Ji Hae Nahm, Hye Sun Lee, Haeryoung Kim, Sun Young Yim, Ji-Hyun Shin, Jeong Eun Yoo, Sang Hoon Ahn, Jin Sub Choi, Ju-Seog Lee, Young Nyun Park
BACKGROUND & AIMS: Late recurrence of hepatocellular carcinoma (HCC) is regarded as de novo HCC from chronic hepatitis. This study investigated clinicopathological and molecular factors to develop a nomogram for predicting late HCC recurrence (> 2 years after curative resection). METHODS: The training and validation cohorts included HCC patients with a major etiology of hepatitis B who underwent curative resection. Clinicopathological features including lobular and porto-periportal inflammatory activity, fibrosis, and liver cell change were evaluated...
February 27, 2021: Liver International: Official Journal of the International Association for the Study of the Liver
Daniel Vest Christophersen, Peter Møller, Morten Baekgaard Thomsen, Jens Lykkesfeldt, Steffen Loft, Håkan Wallin, Ulla Vogel, Nicklas Raun Jacobsen
Airway exposure to eg particulate matter is associated with cardiovascular disease including atherosclerosis. Acute phase genes, especially Serum Amyloid A3 (Saa3), are highly expressed in the lung following pulmonary exposure to particles. We aimed to investigate whether the human acute phase protein SAA (a homolog to mouse SAA3) accelerated atherosclerotic plaque progression in Apolipoprotein E knockout (ApoE-/- ) mice. Mice were intratracheally (i.t.) instilled with vehicle (phosphate buffered saline) or 2 µg human SAA once a week for 10 weeks...
March 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Kannan Sridharan, Muna Al Jufairi, Eman Al Ansari, Reem Al Marzooq, Zakariya Hubail, Sadeq Jaafar Radhi Hasan, Abdulraoof Al Madhoob
WHAT IS KNOWN AND OBJECTIVES: Acetaminophen has been increasingly used in treating patent ductus arteriosus (PDA) in preterm neonates. Variations were observed in the dosing regimen of acetaminophen across the studies. There is hardly any data available for a relatively higher dose of intravenous acetaminophen (15 mg/kg/dose every 6 hours) in the preterm population. We present here the results of a prospective study with this dose of intravenous acetaminophen for treating PDA in critically ill preterm neonates...
February 27, 2021: Journal of Clinical Pharmacy and Therapeutics
Elizabeth P Newberry, Zoe Hall, Yan Xie, Elizabeth A Molitor, Peter O Bayguinov, Gregory W Strout, James A J Fitzpatrick, Elizabeth M Brunt, Julian L Griffin, Nicholas O Davidson
BACKGROUND AND AIMS: Human TM6SF2 variant rs58542926 is associated with nonalcoholic fatty liver disease (NAFLD) and hepatocellular cancer (HCC). However, conflicting reports in germline Tm6sf2 knockout mice suggest no change or decreased VLDL secretion and either unchanged or increased hepatic steatosis, with no increased fibrosis. We generated liver specific Tm6Sf2 knockout mice (Tm6 LKO) to study VLDL secretion and the impact on development and progression of NAFLD. APPROACH AND RESULTS: Two independent lines of Tm6 LKO mice exhibited spontaneous hepatic steatosis...
February 27, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Naotake Funamizu, Takahiro Ozaki, Kohei Mishima, Kazuharu Igarashi, Kenji Omura, Yasutsugu Takada, Go Wakabayashi
BACKGROUND/PURPOSE: Laparoscopic liver mono-segmentectomy (LLMS) may improve patient outcomes, but it is difficult and its accuracy and safety are unknown. We evaluated the accuracy of LLMS using Glissonian approach with indocyanine green fluorescence (ICG) negative staining. METHODS: Seventy-four patients eligible for LLMS except for segment 1 were enrolled. Preoperative three-dimensional CT-based surgical simulation was used to determine estimated liver resection volume (ELRV), which was compared with modified actual liver resection volume (ALRV) obtained from actual liver resection mass (ALRM)...
February 27, 2021: Journal of Hepato-biliary-pancreatic Sciences
Tsung-Chieh Yang, Yi-Hui Wu, Pei-Chang Lee, Chung-Yu Chang, Hsiao-Sheng Lu, Yu-Jen Chen, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou
BACKGROUND AND AIM: It is not clear whether prophylactic clipping after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal lesions (LNPCLs) prevents delayed bleeding (DB). We aimed to conduct a meta-analysis to clarify the efficacy of prophylactic clipping in prevention of DB following EMR of LNPCLs. METHODS: We searched PubMed, EMBASE, Web of Science, ScienceDirect, Cochrane Library databases and for studies that compared clipping versus (vs) non-clipping in prevention of DB following EMR of LNPCLs...
February 27, 2021: Journal of Gastroenterology and Hepatology
Shih-Ting Huang, Tung-Min Yu, Ya-Wen Chuang, Cheng-Hsu Chen, Ming-Ju Wu, I-Kuan Wang, Chi-Yuan Li, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: Pneumococcal disease poses a burden to the community in high risk population. Most early studies focused on invasive pneumococcal disease. However, the epidemiology of pneumococcal pneumonia (PP) requiring hospitalization in solid organ transplant recipients (SOTRs) is poorly defined. METHODS: We conducted a retrospective cohort study (January 1, 2000and December 31, 2012) to evaluate the risk of PP requiring hospitalization in SOTRs. SOTRs and non-SOT cohorts, propensity score-matched at a 1:1 ratio for age, sex, index date, and underlying comorbidities, were identified from the National Health Insurance Research Database...
February 27, 2021: International Journal of Clinical Practice
Julian Hercun, Esha Parikh, David E Kleiner, Ivan Fuss, Gulbu Uzel, Warren Strober, Christopher Koh, Steven M Holland, Theo Heller
Liver involvement is well described in common variable immunodeficiency (CVID) and is an important prognostic marker. While multiple etiologies for liver disease have been reported, nodular regenerative hyperplasia (NRH) is being increasingly recognized with an overall prevalence above 5% (1). In this case series we describe the pre and post-transplant evolution of CVID-related liver disease (CVID-ld). (Table 1.).
February 27, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Melissa Chiu, Justin Garabon, Lina Chen, Natalya Karp, Akshay Kapoor, Jessica P Woolfson
An 11-day-old Mennonite boy with consanguineous (8°) parents and unremarkable prenatal course presented with jaundice, failure to thrive, hypotonia, and dysmorphic features (Figure 1A). His biochemical abnormalities included anemia, increased inflammatory markers, and transaminitis (Table 1). Normal work-up included: liver ultrasound, serum alpha-1 antitrypsin, ammonia, venous blood gas, plasma amino acids, international normalized ratio, albumin, glucose, thyroid stimulating hormone, newborn screen, and chromosomal microarray...
February 27, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Sabine Weber, Andreas Benesic, Jens Neumann, Alexander L Gerbes
INTRODUCTION AND OBJECTIVE: The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features of a case series comprising 32 patients with suspected metamizole-induced DILI. METHODS: For the current analysis, 32 of 238 patients with DILI included in our prospective study on drugs potentially causing DILI were included. Diagnosis of DILI was based on expert opinion and RUCAM (Roussel Uclaf Causality Assessment Method) score and supported by an in vitro test using monocyte-derived hepatocyte-like cells...
February 27, 2021: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Yi Luan, Min Wang, Liding Zhao, Tian Xu, Guosheng Fu, Wenbin Zhang
INTRODUCTION: The SECURE-PCI study supports a perioperative loading dose of statins, although whether an intensive lipid-lowering strategy prior to percutaneous coronary intervention further benefits acute coronary syndrome patients remains controversial. Evolocumab, a proprotein-converting enzyme subtilisin/kexin type 9 (PCSK9) inhibitor, acts more quickly and effectively than statins and reduces the risk of cardiovascular events in post-myocardial infarction (MI) patients. Nonetheless, whether it can be safely used in perioperative MI patients and whether perioperative application can benefit patients are still unknown...
February 27, 2021: Advances in Therapy
Amr Adel Abdel-Khalek, Aliaa Hamed, Wafaa S F Hasheesh
Silver nanoparticles (Ag NPs) have wide medical and industrial applications; therefore, their release into aquatic environments is a problematic issue. The present study aims to evaluate the removal efficiency of Ag NPs from water using orange peel (OP) and banana peel (BP) to moderate their toxicity on Oreochromis niloticus. Fish were divided into 4 groups: control group (dechlorinated tap water), Ag NPs (4 mg/L) exposed group, Ag NPs (4 mg/L) + OP (40 mg/L) group, and Ag NPs (4 mg/L) + BP (40 mg/L) group for 24 h, 48 h, and 96 h...
February 27, 2021: Environmental Science and Pollution Research International
Samia M M Mohafrash, Entesar E Hassan, Nahla H El-Shaer, Abdel-Tawab H Mossa
The pyrethroid imiprothrin is widely used worldwide for control of insects in the agriculture and public health sectors. No sufficient information is however available concerning detoxification gene expression, i.e., cytochrome P450 1A2 (CYP1A2) and metallothionein 1a gene, oxidative stress, lipid peroxidation, DNA damage, cytotoxicity, genotoxicity, and organ injury induced by imiprothrin in mammals. This study is designed to explain the mechanism of imiprothrin induced detoxification gene expression, DNA damage, cytotoxicity, genotoxicity, and organ toxicity in male rats...
February 27, 2021: Environmental Science and Pollution Research International
Apostolos Koffas, Manoj Kumar, Upkar S Gill, Ankur Jindal, Patrick T F Kennedy, S K Sarin
Chronic hepatitis B (CHB) remains a global healthcare burden. Although the recent developments in the field have led to a reduction in incidence, the morbidity and mortality including liver cirrhosis and hepatocellular carcinoma (HCC) remain a formidable challenge. Advances in understanding the immunopathogenesis of CHB have led to a recent change in clinical categorization. EASL introduced the term hepatitis B 'e' antigen (HBeAg)-negative chronic infection, to replace the historical term 'inactive carrier' disease phase, the commonest CHB phase...
February 27, 2021: Hepatology International
Xin Sun, Anzhong Zhang, Tao Zhou, Minghui Wang, Yong Chen, Ting Zhou, Xiaoning Chen, Aiyuan Xiu, Zhi Peng, Baoquan Cheng, Xiaofeng Liu, Yanjing Gao
BACKGROUND: Global research on endoscopic therapies in combination with partial splenic embolization (PSE) for variceal hemorrhage (VH) is limited. Therefore, we aimed to evaluate the efficacy and safety of endoscopy plus PSE (EP) treatment in comparison to endoscopic (E) treatment for the secondary prophylaxis of VH in cirrhosis patients with hypersplenism. METHODS: Cirrhosis patients with hypersplenism (platelet count < 100, 000/µL) and those who had recovered from an episode of VH were enrolled in a multicenter randomized controlled trial...
February 27, 2021: Hepatology International
Pankaj Gupta, Muniraju Maralakunte, Sathya Sagar, Praveen Kumar-M, Harish Bhujade, Sreedhara B Chaluvashetty, Naveen Kalra
OBJECTIVE: The data regarding overall survival (OS) and progression-free survival (PFS) following irreversible electroporation (IRE) is scarce. We performed a systematic review of the safety and efficacy of IRE for liver malignancies. METHODS: Searches of MEDLINE, EMBASE, and SCOPUS databases were performed through September 1, 2019. Studies reporting the survival data (OS and PFS) and complications (graded according to the Society of interventional Radiology classification) were included...
February 27, 2021: European Radiology
Jaeseung Shin, Sunyoung Lee, Ja Kyung Yoon, Yong Eun Chung, Jin-Young Choi, Mi-Suk Park
BACKGROUND: The reported diagnostic performance for hepatocellular carcinoma (HCC) of each major imaging feature on MRI using standardized definitions of the Liver Imaging Reporting and Data System (LI-RADS) is variable. It is important to know the actual performance of each LI-RADS major imaging feature for imaging diagnosis of HCC and determine the sources of heterogeneity between the reported results. PURPOSE: To systematically determine the performance of each major imaging feature of LI-RADS for diagnosing HCC using either extracellular contrast agent-enhanced MRI (ECA-MRI) or gadoxetate disodium-enhanced MRI (EOB-MRI)...
February 27, 2021: Journal of Magnetic Resonance Imaging: JMRI
Marco Bonani, Alexandre Balaphas, Giulia Bedino, Léo Bühler, Philipp Dutkowski, Kathrin Fausch, Silvia Gluderer, Nicole Graf, Patricia Hirt-Minkowski, Beat Müllhaupt, Carlo Schönholzer, Martin Mp Schulz, Reto Venzin, Rudolf P Wüthrich
AIMS OF THE STUDY: Non-adherence to immunosuppressive therapy in patients following solid organ transplantation is associated with an increased risk of transplant rejection and graft loss. A high pill burden can adversely affect patients&rsquo; implementation of their treatment regimens and may lead to omitting doses of medication. The aim of this study was to investigate medication implementation adherence in liver and kidney transplant recipients converted from twice-daily, immediate-release tacrolimus to once-daily, prolonged-release tacrolimus...
February 15, 2021: Swiss Medical Weekly
Amaury Thiabaud, Anne Iten, Carlo Balmelli, Laurence Senn, Nicolas Troillet, Andreas Widmer, Domenica Flury, Peter W Schreiber, Miriam Vázquez, Lauro Damonti, Michael Buettcher, Danielle Vuichard-Gysin, Christoph Kuhm, Alexia Cusini, Thomas Riedel, Yvonne Nussbaumer-Ochsner, Roman Gaudenz, Ulrich Heininger, Christoph Berger, Franziska Zucol, Sara Bernhard-Stirnemann, Natascia Corti, Petra Zimmermann, Anita Uka, Anita Niederer-Loher, Céline Gardiol, Maroussia Roelens, Olivia Keiser
BACKGROUND: SARS-CoV-2/COVID-19, which emerged in China in late 2019, rapidly spread across the world with several million victims in 213 countries. Switzerland was severely hit by the virus, with 43,000 confirmed cases as of 1 September 2020. AIM: In cooperation with the Federal Office of Public Health, we set up a surveillance database in February 2020 to monitor hospitalised patients with COVID-19, in addition to their mandatory reporting system. METHODS: Patients hospitalised for more than 24 hours with a positive polymerase chain-reaction test, from 20 Swiss hospitals, are included...
February 15, 2021: Swiss Medical Weekly
Mohammed Alabed Alhamid, Vlad-Costin Ilie, Sanziana Aioanei, Oana Stanciulea, Corina-Elena Minciuna, Monica Lacatus
Introduction: Cirrhosis is a leading cause of morbidity and mortality around the world. Although cirrhotic patients are considered to have a higher risk for surgical procedures than non-cirrhotic ones, there are certain pathologies such as gallstones cholecystitis that cannot be treated otherwise. The focus of this study is to evaluate the main characteristics of the patients with lithiasic cholecystitis and liver cirrhosis and to assess if there is a correlation between them and postoperative morbidity evaluated with Dindo-Clavien classification...
January 2021: Chirurgia
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