Sara A El-Mokhtar, Noha A Afifi, Mohamed O Abdel-Malek, Waleed A Hassan, Helal Hetta, Omnia El-Badawy
The study aim was to compare the alterations in the expression levels of proinflammatory and chemotactic cytokines as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17A and IL-8, the down regulatory cytokine IL-10, in addition to the vascular cell adhesion molecule-1 (VCAM-1) gene in different groups of patients with cirrhosis due to various etiologies. This case-control study included 84 patients suffering from cirrhosis of viral and non-viral etiologies and 20 sex and age-matched healthy controls...
October 1, 2023: Cytokine
Feng Pei, Wei-Jia Hu, Yu-Liang Zhao
OBJECTIVE: This study aimed to assess the efficacy of Jiao's scalp acupuncture in combination with Xiangshao granules on chronic tension-type headache (CTTH) with concomitant nonalcoholic fatty liver disease (NAFLD) in climacteric women. METHODS: In this study, we enrolled 150 climacteric women with CTTH and concomitant NAFLD. The participants were divided into three groups based on the random number table: medication group, acupuncture group, and acupuncture-medication group...
October 3, 2023: Menopause: the Journal of the North American Menopause Society
Shelley R Wang, Caroline G Mallard, Cassandra A Cairns, Hee Kyoung Chung, Dongyoon Yoo, Suraj K Jaladanki, Lan Xiao, Jian-Ying Wang
Gut barrier dysfunction occurs commonly in patients with critical disorders, leading to the translocation of luminal toxic substances and bacteria to the bloodstream. Connexin 43 (Cx43) acts as a gap junction protein and is crucial for intercellular communication and the diffusion of nutrients. The levels of cellular Cx43 are tightly regulated by multiple factors, including polyamines, but the exact mechanism underlying the control of Cx43 expression remains largely unknown. The RNA-binding protein HuR regulates the stability and translation of target mRNAs and is involved in many aspects of intestinal epithelial pathobiology...
October 3, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology
Irvin Ng, Ian Y Luk, Rebecca Nightingale, Camilla M Reehorst, Mercedes Davalos-Salas, Laura J Jenkins, Chun Fong, David S Williams, Matthew J Watt, Amardeep S Dhillon, John M Mariadason
High fat diets, and inflammation are risk factors for colon cancer, however the underlying mechanisms remain to be fully elucidated. The transcriptional co-repressor HDAC3 has recently emerged as a key regulator of intestinal epithelial responses to diet and inflammation with intestinal-specific Hdac3 deletion ( Hdac3IKO ) in mice increasing lipid oxidation genes and the rate of lipid oxidation in enterocytes. Hdac3IKO mice are also predisposed to experimentally induced colitis, however whether this is driven by the intestinal metabolic reprogramming, and whether this predisposes these mice to intestinal tumourigenesis is unknown...
October 3, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Yasuhiro Maruya, Takuro Fujita, Hajime Imamura, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
We sometimes experience living donor liver transplantation (LDLT) involving very small grafts with graft-to-recipient weight ratio (GRWR) <0.6% when the actual graft size is smaller than predicted. The outcomes in this situation have not been fully investigated. The present study aimed to determine the graft outcomes of LDLT with GRWR <0.6%. We retrospectively reviewed 280 cases of adult LDLT performed at our institution between January 2000 and March 2021. In our institution, the lower limit for graft volume/standard liver volume ratio was 30%...
October 4, 2023: Liver Transplantation
Yasmina Chouik, Christophe Corpechot, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Olivier Chazouillères, Filomena Conti, Sébastien Dharancy, François Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noëlle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallée, Jérôme Dumortier
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) may recur after liver transplantation (LT). The aims of this study were to evaluate the incidence and risk factors for AIH recurrence (rAIH). METHODS: A multicenter retrospective French nationwide study including all patients aged ≥16 transplanted for AIH, with at least one liver biopsy 1 year after LT, was conducted between 1985 and 2018. Risk factors for rAIH were identified using a multivariate Cox regression model...
October 4, 2023: Liver Transplantation
Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo
Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells...
October 3, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
Monday O Ogese, Adam Lister, Liam Farrell, Joshua Gardner, Laila Kafu, Serat-E Ali, Andrew Gibson, Aimee Hillegas, Xiaoli Meng, Munir Pirmohamed, Geoffrey S Williams, Melanie Z Sakatis, Dean J Naisbitt
In vitro preclinical drug-induced liver injury (DILI) risk assessment relies largely on use of hepatocytes to measure drug-specific changes in cell function or viability. Unfortunately, this does not provide indications towards the immunogenicity of drugs and/or the likelihood for idiosyncratic reactions in the clinic. This is because the molecular initiating event in immune DILI is an interaction of the drug-derived antigen with MHC proteins and the T-cell receptor. This study utilised immune cells from drug-naïve donors, recently established immune cell co-culture systems and blinded compounds with and without DILI liabilities to determine whether these new methods offer an improvement over established assessment methods for the prediction of immune-mediated DILI...
October 3, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
Kentaro Ito, Go Tajima, Chikako Kamisato, Miyuki Tsumura, Mitsuhiro Iwamoto, Yukiko Sekiguchi, Yukinobu Numata, Kyoko Watanabe, Yoshiyuki Yabe, Satomi Kanki, Yusuke Fujieda, Koichi Goto, Yoshitaka Sogawa, Masataka Oitate, Hiroyuki Nagase, Shinnosuke Tsuji, Tomohiro Nishizawa, Masayo Kakuta, Takeshi Masuda, Yoshiyuki Onishi, Makoto Koizumi, Hidefumi Nakamura, Satoshi Okada, Masafumi Matsuo, Kiyosumi Takaishi
Glycogen storage disease type 1a (GSD1a) is caused by a congenital deficiency of glucose-6-phosphatase-alpha (G6Pase-α, encoded by G6PC), primarily associated with life-threatening hypoglycemia. Although strict dietary management substantially improves the life expectancy, patients still suffer from intermittent hypoglycemia and develop hepatic complications. Emerging therapies utilizing new modalities such as adeno-associated virus and mRNA with lipid nanoparticles are under development for GSD1a, but potentially require complicated glycemic management throughout life...
October 3, 2023: Journal of Clinical Investigation
Rajni Sharma, Babita Upadhyay, Nitika Lal, Rajesh Sagar, Vandana Jain
OBJECTIVES: To study the impact of carbohydrate counting vs. fixed-meal plan on glycemic control, quality of life (QoL) and diabetes-related emotional distress in children with Type 1 diabetes mellitus (T1DM). METHODS: Children aged 6-18 y with T1DM of duration >1 y were eligible for the study if they were on multiple daily injections of insulin and regularly monitoring blood glucose. Those with celiac disease, hypothyroidism, any underlying chronic renal/liver/systemic disease or HbA1c >13% were excluded...
October 3, 2023: Indian Journal of Pediatrics
Hua Zhong, Shaoyin Li, Xiaojian Wu, Fang Luo
Objective: Compare the clinical efficacy of anterior and posterior Calot's triangle approach in laparoscopic cholecystectomy (LC) for chronic atrophic cholecystitis, to find out which approach is much safer and more reliable. Patients and Methods: From June 2020 to June 2022, 102 patients with chronic atrophic cholecystitis underwent LC in our hospital. They were divided into anterior Calot's triangle approach group and posterior Calot's triangle approach group. In addition, their clinical data, intraoperative conditions, surgical results, and postoperative recovery were analyzed...
October 3, 2023: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Kyle A Lewellen, Thomas K Maatman, Nicholas J Zyromski
BACKGROUND: Sphincter of Oddi dysfunction is a challenging and rare clinical entity resulting in pancreatobiliary pain and stasis of bile and pancreatic juice. This problem was classically treated with surgical therapy, but as classification of the disease has changed and newer methods of endoscopic evaluation and therapy have evolved, operative transduodenal sphincteroplasty is now generally reserved as a final therapeutic option for these patients. In this video and manuscript, we describe our approach to operative transduodenal sphincteroplasty in a patient with type I Sphincter of Oddi dysfunction...
October 3, 2023: Journal of Gastrointestinal Surgery
Shenghong Sun, Ding Shi, Wei Wang
Non-cancer deaths are now becoming a great threat to the health of cancer survivors. There are no comprehensive and systematic reports on chronic liver disease and cirrhosis mortality (CLDCM) among patients with digestive system cancers (DSCs). This research aimed to quantitatively assess the risks and patterns of CLDCM among patients with DSCs. From the surveillance, epidemiology and end results (SEER) program, we extracted the data of patients diagnosed with DSCs between 2000 and 2017. Trends in incidence-based mortality rate (IBMR) were calculated using Joinpoint software...
October 3, 2023: Clinical and Experimental Medicine
Jiashuo Chao, Shanshan Wang, Hao Wang, Nan Zhang, Yunchao Wang, Xu Yang, Chengpei Zhu, Cong Ning, Xinmu Zhang, Jingnan Xue, Longhao Zhang, Mingjian Piao, Mingming Wang, Xiaobo Yang, Ling Lu, Haitao Zhao
BACKGROUND: In clinical practice, some patients with advanced intrahepatic cholangiocarcinoma (ICC) cannot tolerate or refuse chemotherapy due to the toxicity, necessitating alternative treatments. PD-1 blockade combined with lenvatinib showed promising results in phase II studies with small sample size, but there is a lack of data on the routine use with this regimen. This study aimed to evaluate the effectiveness and safety of the regimen in patients with advanced ICC, and to identify predictors for treatment response and prognosis...
October 3, 2023: Cancer Immunology, Immunotherapy: CII
Shunsuke Doi, Satoshi Yasuda, Daisuke Hokuto, Naoki Kamitani, Yasuko Matsuo, Takeshi Sakata, Satoshi Nishiwada, Minako Nagai, Kota Nakamura, Taichi Terai, Yuichiro Kohara, Masayuki Sho
BACKGROUND: The influence of prolonged intermittent Pringle maneuver (IPM) on post-hepatectomy liver failure (PHLF) remains unclear. We evaluated the impact of the prolonged IPM on PHLF in patients undergoing open and laparoscopic hepatectomy. METHODS: We retrospectively included 546 patients who underwent hepatectomy using IPM. The patients were divided into open (n = 294) and laparoscopic (n = 252) groups. Odds ratios for PHLF occurrence were estimated in each group according to cumulative Pringle time (CPT)...
October 3, 2023: World Journal of Surgery
Mukesh Kumar, Mridula Chauhan, Sarvesh Kumar Verma, Arpon Biswas, Alisha Ansari, Anjali Mishra, Sachin Nashik Sanap, Amol Chhatrapati Bisen, Koneni V Sashidhara, Rabi Sankar Bhatta
1. The current investigation was to develop and validate the LC-MS/MS method in order to analyze the various pharmacokinetic parameters of S019-0385. A sensitive, selective, and robust LC-MS/MS approach was established and validated for measuring S019-0385 in female mice plasma and tissue, using optimal multiple reaction monitoring (MRM) transition m/z 488.25/329.12 on positive mode. On a Waters Symmetry Shield C18 column, the analyte was separated using acetonitrile and deionised water with formic acid within 6 minutes at 0...
October 3, 2023: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Jihyun Cha, Seongjin Hong, Junghyun Lee, Jiyun Gwak, Mungi Kim, Sori Mok, Hyo-Bang Moon, Paul D Jones, John P Giesy, Jong Seong Khim
Major aryl hydrocarbon receptor (AhR) agonists were identified in extracts of blubber, liver, and muscle from six long-beaked common dolphins ( Delphinus capensis ) and one fin whale ( Balaenoptera physalus ) collected from Korean coastal waters using effect-directed analysis. Results of the H4IIE- luc bioassay indicated that the polar fractions of blubber and liver extracts from the fin whale exhibited relatively high AhR-mediated potencies. Based on full-scan screening with high-resolution mass spectrometry, 37 AhR agonist candidates, spanning four use categories: pharmaceuticals, pesticides, cosmetics, and natural products, were selected...
October 3, 2023: Environmental Science & Technology
Pedro Vianna, Sara-Ivana Calce, Pamela Boustros, Cassandra Larocque-Rigney, Laurent Patry-Beaudoin, Yi Hui Luo, Emre Aslan, John Marinos, Talal M Alamri, Kim-Nhien Vu, Jessica Murphy-Lavallée, Jean-Sébastien Billiard, Emmanuel Montagnon, Hongliang Li, Samuel Kadoury, Bich N Nguyen, Shanel Gauthier, Benjamin Therien, Irina Rish, Eugene Belilovsky, Guy Wolf, Michaël Chassé, Guy Cloutier, An Tang
Background Screening for nonalcoholic fatty liver disease (NAFLD) is suboptimal due to the subjective interpretation of US images. Purpose To evaluate the agreement and diagnostic performance of radiologists and a deep learning model in grading hepatic steatosis in NAFLD at US, with biopsy as the reference standard. Materials and Methods This retrospective study included patients with NAFLD and control patients without hepatic steatosis who underwent abdominal US and contemporaneous liver biopsy from September 2010 to October 2019...
October 2023: Radiology
Theresa A Tuthill
No abstract text is available yet for this article.
October 2023: Radiology
Hidekatsu Kuroda, Takuma Oguri, Naohisa Kamiyama, Hidenori Toyoda, Satoshi Yasuda, Kento Imajo, Yasuaki Suzuki, Katsutoshi Sugimoto, Tomoyuki Akita, Junko Tanaka, Yutaka Yasui, Masayuki Kurosaki, Namiki Izumi, Atsushi Nakajima, Yudai Fujiwara, Tamami Abe, Keisuke Kakisaka, Takayuki Matsumoto, Takashi Kumada
Background Because of the global increase in the incidence of nonalcoholic fatty liver disease, the development of noninvasive, widely available, and highly accurate methods for assessing hepatic steatosis is necessary. Purpose To evaluate the performance of models with different combinations of quantitative US parameters for their ability to predict at least 5% steatosis in patients with chronic liver disease (CLD) as defined using MRI proton density fat fraction (PDFF). Materials and Methods Patients with CLD were enrolled in this prospective multicenter study between February 2020 and April 2021...
October 2023: Radiology
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