Bin Lin, Smitha Nair, Daniel M J Fellner, Noha Ahmed Nasef, Harjinder Singh, Leonardo Negron, David C Goldstone, Margaret A Brimble, Juliet A Gerrard, Laura Domigan, Jackie C Evans, Jonathan M Stephens, Troy L Merry, Kerry M Loomes
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka ( Leptospermum scoparium ) nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as methotrexate, are used to treat auto-immune and inflammatory diseases, and Mānuka honey reportedly possesses anti-inflammatory properties and is used topically as a wound dressing. MMP-9 is a potential candidate protein target as it is upregulated in recalcitrant wounds and intestinal inflammation...
November 9, 2023: Foods (Basel, Switzerland)