Rosario Pivonello, Maria Fleseriu, John Newell-Price, Xavier Bertagna, James Findling, Akira Shimatsu, Feng Gu, Richard Auchus, Rattana Leelawattana, Eun Jig Lee, Jung Hee Kim, André Lacroix, Audrey Laplanche, Paul O'Connell, Libuse Tauchmanova, Alberto M Pedroncelli, Beverly M K Biller
BACKGROUND: Cushing's disease is a rare endocrine disorder characterised by cortisol overproduction with severe complications. Therapies for cortisol reduction are often necessary. Here we report the outcomes from the pivotal phase III study of osilodrostat (a potent oral inhibitor of cytochrome P450 11B1, mitochondrial [11β-hydroxylase]; Novartis Pharma AG, Basel, Switzerland) in patients with Cushing's disease. METHODS: LINC 3 was a prospective, multicentre, open-label, phase III study with a double-blind randomised withdrawal period, that comprised four periods...
July 27, 2020: Lancet Diabetes & Endocrinology
Bardia Amirlak, Karen B Lu, Cameron R Erickson, Kyle Sanniec, Ali Totonchi, Ziv M Peled, Jonathan C Cheng
BACKGROUND: Migraine surgery is an increasingly popular treatment option for migraine patients. The lesser occipital nerve (LON) is a common trigger point for headache pathologies, but there is a paucity of research regarding the LON and its intimate association with the spinal accessory nerve (SAN). METHODS: Six cadaver necks were dissected. The LON, great auricular nerve (GAN), and SAN were identified and systematically measured and recorded. These landmarks included the longitudinal axis (vertical line drawn in the posterior), the horizontal axis defined as a (line between the most anterosuperior points of the external auditory canals) and the earlobe...
May 21, 2020: Plastic and Reconstructive Surgery
Brooke L Reidy, Emily J Riddle, Scott W Powers, Shalonda K Slater, Joanne Kacperski, Marielle A Kabbouche, Andrew D Hershey
No abstract text is available yet for this article.
April 26, 2020: Cephalalgia: An International Journal of Headache
Anthony Staples, Nicolas R Thompson, Manikum Moodley
AIM: We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center. METHOD: Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of orthostatic intolerance associated with excessive orthostatic tachycardia as determined by tilt table testing with orthostatic heart rate increment of ≥40 bpm within 5 minutes of head-up tilt or absolute orthostatic heart rate ≥130 bpm for patients 13 years old and younger and ≥120 bpm for those 14 years and older...
April 21, 2020: Journal of Child Neurology
Anker Stubberud, Sanjay Cheema, Erling Tronvik, Manjit Matharu
INTRODUCTION: Compression of the duodenum and left renal vein between the aorta and superior mesenteric artery usually leads to symptoms of proximal bowel obstruction or hematuria and, more rarely, nonspecific mild headaches. CASE: A young woman presented with new daily persistent headache refractory to numerous pharmacological treatments, onabotulinumtoxinA, nerve blocks, and occipital nerve stimulation. Following several years of daily severe headache, worsening abdominal pain and intolerance for food intake led to the discovery of aortomesenteric compression...
April 15, 2020: Cephalalgia: An International Journal of Headache
Jaclyn R Duvall, Carrie E Robertson, Mark A Whealy, Ivan Garza
No abstract text is available yet for this article.
January 7, 2020: Neurology
Letícia Volpe de Abreu, Cecília Barbosa Oliveira, Carlos Alberto Bordini, Marcelo Moraes Valença
INTRODUCTION: Dengue fever is currently a significant public health problem as an emerging pandemic-prone viral disease in many parts of the world. Up to 100 million individuals, distributed in over 100 countries, are estimated to be infected annually, putting nearly half of the world's population at risk. The headache associated with dengue fever is considered to be very intense, bilateral, throbbing, frontal, and retro-orbital. New daily persistent headache (NDPH) is a relatively rare headache entity...
January 2020: Headache
Domingo Palacios-Ceña, Blanca Talavera, Víctor Gómez-Mayordomo, David García-Azorín, María Gallego-Gallego, Ángel L Guerrero, María-Luz Cuadrado
OBJECTIVES: This study aimed to explore the views and experiences of a group of Spanish patients suffering from new daily persistent headache (NDPH). METHODS: A qualitative descriptive study was conducted with patients diagnosed with NDPH. Purposeful sampling was performed among patients attending a specialized Headache Unit at 2 university hospitals between February 2017 and December 2018. In total, 18 patients (11 women, 7 men; mean age 45.3, standard deviation 10...
January 2020: Headache
Ahmed M Afifi, Margaret L Schwarze, Emmaline K Stilp, Jason Orne, Jeremy P Smith, Alaa A Abd-Elsayed, Brooke M Anderson, Ahmed Salem, Cameron L Macdonald, Jacqueline S Israel
BACKGROUND: Outcomes after migraine surgery have been previously assessed using quantitative measurements, including the migraine headache index. Qualitative methodologies offer the ability to analyze patients' perceptions and pain experience, and may point to changes in domains not captured by quantitative instruments. The purpose of this study was to characterize individual patients' experiences with migraines and to analyze how patients' experience of headaches changes in relation to surgery...
October 2019: Plastic and Reconstructive Surgery
Vicente González-Quintanilla, Julio Pascual
"Other Primary Headaches" in the ICHD-3 encompasses activity-related headaches, headaches due to direct physical stimuli, epicranial headaches and a miscellanea, including hypnic headache and new daily-persistent headache. They can be primary or secondary and their etiologies differ depending on headache type. For instance, activity-related headaches can be induced by Valsalva maneuvers ("cough headache") or prolonged exercise ("exercise and sexual headaches"). Almost half of cough headaches are secondary to posterior fossa abnormality, whereas only 20% of exertional/sexual headaches are secondary, with subarachnoid hemorrhage the most frequent etiology...
November 2019: Neurologic Clinics
Randolph W Evans
Most primary headaches can be diagnosed using the history and examination. Judicious use of neuroimaging and other testing, however, is indicated to distinguish primary headaches from the many secondary causes that may share similar features. This article evaluates the reasons for diagnostic testing and the use of neuroimaging, electroencephalography, lumbar puncture, and blood testing. The use of diagnostic testing in adults and children who have headaches and a normal neurologic examination, migraine, trigeminal autonomic cephalalgias, hemicrania continua, and new daily persistent headache are reviewed...
November 2019: Neurologic Clinics
Oyindamola Ogunlaja, Niushen Zhang
No abstract text is available yet for this article.
September 18, 2019: Headache
Randolph W Evans
No abstract text is available yet for this article.
September 2019: Headache
Nooshin Yamani, Jes Olesen
BACKGROUND: New daily persistent headache (NDPH) presents with a sudden onset headache which continues without remission within 24 h. Although rare, NDPH is important because it is one of the most treatment refractory primary headache disorders and can be highly disabling to the individuals. In this structured review, we describe the current knowledge of epidemiology, clinical features, trigger factors, pathophysiology, diagnosis and therapeutic options of NDPH to better understand this enigmatic disorder...
July 15, 2019: Journal of Headache and Pain
Pamela Blake, Rami Burstein
Unremitting head and neck pain (UHNP) is a commonly encountered phenomenon in Headache Medicine and may be seen in the setting of many well-defined headache types. The prevalence of UHNP is not clear, and establishing the presence of UHNP may require careful questioning at repeated patient visits. The cause of UHNP in some patients may be compression of the lesser and greater occipital nerves by the posterior cervical muscles and their fascial attachments at the occipital ridge with subsequent local perineural inflammation...
July 2, 2019: Journal of Headache and Pain
Zeshan Tariq, Nathan Board, Alex Eftimiades, Ronnie Ibrahim
New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine...
2019: SAGE open medical case reports
F Di Stani, L Di Lorenzo, V Calistri, A G Ruggeri, F Araimo, S Brauneis
BACKGROUND: Primary essential cutis verticis gyrata is a condition that usually affects healthy subjects associated to convoluted folds and furrows formed from thickened skin of the scalp resembling cerebriform pattern. CASE: we describe a case of association between primary essential cutis verticis gyrata and new daily persistent headache. DISCUSSION/CONCLUSIONS: In our knowledge this is the first description of new daily persistent headache associated with primary essential cutis verticis gyrata...
March 2019: La Clinica Terapeutica
Carlo Cianchetti
No abstract text is available yet for this article.
April 2019: Headache
Emily J Riddle, Jonathan H Smith
PURPOSE OF REVIEW: New daily persistent headache (NDPH) is a rare primary headache disorder, which often has a refractory clinical course. This narrative review seeks to highlight what is known about the development of NDPH, to outline a diagnostic approach to a patient with new daily headache, and to explore management considerations and potential future therapies for patients diagnosed with NDPH. RECENT FINDINGS: Interval work at the level of case series and cohort studies has identified novel triggering factors (e...
March 19, 2019: Current Neurology and Neuroscience Reports
Angeliki Vgontzas, Paul B Rizzoli
The vast majority of headache patients encountered in the outpatient general medicine setting will be diagnosed with a primary headache disorder, mostly migraine or tension-type headache. Other less common primary headaches and secondary headaches, related to or caused by another condition, are the topic of this article. Nonmigraine primary headaches include trigeminal autonomic cephalalgias, primarily cluster headache; facial pain, primarily trigeminal neuralgia; and miscellaneous headache syndromes, such as hemicrania continua and new daily persistent headache...
March 2019: Medical Clinics of North America
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