Tian Hui Zou, Qin Yan Gao, Si De Liu, Yan Qing Li, Xiang Jun Meng, Guo Xin Zhang, Zi Bin Tian, Xiao Ping Zou, Song He, Xiao Hua Hou, Rong Lin, Jing Nan Li, Zhong Yin Zhou, Yan Li, Meng Chun Wang, Bang Mao Wang, De An Tian, Shu Jie Chen, Qian Cao, Liang Ping Li, Zhi Rong Wang, Xi Zhong Shen, Bing Rong Liu, Xiao Yan Yan, Ying Xuan Chen, Jing-Yuan Fang
OBJECTIVE: To investigate the clinical potential and safety of Moluodan to reverse gastric precancerous lesions. METHODS: Patients aged 18-70 years diagnosed with moderate-to-severe atrophy and/or moderate-to-severe intestinal metaplasia, with or without low-grade dysplasia, and negative for Helicobacter pylori were recruited in this randomized, double-blind, parallel-controlled trial. The primary outcome was the improvement of global histological diagnosis at 1-year follow-up endoscopy using the operative link for gastritis assessment, the operative link for gastric intestinal metaplasia assessment, and the disappearance rate of dysplasia...
January 2024: Journal of Digestive Diseases