keyword
https://read.qxmd.com/read/33482651/blunt-injury-of-liver-mechanical-response-of-porcine-liver-in-experimental-impact-test
#1
Anna Malečková, Petra Kochova, Richard Pálek, Václav Liška, Patrik Mik, Tomasz Bońkowski, Miroslav Horák, Zbyněk Tonar
Liver is frequently injured in blunt abdominal trauma caused by road traffic accidents. The testing of safety performance of vehicles, e.g. belt usage, head support, seat shape, or air bag shape, material, pressure, and reaction, could lead to reduction of the injury seriousness. Current trends in safety testing include development of accurate computational human body models (HBM's) based on the anatomical, morphological, and mechanical behavior of tissues under high strain. The aim of this study was to describe the internal pressure changes within porcine liver, the severity of liver injury and the relation between the porcine liver microstructure and rupture propagation in an experimental impact test...
January 22, 2021: Physiological Measurement
https://read.qxmd.com/read/33482612/protective-effect-of-crocin-on-liver-function-and-survival-in-rats-with-traumatic-hemorrhagic-shock
#2
Yang Liu, Caoyuan Yao, Yuan Wang, Xiaolin Liu, Shanggang Xu, Longbin Liang
BACKGROUND: This study investigated the underlying mechanism of crocin in protecting rats with traumatic hemorrhagic shock (THS) from liver injury. MATERIALS AND METHODS: Eighty Sprague Dawley rats were randomly divided into four groups (n = 20), namely, Sham group, THS group, crocin group, and Sodium Acetate Ringer group. A rat model of THS was induced by hemorrhage from the left femur fracture. The effects of crocin on hemodynamics, cardiac output, blood gas, animal survival rate, and liver function in the rats with THS were determined, and its relationship with oxidative stress was also explored...
January 19, 2021: Journal of Surgical Research
https://read.qxmd.com/read/33482578/sleeping-beauty-insertional-mutagenesis-screen-identifies-the-pro-metastatic-roles-of-cnpy2-and-actn2-in-hepatocellular-carcinoma-tumor-progression
#3
Lilian H Lo, Coco Y Lam, Jeffrey C To, Cynthia H Chiu, Vincent W Keng
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing (RNA-seq) to identify transposon-endogenous transcriptome fusion genes, the phylogenetic lineage between the parental liver tumor and secondary metastasis can be determined to provide mechanistic insight to genetic changes involved in the metastatic evolution process...
January 18, 2021: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/33482449/favorable-survival-with-combined-treatment-in-a-metastatic-breast-cancer-patient-undergoing-hemodialysis-a-case-report
#4
Megumi Matsumoto, Hiroshi Yano, Ryota Otsubo, Aya Tanaka, Takeshi Nagayasu
INTRODUCTION: Management of breast cancer patients undergoing hemodialysis (HD) is difficult because of a lack of evidence about drug selection, dose adjustment, and surgical procedures. We herein present a case of metastatic breast cancer in a patient undergoing HD. PRESENTATION OF CASE: A 58-year-old Japanese woman with breast cancer undergoing HD underwent total mastectomy of the left breast and left axillary dissection. Histopathological examination revealed invasive ductal carcinoma, and the diagnosis was pT2N3cM0 Stage ⅢC...
January 15, 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33482444/cholecyst-jejunostomy-for-palliative-surgery
#5
Hideki Kogo, Hideaki Takasaki, Yoshinori Sakata, Yoshiharu Nakamura, Hiroshi Yoshida
INTRODUCTION AND IMPORTANCE: Many cases of unresectable cancer that cause obstructive jaundice require treatment. Depending on the patient's condition in these cases, surgery may be performed to treat jaundice. The main goal of palliative surgery is to improve the quality of life. Therefore, palliative surgery for obstructive jaundice must be performed safely and quickly. CASE PRESENTATION: This case presents a 45-year-old man with fever and back pain who was diagnosed with pancreatic head cancer and multiple liver metastases...
January 15, 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33482394/pharmacological-normalization-of-pancreatic-cancer-associated-fibroblast-secretome-impairs-pro-metastatic-cross-talk-with-macrophages-stromal-csf-1-facilitates-metastasis
#6
R Samain, A Brunel, T Douché, M Fanjul, S Cassant-Sourdy, J Rochotte, J Cros, C Neuzillet, J Raffenne, C Duluc, A Perraud, J Nigri, V Gigoux, I Bieche, M Ponzo, G Carpentier, I Cascone, R Tomasini, H A Schmid, M Mathonnet, R Nicolle, M P Bousquet, Y Martineau, S Pyronnet, C Jean, C Bousquet
BACKGROUND & AIMS: Cancer associated fibroblasts (CAFs) from pancreatic adenocarcinoma (PDA) present high protein synthesis rates. CAFs express the G protein-coupled somatostatin receptor sst1. The sst1 agonist SOM230 blocks CAF pro-tumoral features in vitro and in immunocompromised mice. We have explored here the therapeutic potential of SOM230, and underlying mechanisms, in immunocompetent models of murine PDA mimicking the heavy fibrotic and immunosuppressive stroma observed in patient tumors...
January 19, 2021: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/33482393/exposure-to-p40-in-early-life-prevents-intestinal-inflammation-in-adulthood-through-inducing-a-long-lasting-epigenetic-imprint-on-tgf%C3%AE-sustained-tgf%C3%AE-production-by-neonatal-p40-exposure
#7
Yilin Deng, Oliver G McDonald, Anna L Means, Richard M Peek, M Kay Washington, Sari A Acra, D Brent Polk, Fang Yan
BACKGROUND & AIMS: Colonization by the gut microbiota in early life confers beneficial effects on immunity throughout the host lifespan. We sought to elucidate the mechanisms whereby neonatal supplementation with p40, a probiotic functional factor, reprograms intestinal epithelial cells (IECs) for protection against adult-onset intestinal inflammation. METHODS: p40 was used to treat young adult mouse colonic (YAMC) epithelial cells with and without deletion of a methyltransferase, Setd1β, and mice in early life or in adulthood...
January 19, 2021: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/33482392/the-ubiquitin-e3-ligase-trim21-promotes-hepatocarcinogenesis-by-suppressing-the-p62-keap1-nrf2-antioxidant-pathway
#8
Fang Wang, Ye Zhang, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, Wei-Xing Zong
BACKGROUND AND AIMS: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development. We recently reported that TRIM21 can negatively regulate the p62-Keap1-Nrf2 antioxidant pathway by ubiquitylating p62 and prevents its oligomerization and protein sequestration function. As redox homeostasis plays a pivotal role in many cancers including liver cancer, we sought to determine the role of TRIM21 in hepatocarcinogenesis...
January 19, 2021: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/33482365/post-liver-transplant-outcomes-in-patients-with-major-psychiatric-diagnosis-in-the-united-states
#9
Satish K Kedia, Bilal Ali, Yu Jiang, Hassan Arshad, Sanjaya K Satapathy, Humberto C Gonzalez
INTRODUCTION AND OBJECTIVES: Higher rates of psychiatric disorders are reported among cirrhotic patients. This study examines the demographic and clinical outcomes post-liver transplant (LT) among cirrhotic patients with a major psychiatric diagnosis (cases) compared to those without psychiatric diagnosis (controls). MATERIALS AND METHODS: Retrospective case control design was used among 189 cirrhotic patients who had undergone LT at Methodist University Hospital Transplant Institute, Memphis, TN between January 2006 and December 2014...
January 19, 2021: Annals of Hepatology
https://read.qxmd.com/read/33482364/cumulative-incidence-of-solid-and-hematological-de-novo-malignancy-after-liver-transplantation-in-a-multicentre-cohort
#10
Cristina Lucidi, Marco Biolato, Quirino Lai, Barbara Lattanzi, Ilaria Lenci, Martina Milana, Raffaella Lionetti, Antonio Liguori, Mario Angelico, Giuseppe Tisone, Alfonso Wolfango Avolio, Salvatore Agnes, Massimo Rossi, Antonio Grieco, Manuela Merli
BACKGROUND: Recent innovations in the field of liver transplantation have led to a wealth of new treatment regimes, with potential impact on the onset ofde novo malignancies (DNM). The aim of this multicenter cohort study was to provide contemporary figures for the cumulative incidences of solid and hematological DNM after liver transplantation. METHODS: We designed a retrospective cohort study including patients undergoing LT between 2000 and 2015 in three Italian transplant centers...
January 19, 2021: Annals of Hepatology
https://read.qxmd.com/read/33482347/association-of-periodontitis-and-tooth-loss-with-liver-cancer-a-systematic-review
#11
REVIEW
Sadeq Ali Al-Maweri, Wael Ibraheem Ibraheem, Mohammad Sultan Al-Ak'hali, Anas Shamala, Esam Halboub, Mohammed Nasser Alhajj
A number of epidemiological studies have suggested a positive association between periodontal diseases and oro-digestive cancers, including liver cancer. The purpose of the present systematic review was to analyze the current evidence regarding the potential association between periodontitis and/or tooth loss and the risk of liver cancer. A comprehensive search of PubMed, Scopus and Web of Science databases was conducted in August 2019. The inclusion criteria comprised all observational studies that assessed the relationship between periodontitis or tooth loss and liver cancer...
January 19, 2021: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/33482285/micropollutants-impair-the-survival-of-oreochromis-niloticus-and-threat-local-species-from-igua%C3%A3-u-river-southern-of-brazil
#12
Satar Luciano Gemusse, Nilce Mary Turcatti Folle, Angie Thaisa Costa de Souza, Maristela Azevedo-Linhares, Francisco Filipak Neto, Claudia Feijó Ortolani-Machado, Juan Ramon Esquivel Garcia, Luíse Esquivel, Cléber Pinto da Silva, Sandro Xavier de Santos, Cesar C Martins, Ciro Alberto de Oliveira Ribeiro
The wastewater contamination of urban rivers is a concern for biodiversity and a consequence from poor urban conservation policies. In the current study, the impact of urban and industrial activities was investigated in Iguaçu river (Southern Brazil) male juvenile Oreochromis niloticus, after trophic and chronic exposure (25, 50 and 100%), over 81 days. After exposure liver, gills, gonads, brain, muscle, and blood were sampled for chemical, biochemical, histopathological, genotoxic and molecular analyses. Water levels of persistent organic pollutants such as polychlorinated biphenyls, organochlorine pesticides, polycyclic aromatics hydrocarbon (PAHs) and metals were investigated...
January 19, 2021: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/33482271/nano-designed-carbon-monoxide-donor-sma-corm2-exhibits-protective-effect-against-acetaminophen-induced-liver-injury-through-macrophage-reprograming-and-promoting-liver-regeneration
#13
Bingdong Song, Cheng Zhang, Weirong Hu, Chunyu Guo, Zhengmei Xia, Wanxia Hu, Mingqiang Qin, Weiying Jiang, Jinwei Lv, Dexiang Xu, Shichen Zhang, Jun Fang
Acetaminophen (APAP) induced liver injury is the most common drug-induced liver injury, accounting for the top cause of acute liver failure in the United State, however the therapeutic options for it is very limited. Excess generation of reactive oxygen species (ROS) and the subsequent inflammatory responses are the major factors of the liver injury. Carbon monoxide (CO) is an important gaseous molecule with versatile functions including anti-oxidation and anti-inflammation, and we previous reported the therapeutic potential of a nano-designed CO donor SMA/CORM2 in a dextran sulphate sodium (DSS) induced mouse colitis model...
January 19, 2021: Journal of Controlled Release
https://read.qxmd.com/read/33482193/heat-precondition-is-a-potential-strategy-to-combat-hepatic-injury-triggered-by-severe-heat-stress
#14
Avinash Gupta, Dolly Sharma, Harshita Gupta, Ajeet Singh, Daipayan Chowdhury, Ramesh Chand Meena, Lilly Ganju, Bhuvnesh Kumar
AIM: Environmental heat stress alters physiological and biochemical functions which leads to multiorgan dysfunction including severe hepatic injury in animals. We hypothesize that heat preconditioning can be potential intervention in combating heat illnesses. MAIN METHODS: Sprague-Dawley rats were exposed to moderate heat stress, severe heat stress and heat preconditioning in heat simulation chamber. Mean arterial pressure, heart rate, skin and core temperature were monitored in pre and post heat exposed animals...
January 19, 2021: Life Sciences
https://read.qxmd.com/read/33482192/vaspin-regulated-cartilage-cholesterol-metabolism-through-mir155-lxr%C3%AE-and-participated-in-the-occurrence-of-osteoarthritis-in-rats
#15
Hangyuan He, Mengting Lu, Huasong Shi, Guoping Yue, Hanwen Luo
AIMS: This study intends to explore the role of Vaspin and cholesterol metabolism in the process of osteoarthritis (OA) and its mechanism in vitro and in vivo. MAIN METHODS: In vitro, chondrocytes were treated with interleukin-1β (IL-1β, 20 ng/ml) in combination with Vaspin at different concentrations for 48 h. The expressions of Aggrecan (ACAN), Collagen 2a1 (Col2a1), A Disintegrin And Metalloproteinase with Thrombo Spondin type 1 motifs 5 (ADAMTS 5), and Matrix metalloproteinase 13 (MMP13) were detected...
January 19, 2021: Life Sciences
https://read.qxmd.com/read/33482185/beinaglutide-shows-significantly-beneficial-effects-in-diabetes-obesity-induced-nonalcoholic-steatohepatitis-in-ob-ob-mouse-model
#16
Xiankang Fang, Zhiqiang Du, Chunling Duan, Shanshan Zhan, Tian Wang, Mengyu Zhu, Jiajie Shi, Juan Meng, Xianhua Zhang, Maiyun Yang, Yajun Zuo
AIMS: Beinaglutide has been approved for glucose lowering in type 2 diabetes mellitus (T2DM) in China. In addition to glycemic control, significant weight loss is observed from real world data. This study is designed to investigate the pharmacological and pharmacokinetic profiles of beinaglutide in different models. METHODS: The pharmacological efficacy of beinaglutide was evaluated in C57BL/6 and ob/ob mice after single administration. Pharmacokinetic profiles in mice were investigated after single or multiple administration...
January 19, 2021: Life Sciences
https://read.qxmd.com/read/33482179/aldose-reductase-regulates-doxorubicin-induced-immune-and-inflammatory-responses-by-activating-mitochondrial-biogenesis
#17
Himangshu Sonowal, Ashish Saxena, Sumin Qiu, Sanjay Srivastava, Kota V Ramana
We have recently demonstrated that aldose reductase (AR) inhibitor; fidarestat prevents doxorubicin (Dox)-induced cardiotoxic side effects and inflammation in vitro and in vivo. However, the effect of fidarestat and its combination with Dox on immune cell activation and the immunomodulatory effects are not known. In this study, we examined the immunomodulatory effects of fidarestat in combination with Dox in vivo and in vitro. We observed that fidarestat decreased Dox-induced upregulation of CD11b in THP-1 monocytes...
January 19, 2021: European Journal of Pharmacology
https://read.qxmd.com/read/33482148/characterization-of-aldo-keto-reductase-1c-subfamily-members-encoded-in-two-rat-genes-akr1c19-and-rgd1564865-relationship-to-9-hydroxyprostaglandin-dehydrogenase
#18
Satoshi Endo, Toshiyuki Matsunaga, Akira Hara
Rat genes, akr1c19 and RGD1564865, encode members (R1C19 and 20HSDL, respectively) of the aldo-keto reductase (AKR) 1C subfamily, whose functions, however, remain unknown. Here, we show that recombinant R1C19 and 20HSDL exhibit NAD+ -dependent dehydrogenase activity for prostaglandins (PGs) with 9α-hydroxy group (PGF2α , its 13,14-dihydro- and 15-keto derivatives, 9α,11β-PGF2 and PGD2 ). 20HSDL oxidized the PGs with much lower Km (0.3-14 μM) and higher kcat /Km values (0.064-2.6 min-1 μM-1 ) than those of R1C19...
January 19, 2021: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/33482039/entecavir-induced-interferon-%C3%AE-1-suppresses-type-2-innate-lymphoid-cells-in-patients-with-hepatitis-b-virus-related-liver-cirrhosis
#19
Si-Qi Wang, Yue Shen, Jing Li, Yun Liu, Li-Sha Cheng, Sheng-di Wu, Wei-Min She, Wei Jiang
The immunomodulatory effects of entecavir (ETV) in anti-hepatitis B virus (HBV) therapy have long been recognized. This study aimed to determine the effects of ETV on non-natural killer innate lymphoid cells (non-NK ILCs) in HBV-related liver disease progression. We enrolled treatment-naïve chronic hepatitis B (CHB) and HBV-related liver cirrhosis (LC) patients treated with ETV for 24 months. Before and after therapy, the frequency and cytokine profiles of ILC2s and non-NK ILCs subset homeostasis and their clinical significance were determined, and serial serum interferon (IFN)-λ levels were analyzed...
January 22, 2021: Journal of Viral Hepatitis
https://read.qxmd.com/read/33482027/human-hepatitis-b-virus-negatively-impacts-the-protective-immune-cross-talk-between-natural-killer-and-dendritic-cells
#20
Claudia De Pasquale, Stefania Campana, Chiara Barberi, Giacomo Sidoti Migliore, Daniela Oliveri, Marika Lanza, Cristina Musolino, Giovanni Raimondo, Soldano Ferrone, Teresa Pollicino, Guido Ferlazzo
NK cells play a crucial role in the clearance of human viruses but their activity is significantly impaired in chronic hepatitis B infected patients (CHB). Cooperation with dendritic cells (DCs) is pivotal for obtaining optimal NK cell antiviral function, thus we investigated whether HBV might impact the ability of DCs to sustain NK cell functions. Human DCs were poor stimulators of IFN-γ production by NK cells when exposed to HBV, while maintained capability to trigger NK cell cytotoxicity. HBV prevented DC maturation but did not affect their expression of HLA class I, thus allowing DCs to evade NK cell lysis...
January 22, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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