Eric J Rubin, Lindsey R Baden, Stephen Morrissey
New England Journal of Medicine, Volume 382, Issue 23, June 2020.
June 4, 2020: New England Journal of Medicine
Myron S Cohen
No abstract text is available yet for this article.
June 3, 2020: New England Journal of Medicine
David R Boulware, Matthew F Pullen, Ananta S Bangdiwala, Katelyn A Pastick, Sarah M Lofgren, Elizabeth C Okafor, Caleb P Skipper, Alanna A Nascene, Melanie R Nicol, Mahsa Abassi, Nicole W Engen, Matthew P Cheng, Derek LaBar, Sylvain A Lother, Lauren J MacKenzie, Glen Drobot, Nicole Marten, Ryan Zarychanski, Lauren E Kelly, Ilan S Schwartz, Emily G McDonald, Radha Rajasingham, Todd C Lee, Kathy H Hullsiek
BACKGROUND: Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown. METHODS: We conducted a randomized, double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis...
June 3, 2020: New England Journal of Medicine
Ana Flávia Santarine Laureano, Márcia Riboldi
SARS-CoV-2 is a novel virus from the coronavirus family that emerged in the end of December 2019 in Wuhan, China. The virus is now widespread and causing the current pandemic of COVID-19, a highly pathogenic viral pneumonia, commonly presented with fever and cough, which frequently lead to lower respiratory tract disease with poor clinical outcomes associated with older age and underlying health conditions. Supportive care for patients is typically the standard protocol because no specific effective antiviral therapies have been identified so far...
June 3, 2020: JBRA Assisted Reproduction
Radosław Sierpiński, Jarosław Pinkas, Mateusz Jankowski, Wojciech S Zgliczyński, Waldemar Wierzba, Mariusz Gujski, Łukasz Szumowski
INTRODUCTION: The Coronavirus Disease 2019 (COVID 19) is a communicable disease caused by novel coronavirus. OBJECTIVES: This study aimed to assess self-reported frequency of gastrointestinal symptoms and olfactory or taste disorders in non-hospitalized patients with COVID-19 in Poland. PATIENTS AND METHODS: This cross-sectional survey was conducted between April 17 and 18, 2020, among 4,516 non-hospitalized patients with COVID-19 in Poland...
June 3, 2020: Polish Archives of Internal Medicine
Alberto G Gerli, Stefano Centanni, Monica R Miozzo, J Christian Virchow, Giovanni Sotgiu, G Walter Canonica, Joan B Soriano
BACKGROUND: To date the European experience with COVID-19 mortality has been different to the observed in China and Asia. We aimed to forecast mortality trends in the 27 countries of the European Union (EU), plus Switzerland and the United Kingdom (UK), where lockdown dates and confinement interventions have been heterogeneous, and to explore its determinants. METHODS: We have adapted our predictive model of COVID-19-related mortality, which rested on the observed mortality within the first weeks of the outbreak and the date of the respective lockdown in each country...
June 2, 2020: Minerva Medica
Cem Erdogan
Currently the Covid-19 pandemic forces almost every country to take drastic measures in order to stop the spread of the virus. These include the avoidance of close contact to other humans, staying at home whenever possible and the closure of gyms or sport clubs. Now that people are more or less bound to their home, it is even more important to stay physically active. The occasional walks between sofa and fridge are not enough to keep your body in shape. But why is exercise so important and is there anything one can take to get the most out of every single training session?...
June 3, 2020: Acta Physiologica
Shuyi Yang, Yunfei Zhang, Jie Shen, Yongming Dai, Yun Ling, Hongzhou Lu, Rengyin Zhang, Xueting Ding, Huali Qi, Yuxin Shi, Zhiyong Zhang, Fei Shan
BACKGROUND: Chest computed tomography (CT) has shown tremendous clinical potential for screening, diagnosis, and surveillance of COVID-19. However, safety concerns are warranted due to repeated exposure of X-rays over a short period of time. Recent advances in MRI suggested that ultrashort echo time MRI (UTE-MRI) was valuable for pulmonary applications. PURPOSE: To evaluate the effectiveness of UTE-MRI for assessing COVID-19. STUDY TYPE: Prospective...
June 3, 2020: Journal of Magnetic Resonance Imaging: JMRI
Ling Li, Ru Yang, Jue Wang, Qilu Lv, Ming Ren, Lei Zhao, Hanwei Chen, Haixia Xu, Songli Xie, Jin Xie, Hui Lin, Wenjuan Li, Peng Fang, Li Gong, Xinqiang Gao, Lan Wang, Yanyun Wu, Zhong Liu
BACKGROUND: A novel coronavirus has caused an international outbreak. Currently, there are no specific therapeutic agents for coronavirus infections. Convalescent plasma (CP) therapy is a potentially effective treatment option. METHODS: Patients who had recovered from COVID-19 and had been discharged from the hospital for more than two weeks were recruited. COVID-19 convalescent plasma (CCP)-specific donor screening and selection were performed based the following criteria: 1) aged 18-55 years; 2) eligible for blood donation; 3) diagnosed with COVID-19; 4) had two consecutive negative COVID-19 nasopharyngeal swab tests based on PCR (at least 24 h apart) prior to hospital discharge; 5) had been discharged from the hospital for more than 2 weeks; and 6) had no COVID-19 symptoms prior to convalescent plasma donation...
June 3, 2020: Transfusion
You Zou, Bin-Ru Wang, Liu Sun, Shan Xu, Yong-Gang Kong, Li-Jun Shen, Geng-Tian Liang, Shi-Ming Chen
The current discharge criteria for COVID-19 require that patients have two consecutive negative results for RT-PCR detection. Here, we observed that recurrently positive RT-PCR test results in patients with three consecutive negative results (3xNegRPos, 5.4%) were significantly decreased compared with those in patients with two consecutive negative results (2xNegRPos, 20.6%); such patients reported positive RT-PCR test results within 1 to 12 days after meeting the discharge criteria. These results confirmed that many recovered patients could show a positive RT-PCR test result, and most of these patients could be identified by an additional RT-PCR test prior to discharge...
June 3, 2020: Journal of Infectious Diseases
J E Rod, Oscar Oviedo-Trespalacios, Javier Cortes-Ramirez
The World Health Organization has emphasized that one of the most important questions to address regarding the covid-19 pandemic is to understand risk factors for disease severity. We conducted a brief review that synthesizes the available evidence and provides a judgment on the consistency of the association between risk factors and a composite end-point of severe-fatal covid-19. Additionally, we also conducted a comparability analysis of risk factors across 17 studies. We found evidence supporting a total of 60 predictors for disease severity, of which seven were deemed of high consistency, 40 of medium and 13 of low...
2020: Revista de Saúde Pública
Helena Ribeiro, Keila Valente de Souza de Santana, Sofia Lizarralde Oliver, Patricia Helen de Carvalho Rondó, Marcela Moraes Mendes, Karen Charlton, Susan Lanham-New
The study discusses the possible role of adequate vitamin D status in plasma or serum for preventing acute respiratory infections during the Covid-19 pandemic. Our arguments respond to an article, published in Italy, that describes the high prevalence of hypovitaminosis D in older Italian women and raises the possible preventive and therapeutic role of optimal vitamin D levels. Based on literature review, we highlight the findings regarding the protective role of vitamin D for infectious diseases of the respiratory system...
2020: Revista de Saúde Pública
Cleyton Martins da Silva, Graciela Arbilla
No abstract text is available yet for this article.
2020: Revista da Sociedade Brasileira de Medicina Tropical
Bruno Lima Moreira, Pablo Rydz Pinheiro Santana, Gláucia Zanetti, Edson Marchiori
The full spectrum of COVID-19 is still emerging, although several studies have highlighted that patients infected with the novel coronavirus can potentially develop a hypercoagulable state. However, several aspects related to the incidence and pathophysiology of the association between COVID-19 and pulmonary embolism are not well established. Here, we present a case of a patient with COVID-19 who developed acute pulmonary embolism. Clinical and laboratory data and findings of non-enhanced CT indicate possibility of acute pulmonary embolism, and support the decision to proceed with computed tomography pulmonary angiography that can objectively identify filling defects in pulmonary arterial branches...
2020: Revista da Sociedade Brasileira de Medicina Tropical
Carlos Dornels Freire de Souza
No abstract text is available yet for this article.
2020: Revista da Sociedade Brasileira de Medicina Tropical
Lucas Almeida Andrade, Dharliton Soares Gomes, Marco Aurélio de Oliveira Góes, Mércia Simone Feitosa de Souza, Daniela Cabral Pizzi Teixeira, Caíque Jordan Nunes Ribeiro, José Antônio Barreto Alves, Karina Conceição Gomes Machado de Araújo, Allan Dantas Dos Santos
INTRODUCTION: Coronavirus disease 2019 (COVID-19) has become a global public health emergency with lethality ranging from 1% to 5%. This study aimed to identify active high-risk transmission clusters of COVID-19 in Sergipe. METHODS: We performed a prospective space-time analysis using confirmed cases of COVID-19 during the first 7 weeks of the outbreak in Sergipe. RESULTS: The prospective space-time statistic detected "active" and emerging spatio-temporal clusters comprising six municipalities in the south-central region of the state...
2020: Revista da Sociedade Brasileira de Medicina Tropical
Marcelo Fernandes Costa
OBJECTIVE To use the advantages of a ratio scale with verbal anchors in order to measure the risk perception in the novel coronavirus infection, which causes covid-19, in a health belief model-based questionnaire, as well as its validity and reproducibility. METHOD We used the health belief model, which explores four dimensions: perceived susceptibility (five questions), perceived severity (five questions), perceived benefits (five questions), and perceived barriers (five questions). Additionally, we included a fifth dimension, called pro-health motivation (four questions)...
2020: Revista de Saúde Pública
Dandara Almeida Reis da Silva, Rodrigo Fernandes Weyll Pimentel, Magno Conceição das Merces
No abstract text is available yet for this article.
2020: Revista de Saúde Pública
Leandro F M Rezende, Beatriz Thome, Mariana Cabral Schveitzer, Paulo Roberto Borges de Souza-Júnior, Célia Landmann Szwarcwald
OBJECTIVE To estimate the proportion and total number of the general adult population who may be at higher risk of severe Covid-19 in Brazil. METHODS We included 51,770 participants from a nationally representative, household-based health survey (PNS) conducted in Brazil. We estimated the proportion and number of adults (≥ 18 years) at risk of severe Covid-19 by sex, educational level, race/ethnicity, and state based on the presence of one or more of the following risk factors: age ≥ 65 years or medical diagnosis of cardiovascular disease, diabetes, hypertension, chronic respiratory disease, cancer, stroke, chronic kidney disease and moderate to severe asthma, smoking status, and obesity...
2020: Revista de Saúde Pública
Denise Streit Morsch, Zaira Aparecida de Oliveira Custódio, Zeni Carvalho Lamy
No abstract text is available yet for this article.
2020: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
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