Ok Hee Jeon, Melod Mehdipour, Tae-Hwan Gil, Minha Kang, Nicholas W Aguirre, Zachery R Robinson, Cameron Kato, Jessy Etienne, Hyo Gyeong Lee, Fatouma Alimirah, Vighnesh Walavalkar, Pierre-Yves Desprez, Michael J Conboy, Judith Campisi, Irina M Conboy
Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age-related factors are systemically propagated and have pro-geronic effects in young mice. However, the underlying mechanisms how bloodborne factors promote ageing remain largely unknown. Here, using heterochronic blood exchange in male mice, we show that aged mouse blood induces cell and tissue senescence in young animals after one single exchange...
August 2022: Nature metabolism