keyword
https://read.qxmd.com/read/32753454/reprocessing-filtering-facepiece-respirators-in-primary-care-using-medical-autoclave-prospective-bench-to-bedside-single-centre-study
#1
Ralf E Harskamp, Bart van Straten, Jonathan Bouman, Bernadette van Maltha-van Santvoort, John J van den Dobbelsteen, Joost Rm van der Sijp, Tim Horeman
OBJECTIVE: There are widespread shortages of personal protective equipment as a result of the COVID-19 pandemic. Reprocessing filtering facepiece particle (FFP)-type respirators may provide an alternative solution in keeping healthcare professionals safe. DESIGN: Prospective, bench-to-bedside. SETTING: A primary care-based study using FFP-2 respirators without exhalation valve (3M Aura 1862+ (20 samples), Maco Pharma ZZM002 (14 samples)), FFP-2 respirators with valve (3M Aura 9322+ (six samples) and San Huei 2920V (16 samples)) and valved FFP type 3 respirators (Safe Worker 1016 (10 samples))...
August 4, 2020: BMJ Open
https://read.qxmd.com/read/32745969/determination-of-morphine-and-oxymorphone-in-exhaled-breath-condensate-samples-application-of-microwave-enhanced-three-component-deep-eutectic-solvent-based-air-assisted-liquid-liquid-microextraction-and-derivatization-prior-to-gas-chromatography-mass-spectrometry
#2
Fatemeh Norouzi, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban, Mir Ali Farajzadeh, Mohammad Reza Afshar Mogaddam
In this work, a microwave-enhanced air-assisted liquid-liquid microextraction method combined with gas chromatography-mass spectrometry has been developed for morphine and oxymorphone assessment in EBC samples. For this purpose, choline chloride-menthol-phenylacetic acid deep eutectic solvent (as an extraction solvent), butyl chloroformate (as a derivatization agent), and picoline (as a catalyst) are used. After performing predetermined extraction cycles in the microextraction method, the obtained cloudy solution is exposed to microwave irradiations to enhance extraction and derivatization efficiencies...
June 25, 2020: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/32740499/characterization-of-inflammatory-profile-by-breath-analysis-in-chronic-coronary-syndromes
#3
Andrea Segreti, Raffaele Antonelli Incalzi, Marco Lombardi, Marco Miglionico, Annunziata Nusca, Giorgio Pennazza, Marco Santonico, Simone Grasso, Francesco Grigioni, Germano Di Sciascio
AIMS: Exhaled breath contains thousands of volatile organic compounds (VOCs) produced during various metabolic processes both in health and disease.Analysis of breath with electronic nose BIONOTE-V allows modifications of exhaled VOCs to be studied, which are clinically recognized to be a marker for several disorders, including heart failure. New noninvasive tests based on VOCs analysis might be a useful tool for early detection of chronic coronary syndromes (CCS). METHODS: Exhaled air was collected and measured in individuals with an indication to perform invasive coronary angiography (ICA)...
September 2020: Journal of Cardiovascular Medicine
https://read.qxmd.com/read/32740415/characterization-of-inflammatory-profile-by-breath-analysis-in-chronic-coronary-syndromes
#4
Andrea Segreti, Raffaele Antonelli Incalzi, Marco Lombardi, Marco Miglionico, Annunziata Nusca, Giorgio Pennazza, Marco Santonico, Simone Grasso, Francesco Grigioni, Germano Di Sciascio
AIMS: Exhaled breath contains thousands of volatile organic compounds (VOCs) produced during various metabolic processes both in health and disease.Analysis of breath with electronic nose BIONOTE-V allows modifications of exhaled VOCs to be studied, which are clinically recognized to be a marker for several disorders, including heart failure. New noninvasive tests based on VOCs analysis might be a useful tool for early detection of chronic coronary syndromes (CCS). METHODS: Exhaled air was collected and measured in individuals with an indication to perform invasive coronary angiography (ICA)...
July 17, 2020: Journal of Cardiovascular Medicine
https://read.qxmd.com/read/32732331/exhaled-breath-analysis-by-use-of-enose-technology-a-novel-diagnostic-tool-for-interstitial-lung-disease
#5
Catharina C Moor, Judith C Oppenheimer, Gizal Nakshbandi, Joachim G J V Aerts, Paul Brinkman, Anke-Hilse Maitland-van der Zee, Marlies S Wijsenbeek
BACKGROUND: Early and accurate diagnosis of interstitial lung diseases (ILDs) remains a major challenge. Better non-invasive diagnostic tools are highly needed. We aimed to assess the accuracy of exhaled breath analysis using eNose technology to discriminate between ILD patients and healthy controls, and to distinguish ILD subgroups. METHODS: In this cross-sectional study, exhaled breath of consecutive ILD patients and healthy controls (HCs) was analysed using eNose technology (SpiroNose)...
July 30, 2020: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://read.qxmd.com/read/32726471/flows-and-function-of-the-infant-flow-neonatal-continuous-positive-airway-pressure-device-investigated-with-computational-fluid-dynamics
#6
Thomas Drevhammar, Niclas Berg, Kjell Nilsson, Baldvin Jonsson, Lisa Prahl Wittberg
AIM: The first dedicated neonatal continuous positive airway pressure (CPAP) device using variable flow was the Infant Flow. The system was pressure stable with a low resistance to breathing. The aim of this study was to describe the flow and function of the Infant Flow geometry using simulated breathing and computational fluid dynamics. METHOD: The original Infant Flow geometry was used with simulated term infant breathing at three levels of CPAP. The large eddy simulation methodology was applied in combination with the WALE sub-grid scale model...
July 29, 2020: Acta Paediatrica
https://read.qxmd.com/read/32725968/low-pressure-photoionization-in-a-dual-ion-funnel-injector-coupled-to-an-orbitrap-mass-spectrometer-for-direct-analysis-of-human-breath-and-head-space-sampled-coffee-roasts
#7
Christoph Bookmeyer, Jens Soltwisch, Ulrich Röhling, Klaus Dreisewerd
Low-pressure photoionization (LPPI) is a versatile tool for the mass spectrometric detection of (semi-)volatile organic compounds, (s)VOC. Here, a dual-ion funnel MALDI/ESI ion injector was equipped with a direct-inlet LPPI module. A radio-frequency (RF) drive enabled the implementation of three Kr discharge lamps in a novel design optimized for efficient photoionization and undisturbed ion trajectories. Supported by expansion and collisional cooling and, optionally, dopant vapor, primarily intact radical ions and protonated molecules were generated...
July 2020: ChemPlusChem
https://read.qxmd.com/read/32724623/metabolic-fate-of-newly-developed-nondigestible-oligosaccharide-maltobionic-acid-in-rats-and-humans
#8
Kenichi Tanabe, Asuka Okuda, Fukami Ken, Natsumi Yamanaka, Sadako Nakamura, Tsuneyuki Oku
Maltobionic acid (MA), formed by a gluconic acid and glucose linked by an α-1,4 bond, may have the properties of a nondigestible oligosaccharide. The objective of this study was to elucidate the bioavailability of MA in rats and humans by observing digestion of MA by small intestinal enzymes, the fermentation of MA by gut microbiota, and the effect of adaptation following prolonged ingestion of MA. MA digestion was assessed using brush border membrane vesicles (BBMV) from rat small intestine. A within-subject repeated measures design was used for ingestion experiments in 10 healthy female participants...
July 2020: Food Science & Nutrition
https://read.qxmd.com/read/32719855/positional-repeatability-and-variation-in-internal-and-external-markers-during-volumetric-modulated-arc-therapy-under-end-exhalation-breath-hold-conditions-for-pancreatic-cancer-patients
#9
Makoto Sasaki, Mitsuhiro Nakamura, Tomohiro Ono, Ryo Ashida, Michio Yoshimura, Manabu Nakata, Takashi Mizowaki, Naozo Sugimoto
The purpose of this study was to assess the positional repeatability of internal and external markers among multiple breath-hold (BH) sessions and evaluate the positional variation of these markers within BH sessions for volumetric-modulated arc therapy (VMAT) for pancreatic cancer patients. A total of 13 consecutive pancreatic cancer patients with an internal marker were enrolled. Single full-arc coplanar VMAT was delivered under end-exhalation BH conditions while monitoring the internal marker with kilovoltage (kV) X-ray fluoroscopy...
July 28, 2020: Journal of Radiation Research
https://read.qxmd.com/read/32717211/particle-sizes-of-infectious-aerosols-implications-for-infection-control
#10
REVIEW
Kevin P Fennelly
The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough aerosols and of exhaled breath from patients with various respiratory infections have shown striking similarities in aerosol size distributions, with a predominance of pathogens in small particles (<5 μm). These are immediately respirable, suggesting the need for personal respiratory protection (respirators) for individuals in close proximity to patients with potentially virulent pathogens...
July 24, 2020: Lancet Respiratory Medicine
https://read.qxmd.com/read/32716517/estimation-of-viral-aerosol-emissions-from-simulated-individuals-with-asymptomatic-to-moderate-coronavirus-disease-2019
#11
Michael Riediker, Dai-Hua Tsai
Importance: Individuals with asymptomatic or mild coronavirus disease 2019 (COVID-19) have been reported to frequently transmit the disease even without direct contact. The severe acute respiratory syndrome coronavirus 2 has been found at very high concentrations in swab and sputum samples from such individuals. Objective: To estimate the virus levels released from individuals with asymptomatic to moderate COVID-19 into different aerosol sizes by normal breathing and coughing, and to determine what exposure could result from this in a room shared with such individuals...
July 1, 2020: JAMA Network Open
https://read.qxmd.com/read/32714962/serum-periostin-reflects-dynamic-hyperinflation-in-patients-with-asthma
#12
Takamitsu Asano, Hiroyuki Ohbayashi, Mitsue Ariga, Osamu Furuta, Sahori Kudo, Junya Ono, Kenji Izuhara
Introduction: Dynamic hyperinflation (DH) is sometimes observed and is associated with impaired daily life activities of asthma. We assessed the relationship between DH and asthma biomarkers (blood eosinophil, fractional exhaled nitric oxide ( F eNO ) and serum periostin) in patients with asthma. Methods: Fifty patients with stable asthma were prospectively recruited and underwent blood test, F eNO measurement, spirometry and metronome-paced tachypnoea (MPT) test to assess DH...
April 2020: ERJ Open Research
https://read.qxmd.com/read/32709330/analysis-of-major-bile-acids-in-saliva-samples-of-patients-with-barrett-s-esophagus-using-high-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#13
Pavol Ďurč, Věra Dosedělová, František Foret, Jiří Dolina, Štefan Konečný, Markus Himmelsbach, Wolfgang Buchberger, Petr Kubáň
A fast, non-invasive, high-performance liquid chromatographic screening method with electrospray ionization mass spectrometric detection was developed for the analysis of three major glycine-conjugated bile acids in human saliva. Using a mobile phase composed of 80% methanol and 0.1% formic acid, glycocholic, glycodeoxycholic, and glycochenodeoxycholic acids were separated in less than 4 minutes with sensitivity in the low nM range. Bile acids are thought to contribute to the pathology of various complications in gastroesophageal reflux disease, for instance, Barrett's esophagus, which may eventually lead to esophageal carcinoma...
August 16, 2020: Journal of Chromatography. A
https://read.qxmd.com/read/32707757/copper-alloy-surfaces-and-cleaning-regimens-against-the-spread-of-sars-cov-2-in-dentistry-and-orthopedics-from-fomites-to-anti-infective-nanocoatings
#14
REVIEW
Claudio Poggio, Marco Colombo, Carla Renata Arciola, Tiziana Greggi, Andrea Scribante, Alberto Dagna
The latest diffusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease (COVID-19), has involved the whole world population. Even if huge efforts to control the pandemic have been done, the viral spread is still continuing. COVID-19 is reported as a zoonosis jumped from bats and pangolins to humans. After infection in humans, SARS-CoV-2 is found in the nasopharyngeal and salivary secretions. The virus has also been detected in the blood plasma of infected patients...
July 22, 2020: Materials
https://read.qxmd.com/read/32705965/the-preliminary-efficacy-and-feasibility-of-group-based-smoking-cessation-treatment-program-for-incarcerated-smokers
#15
Pamela Valera, Nicholas Acuna, Ismary Vento
Group-based tobacco dependence treatment has been known to help smokers to quit in general adult populations, but the feasibility and efficacy of this type of smoking cessation treatment in correctional settings remain uncertain. A 6-week group-based smoking cessation treatment with nicotine replacement therapy (NRT) in the form of nicotine patches was implemented in seven male prison facilities, in the Northeast, among smokers who were born biologically as male. Exhaled breath carbon monoxide (CO) levels were collected from participants at each session to confirm smoking status...
July 2020: American Journal of Men's Health
https://read.qxmd.com/read/32698165/identification-of-profiles-of-volatile-organic-compounds-in-exhaled-breath-by-means-of-an-electronic-nose-as-a-proposal-for-a-screening-method-for-breast-cancer-a-case-control-study
#16
Lorena Díaz de León-Martínez, Maribel Rodriguez-Aguilar, Patricia Gorocica-Rosete, Carlos Alberto Domínguez Reyes, Verónica Martínez Bustos, Juan Alberto Tenorio-Torres, Omar Ornelas-Rebolledo, José Alfonso Cruz Ramos, Berenice Balderas-Segura, Rogelio Flores-Ramírez
AIM: The objective of the present study was to identify volatile prints from exhaled breath, termed breath-print, from breast cancer (BC) patients and healthy women by means of an electronic nose and to evaluate its potential use as a screening method. METHOD: A cross-sectional study was performed on 443 exhaled breath samples from women, of whom 262 had been diagnosed with BC by biopsy and 181 were healthy women (control group). Breath-print analysis was performed utilizing the Cyranose 320 electronic nose...
July 22, 2020: Journal of Breath Research
https://read.qxmd.com/read/32693889/-effects-of-pm_-2-5-acute-exposure-on-3-inflammation-and-oxidative-stress-indexes-in-healthy-children
#17
Xiaoyan Yang, Li Li, Jian Kong, Ming Zhang, Jun Wang, Qin Wang, Dongqun Xu
OBJECTIVE: To determine the acute effects of exposure to fine particulate matter(PM_(2. 5))on children&apos;s respiratory inflammation and oxidative stress. METHODS: This study was a cross-sectional study. A total of 115 9-12 year-old children in boarding schools were selected as the research objects. The PM_(2. 5) exposure concentration was continuously monitored for 5 days, and the individual exposure level was estimated by using the time activity mode and the PM_(2...
May 2020: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://read.qxmd.com/read/32691749/real-time-breath-analysis-of-exhaled-compounds-upon-peppermint-oil-ingestion-by-secondary-electrospray-ionization-high-resolution-mass-spectrometry-technical-aspects
#18
Amanda Gisler, Jiayi Lan, Kapil Dev Singh, Jakob Usemann, Urs Frey, Renato Zenobi, Pablo Sinues
Breath analysis by secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) has potential for clinical diagnosis and drug monitoring. However, there is still a lack of benchmarking data that shows the capability of this technique and allows comparability with other breath analysis techniques. In this regard, the goal of this study was the identification of volatile compounds upon ingestion of a specific peppermint oil capsule to get benchmark data for real-time breath analysis with SESI-HRMS...
July 21, 2020: Journal of Breath Research
https://read.qxmd.com/read/32682074/pulmonary-deposition-of-budesonide-glycopyrronium-formoterol-fumarate-dihydrate-metered-dose-inhaler-formulated-using-co-suspension-delivery-technology-in-healthy-male-subjects
#19
Samuel Israel, Ashish Kumar, Kiernan DeAngelis, Magnus Aurivillius, Paul Dorinsky, Nicolas Roche, Omar S Usmani
This gamma scintigraphy imaging study assessed pulmonary, extrathoracic and regional lung deposition patterns of a radiolabelled inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2 -agonist triple fixed-dose combination budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF 320/14.4/10 μg), delivered by pressurised metered dose inhaler (pMDI) using innovative co-suspension delivery technology (Aerosphere™). In this Phase I, randomised, single-centre, single-dose, two-period, crossover study (NCT03740373), 10 healthy male adults received two actuations of BGF MDI (160/7...
July 15, 2020: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/32676677/transmission-of-droplet-conveyed-infectious-agents-such-as-sars-cov-2-by-speech-and-vocal-exercises-during-speech-therapy-preliminary-experiment-concerning-airflow-velocity
#20
Antoine Giovanni, Thomas Radulesco, Gilles Bouchet, Alexia Mattei, Joana Révis, Estelle Bogdanski, Justin Michel
PURPOSE: Infectious agents, such as SARS-CoV-2, can be carried by droplets expelled during breathing. The spatial dissemination of droplets varies according to their initial velocity. After a short literature review, our goal was to determine the velocity of the exhaled air during vocal exercises. METHODS: A propylene glycol cloud produced by 2 e-cigarettes' users allowed visualization of the exhaled air emitted during vocal exercises. Airflow velocities were measured during the first 200 ms of a long exhalation, a sustained vowel /a/ and varied vocal exercises...
July 16, 2020: European Archives of Oto-rhino-laryngology
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