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JOURNAL ARTICLE
Chaohua Cui, Changhong Li, Tonghua Long, Zhenxian Lao, Tianyu Xia
INTRODUCTION: Repeat transcranial magnetic stimulation (rTMS) demonstrates beneficial effects for stroke patients, though its efficacy varies due to the complexity of patient conditions and disease progression. Unsupervised machine learning could be the optimal solution for identifying target patients for transcranial magnetic stimulation treatment. METHODS: We collected data from ischaemic stroke patients treated with rTMS. Unsupervised machine learning methods, including K-means and Hierarchical Clustering, were used to explore the clinical characteristics of patients suitable for rTMS...
April 30, 2024: Neurology and Therapy
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JOURNAL ARTICLE
Santi Di Pietro, Ilaria Ferrari, Giuseppe Bulgari, Maria Lorenza Muiesan, Francesco Falaschi, Annalisa De Silvestri, Luigia Scudeller, Valeria Musella, Simone Saglio, Beatrice Re, Elena Mattiuzzo, Fabio Cherubini, Stefano Perlini
Integrating video clips in the discharge process may enhance patients' understanding and awareness of their condition. To determine the effect of video clip-integrated discharge discussion on patient comprehension of atrial fibrillation (AF) and deep vein thrombosis (DVT), and their main complications (stroke and pulmonary embolism), we designed a multicentre, pragmatic, parallel groups, randomised clinical trial, that was conducted at two Emergency Units in Italy. A convenience sample of 144 adult patients (or their caregivers) discharged home with either AF or DVT were randomised to receive standard verbal instructions (control) or video clip-integrated doctor-patient discharge discussion...
April 30, 2024: NPJ Digital Medicine
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JOURNAL ARTICLE
Emna Bakillah, Adora Moneme, Danielle Brown, James Sharpe, Michael L McGarvey, Rachel R Kelz
BACKGROUND: Language barriers have the potential to influence acute stroke outcomes. Thus, we examined postoperative stroke outcomes among non-English primary language speakers. METHODS: Utilizing the Healthcare Cost and Utilization Project State Inpatient Database (2016-2019), we conducted a retrospective cohort study of adults diagnosed with a postoperative stroke in Michigan, Maryland, and New Jersey. Patients were classified by primary language spoken: English (EPL) or non-English (n-EPL)...
April 24, 2024: American Journal of Surgery
#44
JOURNAL ARTICLE
Aleksi J Sihvonen, Anni Pitkäniemi, Sini-Tuuli Siponkoski, Linda Kuusela, Noelia Martínez-Molina, Sari Laitinen, Essi-Reetta Särkämö, Johanna Pekkola, Susanna Melkas, Gottfried Schlaug, Viljami Sairanen, Teppo Särkämö
Singing-based treatments of aphasia can improve language outcomes, but the neural benefits of group-based singing in aphasia are unknown. Here, we set out to determine the structural neuroplasticity changes underpinning group-based singing induced treatment effects in chronic aphasia. Twenty-eight patients with at least mild nonfluent post-stroke aphasia were randomized into two groups that received a 4-month multicomponent singing intervention (singing group) or standard care control group). High-resolution T1-images and multi-shell diffusion-weighted MRI data were collected in two time points (baseline / 5-month)...
April 30, 2024: ENeuro
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JOURNAL ARTICLE
Akira Mima, Hidemasa Gotoda, Shinji Lee, Rina Lee, Ami Murakami, Ryosuke Akai, Sayumi Kidooka, Keishi Matsumoto, Yuta Saito, Shinji Hishida, Takahiro Nakamoto, Suguru Kido, Takayoshi Hamada
BACKGROUND/AIM: Sacubitril/valsartan (SV), a novel pharmacological class of angiotensin receptor neprilysin inhibitors, is effective in treating heart failure (HF) by inhibiting the degradation of natriuretic peptides and the renin-angiotensin-aldosterone system. However, no studies have observed the long-term effects of SV on patients with HF and preserved left ventricular ejection fraction (LVEF) undergoing hemodialysis (HD) over a long period. PATIENTS AND METHODS: This single-center retrospective study of 21 months duration involved consecutive patients with HF and preserved LVEF undergoing HD, who received 50-200 mg/day...
2024: In Vivo
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JOURNAL ARTICLE
Hiroki Nakamoto, Shoya Hashimoto, Mio Kamei, Munenori Murata, Sachi Ikudome, Kenta Karakida, Yoshifumi Tanaka
The conflicting predictions of ironic process theory and the implicit overcompensation hypothesis have been presented as a framework to explain the characteristics of errors that occur when a certain behavior is prohibited. The former predicts that instructions prohibiting a particular behavior will increase the likelihood of an outcome that should be avoided (ironic error), whereas the latter predicts that the likelihood of an outcome opposite of that to be avoided (overcompensation error) will increase. We examined how these errors, which negatively affect performance, are influenced by pressure and perceived weakness...
April 30, 2024: Journal of Sport & Exercise Psychology
#47
JOURNAL ARTICLE
Xander Jacquemyn, Michel Pompeu Sá, Filip Rega, Peter Verbrugghe, Bart Meuris, Derek Serna-Gallegos, James A Brown, Marie-Annick Clavel, Philippe Pibarot, Ibrahim Sultan
OBJECTIVES: Randomized controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) to surgical aortic valve replacement (SAVR) demonstrate conflicting evidence, particularly in low-risk patients. We aim to reevaluate the evidence using Trial Sequential Analysis (TSA), balancing type I and II errors, and compare to conventional meta-analysis (cMA). METHODS: Databases were searched for RCTs, which were divided into higher-risk and lower-risk RCTs according to a pragmatic risk classification...
April 12, 2024: Journal of Thoracic and Cardiovascular Surgery
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JOURNAL ARTICLE
J Hunter Mehaffey, Mohammad Kawsara, Vikrant Jagadeesan, J W Hayanga, Dhaval Chauhan, Lawrence Wei, Christopher Mascio, J Scott Rankin, Ramesh Daggubati, Vinay Badhwar
OBJECTIVE: Recent approval of transcatheter aortic valve replacement (TAVR) in patients at low surgical risk has resulted in a rapid real-world expansion of TAVR in patients not otherwise examined in recent low-risk trials. We sought to evaluate the outcomes of surgical aortic valve replacement (SAVR) vs TAVR in low-risk Medicare beneficiaries. METHODS: Using the United States Centers for Medicare and Medicaid Services claims database, we evaluated all beneficiaries undergoing isolated SAVR (n=33,210) or TAVR (n=77,885) (2018-2020)...
April 13, 2024: Journal of Thoracic and Cardiovascular Surgery
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JOURNAL ARTICLE
Xinmin Deng, Wen Chang, Jingyi Zhu, Xiaofeng Lv, Rui Lai, Yu Cai, Shanshan Liu, Jingtao Liang
BACKGROUND: The association between hypothyroidism and stroke remains controversial and the association between hypothyroidism and stroke subtypes has not been satisfactorily researched. This study aimed to explore the causal effect of hypothyroidism on the risk of stroke and its subtypes by Mendelian randomization (MR) analysis. METHODS: Single nucleotide polymorphisms (SNPs) were selected from published genome-wide association studies (GWAS) meta-analysis as instrumental variables (IVs) for hypothyroidism...
April 28, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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JOURNAL ARTICLE
Macarena C García, Lauren M Rossen, Kevin Matthews, Gery Guy, Katrina F Trivers, Cheryll C Thomas, Linda Schieb, Michael F Iademarco
PROBLEM/CONDITION: A 2019 report quantified the higher percentage of potentially excess (preventable) deaths in U.S. nonmetropolitan areas compared with metropolitan areas during 2010-2017. In that report, CDC compared national, regional, and state estimates of preventable premature deaths from the five leading causes of death in nonmetropolitan and metropolitan counties during 2010-2017. This report provides estimates of preventable premature deaths for additional years (2010-2022). PERIOD COVERED: 2010-2022...
May 2, 2024: MMWR Surveillance Summaries
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REVIEW
Karim Kouz, Robert Thiele, Frederic Michard, Bernd Saugel
During surgery, various haemodynamic variables are monitored and optimised to maintain organ perfusion pressure and oxygen delivery - and to eventually improve outcomes. Important haemodynamic variables that provide an understanding of most pathophysiologic haemodynamic conditions during surgery include heart rate, arterial pressure, central venous pressure, pulse pressure variation/stroke volume variation, stroke volume, and cardiac output. A basic physiologic and pathophysiologic understanding of these haemodynamic variables and the corresponding monitoring methods is essential...
April 30, 2024: Journal of Clinical Monitoring and Computing
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JOURNAL ARTICLE
Răzvan Alexandru Radu, Vincent Costalat, Michele Romoli, Basel Musmar, James E Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H Cuellar-Saenz, Ajith J Thomas, Ramanathan Kadirvel, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Joshua D Bernstock, Aman B Patel, James D Rabinov, Christopher J Stapleton, Nicole M Cancelliere, Thomas R Marotta, Vitor Mendes Pereira, Kareem El Naamani, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Lukas Meyer, Jens Fiehler, Tobias D Faizy, Helena Guerreiro, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Charbel Mounayer, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina M Chervak, Achala Vagal, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, Andrea M Alexandre, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Ymd, Jessica Jesser, Charlotte Weyland, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Cheng-Yang Hsieh, David S Liebeskind, Illario Tancredi, Robert Fahed, Boris Lubicz, Muhammed Amir Essibayi, Amanda Baker, David Altschul, Luca Scarcia, Erwah Kalsoum, Adam A Dmytriw, Adrien Guenego
BACKGROUND: Optimal anesthetic strategy for the endovascular treatment of stroke is still under debate. Despite scarce data concerning anesthetic management for medium and distal vessel occlusions (MeVOs) some centers empirically support a general anesthesia (GA) strategy in these patients. METHODS: We conducted an international retrospective study of MeVO cases. A propensity score matching algorithm was used to mitigate potential differences across patients undergoing GA and conscious sedation (CS)...
April 30, 2024: Clinical Neuroradiology
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JOURNAL ARTICLE
Laurens Winkelmeier, Máté Maros, Fabian Flottmann, Christian Heitkamp, Gerhard Schön, Götz Thomalla, Jens Fiehler, Uta Hanning
PURPOSE: Randomized controlled trials (RCTs) demonstrated a treatment effect of endovascular thrombectomy in acute ischemic stroke with large infarct, commonly defined as an Alberta Stroke Program Early CT Score (ASPECTS) of 3-5. However, data on endovascular thrombectomy in patients with very low ASPECTS of 0-2 remain scarce. METHODS: We conducted a systematic review and meta-analysis of RCTs comparing endovascular thrombectomy versus medical treatment alone in acute ischemic anterior circulation stroke with very large infarct, defined as ASPECTS of 0-2...
April 30, 2024: Clinical Neuroradiology
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JOURNAL ARTICLE
Chia-Pin Lin, Tzyy-Jer Hsu, Ying-Chang Tung, Fu-Chih Hsiao, Shing-Hsien Chou, Yu-Sheng Lin, Shao-Wei Chen, Pao-Hsien Chu
BACKGROUND: Hypertension and hypercholesterolemia are important risk factors for cardiovascular disease, and treatment with fixed-dose combination (FDC) regimens is recommended by current guidelines. However, the clinical outcomes of different FDC dosages remain unknown. This study aimed to examine the clinical outcomes of FDC regimens and the free combination of amlodipine and atorvastatin at different dosages. METHODS AND RESULTS: Patients with concurrent hypertension and hypercholesterolemia treated daily with an FDC of 5 mg amlodipine and 10 mg atorvastatin (5/10 fixed group), and FDC of 5 mg amlodipine and 20 mg atorvastatin (5/20 fixed group), or free combination of 5 mg amlodipine and 20 mg atorvastatin (5/20 free group) were identified from the National Health Insurance Research Database of Taiwan...
April 30, 2024: Journal of the American Heart Association
#55
JOURNAL ARTICLE
Mohammad Hossein Abbasi, Kristy Yuan, Scott E Kasner, Ellen McPartland, Karrima C Owens, Kelly L Sloane
BACKGROUND: The modified Rankin Scale (mRS) is commonly used to measure disability after stroke, traditionally assessed through telephone or in-person evaluation. Here, we investigated the validity of mRS assessment through an automated text messaging system based on the simplified mRS questionnaire as an alternative method to traditional methods of assessment. METHODS AND RESULTS: A total of 250 patients admitted to 3 hospitals within the University of Pennsylvania Health System with ischemic or hemorrhagic stroke were enrolled...
April 30, 2024: Journal of the American Heart Association
#56
JOURNAL ARTICLE
Xiaoyu Wang, Yuesong Pan, Runhua Zhang, Mengxing Wang, Xia Meng, Zixiao Li, Hao Li, Yilong Wang, Xingquan Zhao, Yongjun Wang, Gaifen Liu
BACKGROUND: Elevated white blood cell count, fibrinogen levels, and lower levels of albumin signify higher systemic inflammatory response, hypercoagulable state, and poorer nutritional status, respectively. However, a consistent conclusion could not be drawn on whether the association between inflammatory markers and cardiovascular disease was affected by the presence of chronic kidney disease (CKD). We aimed to explore the association between inflammation and adverse outcomes in patients with acute ischemic stroke (AIS), as well as whether this association differs due to the presence of CKD...
April 30, 2024: Journal of the American Heart Association
#57
JOURNAL ARTICLE
Dagyeong Lee, In Young Cho, Won Hyuk Chang, Jung Eun Yoo, Hea Lim Choi, Junhee Park, Dong Wook Shin, Kyungdo Han
BACKGROUND: Stroke survivors face physical and cognitive challenges, leading to an increased dependency and a higher fall risk. We aimed to investigate the impact of poststroke disability and stroke type on fracture risk at various sites compared with matched controls. METHODS: This retrospective cohort study used data from the Korean National Health Insurance System database (2010-2018), including patients with stroke and 1:1 matched controls. Stroke survivors were grouped based on the presence and severity of their poststroke disability and stroke type...
April 30, 2024: Stroke; a Journal of Cerebral Circulation
#58
JOURNAL ARTICLE
Andra E Nica, Emilia Rusu, Carmen G Dobjanschi, Florin Rusu, Oana A Parliteanu, Claudia Sivu, Gabriela Radulian
INTRODUCTION: Cardiac autonomic neuropathy (CAN) is a disorder affecting the autonomic nerves that regulate the cardiovascular system, leading to irregular heart rate and blood pressure control. It is commonly associated with diabetes mellitus but can also result from other conditions such as autoimmune disorders, chronic kidney disease, alcohol abuse, and certain medications. Screening for CAN is essential, particularly in individuals with poor glycemic control, cardiovascular risk factors, or complications...
March 2024: Curēus
#59
JOURNAL ARTICLE
Liang Li, Zhihui Liang, Cong Lin, Bao Cui, Qiong Jia
BACKGROUND: Mechanical thrombectomy (MT) is one of the effective treatment methods for acute ischemic stroke (AIS), which requires a period of dual antiplatelet therapy (DAPT) after endovascular treatment. This study aimed to compare the efficacy and safety of 3-month DAPT and 1-month DAPT in AIS patients receiving MT through a retrospective study. METHODS: AIS patients who received MT from May 2018 to March 2023 were grouped into a 1-month group (1-M group) and a 3-month group (3-M group) according to the duration of DAPT after MT...
2024: Frontiers in Neurology
#60
REVIEW
Apostolos Safouris, Lina Palaiodimou, Aristeidis H Katsanos, Odysseas Kargiotis, Konstantinos I Bougioukas, Klearchos Psychogios, Tatiana Sidiropoulou, Stavros Spiliopoulos, Marios-Nikos Psychogios, Georgios Magoufis, Guillaume Turc, Georgios Tsivgoulis
BACKGROUND: The literature on endovascular treatment (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) has been rapidly increasing after the publication of positive randomized-controlled clinical trials (RCTs) and a plethora of systematic reviews (SRs) showing benefit compared to best medical therapy (BMT) for LVO. OBJECTIVES: An overview of SRs (umbrella review) and meta-analysis of primary RCTs were performed to summarize the literature and present efficacy and safety of EVT...
2024: Therapeutic Advances in Neurological Disorders
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