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JOURNAL ARTICLE
Takuma Izumi, Takeo Toshima, Shinji Itoh, Shohei Yoshiya, Yuki Bekki, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi
AIM: Reactivation of hepatitis B virus (HBV) after liver transplantation (LT) remains a problem; thus, development of more effective HBV reactivation prophylaxis is desirable. We evaluated the efficacy of a combination of a long-term nucleotide analog (NA), such as entecavir (ETV) or tenofovir alafenamide (TAF), and short-term hepatitis B immunoglobulin (HBIG) in preventing HBV reactivation and compared it with conventional HBV prophylaxis. METHODS: Between February 1999 and August 2023, 135 patients underwent living-donor liver transplantation for liver cirrhosis or acute liver failure caused by HBV infection or received an LT from a hepatitis B core antibody-positive donor...
September 14, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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JOURNAL ARTICLE
Filip Graczyk, Jakub Gębalski, Dorota Sulejczak, Milena Małkowska, Magdalena Wójciak, Dorota Gawenda-Kempczyńska, Elżbieta Piskorska, Krystian Krolik, Maciej Markiewicz, Aneta Kondrzycka-Dąda, Wiktoria Lepianka, Grzegorz Borowski, Marcin Feldo, Robert Verporte, Daniel Załuski
Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. (ES) has gained popularity for its adaptogenic, immunostimulant, and anti-inflammatory properties. Because of overexploitation of the roots, the species is considered to be endangered and has been put on the Red List in some countries (e.g., the Republic of Korea). Therefore, the fruits of E. senticosus might be explored as a new sustainable source of compounds with adaptogenic activity. This study aimed to assess the chemical composition and the safety profile (hepatotoxicity, blood morphology, biochemical parameters of blood plasma) of E...
August 27, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Jianhua Rao, Zeng Wang, Fei Yu, Junda Li, Wenzhu Li, Zhengfeng Xuan, Yongquan Chi, Feng Zhang, Liming Tang, Feng Cheng
BACKGROUND & AIMS: XBP1, most conserved transcription factor of endoplasmic reticulum (ER) stress, plays important roles in physiological and pathological settings and has profound effects on disease progression and prognosis, so it's necessary to investigate XBP1 in macrophage-originated sterile inflammation during liver ischemia/reperfusion injury (IRI). Macrophage XBP1 expression and liver injury are analyzed in patients undergoing ischemia-related hepatectomy. METHODS: A myeloid-specific male XBP1-knockout (XBP1M-KO ) strain is created for function and mechanism of XBP1 on macrophage-derived sterile inflammation in murine liver IRI with in-vitro parallel research...
September 11, 2024: Cellular and Molecular Gastroenterology and Hepatology
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REVIEW
Andrea Boccatonda, Fabio Piscaglia
Mammalian cells release several membrane-enclosed vesicles called extracellular vesicles. Those vesicles can contain several molecules such as proteins, DNA and various RNA. Therefore, extracellular vesicles can act as a target delivery system and exert multiple biological effects. Several works demonstrated that extracellular vesicles are increased or dysregulated in patients with cirrhosis, and they can be predictive of disease progression, complications and mortality. This review aims to summarize and highlight the role of extracellular vesicles in the cirrhotic patient and how they correlate with the degree of disease and with complications, particularly with the development of portal thrombosis and hepatocellular carcinoma...
September 11, 2024: Annals of Hepatology
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EDITORIAL
João Renato Rebello Pinho, Michele Gomes-Gouvêa, Flair José Carrilho
No abstract text is available yet for this article.
September 11, 2024: Annals of Hepatology
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JOURNAL ARTICLE
Guannan Zong, Wangjia Mao, Ming Wen, Xiaoyun Cheng, Guanghui Liu
INTRODUCTION AND OBJECTIVES: The impact of sleep on metabolic dysfunction-associated steatotic liver disease (MASLD) in American adults remains unclear. This study aimed to address the relationship of sleep patterns and disorders with MASLD and liver fibrosis comprehensively. MATERIALS AND METHODS: This cross-sectional study included adult participants from the National Health and Nutrition Examination Survey 2017-2020. Multivariate adjusted regression analysis were used to examine the association of sleep with MASLD and liver fibrosis...
September 11, 2024: Annals of Hepatology
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REVIEW
Anne F Peery, Hamed Khalili, Andreas Münch, Darrell S Pardi
Microscopic colitis is an inflammatory bowel disease that commonly presents with debilitating chronic watery diarrhea. Recent epidemiologic studies and randomized trials of therapeutics have improved our understanding of the disease. Medications such as non-steroidal anti-inflammatories, proton pump inhibitors, and antidepressants have traditionally been considered as the main risk factors for microscopic colitis. However, recent studies have challenged this observation. Additionally, a number of epidemiologic studies have identified other risk factors for the disease including older age, female sex, smoking, alcohol use, immune-mediated diseases, and select gastrointestinal infections...
September 11, 2024: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Xu-Fen Zeng, Krista A Varady, Xiang-Dong Wang, Giovanni Targher, Christopher D Byrne, Reema Tayyem, Giovanni Latella, Ina Bergheim, Rodrigo Valenzuela, Jacob George, Carolyn Newberry, Ju-Sheng Zheng, Elena S George, C Wendy Spearman, Meropi D Kontogianni, Danijela Ristic-Medic, Wilza Arantes Ferreira Peres, Gamze Yurtdaş Depboylu, Wanshui Yang, Xu Chen, Fredrik Rosqvist, Christos S Mantzoros, Luca Valenti, Hannele Yki-Järvinen, Antonella Mosca, Silvia Sookoian, Anoop Misra, Yusuf Yilmaz, Won Kim, Yasser Fouad, Giada Sebastiani, Vincent Wai-Sun Wong, Fredrik Åberg, Yu Jun Wong, Pianhong Zhang, Francisco-Javier Bermúdez-Silva, Yan Ni, Monica Lupsor-Platon, Wah Kheong Chan, Nahum Méndez-Sánchez, Robert J de Knegt, Shahinul Alam, Sombat Treeprasertsuk, Li Wang, Mulong Du, Tiejun Zhang, Ming-Lung Yu, Huijie Zhang, Xingshun Qi, Xin Liu, Kanokwan Pinyopornpanish, Yu-Chen Fan, Niu Kaijun, Josep C Jimenez-Chillaron, Ming-Hua Zheng
Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for MAFLD are not standardized. This study aimed to achieve consensus on prevention of MAFLD through dietary modification. A multidisciplinary panel of 55 international experts, including specialists in hepatology, gastroenterology, dietetics, endocrinology and other medical specialties from six continents collaborated in a Delphi-based consensus development process...
September 11, 2024: Metabolism: Clinical and Experimental
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JOURNAL ARTICLE
Hanna Blaney, Luis Antonio Díaz, Nhi Li, Gurpreet Malhi, Rokhsana Mortuza, Xiaolong Qi, Anand V Kulkarni, Ramon Bataller, Joaquin Cabezas, Alexandre Louvet, Elliot B Tapper, Juan Pablo Arab
No abstract text is available yet for this article.
September 10, 2024: Lancet. Gastroenterology & Hepatology
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JOURNAL ARTICLE
Xueying Lyu, Karen Man-Fong Sze, Joyce Man-Fong Lee, Abdullah Husain, Lu Tian, Sandrine Imbeaud, Jessica Zucman-Rossi, Irene Oi-Lin Ng, Daniel Wai-Hung Ho
Oncoviruses can integrate into the host genome and cause tumorigenesis. In particular, hepatitis B virus (HBV) infection accounts for more than 50% of hepatocellular carcinoma (HCC) worldwide. We revealed the global geographical disparity of HBV integration that the landscape of HBV integration between HCC tumor and non-tumorous liver varied in regional cohorts, suggesting the different degrees of clonal enrichment. Most HBV integrations were positionally enriched at telomeres and centromeres (T&C) and they highlighted the novel co-involvement of HBV integration, which likely introduces genomic instability in HCC development...
September 13, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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JOURNAL ARTICLE
Paola López-Marte, Bianca Goyco-Cortés, Bárbara Rosado-Carrión
OBJECTIVE: Direct-acting antiviral (DAA) drugs have resulted in high rates of virological cure in chronic hepatitis C (CHC)-infected patients. We used noninvasive tests to assess fibrosis in subjects who had been cured with DAA. METHODS: Retrospective data collection (2014-2019) from the medical record of CHC patients at the hepatology clinic was performed. Subjects co-infected with HIV and hepatitis B, post-liver transplant, and lost to follow-up were excluded...
September 2024: Puerto Rico Health Sciences Journal
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Journal of Gastroenterology and Hepatology
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