keyword
https://read.qxmd.com/read/32940079/macromolecular-biomarkers-of-chronic-obstructive-pulmonary-disease-in-exhaled-breath-condensate
#1
Somayeh Kazeminasab, Babak Emamalizadeh, Abolghasem Jouyban, Mohammadali M Shoja, Maryam Khoubnasabjafari
Biomarkers provide important diagnostic and prognostic information on heterogeneous diseases such as chronic obstructive pulmonary disease (COPD). However, finding a suitable specimen for clinical analysis of biomarkers for COPD is challenging. Exhaled breath condensate (EBC) sampling is noninvasive, rapid, cost-effective and easily repeatable. EBC sampling has also provided recent progress in the identification of biological macromolecules, such as lipids, proteins and DNA in EBC samples, which has increased its utility for clinical scientists...
July 2020: Biomarkers in Medicine
https://read.qxmd.com/read/32932012/can-breathing-gases-be-analyzed-without-a-mouth-mask-proof-of-concept-and-concurrent-validity-of-a-newly-developed-design-with-a-mask-less-headset
#2
C C Roossien, L A Krops, J B Wempe, G J Verkerke, M F Reneman
A portable headset has been developed to analyze breathing gases and establish the energetic workload of physically active workers. This proof-of-concept study aimed to investigate the following: (1) the validity of the headset compared to indirect calorimetry using a mouth mask; (2) the validity of the headset compared to the validity of oxygen consumption (V̇O2) estimated on the basis of heart rate; (3) the influence of wind on validity; and (4) user experiences of the headset. Fifteen subjects performed a submaximal cycling test twice, once with the headset, and once with a mouth mask and heartrate monitor...
September 12, 2020: Applied Ergonomics
https://read.qxmd.com/read/32930802/determination-of-reproducibility-of-end-exhaled-breath-holding-in-stereotactic-body-radiation-therapy
#3
Motoharu Sasaki, Hitoshi Ikushima, Kanako Sakuragawa, Michihiro Yokoishi, Akira Tsuzuki, Wataru Sugimoto
Methods to evaluate the positional reproducibility of breath-hold irradiation mostly require manual operation. The purpose of this study is to propose a method to determine the reproducibility of breath-hold irradiation of lung tumors between fractions using non-artificial methods. This study included 13 patients who underwent terminal exhaled breath-hold irradiation for primary and metastatic lung cancer. All subjects received a prescribed dose of 60 Gy/8 fractions. The contours of the gross tumor volume (GTV) were extracted by threshold processing using treatment-planning computed tomography (CT) and cone-beam CT (CBCT), which was done just before the beginning of the treatment...
September 15, 2020: Journal of Radiation Research
https://read.qxmd.com/read/32929151/breath-methane-to-hydrogen-ratio-as-a-surrogate-marker-of-intestinal-dysbiosis-in-head-and-neck-cancer
#4
Nuwan Dharmawardana, Thomas Goddard, Charmaine Woods, David I Watson, Ross Butler, Eng H Ooi, Roger Yazbeck
Exhaled breath compounds can non-invasively detect head and neck squamous cell carcinoma (HNSCC). Here we investigated exhaled compounds related to intestinal bacterial carbohydrate fermentation. Fasting breath samples were collected into 3 litre FlexFoil PLUS bags from patients awaiting a biopsy procedure for suspected HNSCC. Samples were analysed using a Syft selected ion flow-tube mass spectrometer and a Quintron BreathTracker. Two tailed non-parametric significance testing was conducted with corrections for multiple imputations...
September 14, 2020: Scientific Reports
https://read.qxmd.com/read/32928476/an-exploratory-study-on-online-quantification-of-isoprene-in-human-breath-using-cavity-ringdown-spectroscopy-in-the-ultraviolet
#5
Qingyuan Li, Jing Li, Xin Wei, Yingxin Li, Meixiu Sun
Breath analysis offers a promising method of noninvasive analyses of volatile metabolites and xenobiotics present in human body. Isoprene is one of the highest abundant volatile organic compounds (VOCs) present in human exhaled breath. Breath isoprene (50-200 part per billion by volume (ppbv) or higher) can be analyzed by using mass spectroscopy-based methods, yet laser absorption spectral detection of breath isoprene has not been much reported, partially due to its ultraviolet (UV) absorption wavelength and the spectral overlap with other breath VOCs such as acetone in the same wavelength region...
September 22, 2020: Analytica Chimica Acta
https://read.qxmd.com/read/32925598/aerosol-exposure-during-surgical-tracheotomy-in-sars-cov-2-positive-patients
#6
Andreas German Loth, Daniela Brigitta Guderian, Birgit Haake, Kai Zacharowski, Timo Stöver, Martin Leinung
INTRODUCTION: Since December 2019, the novel coronavirus SARS-CoV-2 has been spreading worldwide. Since the main route of infection with SARS-CoV-2 is probably via contact with virus-containing droplets of the exhaled air, any method of securing the airway is of extremely high risk for the health care professionals involved. We evaluated the aerosol exposure to the interventional team during a tracheotomy in a semi-quantitative fashion. In addition, we present novel protective measures...
September 9, 2020: Shock
https://read.qxmd.com/read/32922301/pathways-in-the-pathophysiology-of-coronavirus-19-lung-disease-accessible-to-prevention-and-treatment
#7
Michael Eisenhut, Jae Il Shin
Background: In COVID 19 related lung disease, which is a leading cause of death from this disease, cytokines like tumor necrosis factor-alpha (TNF alpha) may be pivotal in the pathogenesis. TNF alpha reduces fluid absorption due to impairment of sodium and chloride transport required for building an osmotic gradient across epithelial cells, which in the airways maintains airway surface liquid helping to keep airways open and enabling bacterial clearance and aids water absorption from the alveolar spaces. TNF alpha can, through Rho-kinase, disintegrate the endothelial and epithelial cytoskeleton, and thus break up intercellular tight junctional proteins, breaching the intercellular barrier, which prevents flooding of the interstitial and alveolar spaces with fluid...
2020: Frontiers in Physiology
https://read.qxmd.com/read/32920883/metabolomicdifferences-of-exhaled-breath-condensate-amongchildren-with-and-withoutasthma
#8
Ju Chang-Chien, Hsin-Yi Huang, Hui-Ju Tsai, Chi-Jen Lo, Wan-Chen Lin, Yu-Lun Tseng, Shih-Ling Wang, Hung-Yao Ho, Mei-Ling Cheng, Tsung-Chieh Yao
BACKGROUND: There remains an unmet need in objective tests for diagnosing asthma in children. The objective of this study was to investigate the potential of metabolomic profiles of exhaled breath condensate (EBC) to discriminate stable asthma in Asian children in the community. METHODS: One hundred sixty-fiveAsian children (92 stable asthma and 73 non-asthmatic controls) participating in a population-based cohort were enrolled and divided into training and validation sets...
September 13, 2020: Pediatric Allergy and Immunology
https://read.qxmd.com/read/32920481/breath-analysis-of-smokers-non-smokers-and-e-cigarette-users
#9
E Papaefstathiou, M Stylianou, C Andreou, A Agapiou
Solid phase micro extraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS) analysis was performed in exhaled breath samples of 48 healthy volunteers: 20 non-smokers, 10 smokers and 18 e-cigarette (EC, vape) users. Each volunteer provided 1 L of exhaled breath in a pre-cleaned Tedlar bag, in which an SPME fiber was exposed to absorb the emitted breath volatile organic compounds (VOCs). The acquired data were processed using multivariate data analysis (MDA) methods in order to identify the characteristic chemicals of the three groups...
August 28, 2020: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/32919397/exhaled-volatile-organic-compounds-analysis-in-clinical-pediatrics-a-systematic-review
#10
REVIEW
Rosa A Sola Martínez, José M Pastor Hernández, Óscar Yanes Torrado, Manuel Cánovas Díaz, Teresa de Diego Puente, María Vinaixa Crevillent
BACKGROUND: Measured exhaled volatile organic compounds (VOCs) in-breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled volatilome in clinical practice remains to be demonstrated, particularly in pediatrics where the need for improved non-invasive diagnostic and monitoring methods is most urgent. This work presents the first formal evidence-based judgment of the clinical potential of breath volatilome in the pediatric population...
September 12, 2020: Pediatric Research
https://read.qxmd.com/read/32902083/-breathing-micelles-for-combinatorial-treatment-of-rheumatoid-arthritis
#11
Jinming Hu, Siyue Tao, Jian Cheng, Gai Su, Dan Li, Zhiqiang Shen, Fenghua Tao, Tao You
Breathing process involves inhalation and exhalation of different gases in animals. The gas exchange of the breathing process plays a critical role in maintaining the physiological functions of living organisms. Although artificial breathing materials exhibiting volume expansion and contraction upon alternate exposure to different gases have been well explored, those being able to realize the gas exchange remain elusive. Herein, we report breathing micelles (BM) capable of inhaling nitric oxide (NO) and exhaling carbon monoxide (CO), both of which are endogenous gaseous signaling molecules ...
September 9, 2020: Angewandte Chemie
https://read.qxmd.com/read/32901136/development-of-a-non-invasive-exhaled-breath-test-for-the-diagnosis-of-head-and-neck-cancer
#12
Nuwan Dharmawardana, Thomas Goddard, Charmaine Woods, David I Watson, Eng H Ooi, Roger Yazbeck
BACKGROUND: Improving the ability to identify early-stage head and neck squamous cell carcinoma (HNSCC) can improve treatment outcomes and patient morbidity. We sought to determine the diagnostic accuracy of breath analysis as a non-invasive test for detecting HNSCC. METHODS: Standardised breath samples were collected from 181 patients suspected of HNSCC prior to any treatment. A selected ion flow-tube mass spectrometer was used to analyse breath for volatile organic compounds...
September 9, 2020: British Journal of Cancer
https://read.qxmd.com/read/32894912/-the-predictive-value-of-ultrasonic-measurement-of-the-diaphragmatic-thickening-fraction-combined-with-the-maximal-inspiratory-pressure-in-mechanical-ventilation-patients
#13
P Zhang, H J Jiang, Q Zhou, X M Ye, Z Li, L P Yuan, J F Wu, L Y Zhang, X G Jiang, J Y Wu, W H Lu, X B Tao
Objective: To evaluate the value of the diaphragmatic thickening fraction (DTF) combined with the maximum inspiratory pressure (MIP) for the prediction of weaning success in mechanically ventilated patients. Methods: Patients admitted to the intensive care unit (ICU) of Yijishan Hospital of Wannan Medical College and on mechanical ventilation for 24 hours from June 2018 to April 2019 were selected as the study subjects. A low-level pressure support ventilation (PSV) method was applied to conduct a spontaneous breathing test (SBT) for 30 minutes after the patients met the screening conditions for clinical weaning; and the patients were weaned when they met the clinical weaning criteria...
September 12, 2020: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/32894829/assessment-of-a-personal-interactive-carbon-monoxide-breath-sensor-in-people-who-smoke-cigarettes-cohort-study
#14
Jennifer D Marler, Craig A Fujii, Kristine S Wong, Joseph A Galanko, Daniel J Balbierz, David S Utley
BACKGROUND: Tobacco use is the leading cause of preventable morbidity and mortality. Existing evidence-based treatments are under-utilized and have seen little recent innovation. The success of personal biofeedback interventions in other disease states portends a similar opportunity in smoking cessation. The Pivot Breath Sensor is a personal interactive FDA-cleared (over-the-counter) device that measures carbon monoxide (CO) in exhaled breath, enabling users to link their smoking behavior and CO values, and track their progress in reducing or quitting smoking...
September 7, 2020: Journal of Medical Internet Research
https://read.qxmd.com/read/32893485/recent-advances-in-nanomaterial-enabled-wearable-sensors-material-synthesis-sensor-design-and-personal-health-monitoring
#15
REVIEW
Bo Peng, Fengnian Zhao, Jianfeng Ping, Yibin Ying
Wearable sensors have gained much attention due to their potential in personal health monitoring in a timely, cost-effective, easy-operating, and noninvasive way. In recent studies, nanomaterials have been employed in wearable sensors to improve the sensing performance in view of their excellent properties. Here, focus is mainly on the nanomaterial-enabled wearable sensors and their latest advances in personal health monitoring. Different kinds of nanomaterials used in wearable sensors, such as metal nanoparticles, carbon nanomaterials, metallic nanomaterials, hybrid nanocomposites, and bio-nanomaterials, are reviewed...
September 6, 2020: Small
https://read.qxmd.com/read/32891041/derivatization-and-deep-eutectic-solvent-based-air-assisted-liquid-liquid-microextraction-of-salbutamol-in-exhaled-breath-condensate-samples-followed-by-gas-chromatography-mass-spectrometry
#16
Abolghasem Jouyban, Mir Ali Farajzadeh, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Mohammad Reza Afshar Mogaddam
A microwave-induced air-assisted liquid-liquid microextraction method has been proposed for the pretreatment/quantization of salbutamol in exhaled breath condensate (EBC) samples prior to gas chromatography-mass spectrometry. In this procedure, 1-fluoro-2,4-dinitrobenzene and N,N-diethylethanolammonium chloride: dichloroacetic acid: octanoic acid deep eutectic solvent were exploited as derivatization reagent and extraction solvent, respectively. A mixture of the sample solution and pyridine was transferred into a test tube...
August 23, 2020: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/32881194/probing-for-the-presence-of-doping-agents-in-exhaled-breath-using-chromatographic-mass-spectrometric-approaches
#17
Ann-Marie Garzinsky, Andreas Thomas, Oliver Krug, Mario Thevis
RATIONALE: Exhaled breath (EB) has been demonstrated to be a promising alternative matrix in sports drug testing due to its non-invasive and non-intrusive nature compared with urine and blood collection protocols. In this study, a pilot-test system was employed to create drug-containing aerosols simulating EB in support of the analytical characterization of EB sampling procedures, and the used analytical method was extended to include a broad spectrum of prohibited substances. METHODS: Artificial and authentic EB samples were collected using sampling devices containing an electret filter, and doping agents were detected by means of liquid chromatography and tandem mass spectrometry with unispray ionization...
September 2, 2020: Rapid Communications in Mass Spectrometry: RCM
https://read.qxmd.com/read/32869265/are-level-of-il-13-and-il-4-predictive-for-formation-of-chronic-inflammation-in-children-with-asthma
#18
Nataliia Makieieva, Valeriia Malakhova, Yuliia Vasylchenko, Valentyn Tsymbal
INTRODUCTION: Asthma diagnosis in young children may represent a clinical challenge. There are no standard prognostic and dia-gnostic methods. The aim of the study was to evaluate the clinical and prognostic assessment of IL-4 and IL-13 concentrations in children with recurrent wheezing. MATERIAL AND METHODS: The study included 96 children with recurrent wheezing. 81 patients were diagnosed as transient wheezing, 15 patients with asthma, and 25 healthy children were selected as controls...
2020: Advances in Respiratory Medicine
https://read.qxmd.com/read/32869085/microrna-levels-in-exhaled-breath-condensate-of-patients-with-esophageal-atresia
#19
T Soyer, E Birben, Ö B Türer, M Kahveci, G D Tuğcu, Ö U Soyer, E Yalçın, D Doğru, U Özçelik, N Kiper, B E Şekerel, F C Tanyel
MicroRNAs (miRNAs) are noncoding RNAs that play an important role in the regulation of inflammation and have not been evaluated in exhaled breath condensates (EBC) of patients with esophageal atresia and tracheoesophageal fistula (EA-TEF). It is aimed to evaluate the levels of miRNA-21 and miRNA-24 in EBC of patients with EA-TEF. Patients who received surgery for EA-TEF (EA) were assessed for age, sex, types of anomaly, surgical treatments, and respiratory problems. A 500-1000 mL of EBC was obtained from each participant with EcoScreen...
September 1, 2020: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/32864957/real-time-monitoring-of-13c-and-18o-isotopes-of-human-breath-co2-using-a-mid-infrared-hollow-waveguide-gas-sensor
#20
Tao Zhou, Tao Wu, Qiang Wu, Weidong Chen, Mingwei Wu, Chenwen Ye, Xingdao He
Real-time measuring CO2 isotopes (13CO2, 12CO2, and 18OC16O) in exhaled breath using a mid-infrared hollow waveguide (HWG) gas sensor incorporating a 2.73 μm DFB laser was proposed and demonstrated first time based on calibration-free wavelength modulation spectroscopy (CF-WMS). The measurement precisions for δ13C and δ18O were respectively 0.26‰ and 0.57‰ for an integration time of 131 s by Allan variance analysis. These measurement precisions achieved in the present work were at least 3.5 times better than those reported using direct absorption spectroscopy (DAS) and 1...
August 30, 2020: Analytical Chemistry
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