keyword
https://read.qxmd.com/read/33098747/expanding-the-scope-of-dcd-liver-transplantation
#1
EDITORIAL
Peter J Friend, Fungai Dengu
Ghinolfi, Dondossola, and colleagues from Italy in this issue describe a significant step in utilization of organs that are currently not transplanted. The particular constraints that apply to DCD organ donation in Italy (the requirement for 20 minutes of asystole on ECG) provide the incentive to innovate: this length of warm ischemia effectively precludes conventional organ retrieval. However, the approach described is not only important in Italy but also relevant anywhere DCD liver transplantation (LT) is undertaken ...
October 24, 2020: Liver Transplantation
https://read.qxmd.com/read/33098728/the-blockade-of-interleukin-33-released-by-hepatectomy-would-be-a-promising-treatment-option-for-cholangiocarcinoma
#2
Satoshi Nagaoka, Daisaku Yamada, Hidetoshi Eguchi, Yuki Yokota, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Eiji Miyoshi, Yuichiro Doki, Masaki Mori
Interleukin-33 (IL-33), an alarmin released during tissue injury, facilitates the development of cholangiocarcinoma (CCA) in a murine model. However, it is unclear whether IL-33 is associated with human CCA. The aim of this study was to support the following hypothesis: IL-33 is released during hepatectomy for CCA, subsequently facilitating the development of subclinical CCA and eventually leading to recurrent disease. IL-33 expression was assessed in various samples from both humans and mice including resected liver and paired plasma samples collected at hepatectomy and after surgery, and its influences on recurrent disease and patient prognosis were determined...
October 24, 2020: Cancer Science
https://read.qxmd.com/read/33098723/hdl-cholesterol-protects-from-liver-injury-in-mice-with-intestinal-specific-lxr%C3%AE-activation
#3
Irene Pierantonelli, Gessica Lioci, Fabio Gurrado, Debora Maria Giordano, Chiara Rychlicki, Claudia Bocca, Luciano Trozzi, Erica Novo, Nadia Panera, Cristiano De Stefanis, Valentina D'Oria, Marco Marzioni, Luca Maroni, Maurizio Parola, Anna Alisi, Gianluca Svegliati-Baroni
BACKGROUND AND AIMS: Liver X receptors (LXRs) exert anti-inflammatory effects even though their hepatic activation is associated with hypertriglyceridemia and hepatic steatosis. Selective induction of LXRs in the gut might provide protective signal(s) in the aberrant wound healing response that induces fibrosis during chronic liver injury, without hypertriglyceridemic and steatogenic effects. METHODS: Mice with intestinal constitutive LXRα activation (iVP16-LXRα) were exposed to intraperitoneal injection of carbon tetrachloride (CCl4 ) for 8 weeks, and in vitro cell models were used to evaluate the beneficial effect of high-density lipoproteins (HDL)...
October 24, 2020: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/33098624/the-ongoing-evolution-of-liver-transplantation-in-alcohol-associated-liver-disease
#4
John P Rice
Liver transplantation (LT) for alcohol-associated liver disease (ALD) has now become the most common indication for LT.(1). Patients with alcohol use disorder (AUD) have excellent outcomes after LT with most recipients remaining abstinent or drinking in a moderate fashion(2). The "6-month" rule, which imposed a fixed interval of sobriety prior to LT consideration, has increasingly been abandoned as scientific evidence demonstrates such intervals to be, at best, a weak predictor of future harmful alcohol relapse and arbitrarily excluding many patients who would do well with LT and who will almost certainly die otherwise(3)...
October 24, 2020: Liver Transplantation
https://read.qxmd.com/read/33098580/long-term-outcome-of-mpi-cdg-patients-on-d-mannose-therapy
#5
Muriel Girard, Claire Douillard, Dominique Debray, Florence Lacaille, Manuel Schiff, Sandrine Vuillaumier-Barrot, Thierry Dupré, Monique Fabre, Lena Damaj, Alice Kuster, Stéphanie Torre, Karine Mention, Valérie McLin, Dries Dobbelaere, Delphine Borgel, Eric Bauchard, Nathalie Seta, Arnaud Bruneel, Pascale De Lonlay
BACKGROUND: Mannose Phosphate Isomerase MPI-CDG (formerly CDG-1b) is a potentially fatal inherited metabolic disease which is readily treatable with oral D-mannose. We retrospectively reviewed long-term outcomes of patients with MPI-CDG, all but one of whom were treated with D-mannose. METHODS: Clinical, biological and histological data were reviewed at diagnosis and on D-mannose treatment. RESULTS: Nine patients were diagnosed with MPI-CDG at a median age of 3 months...
July 17, 2020: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/33098559/wild-black-rats-rattus-rattus-linnaeus-1758-as-zoomonitor-of-genotoxicity-and-systemic-toxicity-induced-by-hazardous-emissions-from-abule-egba-unsanitary-landfill-lagos-nigeria
#6
Chibuisi G Alimba, Olusoji O Adewumi, Olufisayo M Binuyo, Peter G C Odeigah
Wild black rats (Rattus rattus) inhabiting Abule Egba landfill (AEL) were used as zoomonitor to assess health risk associated with exposure to hazardous chemicals from landfills. Twenty five R. rattus (16♂ and 9♀) captured within AEL and 15 (9♂ and 6♀) (control) caught from Iyano Ipaja (10 km away from AEL) were examined for bone marrow micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio, abnormal sperm morphology, alterations in hematological indices and erythrocyte morphology, and histopathology of the viscera using standard protocols...
October 24, 2020: Environmental Science and Pollution Research International
https://read.qxmd.com/read/33098521/fgf21-enhances-therapeutic-efficacy-and-reduces-side-effects-of-dexamethasone-in-treatment-of-rheumatoid-arthritis
#7
Xu Sun, Yin-Zhuo Xie, Yuan-Yuan Jiang, Guan-Ying Wang, Yu-Jia Wang, Yu Mei, Rong-Hui Gao, Yan-Hua Li, Wei Xiao, Wen-Fei Wang, De-Shan Li
In order to investigate efficacy of FGF21 combine dexamethasone (Dex) on rheumatoid arthritis (RA) meanwhile reduce side effects of dexamethasone. We used combination therapy (Dex 15 mg/kg + FGF21 0.25 mg/kg, Dex 15 mg/kg + FGF21 0.5 mg/kg or Dex 15 mg/kg + FGF21 1 mg/kg) and monotherapy (Dex 15 mg/kg or FGF21 1 mg/kg) to treat CIA mice induced by chicken type II collagen, respectively. The effects of treatment were determined by arthritis severity score, histological damage, and cytokine production. The levels of oxidative stress parameters, liver functions, and other blood biochemical indexes were detected to determine FGF21 efficiency to side effects of dexamethasone...
October 24, 2020: Inflammation
https://read.qxmd.com/read/33098506/the-effect-of-tlr4-blockade-on-some-indicators-of-systemic-inflammatory-response-to-proteus-mirabilis-lps-in-rats
#8
K V Sivak, K I Stosman, T A Rassokha, A G Aleksandrov, N N Kuzmich, Ya R Orshanskaya, T N Savateeva-Lubimova, E E Lesiovskaya
The effects of TLR4 blocker on blood cell morphology, concentrations proinflammatory cytokines, and functional state of the liver and kidneys were studied in outbred male rats (n=60) after intravenous injection of 20 mg/kg LPS isolated from opportunistic Proteus mirabilis strain ATCC 51393. TLR4 blocker TLR4-IN-C34 was injected intravenously in a dose of 1 mg/kg/day over 3 days. Systemic inflammatory reaction induced by LPS was characterized by elevation of serum TNFα, IL-1β, IL-6, erythrocyte sedimentation rate, leukocytosis, and thrombocytosis...
October 24, 2020: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/33098479/assessment-of-se-mre-derived-shear-stiffness-at-3-0-tesla-for-solid-liver-tumors-characterization
#9
Andrés Dominguez, Daniel Fino, Juan Carlos Spina, Nicolas Moyano Brandi, Joaquín Capó, Maximiliano Noceti, Pedro Pablo Ariza, Guilherme Moura Cunha
OBJECTIVES: To evaluate the feasibility and diagnostic value of using a 2D spin-echo MR elastography (SE-MRE) sequence at 3.0 Tesla for solid focal liver lesions (FLL) characterization. METHODS: This prospective study included 55 patients with solid FLL (size > 20 mm), who underwent liver SE-MRE at 3 Tesla between 2016 and 2019. Stiffness measurements were performed by two independent readers blinded to the complete MRI exam or patient information. Histological confirmation or typical behavior on the complete MRI exam evaluated in consensus by expert abdominal radiologists was used as reference standard...
October 24, 2020: Abdominal Radiology
https://read.qxmd.com/read/33098447/the-clinical-relevance-of-the-hippo-pathway-in-pancreatic-ductal-adenocarcinoma
#10
Richard Drexler, Mirco Küchler, Kim C Wagner, Tim Reese, Bernd Feyerabend, Moritz Kleine, Karl J Oldhafer
PURPOSE: The Hippo pathway has broadened in cancer research in the past decade and revealed itself to be an important driver for tumorigenesis and metastatic spread. In this study, we investigated the clinical relevance of the Hippo pathway with regard to metastatic invasion, patients' outcome and histopathological features. METHODS: Protein expression of components of the Hippo pathway were analyzed by immunohistochemistry (IHC) using paraffin-embedded tissue from 103 patients who had been diagnosed with pancreatic ductal adenocarcinoma and had undergone surgery...
October 24, 2020: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/33098390/zinc-protects-against-mdma-induced-apoptosis-of-sertoli-cells-in-mouse-via-attenuation-of-caspase-3
#11
Nadia Hossein-Zadeh, Morteza Bagheri, Isa Abdi Rad, Marziyeh Lozeie, Mahdieh Nasir-Zadeh
Background: 3,4-Methylenedioxymethamphetamine (MDMA) disrupts function of the endocrine system and different organs such as heart, blood vessels, kidney, liver and nervous systems. This revision was conducted to evaluate impact of MDMA on apoptosis and Zinc in the MDMA-induced apoptosis of cultured Sertoli cells by measuring Caspase-3 gene expression. Materials and Methods: In this experimental study, Sertoli cells were incubated with MDMA (0, 0.5, 1, 3 and 5 mM), Zinc (0, 8, 16, 32, 64 μM) and Zinc (8 μM) prior to adding MDMA (5 mM) for 24 and 48 hours...
October 2020: International Journal of Fertility & Sterility
https://read.qxmd.com/read/33098374/proteome-analyses-reveal-s100a11-s100p-and-rbm25-are-tumor-biomarkers-in-colorectal-cancer
#12
Ai-Jun Guo, Feng-Jie Wang, Qiang Ji, Hui-Wu Geng, Xu Yan, Lin-Qi Wang, Wei-Wei Tie, Xiao-Ying Liu, Rick F Thorne, Gang Liu, A-Man Xu
PURPOSE: The prognosis for colorectal cancer (CRC) patients is drastically impacted by the presence of lymph node or liver metastases at diagnosis or resection. On this basis we sought to identify novel proteins as biomarkers and determinants of CRC metastasis. EXPERIMENTAL DESIGN: Proteomic analyses were undertaken using primary tissues from ten Chinese CRC patients presenting with or without liver metastases and immunohistochemistry used to validate selected proteins in an independent patient cohort...
October 24, 2020: Proteomics. Clinical Applications
https://read.qxmd.com/read/33098338/prognostic-impact-of-metastatic-site-and-pattern-in-patients-with-metastatic-head-and-neck-cancer
#13
Craig A Bollig, Christopher I Newberry, Tabitha L I Galloway, Robert P Zitsch, Elyse K Hanly, Vivian L Zhu, Nitin Pagedar, Rohit Nallani, Andres M Bur, William C Spanos, Jeffrey B Jorgensen
OBJECTIVES/HYPOTHESIS: Investigate the relationship between site and pattern of distant metastasis (DM) and overall survival (OS) in a multi-institutional cohort of patients with DM head and neck cancer (HNC). STUDY DESIGN: Retrospective review. METHODS: 283 patients treated at 4 academic centers in the Midwest HNC Consortium between 2000 and 2015 were retrospectively reviewed. Disease patterns were divided between solitary metastatic versus polymetastatic (≥2 sites) disease...
October 24, 2020: Laryngoscope
https://read.qxmd.com/read/33098277/liver-transplantation-using-hepatitis-c-virus-viremic-donors-into-hepatitis-c-virus-aviremic-recipients-as-standard-of-care
#14
Humberto Bohorquez, Emily Bugeaud, Natalie Bzowej, Jennifer Scheuermann, Jonathan Hand, David Bruce, Ian Carmody, Ari Cohen, Shobha Joshi, John Seal, Dennis Sonnier, George Therapondos, Nigel Girgrah, Stephanie Anders, George E Loss
Liver transplantation (LT) using allografts from hepatitis C virus (HCV)-viremic/nucleic acid testing-positive donors' (DNAT+) organs into HCV-aviremic recipients (rHCV-) has been limited due to nearly universal HCV transmission and concerns regarding availability, safety, and efficacy post-LT with direct-acting antiviral (DAAs) therapy. We report our experience of LT using DNAT+ organs into rHCV- as a routine standard of care. Following verification of DAAs access, absence of critical drug-drug interactions (DDIs) with DAAs, and informed consent, allocated DNAT+ organs were offered to patients on the waiting list for LT irrespective of recipient HCV status...
October 24, 2020: Liver Transplantation
https://read.qxmd.com/read/33098253/triple-phase-ct-may-replace-dual-energy-x-ray-absorptiometry-scan-for-evaluation-of-osteoporosis-in-liver-transplant-candidates
#15
Manhal Izzy, Benyam D Addissie, Juan Pablo Arab, Moira B Hilscher, Amanda Cartee, David C Lee, Yong Lee, Joel G Fletcher, Tony M Keaveny, William Sanchez
BACKGROUND: Assessment of bone density is an important part of liver transplant (LT) evaluation for early identification and treatment of osteoporosis (OP). Dual-energy X-ray absorptiometry (DXA) is currently the standard clinical test for osteoporosis; however, it may contribute to the appointment burden on LT candidates during the cumbersome evaluation process and there are limitations affecting its accuracy. In this study, we evaluate the utility of biomechanical analysis of vertebral images obtained during triple phase dual-energy abdominal CT (TPCT) in diagnosing osteoporosis among LT candidates...
October 23, 2020: Liver Transplantation
https://read.qxmd.com/read/33098240/glucose-effectiveness-lessons-from-studies-on-insulin-independent-glucose-clearance-in-mice
#16
REVIEW
Bo Ahrén, Giovanni Pacini
Besides insulin-mediated transport of glucose into the cells, an important role is also played by the non-insulin-mediated transport. This latter process is called glucose effectiveness (acronym SG ), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration and accounts for ≈70% of glucose disposal. This review summarizes studies on SG , mainly in humans and rodents with focus on results achieved in model experiments in mice. In humans, SG is reduced in type 2 diabetes, in obesity, in liver cirrhosis and in some elderly populations...
October 23, 2020: Journal of Diabetes Investigation
https://read.qxmd.com/read/33098235/gdf15-knockdown-suppresses-cervical-cancer-cell-migration-in-vitro-through-the-tgf-%C3%AE-smad2-3-snail1-pathway
#17
Li Li, Ruihong Zhang, Hailei Yang, Donghua Zhang, Jiwei Liu, Jinfang Li, Bin Guo
Growth differentiation factor 15 (GDF15), a member of the TGF-β superfamily, is a prognostic biomarker of cervical cancer. In addition, GDF15 has been reported to enhance the migration of colorectal cancer cells and liver cancer stem-like cells. However, the mechanism by which GDF15 promotes cervical cancer cell migration is not completely understood. Here, we report that GDF15 expression is enhanced in cervical cancer tissues as well as in cultured cervical cancer cells. ShGDF15 transfection markedly inhibited expression of Vimentin, N-cadherin, and Snail1, and resulted in upregulation of E-cadherin expression in HT-3 and HeLa cells...
October 23, 2020: FEBS Open Bio
https://read.qxmd.com/read/33098209/variceal-recurrence-4-years-post-endoscopic-band-ligation-in-hepatitis-c-patients-who-achieved-sustained-virological-response-with-oral-direct-acting-antiviral-therapy
#18
El-Sayed Ibrahim, Mohamed Abdel-Samiee, Mohamed I Youssef, Helmy El-Shazly, Abd-ElAleem A El-Gendy, Ayman Ahmed Sakr, Doaa Elwazzan, Mervat Ragab Nassar, Amr Aly Elshormilisy, Ahmad Madkour, Mostafa Kamal, Yasmine M Amrousy, Sally Waheed Elkhadry, Eman Abdelsameea
Oral Direct-acting antivirals (DAAs) are safe, highly effective altering disease burden and prognosis in hepatitis C patients. Sustained virologic response (SVR) is achieved nowadays in more than 90 percent of the treated patients and related to the improvements in functions of the liver, fibrosis plus survival. Furthermore, portal hypertension is thought to be improved with achievement of virological response, parallel to the improvements in hepatic inflammation and fibrosis.We aimed assess the recurrence rate of esophageal varices by long term follow up in patients treated with different DAAs regimens who had achieved SVR...
October 23, 2020: Journal of Viral Hepatitis
https://read.qxmd.com/read/33098200/covid-19-in-transplant-recipients-the-spanish-experience
#19
Elisabeth Coll, Mario Fernández-Ruiz, J Emilio Sánchez-Álvarez, José Ramón Martínez-Fernández, Marta Crespo, Jorge Gayoso, Teresa Bada-Bosch, Federico Oppenheimer, Francesc Moreso, María O López-Oliva, Edoardo Melilli, Mª Luisa Rodríguez-Ferrero, Elena Burgos, Carme Facundo, Inmaculada Lorenzo, Íñigo Yañez, Cristina Galeano, Ana Roca, Mercedes Cabello, Manuel Gómez-Bueno, Javier Graus, Laura Lladó, Alicia de Pablo, Carmelo Loinaz, Beatriz Aguado, Domingo Hernández, Beatriz Domínguez-Gil
We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. We compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), and 66% were male. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population...
October 23, 2020: American Journal of Transplantation
https://read.qxmd.com/read/33098140/the-application-of-artificial-intelligence-for-the-diagnosis-and-treatment-of-liver-diseases
#20
REVIEW
Joseph C Ahn, Alistair Connell, Douglas A Simonetto, Cian Hughes, Vijay H Shah
Modern medical care produces large volumes of multi-modal patient data, which many clinicians struggle to process and synthesize into actionable knowledge. In recent years, artificial intelligence (AI) has emerged as an effective tool in this regard. The field of hepatology is no exception, with a growing number of studies published that apply artificial intelligence techniques to the diagnosis and treatment of liver diseases. These have included Machine Learning algorithms (such as regression models, Bayesian networks, and support vector machines) to predict disease progression, the presence of complications, and mortality; Deep Learning algorithms to enable rapid, automated interpretation of radiologic and pathologic images; and Natural Language Processing to extract clinically meaningful concepts from vast quantities of unstructured data in Electronic Health Records...
October 23, 2020: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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