Anders Tegnell
The Swedish COVID-19 response has received excessive attention, despite not having distinctively different goals or features than other countries. The overall response has included almost all sectors of society and cannot be described here. Instead, this paper provides a general, brief description of the response from a public health perspective, but hopefully it gives a somewhat more nuanced picture of the efforts to combat COVID-19 in Sweden.
February 23, 2021: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Andreas Eilersen, Kim Sneppen
The first wave of the COVID-19 pandemic was characterized by an initial rapid rise in new cases followed by a peak and a more erratic behaviour that varies between regions. This is not easy to reproduce with traditional SIR models, which predict a more symmetric epidemic. Here, we argue that superspreaders and population heterogeneity would predict such behaviour even in the absence of restrictions on social life. We present an agent-based lattice model of a disease spreading in a heterogeneous population. We predict that an epidemic driven by superspreaders will spread rapidly in cities, but not in the countryside where the sparse population limits the maximal number of secondary infections...
February 23, 2021: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Alessandra Amato, Carolina Ciacci, Stefano Martina, Mario Caggiano, Massimo Amato
OBJECTIVES:  The present study aimed to investigate the dentists' knowledge of the risks from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and how it will impact their practice. MATERIALS AND METHODS:  An ad hoc self-administered anonymous questionnaire was submitted to Italian dentists. STATISTICAL ANALYSIS:  Differences in rates were calculated using the chi-square test. The level of significance was set at p < 0...
February 23, 2021: European Journal of Dentistry
Giulio Petrocelli, Lorenzo Dioscoridi, Edoardo Forti, Francesco Pugliese, Marcello Cintolo, Giulia Bonato, Roberto Rosa, Massimiliano Mutignani
No abstract text is available yet for this article.
February 23, 2021: Endoscopy
Ermanno Rampinini, Federico Donghi, Marco Martin, Andrea Bosio, Marco Riggio, Nicola A Maffiuletti
In March 2020, the COVID-19 pandemic forced most activities in Italy, including soccer, to cease. During lockdown, players could only train at home, with limited evidence regarding the effect of this period. Therefore, this study aimed to investigate the effect of COVID-19 lockdown on professional soccer players' physical performance. Aerobic fitness and vertical jump were assessed before and after four periods in two different seasons: COVID-19 lockdown, competitive period before lockdown, competitive period and summer break of the 2016-2017 season...
February 23, 2021: International Journal of Sports Medicine
Stefan Isenmann, Antje Haehner, Thomas Hummel
In this review article, current information on the frequency and relevance of chemosensory disorders in Covid-19 was recorded, assigned pathophysiologically and statements on prognostic significance were derived. The results are based on a comprehensive literature search of all literature on this topic and our own experience in the treatment of patients with smell and taste disorders since the beginning of the pandemic.Current study results indicate that clinically less affected Covid-19 patients without inpatient treatment and who do not require ventilation often have disorders of the chemosensory system...
February 23, 2021: Fortschritte der Neurologie-Psychiatrie
Behnam Keshavarz, Joesph R Wiencek, Lisa J Workman, Matthew D Straesser, Lyndsey M Muehling, Glenda Canderan, Fabrizio Drago, Catherine A Bonham, Jeffrey M Sturek, Chintan Ramani, Coleen A McNamara, Judith A Woodfolk, Alexandra Kadl, Thomas A E Platts-Mills, Jeffrey M Wilson
BACKGROUND: Detailed understanding of the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV)-2, the cause of coronavirus disease 2019 (CO-VID-19) has been hampered by a lack of quantitative antibody assays. OBJECTIVE: The objective was to develop a quantitative assay for IgG to SARS-CoV-2 proteins that could be implemented in clinical and research laboratories. METHODS: The biotin-streptavidin technique was used to conjugate SARS-CoV-2 spike receptor-binding domain (RBD) or nucleocapsid protein to the solid phase of the ImmunoCAP...
February 23, 2021: International Archives of Allergy and Immunology
Sandeep Budhiraja, Arun Dewan, Ritesh Aggarwal, Omender Singh, Deven Juneja, Sangeeta Pathak, Y P Singh, Ajay Gupta, Reeta Rai, Abhaya Indrayan, Vinitaa Jha, Rahul Naithani
BACKGROUND: Convalescent plasma (CP) is being used as a treatment option in hospitalized patients with COVID-19. Till date, there is conflicting evidence on efficacy of CP in reducing COVID-19 related mortality. OBJECTIVE: To evaluate the effect of CP on 28-day mortality reduction in patients with COVID-19. METHODS: We did a multi-centre, retrospective case control observational study from 1st May 2020 to 31st August 2020. A total of 1079 adult patients with moderate and severe COVID-19 requiring oxygen, were reviewed...
February 18, 2021: Blood Cells, Molecules & Diseases
John J L Jacobs
COVID-19 is a serious disease that has infected more than 40 million people. Beside significant mortality, the SARS-CoV-2 infection causes considerable and sustained morbidity, dubbed long COVID. This paper argues that some of this morbidity may be due to a persistent systemic infection. Persistent infection is indicated by continued virus RNA shedding. The virus' superantigen could overstimulate anti-virus immune responses, and thereby induce negative feedback loops, that paradoxically allow the virus to persist...
February 16, 2021: Medical Hypotheses
İsmet Sayan, Mustafa Altınay, Ayşe Surhan Çınar, Hacer Şebnem Türk, Nebia Peker, Kerim Şahin, Nurcan Coşkun, Gamze Dilara Demir
BACKGROUND: In Covid-19 pneumonia, high mortality rates reported in intubated patients have raised non-invasive methods of respiratory support. OBJECTIVE: We aimed to evaluate the impact of HFNC application on intubation requirement, intensive care length of stay, and short-term mortality in patients with COVID-19 pneumonia. MATERIAL-METHOD: Patients receiving oxygen by reservoir mask or HFNC therapy in our intensive care units due to COVID-19 pneumonia were included in the study...
February 10, 2021: Heart & Lung: the Journal of Critical Care
Daniel J Greenberg, Christopher Nabors, Dipak Chandy, Abhay Dhand
No abstract text is available yet for this article.
February 20, 2021: Heart & Lung: the Journal of Critical Care
Anna Mania, Katarzyna Mazur-Melewska, Karol Lubarski, Jadwiga Kuczma-Napierała, Justyna Mazurek, Katarzyna Jończyk-Potoczna, Wojciech Służewski, Magdalena Figlerowicz
INTRODUCTION: Children account for a relatively small proportion of laboratory-confirmed SARS-CoV-2 infections. In children, COVID-19 usually has a relatively mild course. However, in rare cases, severe disorders can be observed, and clinical manifestations may differ from adults. PURPOSE: The aim of this study is to analyse the frequency, clinical picture and outcome of COVID-19 in children based on the experience from the tertiary care centre and regional sanitary-epidemiological office...
December 29, 2020: Journal of Infection and Public Health
Maaike Versyck, Wafa Zarrougui, Fabien Lambiotte, Nabil Elbeki, Piehr Saint-Leger
INTRODUCTION: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular for invasive pulmonary aspergillosis. The main objective here is to define the prevalence of invasive pulmonary aspergillosis (IPA) in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS)...
February 16, 2021: Journal de Mycologie Médicale
Turgut Celik, Agit Simsek, Cigdem Firat Koca, Sukru Aydin, Seyma Yasar
PURPOSE: The novel coronavirus (SARS-CoV-2) caused an acute respiratory illness named COVID-19 and the disease spread all over the World. Fever, cough, fatigue, gastrointestinal infection symptoms form the main clinical symptoms. Pregnants and newborns form a vulnerable population and urgent measures must be addressed. Studies about the effect of COVID-19 on pregnant women, developing fetuses, and infants are limited. Various viral diseases can cause congenital or acquired, unilateral or bilateral hearing loss...
February 18, 2021: American Journal of Otolaryngology
Megan R Donnelly, Areg Grigorian, Kenji Inaba, Catherine M Kuza, Dennis Kim, Matthew Dolich, Michael Lekawa, Jeffry Nahmias
BACKGROUND: This study sought to determine the impact of coronavirus disease 2019 stay-at-home (SAH) and reopening orders on trends and types of firearm violence in California, Ohio, and the United States, hypothesizing increased firearm violence after SAH. MATERIALS AND METHODS: Retrospective data (January 1, 2018, to July 31, 2020) on firearm incidents/injuries/deaths and types of firearm violence were obtained from the Gun Violence Archive. The periods for SAH and reopening for the US were based on dates for California...
February 2, 2021: Journal of Surgical Research
J M Maaskant, I P Jongerden, J Bik, M Joosten, S Musters, M N Storm-Versloot, J Wielenga, A M Eskes
BACKGROUND: The outbreak of the COVID-19 pandemic influenced family-centred care dramatically due to restricting visiting policies. In this new situation, nurses were challenged to develop new approaches to involve family members in patient care. A better understanding of these changes and the experiences of nurses is essential to make an adaptation of procedures, and to secure a family-centred approach in care as much as possible. OBJECTIVES: The aim of this study was to investigate how family involvement had taken place, and to explore the experiences of nurses with family involvement during the COVID-19 outbreak...
December 24, 2020: International Journal of Nursing Studies
Francesco D'Antonio, Cihat Sen, Daniele DI Mascio, Alberto Galindo, Cecilia Villalain, Ignacio Herraiz, Resul Arısoy, Ali Ovayolu, Hasan Eroğlu, Manuel Guerra Canales, Subhashini Ladella, Liviu Cojocaru, Ozhan Turan, Sifa Turan, Eran Hadar, Noa A Brzezinski-Sinai, Sarah Dollinger, Ozlem Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha Atak, Tanja Premru-Srsen, Lilijana Kornhauser-Cerar, Mirjam Druškovič, Liana Ples, Reyhan Gündüz, Elif Ağaçayak, Javier Alfonso Schvartzman, Mercedes Negri Malbran, Marco Liberati, Francesca Di Sebastiano, Ludovica Oronzi, Chiara Cerra, Danilo Buca, Angelo Cagnacci, Arianna Ramone, Fabio Barra, Andrea Carosso, Chiara Benedetto, Stefano Cosma, Axelle Pintiaux, Caroline Daelemans, Elena Costa, Ayşegül Özel, Murat Muhçu, Jesús S Jimenez Lopez, Clara Alvarado, Anna Luengo Piqueras, Dolores Esteban Oliva, Giovanni Battista Luca Schera, Nicola Volpe, Tiziana Frusca, Igor Samardjiski, Slagjana Simeonova, Irena Aleksioska Papestiev, Javier Hojman, Ilgin Turkcuoglu, Antonella Cromi, Antonio Simone Laganà, Fabio Ghezzi, Angelo Sirico, Alessandra Familiari, Giovanni Scambia, Zulfiya Khodjaeva Gennady T Sukhikh, Ksenia A Gorina, Renato Augusto Moreira de Sa, Mariana Vaz, Otto Henrique May Feuerschuette, Anna Nunzia Della Gatta, Aly Youssef, Gaetana Di Donna, Alicia Martinez-Varea, Gabriela Loscalzo, José Morales Roselló, Vedran Stefanovic, Irmeli Nupponen, Kaisa Nelskylä, Rodrigo Ayala, Rebeca Garrote Molpeceres, Asunción Pino Vázquez, Fabrizio Sandri, Ilaria Cataneo, Marinella Lenzi, Esra Tustas Haberal, Erasmo Huertas, Amadeo Sanchez, Pedro Arango, Amanda Bermejo, María Monica Gonzalez Alcantara, Gökhan Göynümer, Erhan Okuyan, Ciuhodaru Madalina, Ana Concheiro Guisan, Alejandra Martínez Schulte, Valentina Esposito, Valentina De Robertis, Snezana Zdjelar, Milan Lackovic, Sladjana Mihajlovic, Nelly Jekova, Gabriele Saccone, Mehmet Musa Aslan, Maria Carmela Di Dedda, Maisuri Chalid, Jose Enrique Moros Canache, George Daskalakis, Panos Antsaklis, Enrique Criado Vega, Elisa Cueto, Chiara Taccaliti, Alicia Yeliz Aykanat, Şerife Özlem Genç, Bernd Froessler, Petya Angelova Radulova, Danila Morano, Beatrice Bianchi, Maria Giulia Lombana Marino, Gabriella Meccariello, Bindu Rohatgi, Antonio Schiattarella, Maddalena Morlando, Nicola Colacurci, Andrea Villasco, Nicoletta Biglia, Ana Luiza Santos Marques, Alessandra Gatti, Daniela Luvero, Roberto Angioli, Alejandro Pittaro, Albert Lila, Blanka Zlatohlávková
OBJECTIVES: To evaluate maternal and perinatal outcomes in high compared to low-risk pregnancies complicated by SARS-COV-2 infection. METHODS: This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 76 centers from 25 different countries in Europe, United States, South America, Asia and Australia from 04 April 2020 till 28 October 2020. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death...
February 20, 2021: American journal of obstetrics & gynecology MFM
M Cristina Polidori, Helmut Sies, Luigi Ferrucci, Thomas Benzing
Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19...
February 20, 2021: Ageing Research Reviews
Vikramjeet Singh, Alexander Beer, Andreas Kraus, Felix Mang, Xiaoni Zhang, Jinhua Xue, Nina Hagemann, Dirk M Hermann, Matthias Gunzer
BACKGROUND: The newly emerged severe acute respiratory syndrome coronavirus (SARS-CoV-2) has caused a worldwide pandemic of human respiratory disease. Angiotensin-converting enzyme (ACE) 2 is the key receptor on lung epithelial cells to facilitate initial binding and infection of SARS-CoV-2. The binding to ACE2 is mediated via the spike glycoprotein present on the viral surface. Recent clinical data have demonstrated that patients with previous episodes of brain injuries are a high-risk group for SARS-CoV-2 infection...
February 20, 2021: Brain, Behavior, and Immunity
Sara Ghandehari, Yuri Matusov, Samuel Pepkowitz, Donald Stein, Tamana Kaderi, Divya Narayanan, Josephine Hwang, Stephanie Chang, Robert Goodman, Heli Ghandehari, James Mirocha, Catherine Bresee, Victor Tapson, Michael Lewis
BACKGROUND: Severity of illness in COVID-19 is consistently lower in women. Focus on sex as a biologic factor may suggest a potential therapeutic intervention for this disease. We assessed whether adding progesterone to standard of care would improve clinical outcomes of hospitalized men with moderate to severe COVID-19. RESEARCH QUESTION: Does short-term subcutaneous administration of progesterone safely improve clinical outcome in hypoxemic men hospitalized with COVID-19? STUDY DESIGN AND METHODS: We conducted a pilot, randomized, open-label, controlled trial of subcutaneous progesterone in men hospitalized with confirmed moderate to severe COVID-19...
February 20, 2021: Chest
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