Hiroshi Takahashi, Masamitsu Hamakawa, Tadashi Ishida, Akira Watanabe
Schizophyllum commune is the third most common causative fungus of allergic bronchopulmonary mycosis(ABPM). Two-thirds of ABPM caused by S. commune can be positive for Aspergillus fumigatus -specific IgE, which can be difficult to diagnose. Our patient presented to our hospital with wet cough for 3 months and chest pain for 3 days. Blood tests showed IgE 1522 IU/mL, eosinophils 688/mm3 , A. fumigatus -specific IgE 2.24 UA/mL, and chest computed tomography showed high-attenuation mucus. Bronchoscopy showed mucus plugs and speculum examination showed filamentous fungi, but various culture tests did not detect A...
July 2024: Respirology Case Reports
Hongxia Zhang, Wei Zhang, Maochen Li, Bu Wang, Zhihua Zhang
A 91-year-old Chinese male was hospitalized on June 28, 2021, due to a sudden fever. The patient had a long history of smoking, a 10-year history of type 2 diabetes, a family history of hypertension, and a history of coronary heart disease and lower extremity arterial occlusive disease. He presented with cough, sputum, and dry and wet rales in both lungs. A computed tomography scan revealed multiple infectious lesions in both lungs and a small pleural effusion. His procalcitonin level was 1.75 ng/mL. Microscopic examination of the sputum revealed abundant fungal spores and hyphae...
June 30, 2024: Heliyon
Rim Hjeij, Joseph Leslie, Hoda Rizk, Bernd Dworniczak, Heike Olbrich, Johanna Raidt, Sebastian Felix Nepomuk Bode, Alice Gardham, Karen Stals, Mohammad Al-Haggar, Engy Osman, Andrew Crosby, Tarek Eldesoky, Emma Baple, Heymut Omran
Defects in motile cilia, termed motile ciliopathies, result in clinical manifestations affecting the respiratory and reproductive system, as well as laterality defects and hydrocephalus. We previously defined biallelic MNS1 variants causing situs inversus and male infertility, mirroring the findings in Mns1 -/- mice. Here, we present clinical and genomic findings in five newly identified individuals from four unrelated families affected by MNS1 -related disorder. Ciliopathy panel testing and whole exome sequencing identified one previously reported and two novel MNS1 variants extending the genotypic spectrum of disease...
June 11, 2024: Cells
Teng Zhou, Wenming Wu, Chao Cheng, Hui Wang, Xiaochuan Hu, Zhenhui Jiang
INTRODUCTION: Bronchobiliary fistulas are rare and difficult to treat. Peacock first reported this entity in 1850 while treating a patient with hepatic encopresis. CASE PRESENTATION: A 67-year-old Chinese male patient presented to the outpatient clinic with a complaint of coughing up phlegm with chest tightness for 4 days with symptoms of intermittent bilirubin sputum with a sputum volume of about 500 ml per day but no symptoms of abdominal pain or jaundice and no yellow urine or steatorrhea...
June 24, 2024: Journal of Medical Case Reports
Hinse Wiltingh, Julie Maree Marchant, Vikas Goyal
Chronic cough in children is a common condition for which patients seek medical attention, and there are many etiologies. Of the various causes of chronic cough in children, protracted bacterial bronchitis (PBB) is one of the commonest causes, and bronchiectasis is one of the most serious. Together, they lie on different ends of the spectrum of chronic wet cough in children. Cough is often the only symptom present in children with PBB and bronchiectasis. This review highlights the role of cough as a marker for the presence of these conditions, as well as an outcome endpoint for treatment and research...
June 4, 2024: Journal of Clinical Medicine
Debasis Mondal, Prantick Kumar Bhunia, Dipamoy Bhattacharya, Ashim Sarkar
Granulomatous amoebic encephalitis due to Acanthamoeba spp is a rare, near-fatal central nervous system infection. It is often seen in immunocompromised individuals. Here we describe a survivor of this infection who was co-infected with multidrug-resistant tuberculosis. He presented to us with features of meningitis and a history of chronic cough. The chest X-ray was classical for pulmonary tuberculosis. Neuroimaging was suggestive of encephalitis; herpes simplex virus PCR was negative. Cerebrospinal fluid (CSF) showed lymphocytic pleocytosis...
June 13, 2024: BMJ Case Reports
Juliana Ribeiro Fonseca Franco de Macedo, Anne-Sophie Aubriot, Gregory Reychler, Morgane Penelle, Sophie Gohy, William Poncin
BACKGROUND: Cystic fibrosis (CF) is a muco-obstructive lung disease characterized by thick sputum with abnormal rheological properties. The intermittent intrapulmonary deflation (IID) is a new instrumental airway clearance technique (ACT) that aims to decrease the sputum viscoelastic properties. This study assessed the benefits of adding the IID technique to a conventional ACT in patients with CF hospitalized for intravenous antibiotic therapy. METHODS: Participants with CF accustomed to autogenic drainage (AD) as their standard ACT received, in a randomized order, a 30-min session of either AD alone or AD combined with IID (AD+IID)...
February 29, 2024: Respiratory medicine and research
Yusuke Sunanaga, Takayuki Suetsugu, Yusuke Nagata, Marina Miyata, Kiyotaka Kondo, Hideo Mitsuyama, Shingo Kubota, Keiko Mizuno, Kentaro Tanaka, Hiromasa Inoue
Cavitary lung lesions are uncommon radiological findings in cytomegalovirus pneumonia, and tissue biopsy is rarely performed for diagnosis. A 67-year-old man presented with a wet cough. Extensive white moss in the oral cavity was found on physical examination, and chest computed tomography revealed an approximately 4 cm cavitary lesion in the upper lobe of the right lung. Blood tests showed a critically low CD4+ T lymphocyte count and positivity for human immunodeficiency virus type 1 antibodies. A transbronchial biopsy of the cavitary lung lesion was performed, and inclusion bodies in the nuclei of enlarged alveolar epithelial cells were seen in the histopathological findings...
May 2024: Respirology Case Reports
Shailesh Bhanudas Meshram, Hiral Gulab Ramnani, Spandana Chaudhury
Schistosomiasis is a parasitic disease caused by trematodes (body flukes), affecting millions worldwide. However, its pulmonary manifestations are rare. We report a rare case of a 51-year-old People Living with HIV male, managed in a tertiary care hospital in west India in May 2023, vegetable vendor who was admitted with complaints of dysphagia, odynophagia, fever and chest pain for 3 days, cough and breathlessness for 1 month. Chest x-ray and CT scan were suggestive of hypodense fluid collection with rim enhancement along right lateral and posterior aspect of thoracic esophagus...
2024: Iranian Journal of Parasitology
Ashlyn C Heniff, Denise McAloose, Erika Crook, Tara M Harrison
OBJECTIVE: Evaluate SARS-CoV-2 morbidity, mortality, clinical signs, treatment interventions, and vaccination practices in tigers under professional care. ANIMALS: Amur (Panthera tigris altaica), Sumatran (Panthera tigris sumatrae), and Malayan (Panthera tigris jacksoni) tigers managed under the Tiger Species Survival Plan (SSP). METHODS: A retrospective, voluntary online survey was sent to all North American zoos holding SSP tigers between January 2020 and June 2023...
April 19, 2024: Journal of the American Veterinary Medical Association
Camille Doras, Ranya Özcelik, Mahamat Fayiz Abakar, Ramadan Issa, Pidou Kimala, Soumaya Youssouf, Isabelle Bolon, Salome Dürr
One Health Syndromic Surveillance has a high potential for detecting early epidemiological events in remote and hard-to-reach populations. Chadian pastoralists living close to their animals and being socio-economically unprivileged have an increased risk for zoonosis exposure. Engaging communities in disease surveillance could also strengthen preparedness capacities for outbreaks in rural Chad. This study describes a retrospective cross-sectional survey that collected data on clinical symptoms reported in people and livestock in Chadian agro-pastoral communities...
March 6, 2024: Acta Tropica
Yu Shi, Qihong Lei, Qing Han
RATIONALE: To analyze clinical and imaging features, ciliary structure and family gene mutation loci of a primary ciliary dyskinesia (PCD) boy with a dual-allele heterozygous mutation of DNAH5. PATIENT CONCERNS: Clinical data of the proband and relatives. Electronic bronchoscopy, transmission electron microscope (TEM) of the cilia and next-generation sequencing (NGS) were performed. PCD-related DNAH5 exon mutation sites were searched. DIAGNOSES: A 10-year and 10-month-old boy was hospitalized due to "recurrent cough, expectoration, sputum and shortness of breathing after activity for over 7 years, and aggravated for 1 week...
December 29, 2023: Medicine (Baltimore)
Brianna Atto, Yitayal Anteneh, Seweryn Bialasiewicz, Michael J Binks, Mostafa Hashemi, Jane Hill, Ruth B Thornton, Jacob Westaway, Robyn L Marsh
Chronic wet cough for longer than 4 weeks is a hallmark of chronic suppurative lung diseases (CSLD), including protracted bacterial bronchitis (PBB), and bronchiectasis in children. Severe lower respiratory infection early in life is a major risk factor of PBB and paediatric bronchiectasis. In these conditions, failure to clear an underlying endobronchial infection is hypothesised to drive ongoing inflammation and progressive tissue damage that culminates in irreversible bronchiectasis. Historically, the microbiology of paediatric chronic wet cough has been defined by culture-based studies focused on the detection and eradication of specific bacterial pathogens...
December 28, 2023: Journal of Clinical Medicine
Syrine Ghrabli, Mohamed Elgendi, Carlo Menon
Coughing, a prevalent symptom of many illnesses, including COVID-19, has led researchers to explore the potential of cough sound signals for cost-effective disease diagnosis. Traditional diagnostic methods, which can be expensive and require specialized personnel, contrast with the more accessible smartphone analysis of coughs. Typically, coughs are classified as wet or dry based on their phase duration. However, the utilization of acoustic analysis for diagnostic purposes is not widespread. Our study examined cough sounds from 1183 COVID-19-positive patients and compared them with 341 non-COVID-19 cough samples, as well as analyzing distinctions between pneumonia and asthma-related coughs...
January 5, 2024: Scientific Reports
Aoife Corcoran, Walter Faig, Clement L Ren
RATIONALE: Diagnosing cystic fibrosis (CF) pulmonary exacerbations (PEx) in very young people with CF <3 years (VY-PwCF) is challenging because of the frequency of respiratory viral infections in this age group, and there are limited data on the clinical features associated with the diagnosis of PEx in this age group. The goal of this study was to identify clinical features associated with the diagnosis of PEx in VY-PwCF. METHODS: We reviewed the medical records of VY-PwCF followed at the Children's Hospital of Philadelphia born between 2013 and 2019...
December 22, 2023: Pediatric Pulmonology
Simon J Hardman, Fiona M Shackley, Kelechi Ugonna, Thomas C Darton, Alan S Rigby, Debby Bogaert, Justyna M Binkowska, Alison M Condliffe
Protracted bacterial bronchitis (PBB) causes chronic wet cough for which seasonal azithromycin is increasingly used to reduce exacerbations. We investigated the impact of seasonal azithromycin on antimicrobial resistance and the nasopharyngeal microbiome. In an observational cohort study, 50 children with PBB were enrolled over two consecutive winters; 25/50 at study entry were designated on clinical grounds to take azithromycin over the winter months and 25/50 were not. Serial nasopharyngeal swabs were collected during the study period (12-20 months) and cultured bacterial isolates were assessed for antimicrobial susceptibility...
November 7, 2023: International Journal of Molecular Sciences
Julie M Marchant, Anne B Chang, Emma Kennedy, David King, Jennifer L Perret, Andre Schultz, Maree R Toombs, Lesley Versteegh, Shyamali C Dharmage, Rebecca Dingle, Naomi Fitzerlakey, Johnson George, Anne Holland, Debbie Rigby, Jennifer Mann, Stuart Mazzone, Mearon OBrien, Kerry-Ann O'Grady, Helen L Petsky, Jonathan Pham, Sheree Ms Smith, Danielle F Wurze, Anne E Vertigan, Peter Wark
INTRODUCTION: Cough is the most common symptom leading to medical consultation. Chronic cough results in significant health care costs, impairs quality of life, and may indicate the presence of a serious underlying condition. Here, we present a summary of an updated position statement on cough management in the clinical consultation. MAIN RECOMMENDATIONS: Assessment of children and adults requires a focused history of chronic cough to identify any red flag cough pointers that may indicate an underlying disease...
November 19, 2023: Medical Journal of Australia
Mayuko Watase, Jun Miyata, Hideki Terai, Keeya Sunata, Emiko Matsuyama, Takanori Asakura, Ho Namkoong, Katsunori Masaki, Kazuma Yagi, Keiko Ohgino, Shotaro Chubachi, Ichiro Kawada, Takao Mochimaru, Ryosuke Satomi, Yoshitaka Oyamada, Keigo Kobayashi, Toshiyuki Hirano, Takashi Inoue, Ho Lee, Kai Sugihara, Nao Omori, Koichi Sayama, Shuko Mashimo, Yasushi Makino, Tatsuya Kaido, Makoto Ishii, Koichi Fukunaga
BACKGROUND: Multiple prolonged symptoms are observed in patients who recover from acute coronavirus disease 2019 (COVID-19), defined as long COVID. Cough and sputum are presented by patients with long COVID during the acute and post-acute phases. This study aimed to identify specific risk factors for cough and sputum in patients with long COVID. METHODS: Hospitalized patients with COVID-19 aged 18 years were enrolled in a multicenter cohort study at 26 medical institutions...
November 14, 2023: Respiratory Research
Aoi Kuroda, Ho Namkoong, Eri Iwami, Akihiro Tsutsumi, Takahiro Nakajima, Hajime Shinoda, Yusaku Katada, Jiro Iimura, Hisato Suzuki, Kenjiro Kosaki, Takeshi Terashima
Bronchiectasis is a chronic respiratory condition characterized by irreversible bronchial dilation, often caused by infection or inflammation. It can be associated with primary ciliary dyskinesia (PCD), a hereditary disorder affecting cilia function in various organs and flagella. PCD's genetic heterogeneity leads to varying disease severity. PCD may be more prevalent in Asia, but its diagnosis is often delayed in Japan. This study reviewed a case of PCD and retinitis pigmentosa (RP) with the relevant literature...
December 2023: Respirology Case Reports
Ali Alsuheel Asseri, Ayed A Shati, Ibrahim A Asiri, Reem H Aldosari, Hassan A Al-Amri, Mohammed Alshahrani, Badriah G Al-Asmari, Haleimah Alalkami
BACKGROUND: Primary ciliary dyskinesia (PCD, MIM 244400) is an inherited ciliopathy disorder characterized by recurrent sinopulmonary infections, subfertility, and laterality defects. The true incidence of PCD in Saudi Arabia is not known, but it is likely underdiagnosed due to the high prevalence of consanguineous marriages. In this study, we aim to study the clinical and genetic characteristics of PCD patients in the southwestern region of Saudi Arabia to provide guidance to clinicians and researchers studying PCD...
October 13, 2023: Children
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