William N Voss, Michael A Mallory, Patrick O Byrne, Jeffrey M Marchioni, Sean A Knudson, John M Powers, Sarah R Leist, Bernadeta Dadonaite, Douglas R Townsend, Jessica Kain, Yimin Huang, Ed Satterwhite, Izabella N Castillo, Melissa Mattocks, Chelsea Paresi, Jennifer E Munt, Trevor Scobey, Allison Seeger, Lakshmanane Premkumar, Jesse D Bloom, George Georgiou, Jason S McLellan, Ralph S Baric, Jason J Lavinder, Gregory C Ippolito
UNLABELLED: We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with >60% of the ensuing serological response originating from the initial antibodies generated during the first exposure...
January 23, 2024: bioRxiv