Eduardo de Faria Viana, Heloisa Helena de Carvalho Mello, Fabyola Barros Carvalho, Marcos Barcellos Café, Nadja Susana Mogyca Leandro, Emmanuel Arnhold, José Henrique Stringhini
Objective: An experiment was conducted to evaluate the effect of different levels of crude protein (CP) and two rearing systems (cage and floor), on blood parameters and digestive and reproductive organ development of brown laying hens. Methods: A total of 400 Hisex Brown laying hens between 30 and 45 weeks of age were distributed in a completely randomized design and a 2×4 factorial arrangement, with main effects including two rearing systems (cage and floor) and levels of CP (140, 150, 160, and 180 g/kg), in a total of eight treatments and five replicates of 10 birds each with initial body weight of 1,877 g (laying hen in cage) and 1,866 g (laying hens in floor)...
June 24, 2021: Animal bioscience
Olivier Roux, François Durand, Jacques Bernuau
No abstract text is available yet for this article.
August 1, 2021: Obstetrics and Gynecology
Jungwook Shin, Shu Xing, Lucas McCullum, Abdelkhalek Hammi, Jennifer Pursley, Camilo M Correa Alfonso, Julia Withrow, Sean Domal, Wesley E Bolch, Harald Paganetti, Clemens Grassberger
We have developed a time-dependent computational framework, HEDOS (HEmatological DOSe), to estimate dose to circulating blood cells from radiation therapy treatment fields for any treatment site. Two independent dynamic models were implemented in HEDOS: one describing the spatiotemporal distribution of blood particles (BPs) in organs and the second describing the time-dependent radiation field delivery. A whole-body blood flow network based on blood volumes and flow rates from ICRP Publication 89 was simulated to produce the spatiotemporal distribution of BPs in organs across the entire body using a discrete-time Markov process...
July 22, 2021: Physics in Medicine and Biology
Pengfei Yang, Lei Xu, Yidong Wan, Jing Yang, Yi Xue, Yangkang Jiang, Chen Luo, Xi Hu, Jing Wang, Tianye Niu
OBJECTIVES: To test the effect of traditional up-sampling slice thickness (ST) methods on the reproducibility of CT radiomics features of liver tumors and investigate the improvement using a deep neural network (DNN) scheme. METHODS: CT images with ≤ 1 mm ST in the public dataset were converted to low resolution (3 mm, 5 mm) CT images. A DNN model was trained for the conversion from 3 mm-ST and 5 mm-ST to 1 mm-ST and compared with conventional interpolation-based methods (cubic, linear, nearest) using structural similarity (SSIM) and peak-signal-to-noise-ratio (PSNR)...
July 22, 2021: Physics in Medicine and Biology
Héctor G van den Boorn, Willemieke P M Dijksterhuis, Lydia G M van der Geest, Judith de Vos-Geelen, Marc G Besselink, Johanna W Wilmink, Martijn G H van Oijen, Hanneke W M van Laarhoven
BACKGROUND: A prediction model for overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (PDAC) including patient and treatment characteristics is currently not available, but it could be valuable for supporting clinicians in patient communication about expectations and prognosis. We aimed to develop a prediction model for OS in metastatic PDAC, called SOURCE-PANC, based on nationwide population-based data. MATERIALS AND METHODS: Data on patients diagnosed with synchronous metastatic PDAC in 2015 through 2018 were retrieved from the Netherlands Cancer Registry...
July 21, 2021: Journal of the National Comprehensive Cancer Network: JNCCN
Michele Ghielmetti, Helen Dorothea Schaufelberger, Giorgina Mieli-Vergani, Andreas Cerny, Eric Dayer, Diego Vergani, Benedetta Terziroli Beretta-Piccoli
Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis...
July 15, 2021: Journal of Autoimmunity
Chao Han, Yuqing Cui, Yiwei Guo, Di Zhang, Xiao Wang, Yumeng Geng, Wanyu Shi, Yongzhan Bao
In order to explore the mechanism of liver injury induced by florfenicol (FFC) in broilers. Sixty broilers were randomly divided into 2 groups: control group: normal drinking water and feed were given every d; FFC group: tap water containing FFC (0.15g/L) was given every d and feed was taken freely; each group was given 5 dd of continuous medication and feed was taken freely. The results showed that compared with the control group, FFC could significantly inhibit the weight gain of broilers (P < 0.05), and significantly inhibit the expression of CYP1A1 and CYP2H1 in liver tissue (P < 0...
May 4, 2021: Poultry Science
Mia Levite, Rifaat Safadi, Yael Milgrom, Muhammad Massarwa, Eithan Galun
T cells of aged people, and of patients with either cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter and Neuropeptide receptors, and in the magnitude of the corresponding effects. Therefore, we performed an individual-based study on T cells of 3 healthy subjects, and 3 Hepatocellular Carcinoma (HCC) patients...
May 12, 2021: Neuropeptides
Liuting Shi, Ruili Pan, Guopeng Lin, Xi Liang, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Perfluorooctanoic acid (PFOA) is an environmental pollutant that has multiple toxic effects. Although some medicines and functional food ingredients are currently being used to alleviate the biological toxicity effects caused by PFOA, these candidates all show potential side effects and cannot prevent the accumulation of PFOA in the body, making them unable to be used as a daily dietary supplement to relieve the toxic effects of PFOA. However, new research has shown that lactic acid bacteria (LAB) can alleviate toxicity caused by exposure to foreign substances...
July 19, 2021: Ecotoxicology and Environmental Safety
Ji Jiang, Yanfei Tan, Amin Liu, Rentai Yan, Yanzhe Ma, Likun Guo, Jing Sun, Zhenzhen Guo, Hongsong Fan
In alcoholic liver disease (ALD) research, animal models, as one of the most popular methods to explore pathology and therapeutic drug screening, show the limitations of expensive cost and ethic, as well as long modeling time. To minimize the use of animal models in ALD research, an artificial liver model has been developed by incorporating HepG2 cells into hydrogel matrix based on difunctional hyaluronan and collagen. And on this basis an alcohol-induced ALD model in vitro by adding alcohol in the engineering process has been established...
July 16, 2021: Colloids and Surfaces. B, Biointerfaces
Li Jing, Yanmin Sun, Ji Wang, Xianqing Zhou, Zhixiong Shi
Decabromodiphenyl ethane (DBDPE) is one of the most commonly used novel brominated flame retardants (NBFRs), and its mass production and widespread application have caused health threats to the human being. Existing studies have shown that DBDPE has hepatotoxicity. And we have found that DBDPE could change cytochrome P450 3A (CYP3A) expression levels in rat livers, whereas the mechanism is unclear. In this study, we exposed human normal hepatocyte (L-02) to DBDPE to further study the effect and mechanism of DBDPE on hepatocellular injury and liver metabolic enzyme CYP3A changes in vitro...
July 13, 2021: Chemosphere
Yiyin Chen, Banglun Pan, Jiacheng Qiu, Zhanfei Chen, Xiaoqian Wang, Nanhong Tang
As the occurrence and development of HCC are often accompanied by inflammation, the combination of sorafenib with other therapeutic drugs, especially anti-inflammatory drugs, is one of the directions to be explored at present. Our previous research has been focused on the anti-inflammatory drug 2,5-dimethylcelecoxib (DMC), whether DMC combined with sorafenib could elevate the effect of inhibiting HCC deserves further exploration. In this study, we found that DMC induced CYP3A5 expression in HCC cells in a time-dependent and concentration dependent manner...
July 19, 2021: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Luis A Rodriguez, Alka M Kanaya, Stephen C Shiboski, Alicia Fernandez, David Herrington, Jingzhong Ding, Patrick T Bradshaw
PURPOSE: To estimate the effect of obesity on type 2 diabetes (T2DM) risk and evaluate to what extent non-alcoholic fatty liver disease (NAFLD) mediates this association. METHODS: Data came from 4,522 adults ages 45-84 participating in the Multi-Ethnic Study of Atherosclerosis cohort. Baseline obesity was defined using established BMI categories. NAFLD was measured by CT scans at baseline and incident T2DM defined as fasting glucose ≥126 mg/dL or use of diabetes medications...
July 19, 2021: Annals of Epidemiology
Wenhao Jiang, Hongkang Zhu, Wenqian Xu, Chang Liu, Bin Hu, Yahui Guo, Yuliang Cheng, He Qian
Oxidative damage and intestinal dysbiosis are regarded as crucial culprits in alcoholic liver disease (ALD). This study aimed to examine the protective effects of Echinacea purpurea polysaccharides (EPPs) against ALD and explore the underlying mechanisms based on hepatic oxidative stress, inflammation, and intestinal barrier function. Three polysaccharide fractions, namely, EPP40, EPP60, and EPP80, were obtained by stepwise ethanol precipitation, and their antioxidant activity in vitro was investigated. The results showed that EPP80 with Mw 11...
July 19, 2021: International Journal of Biological Macromolecules
Alvaro Gonzalez-Cantero, Meron Teklu, Alexander V Sorokin, Ronald Prussick, Jorge González-Cantero, Jose Luis Martin-Rodriguez, Nidhi Patel, Philip M Parel, Grigory A Manyak, Heather L Teague, Justin A Rodante, Andrew Keel, Cristina Pérez-Hortet, Ana I Sanchéz-Moya, Natalia Jiménez, Asunción Ballester, Jorge Solis, Leticia Fernandez-Friera, María G Barderas, Jorge L Gonzalez-Calvin, Pedro Jaen, Martin P Playford, Amit K Dey, Joel M Gelfand, Nehal N Mehta
Psoriasis is associated with a higher risk of liver diseases. We investigated the impact of hepatic steatosis (European cohort) and hepatic inflammation (United States cohort) on subclinical atherosclerosis. In the European cohort (n=76 psoriasis participants and 76 controls), non-alcoholic fatty liver disease (NAFLD), assessed by the sonographic hepatorenal index (SHRI), was more prevalent in psoriasis than controls (61% vs 45%; p=.04). Psoriasis participants with NAFLD had a higher prevalence of subclinical atherosclerosis (ultrasonographic presence of plaque in femoral or carotid arteries) than psoriasis without NAFLD (61% vs 23%; p=...
July 19, 2021: Journal of Investigative Dermatology
Alan S Go, Kristi Reynolds, Grace H Tabada, Priya A Prasad, Sue Hee Sung, Elisha Garcia, Cecilia Portugal, Dongjie Fan, Ashok P Pai, Margaret C Fang
BACKGROUND: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking. RESEARCH QUESTION: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19? STUDY DESIGN AND METHODS: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals...
July 19, 2021: Chest
Huinian Liu, Wenli Hu, Xin Li, Fangwen Hu, Yanni Xi, Zhu Su, Yicai Huang, Bo Liu, Chang Zhang
BACKGROUND: Since 2016, more and more studies have been conducted to explore the combination of obesity and perfluoroalkyl substances (PFASs) exposure, and the results indicate that PFASs may be connected with the occurrence of obesity-associated glucolipid metabolic disease (GLMD). OBJECTIVES: This article summarizes the epidemiological studies on PFASs and obesity-related GLMD, as well as relevant experimental evidence. RESULTS: (i) Both obesity and PFASs exposure can cause disorder of glucose and lipid metabolism (GLM)...
July 19, 2021: Environmental Research
Nadim Mahmud, Sara E Chapin, David E Kaplan, Serper Marina
Since the start of the Coronavirus disease 2019 (COVID-19) pandemic, patients with cirrhosis have demonstrated higher rates of hospitalization, decompensation, and death in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.1 Given the higher risk for a severe COVID-19 course in patients with cirrhosis, 1 vaccination is of the utmost importance.
July 22, 2021: Liver Transplantation
Puneeta Tandon, Corey R Tomczak, Calvin Kruger, Cynthia Tsien, Mark J Haykowsky, Richard Thompson
Reduced exercise tolerance (whole body peak oxygen uptake, VO2 ) is a hallmark feature of both heart failure (HF) and cirrhosis1,2 . By the Fick equation, whole body peak VO2 is the product of cardiac output (central component) and O2 extraction (i.e., the arteriovenous O2 difference, peripheral component). In HF, multiple studies have described the important contributions of central and peripheral components to reduced peak VO2 3,4 .
July 22, 2021: Liver Transplantation
Yogesh Khachane, Robert Halliday, Gordon Thomas, Rajesh Maheshwari, Kathryn Browning Carmo
AIM: To report the outcome for infants with congenital diaphragmatic hernia (CDH) and identify clinical factors affecting outcome from a tertiary perinatal surgical campus where extracorporeal membrane oxygenation (ECMO) is available however rarely utilised. METHODS: A retrospective cohort study of infants with CDH born in a co-located perinatal neonatal intensive care unit (NICU) or retrieved into and managed at a surgical NICU: 2003-2018. RESULTS: One hundred and fifty-nine infants with CDH were identified...
July 22, 2021: Journal of Paediatrics and Child Health
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