Yumeng Wang, Anouk W van Beurden, Mayke M H Tersteeg, Stephan Michel, Anneke Kastelein, Jacques Neefjes, Jos H T Rohling, Johanna H Meijer, Tom Deboer
BACKGROUND: Cancer survivors can experience long lasting fatigue resulting in a lower quality of life. How chemotherapy treatment contributes to this fatigue is poorly understood. Previously we have shown in a mouse model of cancer related fatigue that doxorubicin treatment induces fatigue-like symptoms related to disturbed circadian rhythms. However, the specific components of the circadian regulatory circuitry affected by doxorubicin treatment remained unclear. Therefore we investigated the role of the central circadian clock, the suprachiasmatic nucleus (SCN), in chemotherapy-induced fatigue...
November 18, 2023: Brain, Behavior, and Immunity