Yu Mikami, Barbara R Grubb, Troy D Rogers, Hong Dang, Takanori Asakura, Pradeep Kota, Rodney C Gilmore, Kenichi Okuda, Lisa C Morton, Ling Sun, Gang Chen, Jason A Wykoff, Camille Ehre, Juan Vilar, Catharina van Heusden, Alessandra Livraghi-Butrico, Martina Gentzsch, Brian Button, M Jackson Stutts, Scott H Randell, Wanda K O'Neal, Richard C Boucher
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than the vasculature. Many pulmonary diseases are associated with intraluminal airway obstruction caused by aspirated foreign bodies, virus infection, tumors, or mucus plugs intrinsic to airway disease, including cystic fibrosis (CF). Consistent with requirements for luminal O2 , airway epithelia surrounding mucus plugs in chronic obstructive pulmonary disease (COPD) lungs are hypoxic. Despite these observations, the effects of chronic hypoxia (CH) on airway epithelial host defense functions relevant to pulmonary disease have not been investigated...
June 7, 2023: Science Translational Medicine