Ravi Gupta, Rohit Gupta, Niraj Kumar, Vikram Singh Rawat, Jan Ulfberg, Richard Putnam Allen
Sleep disturbances are commonly reported in patients with chronic liver disease (CLD). Changes in quality of sleep in patients with CLD could be related to multiple factors viz., elevated levels of tryptophan, histamine, and increased turnover of dopamine in caudate-putamen and cingulate cortex. Also, iron metabolism disturbances are reported in patients with CLD. These changes may result in restless legs syndrome (RLS) that worsens sleep-quality. There have been reports suggesting an increased prevalence of RLS among patients with CLD...
March 11, 2021: Sleep Medicine Reviews
Qianhua Ke, Jiao Yang, Huan Liu, Zhuoquan Huang, Lingling Bu, Dengpeng Jin, Chunhong Liu
Nonylphenol (NP) is a representative environmental endocrine-disrupting compound that can induce oxidative stress in organisms. The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway acts an important role in preventing oxidative stress. The aim of this study was to investigate the influence of oxidative stress caused by NP on Keap1-Nrf2 pathway in rats. Rats were treated with NP (30, 90, 270 mg/kg) for different exposure time (7, 14 and 28 days)...
April 6, 2021: Ecotoxicology and Environmental Safety
Hsiang-Chih Lu, Iván A González, Kathleen Byrnes
Ground-glass (GG) hepatocytes are classically associated with chronic hepatitis B (HBV) infection, storage disorders, or cyanamide therapy. In a subset of cases, an exact etiology cannot be identified. In this study, we sought to characterize the clinical, histological, and ultrastructural findings associated with HBV-negative GG hepatocytes. Our institutional laboratory information system was searched from 2000 to 2019 for all cases of ground-glass hepatocytes. Ten liver biopsies with GG hepatocellular inclusions and negative HBV serology, no known history of storage disorders, or cyanamide therapy were reviewed...
March 31, 2021: Annals of Diagnostic Pathology
Ruiming Zhang, Pengfei Li, Xiangli Shi, Ruiying Zhang, Junjie Wang, Yanwei Li, Qingzhu Zhang, Wenxing Wang
Elucidating the metabolic mechanism and the derivatives of polybrominated diphenyl ethers (PBDEs) is significant to risk assessment. This study delineated the metabolic mechanism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) catalyzed by P450 enzymes using a combination of molecular dynamic (MD), quantum mechanics/molecular mechanics (QM/MM) and density functional theory (DFT). The calculation results reveal that the electrophilic addition is the main pathway for the biotransformation of BDE-47 catalyzed by P450 enzymes...
March 31, 2021: Chemosphere
Carolina Madeira, Diana Madeira, Nemiah Ladd, Carsten J Schubert, Mário S Diniz, Catarina Vinagre, Miguel C Leal
Climate warming is causing rapid spatial expansion of ocean warm pools from equatorial latitudes towards the subtropics. Sedentary coral reef inhabitants in affected areas will thus be trapped in high temperature regimes, which may become the "new normal". In this study, we used clownfish Amphiprion ocellaris as model organism to study reef fish mechanisms of thermal adaptation and determine how high temperature affects multiple lipid aspects that influence physiology and thermal tolerance. We exposed juvenile fish to two different experimental conditions, implemented over 28 days: average tropical water temperatures (26 °C, control) or average warm pool temperatures (30 °C)...
March 26, 2021: Science of the Total Environment
Hyo-Jin Kang, Dong Ho Lee, Sae Jin Park, Joon Koo Han
PURPOSE: This study aimed to investigate the correlation of attenuation between virtual noncontrast (VNC) and true noncontrast (TNC) CT images and compare the diagnostic performance for hepatic steatosis using MR spectroscopy (MRS) as the reference standard. METHODS: A total of 131 consecutive hepatic donor candidates who underwent dual-source dual-energy CT and MRS within one month from January 2018 to April 2019 were included. An MRS value > 5.8 % was regarded as substantial hepatic steatosis...
March 27, 2021: European Journal of Radiology
Jennifer Yu, Neeta Vachharajani, Ola Ahmed, Meranda D Scherer, Sarah C Matson, Jason R Wellen, Surendra Shenoy, William C Chapman, Maria B Doyle, Adeel S Khan
BACKGROUND: The majority of liver transplants (LT) in North America are performed by transplant surgery fellows with attending surgeon supervision. While a strict case volume requirement is mandatory for graduating fellows, no guidelines exist on providing constructive feedback to trainees during fellowship. STUDY DESIGN: A retrospective review of all adult LTs performed by abdominal transplant surgery fellows at a single ASTS-accredited academic institution from 2005-2019 was conducted...
April 6, 2021: Journal of the American College of Surgeons
M Annala, S Fu, J V W Bacon, J Sipola, N Iqbal, C Ferrario, M Ong, D Wadhwa, S J Hotte, G Lo, B Tran, L A Wood, J R Gingerich, S A North, C J Pezaro, J D Ruether, S S Sridhar, H M L Kallio, D J Khalaf, A Wong, K Beja, E Schönlau, S Taavitsainen, M Nykter, G Vandekerkhove, A A Azad, A W Wyatt, K N Chi
PURPOSE: Treatment for poor prognosis metastatic castration-resistant prostate cancer (mCRPC) includes taxane chemotherapy and androgen receptor pathway inhibitors (ARPI). We sought to determine optimal treatment in this setting. PATIENTS AND METHODS: This multicentre, randomised, open-label, phase 2 trial recruited patients with ARPI-naïve mCRPC and poor prognosis features (presence of liver metastases, progression to mCRPC after <12 months of androgen deprivation therapy, or ≥4 of 6 clinical criteria)...
April 6, 2021: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Y Li, M Gao, L-H Yin, L-N Xu, Y Qi, Pengyuan Sun, J-Y Peng
Dioscin, one natural product, has various pharmacological actions. However, its effects on methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present study, the data manifested that dioscin restored the viabilities of L-02 and NRK-52E cells, reduced ALT, AST, Cr, BUN levels, and ameliorated histopathological changes of liver and kidney. Besides, dioscin decreased ROS levels in cells, and adjusted SOD, MDA, GSH and GSH-Px levels in rats. Dioscin reduced the expression levels of miR-145-5p which directly targeted Sirt5, and then regulated the expression levels of SOD1, Nrf2, Gst, Keap1, HO-1, GCLC and NQO1...
April 6, 2021: Free Radical Biology & Medicine
Priya Wadgaonkar, Fei Chen
Arsenic exposure in contaminated drinking water is a global health issue, as more than 200 million people are affected globally. Arsenic has been known to cause skin, liver, lung, bladder and prostate cancers. Accordingly, it has been categorized as a group I human carcinogen by the International Agency for Research on Cancer (IARC). Various natural and anthropogenic activities lead to the release of arsenic in the environment, contaminating air, water and food sources. Traditionally, genetic mutations have been the center of cancer research...
April 6, 2021: Seminars in Cancer Biology
Guanghui Ren, Guorong Li
Deleted in liver cancer 1 (DLC1) is a recognized tumor suppressor gene that negatively regulates Rho family proteins by hydrolyzing the active GTP-bound state to its inactive GDP-bound state. Active Rho proteins play a positive role in tumorigenesis. Numerous in vitro and in vivo experiments have shown that DLC1 is downregulated or inactivated in various solid tumors, which may be due to the following five reasons: genomic deletion, epigenetic modification, and ubiquitin-dependent proteasomal degradation may cause DLC1 underexpression; phosphorylation at the post-translation level may cause DLC1 inactivation; and failure to localize at focal adhesions (FAs) may prevent DLC1 from exerting full activity...
April 6, 2021: International Journal of Biological Macromolecules
Stéphane Chappaz, Tahnee L Saunders, Benjamin T Kile
The generation of radiation chimeras allows researchers to substitute the hematopoietic system of a mouse with that of one or more donors. A suspension of hematopoietic stem cells (HSCs) is prepared from the bone marrow (BM) or the fetal liver (FL) of a donor mouse and adoptively transferred into an irradiated recipient. Within days, the donor's HSCs will engraft, and their progeny will quickly replace the blood cells of the recipient. This simple tool, together with the large availability of genetically modified mouse lines, can be harnessed to manipulate and study various aspects of blood cell biology in vivo...
April 2021: Current protocols
Ranim Saleem, Rasha Al-Attar, Kenneth B Storey
AbstractHibernation is a strategy used by some mammals to survive harsh winter conditions. Many small mammals, such as the little brown bat, Myotis lucifugus , enter a long-term state of hibernation characterized by a period of deep torpor that can range from days to weeks. Torpid bats undergo metabolic rate depression that not only results in physiological changes but also promotes biochemical changes that favor survival. The present study utilizes multiplex technology to assess key early apoptosis markers and a select group of antioxidant enzymes in muscle, heart, and liver in euthermic controls and torpid bats...
May 2021: Physiological and Biochemical Zoology: PBZ
S Kaleem Ahmed, Nicole N Haese, Jaden T Cowan, Vibha Pathak, Omar Moukha-Chafiq, Valerie J Smith, Kevin J Rodzinak, Fahim Ahmad, Sixue Zhang, Kiley M Bonin, Aaron D Streblow, Cassilyn E Streblow, Craig N Kreklywich, Clayton Morrison, Sanjay Sarkar, Nathaniel Moorman, Wes Sander, Robbie Allen, Victor DeFilippis, Babu L Tekwani, Mousheng Wu, Alec J Hirsch, Jessica L Smith, Nichole A Tower, Lynn Rasmussen, Robert Bostwick, Joseph A Maddry, Subramaniam Ananthan, John M Gerdes, Corinne E Augelli-Szafran, Mark J Suto, Thomas E Morrison, Mark T Heise, Daniel N Streblow, Ashish K Pathak
A benzo[6]annulene, 4-( tert -butyl)- N -(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide ( 1a ), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC90 = 1.45 μM and viral titer reduction (VTR) of 2.5 log at 10 μM with no observed cytotoxicity (CC50 = 169 μM) in normal human dermal fibroblast cells. Chemistry efforts to improve potency, efficacy, and drug-like properties of 1a resulted in a novel lead compound 8q , which possessed excellent cellular antiviral activity (EC90 = 270 nM and VTR of 4...
April 9, 2021: Journal of Medicinal Chemistry
Sunjian Lyu, Xuemei Yuan, Li Liu, Haiqi Zhang, Zhe Yu, Xiaoying Hang, Weida Shi, Yinglei Wu
Trionyx sinensis Hemorrhagic Syndrome Virus (TSHSV) is an arterivirus newly discovered in Chinese softshell turtles. Little is known about the effect of antibodies against the virus or the distribution of the virus in different organs of infected turtles. In this study, a partial protein of TSHSV-HP4 was produced using a prokaryotic expression system, and its polyclonal antibody was generated. The polyclonal antibody was confirmed by western blot and dot enzyme-linked immunosorbent assay (dot-ELISA). The distribution of TSHSV in different organs of T...
April 15, 2021: Journal of Zhejiang University. Science. B
Yuto Yamada, Takashi Sasaki, Tsuyoshi Takeda, Takafumi Mie, Takaaki Furukawa, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Yoshinori Igarashi, Naoki Sasahira
BACKGROUND: Stenting against recurrent biliary obstruction (RBO) after placement of covered metal stent (CMS) for distal malignant biliary obstruction (MBO) is still challenging. This study investigated the feasibility of a novel laser-cut fully-covered metal stent with anti-reflux valve in patients with distal MBO refractory to conventional CMS. METHODS: Patients who underwent Duckbill-type metal stent (DMS) placement between June 2019 and May 2020 were included...
April 9, 2021: Journal of Hepato-biliary-pancreatic Sciences
Aránzazu Caballero-Marcos, Magdalena Salcedo, Roberto Alonso-Fernández, Manuel Rodríguez-Perálvarez, María Olmedo, Javier Graus Morales, Valentín Cuervas-Mons, Alba Cachero, Carmelo Loinaz-Segurola, Mercedes Iñarrairaegui, Lluís Castells, Sonia Pascual, Carmen Vinaixa-Aunés, Rocío González-Grande, Alejandra Otero, Santiago Tomé, Javier Tejedor-Tejada, José María Álamo-Martínez, Luisa González-Diéguez, Flor Nogueras-Lopez, Gerardo Blanco-Fernández, Gema Muñoz-Bartolo, Francisco Javier Bustamante, Emilio Fábrega, Mario Romero-Cristóbal, Rosa Martin-Mateos, Julia Del Rio-Izquierdo, Ana Arias-Milla, Laura Calatayud, Alberto A Marcacuzco-Quinto, Víctor Fernández-Alonso, Concepción Gómez-Gavara, Jordi Colmenero, Patricia Muñoz, José Antonio Pons
The protective capacity and duration of humoral immunity after SARS-CoV-2 infection is not yet understood in solid organ transplant recipients. A prospective multicenter study was performed to evaluate the persistence of anti-nucleocapsid IgG antibodies in liver transplant recipients 6 months after coronavirus disease 2019 (COVID-19) resolution. A total of 71 liver transplant recipients were matched with 71 immunocompetent controls by a propensity score including variables with a well-known prognostic impact in COVID-19...
April 9, 2021: American Journal of Transplantation
Daniele Dondossola, Matteo Ravaioli, Caterina Lonati, Lorenzo Maroni, Alessia Pini, Caterina Accardo, Giuliana Germinario, Barbara Antonelli, Federica Odaldi, Alberto Zanella, Antonio Siniscalchi, Matteo Cescon, Giorgio Rossi
Hypothermic-oxygenated machine perfusion (HOPE) has the potential to counterbalance the detrimental consequences of cold and warm ischemia time in both brain death donors (DBD) and donors after circulatory death (DCD). Herein, we investigated the protective effects of HOPE in extended criteria (ECD) DBD and over-extended warm ischemia time (WIT) DCD grafts. The present retrospective case-series study included 50 livers subjected to end-ischemic HOPE or dual (D)HOPE in two liver transplant (LT) Centers from January 2018 to December 2019...
April 9, 2021: Liver Transplantation
Joel Reis, André Coelho, Virgínia Lopes, Judit Gandara, Glória Cunha Velho, Manuela Selores
Dermatophytes are common keratinophilic fungi responsible for superficial skin infections. Deep dermatophytosis is a rare form of invasive skin infection described in immunocompromised patients. We report the case of a 65-year-old man with a history of an orthotopic liver transplant for hepatocarcinoma 6 months earlier, who presented with small painless erythematous papules in lower limbs, some of which were umbilicated. Skin biopsy showed an intense non-necrotizing granulomatous reaction in the dermis around fungal structures...
April 9, 2021: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Mina Kim, Taegyu Kim, Hyun Young Lee, Sung Yeon Hong, Hee-Jung Wang, Bong-Wan Kim
Hepatic resection (HR) is considered a treatment of choice for a single hepatocellular carcinoma (HCC) ≤5 cm in patients with preserved liver function. However, it is possible for these patients to develop a severe form of recurrence (beyond Milan recurrence [BMR] criteria). This recurrence could have been avoided if liver transplantation (LT) was performed primarily, as LT is believed to yield a more favorable oncological outcome compared with HR. The aim of this study is to determine the risk factors for BMR after HR and to verify whether primary LT can provide a more favorable outcome in patients with BMR risk factors...
April 9, 2021: Liver Transplantation
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