, Raja Farhat, Naila Shahbaz, Husnain Hashim, Wasim Alamgir, Athar Iqbal, Maria Khan
BACKGROUND AND PURPOSE: Coronavirus disease 2019 (CO-VID-19) has an increased propensity for systemic hypercoagulability and thromboembolism. An association with cerebrovascular diseases, especially cerebral venous thrombosis (CVT), has been reported among these patients. The objective of the present study was to identify risk factors for CVT as well as its presentation and outcome in COVID-19 patients. METHODS: This is a multicenter and multinational observational study...
May 11, 2021: Cerebrovascular Diseases Extra
Sophia Alison Zweig, Alexander John Zapf, Hanmeng Xu, Qingfeng Li, Smisha Agarwal, Alain Bernard Labrique, David H Peters
BACKGROUND: The United States of America (US) has the highest global number of COVID-19 cases and deaths, which may be due in part to delays and inconsistencies in implementing public health and social measures (PHSMs). OBJECTIVE: In this descriptive analysis, we analyzed the epidemiological evidence for PHSM impact on COVID-19 transmission in the US compared to that in ten other countries of varying income levels, population sizes, and geographies. METHODS: We compared PHSM implementation timing and stringency against COVID-19 daily case counts in the US to that in Canada, China, Ethiopia, Japan, Kazakhstan, New Zealand, Singapore, South Korea, Vietnam, and Zimbabwe from January 1 to November 25, 2020...
April 21, 2021: JMIR Public Health and Surveillance
Jennifer Price Wolf, Bridget Freisthler, Caileigh Chadwick
BACKGROUND: Emerging research suggests that parents are experiencing heightened stress during the COVID-19 pandemic. Parental stress is a risk factor for harsh or punitive parenting, and this association may be exacerbated by the use of alcohol. OBJECTIVE: We examine whether parental stress is associated with use of punitive parenting, as well as whether this association is modified by drinking pattern. PARTICIPANTS & SETTING: We used advertisements and word-of-mouth to recruit 342 parents living in Central Ohio during the initial stay-at-home order for COVID-19...
April 30, 2021: Child Abuse & Neglect
R Nandini Asha, B Ravindran Durai Nayagam, Nattamai Bhuvanesh
Nowadays, over 200 countries face a wellbeing emergency because of epidemiological disease COVID-19 caused by the SARS-CoV-2 virus. It will cause a very high effect on the world's economy and the worldwide health sector. The present work is an investigation of the newly synthesized 4-benzyl-1-(2,4,6-trimethyl-benzyl)-piperidine (M1BZP) molecule's inhibitory potential against important protein targets of SARS-CoV-2 using computational approaches. M1BZP crystallizes in monoclinic type with P1211 space group. For the title compound M1BZP, spectroscopic characterization like 1 H NMR, 13 C NMR, FTIR, were carried out...
May 5, 2021: Bioorganic Chemistry
Hicham Achebak, Hervé Petetin, Marcos Quijal-Zamorano, Dene Bowdalo, Carlos Pérez García-Pando, Joan Ballester
The emergence of the COVID-19 pandemic forced most countries to put in place lockdown measures to slow down the transmission of the virus. These lockdowns have led to temporal improvements in air quality. Here, we evaluate the changes in NO2 and O3 levels along with the associated impact upon premature mortality during the COVID-19 lockdown and deconfinement periods along the first epidemic wave across the provincial capital cities of Spain. We first quantify the change in pollutants solely due to the lockdown as the difference between business-as-usual (BAU) pollution levels, estimated with a machine learning-based meteorological normalization technique, and observed concentrations...
May 4, 2021: Environmental Pollution
Acácio Moreira-Neto, Bruce Martins, Angelo Miliatto, Mariana Penteado Nucci, Carla Silva-Batista
The main objective of this cross-sectional study was to compare the self-reported depressive symptoms and physical activity (PA) levels among participants who performed self- nonexercising (NE), guided exercise (SGE), remotely supervised exercise (RSE), and face-to-face supervised exercise (FFE) during social distancing. Three hundred and forty-four individuals (≥18 years and 67% women) answered a self-reported online survey that included questions related to the physical exercise practice (e.g., supervised and remote) during social distancing and questions about perceptions of depressive symptoms (Montgomery-Åsberg Depression Rating Scale-Self Rated [MADRS-S] scores) and metabolic equivalent task minutes per week (METs min•wk-1 ) of moderate- and vigorous-intensity PA, and total PA scores (International Physical Activity Questionnaire-Short Form) before and during social distancing...
April 25, 2021: Psychiatry Research
Nancy K Glober, Michael Supples, Greg Faris, Thomas Arkins, Shawn Christopher, Tyler Fulks, David Rayburn, Elizabeth Weinstein, Mark Liao, Daniel O'Donnell, Thomas Lardaro
AIM: The COVID-19 pandemic has significantly impacted Emergency Medical Services (EMS) operations throughout the country. Some studies described variation in total volume of out-of-hospital cardiac arrests (OHCA) during the pandemic. We aimed to describe the changes in volume and characteristics of OHCA patients and resuscitations in one urban EMS system. METHODS: We performed a retrospective cohort analysis of all recorded atraumatic OHCA in Marion County, Indiana, from January 1, 2019 to June 30, 2019 and from January 1, 2020 to June 30, 2020...
April 27, 2021: American Journal of Emergency Medicine
Nicholas Kassis, Christine Tanaka-Esposito, Roy Chung, Ankur Kalra, Mingyuan Shao, Ashish Kumar, Jafar Alzubi, Mina K Chung, Umesh N Khot
BACKGROUND: Minimizing direct patient contact among healthcare personnel is crucial for mitigating infectious risk during the coronavirus disease 2019 (COVID-19) pandemic. The use of remote cardiac telemetry as an alternative to 12‑lead electrocardiography (ECG) for continuous QTc monitoring may facilitate this strategy, but its application has not yet been validated or implemented. METHODS: In the validation component of this two-part prospective cohort study, a total of 65 hospitalized patients with simultaneous ECG and telemetry were identified...
April 27, 2021: Journal of Electrocardiology
Ava K Mokhtari, Lydia R Maurer, Mathias A Christensen, Mohamad El Moheb, Leon Naar, Osaid Alser, Apostolos Gaitanidis, Kimberly Langeveld, Carolijn Kapoen, Kerry Breen, George C Velmahos, Haytham M A Kaafarani
BACKGROUND: Bedside experience and studies of critically ill patients with coronavirus disease 2019 (COVID-19) indicate COVID-19 to be a devastating multisystem disease. We aim to describe the incidence, associated variables, and outcomes of rhabdomyolysis in critically ill COVID-19 patients. MATERIALS AND METHODS: Data for all critically ill adult patients (≥18 years old) admitted to the ICU at a large academic medical center with confirmed COVID-19 between March 13, 2020 and April 18, 2020 were prospectively collected...
April 6, 2021: Journal of Surgical Research
Matheus Filgueira Bezerra, Lais Ceschini Machado, Viviane do Carmo Vasconcelos de Carvalho, Cássia Docena, Sinval Pinto Brandão-Filho, Constância Flávia Junqueira Ayres, Marcelo Henrique Santos Paiva, Gabriel Luz Wallau
The global spread of new SARS-CoV-2 variants of concern underscore an urgent need of simple deployed molecular tools that can differentiate these lineages. Several tools and protocols have been shared since the beginning of the COVID-19 pandemic, but they need to be timely adapted to cope with SARS-CoV-2 evolution. Although whole-genome sequencing (WGS) of the virus genetic material has been widely used, it still presents practical difficulties such as high cost, shortage of available reagents in the global market, need of a specialized laboratorial infrastructure and well-trained staff...
May 8, 2021: Infection, Genetics and Evolution
Anat Achiron, Michael Gurevich, Rina Falb, Sapir Dreyer-Alster, Polina Sonis, Mathilda Mandel
OBJECTIVES: Worldwide spread of COVID-19 disease highlights the need for assessment of long-term humoral immunity in convalescent subjects. Our objectives were to evaluate long-term IgG SARS-CoV-2 antibody response and B-cell memory response in COVID-19 convalescent subjects. METHODS: Blood samples were collected from a cohort of subjects recovering from COVID-19 disease and from healthy subjects that donated blood. SARS-CoV-2 IgG antibodies were quantitatively detected by ELISA using anti-S1 spike IgG...
May 8, 2021: Clinical Microbiology and Infection
Julien Favresse, Jean-Louis Bayart, François Mullier, Jean-Michel Dogné, Mélanie Closset, Jonathan Douxfils
OBJECTIVES: Data on the immune response after two doses of BNT162b2 are so far limited. Previously infected individuals were excluded from pivotal clinical trials and the optimal dose regimen in this population has not been clearly studied. The CRO-VAX HCP study aims at investigate the early antibody response in a population of healthcare professionals having received two doses of the BNT162b2 mRNA COVID-19 vaccine. METHODS: The CRO-VAX HCP study is a multicenter, prospective, interventional study conducted in several sites in Belgium...
May 8, 2021: Clinical Microbiology and Infection
David S Y Ong, Paraskevi C Fragkou, Valentijn A Schweitzer, Roy F Chemaly, Charalampos D Moschopoulos, Chrysanthi Skevaki
BACKGROUND: Although molecular tests are considered the gold standard for coronavirus disease 2019 (COVID-19) diagnostics, serological and immunological tests may be useful in specific settings. OBJECTIVES: This review summarises the underlying principles and performance of COVID-19 serological and immunological testing. SOURCES: Selected peer-reviewed publications on COVID-19 related serology and immunology published between December 2019 and March 2021...
May 8, 2021: Clinical Microbiology and Infection
Balkan Sahin, Sahin Hanalioglu
OBJECTIVE: The impact of COVID-19 pandemic has led to a significant transformation in medical practice and training. This nationwide survey study aims to evaluate the 1-year impact of the pandemic on training of neurosurgical residents. METHODS: A 38-question web-based survey was sent to 356 neurosurgery residents. Two hundred thirty-five participated in the study (66% response rate) representing more than half of all neurosurgical residents in the country. RESULTS: Assignment to direct COVID-19 medical care was very common (85...
May 8, 2021: World Neurosurgery
Anum Minhas, Julie K Shade, Sung-Min Cho, Erin D Michos, Thomas Metkus, Nisha A Gilotra, Garima Sharma, Natalia Trayanova, Allison G Hays
OBJECTIVE: Higher mortality in COVID-19 in men compared to women is recognized, but sex differences in cardiovascular events are less well established. We aimed to determine the independent contribution of sex to stroke, myocardial infarction and death in the setting of COVID-19 infection. METHODS: We performed a retrospective cohort study of hospitalized COVID-19 patients in a racially/ethnically diverse population. Clinical features, laboratory markers and clinical events were initially abstracted from medical records, with subsequent clinician adjudication...
May 8, 2021: International Journal of Cardiology
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