Nabila Fritez, Marie-Laure Sobrier, Hinde Iraqi, Marie-Pierre Vié-Luton, Irène Netchine, Abdessamad El Annas, Jacques Pantel, Nathalie Collot, Sophie Rose, William Piterboth, Marie Legendre, Abdelmjid Chraibi, Serge Amselem, Abdelkrim Kadiri, Latifa Hilal
BACKGROUND/OBJECTIVES: Congenital hypopituitarism is a rare disease which, for most patients, has no identified molecular cause. We aimed to document the molecular basis of growth retardation in a Moroccan cohort. DESIGN/PATIENTS: 80 index cases [54 with isolated growth hormone deficiency (IGHD), 26 with combined pituitary hormone deficiency (CPHD)] were screened for molecular defects in GH1 (including LCR-GH1), GHRHR, GHSR, GHRH, PROP1, POU1F1, HESX1, LHX3, LHX4 and SOX3...
June 2015: Clinical Endocrinology