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JOURNAL ARTICLE
Yu Lin, Zhen Xing, Shaomao Lv, Xiefeng Yang, Jianghe Kang, Nannan Kang, Jinan Wang, Dairong Cao
OBJECTIVES: To investigate whether cerebral collateral and venous outflow patterns on color-coded multi-phase computed tomography angiography (mCTA) can estimate ischemic core growth rate (IGR) and predict 90-day functional independence for patients with late-presenting acute ischemic stroke (AIS). METHODS: The retrospective analysis included 127 AIS patients with a late time window. All patients underwent baseline mCTA with color-coded reconstruction and computed tomography perfusion...
May 16, 2024: British Journal of Radiology
#2
JOURNAL ARTICLE
Roman Rohner, Markus Kneihsl, Martina B Goeldlin, Arsany Hakim, Mattia Branca, Stefanie Abend, Waldo Valenzuela Pinilla, Sabine Fenzl, Beata Rezny-Kasprzak, Daniel Strbian, Sven Trelle, Maurizio Paciaroni, Götz Thomalla, Patrik Michel, Krassen Nedeltchev, Thomas Gattringer, Else C Sandset, Leo Bonati, Diana Aguiar de Sousa, P N Sylaja, George Ntaios, Masatoshi Koga, Zuzana Gdovinova, Robin Lemmens, Natan M Bornstein, Peter Kelly, Mira Katan, Thomas Horvath, Jesse Dawson, Urs Fischer
BACKGROUND: Whether hemorrhagic transformation (HT) modifies the treatment effect of early versus late initiation of direct oral anticoagulation (DOAC) in people with ischemic stroke and atrial fibrillation is unknown. METHODS: This is a post-hoc analysis of the ELAN trial. The primary outcome was a composite of recurrent ischemic stroke, symptomatic intracranial hemorrhage (sICH), major extracranial bleeding, systemic embolism, or vascular death within 30 days...
May 16, 2024: Circulation
#3
JOURNAL ARTICLE
Pierre Seners, Anke Wouters, Adrien Ter Schiphorst, Nicole Yuen, Michael Mlynash, Caroline Arquizan, Jeremy J Heit, Stephanie Kemp, Soren Christensen, Denis Sablot, Anne Wacongne, Thibault Lalu, Vincent Costalat, Maarten G Lansberg, Gregory W Albers
BACKGROUND: Patients with acute ischemic stroke harboring a large vessel occlusion admitted to nonendovascular-capable centers often require interhospital transfer for thrombectomy. We evaluated the incidence and predictors of arterial recanalization during transfer, as well as the relationship between interhospital recanalization and clinical outcomes. METHODS: We analyzed data from 2 cohorts of patients with an anterior circulation large vessel occlusion transferred for consideration of thrombectomy to a comprehensive center, with arterial imaging at the referring hospital and on comprehensive stroke center arrival...
May 16, 2024: Stroke; a Journal of Cerebral Circulation
#4
JOURNAL ARTICLE
Gang Li, Yapeng Lin, Jie Yang, Craig S Anderson, Chen Chen, Feifeng Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Xiaoqiu Liu, Xinwen Ren, Chunfang Zhang, Ping Xu, Lijun Wu, Feng Wang, Daijun Qiu, Mei Jiang, Yiqian Peng, Chaohui Li, Yiyang Huang, Xiaohui Zhao, Jiye Liang, Yao Wang, Xiangjun Wu, Xiaoyun Xu, Guofang Chen, Dongya Huang, Yue Zhang, Lian Zuo, Guozhao Ma, Yumei Yang, Junjie Hao, Xiahong Xu, Xinli Xiong, Yueyu Tang, Yijia Guo, Jianping Yu, Shuping Li, Song He, Fengkai Mao, Quandan Tan, Song Tan, Nengwei Yu, Ruxiang Xu, Mingwei Sun, Binghu Li, Jiang Guo, Leibo Liu, Hueiming Liu, Menglu Ouyang, Lei Si, Hisatomi Arima, Philip M Bath, Gary A Ford, Thompson Robinson, Else Charlotte Sandset, Jeffrey L Saver, Nikola Sprigg, H Bart van der Worp, Lili Song
BACKGROUND: Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is uncertain. METHODS: We randomly assigned patients with suspected acute stroke that caused a motor deficit and with elevated systolic blood pressure (≥150 mm Hg), who were assessed in the ambulance within 2 hours after the onset of symptoms, to receive immediate treatment to lower the systolic blood pressure (target range, 130 to 140 mm Hg) (intervention group) or usual blood-pressure management (usual-care group)...
May 16, 2024: New England Journal of Medicine
#5
JOURNAL ARTICLE
Emma Christensen, Helge Fagerheim Bugge, Jostein Hagemo, Karianne Larsen, Astrid Kv Harring, Jostein Gleditsch, Jørgen Ibsen, Mona Guterud, Else Charlotte Sandset, Maren Ranhoff Hov
INTRODUCTION: The optimal pathway for ultra-early diagnostics and treatment in patients with acute stroke remains uncertain. The aim of this study was to investigate how three different methods of simulated, rural prehospital computed tomography (CT) affected the time to prehospital treatment decision in acute stroke. MATERIALS AND METHODS: In this pragmatic, simulation, pilot study of prehospital CT we investigated a conventional ambulance with transport to a standard care rural stationary CT machine managed by paramedics, a Mobile Stroke Unit (MSU), and a helicopter with a simulated CT machine...
May 16, 2024: European Stroke Journal
#6
JOURNAL ARTICLE
Muhammad Farhan Khan, Sundus Rasool, Muhammad Ijaz, Muheer Khan, Sohail Ahmad
OBJECTIVE: To assess the economic burden of acute stroke, and to determine the average cost of acute stroke care for a single hospital stay in a public tertiary care hospital. METHODS: The cross-sectional study was conducted at the Medical Teaching Institute, Bacha Khan Medical Complex, Swabi, Pakistan, from May 16 to September 19, 2022, and comprised patients of either gender who were hospitalised with an acute stroke for the first time. All costs incurred during the care of the patients were measured using the micro-costing methodology, and the association of the cost with other variables was evaluated...
April 2024: JPMA. the Journal of the Pakistan Medical Association
#7
EDITORIAL
Jacobus F A Jansen
No abstract text is available yet for this article.
May 15, 2024: Journal of Magnetic Resonance Imaging: JMRI
#8
JOURNAL ARTICLE
Alexander P Nissen, Lauren V Huckaby, Yazan M Duwayri, William D Jordan, Woodrow J Farrington, W Brent Keeling, Bradley G Leshnower
BACKGROUND: Thoracic endovascular aortic repair (TEVAR) represents optimal therapy for complicated acute type B aortic dissection (aTBAD). Persistent knowledge gaps remain, including optimal length of aortic coverage, impact on distal aortic remodeling, and fate of the dissected abdominal aorta. METHODS: Review of the Emory Aortic Database identified 92 patients who underwent TEVAR for complicated aTBAD from 2012-2018. Standard TEVAR covered aortic zones 3 and 4 (from the left subclavian to the mid-descending thoracic aorta)...
May 13, 2024: Journal of Vascular Surgery
#9
JOURNAL ARTICLE
Weiqiang Ruan, Xiaoqin Zhou, Jing Li, Ting Wang, Huizhen Liu, Guiying Zhang, Ke Lin
BACKGROUND: Thyroid hormones play a crucial role in cardiovascular physiology. Subclinical thyroid dysfunction has been associated with adverse cardiovascular outcomes, but evidence is mixed regarding causality. OBJECTIVE: To investigate the potential causal relationships of thyroid-stimulating hormone (TSH), free thyroxine, hypothyroidism, and hyperthyroidism with cardiovascular outcomes, including atrial fibrillation (AF), coronary artery disease, myocardial infarction, heart failure, and ischemic stroke, as well as their impact on cardiac structure and function assessed by cardiac magnetic resonance imaging...
May 13, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#10
JOURNAL ARTICLE
Tiantian Li, Chengqun Qian, Zhuo Chen, Tianle Wang, Qingjie Chi, Li Zhu
OBJECTIVE: To investigate the relationship between short-term glycemic variability in patients with T2DM and the vulnerability of intracranial atherosclerotic plaques using HR-MR-VWI. MATERIALS AND METHODS: In total, 203 patients with acute ischemic stroke (AIS)/transient ischemia (TIA) combined with T2DM were enrolled. All of them underwent HR-MR-VWI during the period between July 2020 and July 2023. 203 patients were divided into groups with higher (1,5-AG≤30...
May 13, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#11
JOURNAL ARTICLE
Chunwang Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Qixuan Li, Ke Ma, Shuna Huang, Xinru Lin, Weiheng Zhuang, Haojie Wang, Darong Chen, Huimin Wang, Qiu He, Zhuyu Gao, Xuegang Niu, Yajun Jing, Lingjun Yan, Bin Gao, Dengliang Wang, Shaowei Lin, Siying Wu, Yuanxiang Lin, Dezhi Kang, Fuxin Lin
OBJECTIVE: This study aims to investigate the prevalence of familial cerebral cavernous malformations (FCCMs) in first-degree relatives (FDRs) using familial screening, to describe the distribution of initial symptoms, lesion count on cranial MRI and pathogenic gene in patients. METHODS: Patients with multiple CCMs who enrolled from the Treatments and Outcomes of Untreated Cerebral Cavernous Malformations in China database were considered as probands and FDRs were recruited...
May 15, 2024: Stroke and Vascular Neurology
#12
JOURNAL ARTICLE
Shingo Numoto, Syuntaro Takasu, Tomomi Nakamura, Mizuki Takagi, Hirokazu Kurahashi, Yoshiteru Azuma, Akihisa Okumura
BACKGROUND: To describe the diffusion-weighted imaging (DWI) findings in young children with moyamoya disease (MMD) during the acute period of the condition. METHODS: Clinical data were collected from 12 children with MMD aged less than six years, in whom abnormalities were observed on DWI scans obtained within one week after the appearance of symptoms related to MMD. The DWI abnormalities were classified into gyral, atypical territorial, honeycomb, classical territorial, multiple-dot, border zone, and deep lacunar patterns...
April 3, 2024: Pediatric Neurology
#13
REVIEW
Roberta Scicolone, Sebastiano Vacca, Francesco Pisu, John C Benson, Valentina Nardi, Giuseppe Lanzino, Jasjit S Suri, Luca Saba
Carotid atherosclerosis plays a substantial role in cardiovascular morbidity and mortality. Given the multifaceted impact of this disease, there has been increasing interest in harnessing artificial intelligence (AI) and radiomics as complementary tools for the quantitative analysis of medical imaging data. This integrated approach holds promise not only in refining medical imaging data analysis but also in optimizing the utilization of radiologists' expertise. By automating time consuming tasks, AI allows radiologists to focus on more pertinent responsibilities...
May 6, 2024: European Journal of Radiology
#14
JOURNAL ARTICLE
Vitor M Pereira, Pedro Lylyk, Nicole Cancelliere, Pedro N Lylyk, Ivan Lylyk, Vania Anagnostakou, Carlos Bleise, Hidehisa Nishi, Mark Epshtein, Robert M King, Mohammed Salman Shazeeb, Ajit S Puri, Conrad W Liang, Ricardo A Hanel, Julian Spears, Thomas R Marotta, Demetrius K Lopes, Matthew J Gounis, Giovanni J Ughi
Endovascular interventions are increasingly becoming the preferred approach for treating strokes and cerebral artery diseases. These procedures rely on sophisticated angiographical imaging guidance, which encounters challenges because of limited contrast and spatial resolution. Achieving a more precise visualization of the underlying arterial pathology and neurovascular implants is crucial for accurate procedural decision-making. In a human study involving 32 patients, we introduced the clinical application of a miniaturized endovascular neuro optical coherence tomography ( n OCT) imaging probe...
May 15, 2024: Science Translational Medicine
#15
JOURNAL ARTICLE
Jelle Demeestere, Muhammad M Qureshi, Lieselotte Vandewalle, Anke Wouters, Daniel Strbian, Raul G Nogueira, Simon Nagel, Hiroshi Yamagami, Volker Puetz, Mohamad Abdalkader, Diogo C Haussen, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olivé-Gadea, Simon Winzer, Marc Ribo, Patrik Michel, João Pedro Marto, Kanta Tanaka, Shinichi Yoshimura, Nicolas Martinez-Majander, Francois Caparros, Hilde Henon, Liisa Tomppo, Anne Dusart, Flavio Bellante, João Nuno Ramos, Jessica Jesser, Sunil A Sheth, Santiago Ortega-Gutiérrez, James E Siegler, Stefania Nannoni, Johannes Kaesmacher, Tomas Dobrocky, Sergio Salazar-Marioni, Mudassir Farooqui, Pekka Virtanen, Rita Ventura, Syed F Zaidi, Alicia C Castonguay, Kazutaka Uchida, Ajit S Puri, Nobuyuki Sakai, Kazunori Toyoda, Behzad Farzin, Hesham E Masoud, Piers Klein, Jenny Bui, Federica Rizzo, Daniel P O Kaiser, Philippe Desfontaines, Davide Strambo, Charlotte Cordonnier, Eugene Lin, Peter A Ringleb, Daniel Roy, Osama O Zaidat, Urs Fischer, Jean Raymond, Robin Lemmens, Thanh N Nguyen
BACKGROUND: Studies comparing bridging intravenous thrombolysis (IVT) with direct endovascular therapy (EVT) in patients with acute ischemic stroke who present late are limited. We aimed to compare the clinical outcomes and safety of bridging IVT in patients with acute ischemic stroke due to anterior circulation large vessel occlusion who underwent EVT 6 to 24 hours after time last known well. METHODS: We enrolled patients with anterior circulation large vessel occlusion stroke and a National Institutes of Health Stroke Scale score of ≥6 from 20 centers across 10 countries in the multicenter retrospective CLEAR study (CT for Late Endovascular Reperfusion) between January 2014 and May 2022...
May 15, 2024: Stroke; a Journal of Cerebral Circulation
#16
JOURNAL ARTICLE
Katharina Millesi, Monika Killer-Oberpfalzer, Johannes A R Pfaff, J Sebastian Mutzenbach, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Judith Wagner, Matthias Millesi, Slaven Pikija, Constantin Hecker
BACKGROUND: Stroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of independence. This study aimed to investigate the relationship between the distance to the thrombus (DT) and both ischemic lesion volume (ILV) and clinical outcomes. METHODS: We retrospectively evaluated patients with thromboembolic MCA M1 segment occlusion who underwent neurovascular imaging followed by endovascular thrombectomy (EVT) at two comprehensive stroke centers over a 3-year period (2018-2020)...
May 15, 2024: Wiener Klinische Wochenschrift
#17
JOURNAL ARTICLE
Yunhe Luo, Daosheng Wang, Yiming Jia, Xin Gu, Yuhan Zang, Zhengbao Zhu, Jin Zheng, Ligang Huang, Jing Zhao
BACKGROUND: The evidence for the association between white matter hyperintensity (WMH) severity and neurological deterioration (ND) in patients with single subcortical infarction (SSI) remains unclear and whether the association between them is modified by anterior circulation parent artery steno-occlusion (PAS) is unknown. Herein, we aimed to prospectively investigate the internal relevance. METHODS: In this prospective study, the severity of WMH and PAS were assessed in 288 consecutive patients with anterior circulation SSI arriving at our hospital, a tertiary teaching hospital affiliated with Fudan University, 24 h after onset from January 2017 to December 2018...
May 2024: Brain and Behavior
#18
JOURNAL ARTICLE
Peng Ding, Guojuan Chen, Yuling Yang, Tong Zhang, Wenxia Li, Liqin Yang, Xueqing Liu, Delin Yu, Wei Yue
BACKGROUND AND AIMS: Stress ulcer (SU) is a common complication in patients with acute ischemic stroke. The relationship of infarction location and the incidence of SU was unclear. Herein, we aim to investigate the association between ischemic insular damage and the development of SU. METHODS: Data were retrieved from the SPARK study (Effect of Cardiac Function on Short-Term Functional Prognosis in Patients with Acute Ischemic Stroke). We included the patients who had experienced an ischemic stroke within 7 days...
May 2024: Brain and Behavior
#19
JOURNAL ARTICLE
Danny Dvir, Didier Tchétché, Martin B Leon, Philippe Généreux, Benjamin Seguy, Raj Makkar, Philippe Pibarot, Hemal Gada, Tamim Nazif, David Hildick-Smith, Jörg Kempfert, Nicolas Dumonteil, Axel Unbehaun, Thomas Modine, Brian Whisenant, Christophe Caussin, Lenard Conradi, Thomas Waggoner, Jacob M Mishell, Stanley J Chetcuti, Saibal Kar, Michael J Rinaldi, Molly Szerlip, Ravi K Ramana, Daniel J Blackman, Itsik Ben-Dor, Ran Kornowski, Ron Waksman, Ulrich Gerckens, Paolo Denti, Marian Kukucka, Julien Ternacle, Sabah Skaf, Jan Kovac, Hasan Jilaihawi, Vivek Patel, Rami Jubeh, Mohamed Abdel-Wahab, Susheel Kodali
BACKGROUND AND AIMS: This trial sought to assess the safety and efficacy of ShortCut, the first dedicated leaflet modification device, prior to transcatheter aortic valve implantation (TAVI) in patients at risk for coronary artery obstruction. METHODS: This pivotal prospective study enrolled patients with failed bioprosthetic aortic valves scheduled to undergo TAVI and were at risk for coronary artery obstruction. The primary safety endpoint was procedure-related mortality or stroke at discharge or 7 days, and the primary efficacy endpoint was per-patient leaflet splitting success...
May 15, 2024: European Heart Journal
#20
JOURNAL ARTICLE
Rui Mao, Fan Wang, Yun Zhong, Xin Meng, Tongtong Zhang, Ji Li
BACKGROUND: Advanced age is associated with an increased risk of adverse cardiovascular events. The relationship between biological age acceleration (BAA), cardiac size, cardiac function, and heart failure (HF) is not well-defined. METHODS: Utilizing the UK Biobank cohort, we assessed biological age using the Klemera-Doubal and PhenoAge method. BAA was quantified by residual analysis compared to chronological age. Cardiovascular magnetic resonance (CMR) imaging provided detailed insights into cardiac structure and function...
May 15, 2024: European Heart Journal Cardiovascular Imaging
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