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M Timmermans, N Zwakman, G S Sonke, K K Van de Vijver, M J Duk, M A van der Aa, R F Kruitwagen
OBJECTIVE: Despite being the most important prognostic factor for prolonged overall survival in epithelial ovarian cancer (EOC), the measurement of residual disease is hampered by its subjective character. Additional assessment tools are needed to establish the success of cytoreductive surgery in order to predict patients' prognosis more accurately. The aim of this study is to evaluate the independent prognostic value of perioperative CA125 change in advanced stage EOC patients. STUDY DESIGN: We identified all patients who underwent primary cytoreductive surgery for advanced stage (FIGO IIB-IV) EOC between 2008 and 2015, from the Netherlands Cancer Registry...
July 26, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Bing Xin, Kai-Qiang Ji, Yi-Si Liu, Xiao-Dong Zhao
BACKGROUND: The role of calcineurin/NFAT signaling in ovarian cancer has been unknown. NFAT was significantly overexpressed in ovarian cancer tissues and that overexpression of NFAT was significantly associated with metastasis and poor prognosis on clinical tissue level. To investigate whether NFAT upstream protein, calcineurin (CN), affects the prognosis in various histological subtype of ovarian cancer (OC). METHODS: The association between CN and clinical features was analyzed in 50 OC patients treated from 2007 to 2012...
August 9, 2019: Journal of Ovarian Research
Charles Dunton, Rowan G Bullock, Herbert Fritsche
Aim : Based on evidence that African-American (AA) women have lower CA125 values than Caucasian (C) women, we investigated this to see if this disparity would have an impact on ovarian cancer detection using CA125 and multivariate index assay (MIA). Materials & methods : Serum from two prospective trials of 1029 (274 malignancies [250 C/24AA]) were analyzed for CA125 and MIA results. Clinical performance was calculated. Results : Sensitivity of MIA in Caucasian women was 93.2%, 74.4% for CA125 at the ACOG approved cut-off level of 200 U/ml cutoff, and 80...
August 9, 2019: Future Oncology
Evelyn Minis, Kevin Holcomb, Giovanni Sisti, Dimitrios Nasioudis, Tomi T Kanninen, Aikaterini Athanasiou, Melissa K Frey, Eloise Chapman-Davis, Thomas A Caputo, Steven S Witkin
There remains a need to differentiate between women with a benign or a malignant adnexal mass prior to surgery. As part of an ongoing evaluation of vaginal fluid compounds as potential tumor biomarkers we evaluated whether vaginal lysophosphatidic acid (LPA) predicted the subsequent diagnosis of a malignant adnexal mass. In this prospective pilot study vaginal fluid was obtained from 100 post-menopausal women referred for evaluation of a suspicious adnexal mass and tested for LPA by ELISA. Clinical data and serum CA125 results were obtained only after completion of all laboratory testing...
April 2019: European journal of obstetrics & gynecology and reproductive biology: X
Xiaofei Liu, Wenhua Zhu, Xiaohong Zhou, Hao Yao, Jiagui Su, Xiaohui Ouyang, Baoming He
RATIONALE: Solitary fibrous tumor(SFT) is a rare and distinct clinical entity. There are few descriptions in the literature regarding the PET manifestations of SFTs. Herein,we report a case of multiple malignant SFT with PET/CT imaging findings and PET/Contrast Enhanced CT image findings. PATIENT CONCERNS: A 30-year-old woman presented with a history of a mass in neck increased gradually over 6 months without jaundice or other symptoms of obstruction.Serum laboratory results and tumor markers (AFP, CEA,CA199,CA724,CA153 and CA125)were normal...
August 2019: Medicine (Baltimore)
Manikandan Lakshmanan, Vijay Kumar, Arun Chaturvedi, Sanjeev Misra, Sameer Gupta, Naseem Akhtar, Shiv Rajan, Kavitha Jain, Sudeep Garg
BACKGROUND: Epithelial ovarian cancer is the second most common gynecological cancer. Human Epididymis Protein 4 is a novel biomarker for ovarian cancer. This study aims to explore the role of HE4 in monitoring recurrence and prognostication of ovarian cancer by predicting overall survival (OS) and progression-free survival (PFS). MATERIALS AND METHODS: In total, 149 patients with ovarian carcinoma were enrolled in the study. Baseline and post-treatment 3 monthly biomarker levels were recorded...
July 2019: Indian Journal of Cancer
Matthew R Russell, Ciaren Graham, Alfonsina D'Amato, Aleksandra Gentry-Maharaj, Andy Ryan, Jatinderpal K Kalsi, Anthony D Whetton, Usha Menon, Ian Jacobs, Robert L J Graham
BACKGROUND: An early detection tool for EOC was constructed from analysis of biomarker expression data from serum collected during the UKCTOCS. METHODS: This study included 49 EOC cases (19 Type I and 30 Type II) and 31 controls, representing 482 serial samples spanning seven years pre-diagnosis. A logit model was trained by analysis of dysregulation of expression data of four putative biomarkers, (CA125, phosphatidylcholine-sterol acyltransferase, vitamin K-dependent protein Z and C-reactive protein); by scoring the specificity associated with dysregulation from the baseline expression for each individual...
August 7, 2019: British Journal of Cancer
Huaying Yu, Baijia Li, TinChiu Li, Songying Zhang, Xiaona Lin
This study means to investigate a combination of noninvasive methods in diagnosis of minimal or mild endometriosis expecting to narrow down the range of laparoscopic exploration for female infertility.It is a retrospective case control study of totally 447 patients suspected unexplained infertility before surgery were eligible from May 2012 to February 2017. Of these, 299 patients were laparoscopy-proved minimal or mild endometriosis group, the remaining 148 patients served as control group (normal pelvis)...
August 2019: Medicine (Baltimore)
Guang-Qing Huang, Yuan-Yuan Xi, Chang-Jun Zhang, Xing Jiang
Objective: To evaluate the overall diagnostic value of human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) in endometrial carcinoma (EC) based on a meta-analysis of all eligible studies. Methods: The PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP databases were searched by index words to identify eligible studies and also to search for relevant literature sources that had been published by January 2019. Eligible studies included prospective cohort studies or cross-sectional studies...
August 2019: Genetic Testing and Molecular Biomarkers
Jie-Ping Chen, Qi-Dan Huang, Ting Wan, Hua Tu, Hai-Feng Gu, Jun-Ya Cao, Ji-Hong Liu
BACKGROUND: The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflammation and immune evasion in EOC. This study intended to assess the prognostic value of pretreatment PLT count and CA125 level in FIGO stage IV EOC. METHODS: The study included 108 patients diagnosed with FIGO stage IV EOC and treated with surgery and/or chemotherapy between January 1995 and December 2016...
July 31, 2019: Journal of Ovarian Research
Minghua Wang, Mengyao Hu, Zhenzhen Li, Linghao He, Yingpan Song, Qiaojuan Jia, Zhihong Zhang, Miao Du
Combining different metal-organic frameworks (MOFs) into a conjugate material can integrate the properties of each MOF component and further lead to emergent properties from the synergistic heterostructured units. In this work, two kinds of bimetallic TbFe-MOFs have been designed by MOF-on-MOF strategy and utilized as a platform for anchoring carbohydrate antigen 125 (CA125) aptamer to detect CA125 and living michigan cancer foundation-7 (MCF-7) cells. Although the integrated MOF-on-MOF architectures show similar chemical and structural features to that of the top layer, the Fe-MOF-on-Tb-MOF and Tb-MOF-on-Fe-MOF have different surface nanostructures to their parent MOFs...
July 25, 2019: Biosensors & Bioelectronics
Xiaolu Ren, Yixun Zhang, Yi Ly, Baoli Jin, Hongxia Guo, Jing Wu, Xiaomin Li, Xuejun Liu
BACKGROUND: No tumor biomarker (TM) is available for de novo metastatic lung adenocarcinoma. OBJECTIVE: To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen (CA) 19-9, CA125, tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS), and lactate dehydrogenase (LDH) to predict de novo metastatic lung adenocarcinoma. METHODS: This was a retrospective study of geriatric (> 60 years of age) patients with lung cancer diagnosed at Shanxi Cancer Hospital from 02/2012 to 12/2017...
July 19, 2019: Cancer Biomarkers: Section A of Disease Markers
Josephine S Kim, Margaret I Liang, Emily N Prendergast, Jill Alldredge, Avisek Datta, Jean A Hurteau, Carolyn V Kirschner, Gustavo Rodriguez, Tilley J Vogel, Rebecca A Brooks, Ilana Cass, Joshua G Cohen, Kristine R Penner, Chi E Wang, Elena S Diaz Moore
OBJECTIVES: To compare clinical outcomes for stage IIIC and IV ovarian cancer patients receiving neoadjuvant chemotherapy and interval cytoreductive surgery followed by up to three versus more cycles of post-operative chemotherapy. METHODS: We conducted a multi-institution retrospective cohort study of patients treated from January 2005 to February 2016 with neoadjuvant platinum-based therapy followed by interval surgery and post-operative chemotherapy. The following were exclusion criteria: more than four cycles of neoadjuvant chemotherapy, bevacizumab with neoadjuvant chemotherapy, non-platinum therapy, prior chemotherapy, and elevated CA125 values after three post-operative chemotherapy cycles...
July 27, 2019: International Journal of Gynecological Cancer
Aleksandra Gentry-Maharaj, Matthew Burnell, James Dilley, Andy Ryan, Chloe Karpinskyj, Richard Gunu, Susan Mallett, Jon Deeks, Stuart Campbell, Ian Jacobs, Sudha Sundar, Usha Menon
BACKGROUND: Transvaginal ultrasound and serum CA125 are routinely used for differential diagnosis of pelvic adnexal mass. Use of Human Epididymis 4 (HE4) was approved in the United States in 2011. However, there is scarcity of studies evaluating the additional value of HE4. OBJECTIVE: To evaluate the performance characteristics of transvaginal ultrasound, CA125 and HE4 for differential diagnosis of ovarian cancer in postmenopausal women with adnexal masses. STUDY DESIGN: Cohort study nested within the screen arms of the multicentre randomised controlled trial United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), based in England, Wales and Northern Ireland...
July 24, 2019: American Journal of Obstetrics and Gynecology
Denise R Nebgen, Karen H Lu, Robert C Bast
PURPOSE OF REVIEW: Both conventional and novel approaches to early detection of ovarian cancer are reviewed in the context of new developments in our understanding of ovarian cancer biology. RECENT FINDINGS: While CA125 as a single value lacks adequate specificity or sensitivity for screening, large studies have shown that a 2-stage strategy which tracks CA125 change over time and prompts transvaginal ultrasound (TVS) for a small subset of women with abnormally rising biomarker values achieves adequate specificity and detects a higher fraction of early-stage disease...
July 26, 2019: Current Oncology Reports
Omar Weitzner, Yael Yagur, Yfat Kadan, Mario E Beiner, Ami Fishman, Emilie Ben Ezry, Daphna Amitai Komem, Limor Helpman
OBJECTIVE: BRCA mutations are the most frequent mutations causing homologous recombination defects in epithelial ovarian cancers (EOC). Germline mutation carriers are heterozygous for the mutation and harbor one defective allele in all cells. This has been hypothesized to cause increased susceptibility to DNA damage in healthy cells as well as neoplastic ones. Our objective was to assess chemotherapy-associated toxicities in patients with epithelial ovarian cancer with and without a germline BRCA mutation...
July 25, 2019: Oncologist
Jesper Friis Petersen, Lennart J Friis-Hansen, Andreas Kryger Jensen, Anders Nyboe Andersen, Ellen C L L√łkkegaard
Background Pregnancy introduces major physiological changes that also alter biochemical analytes. Maternal and perinatal health can be optimized by early intervention and therefore, pregnancy-specific reference intervals (RIs) for the local population are warranted. While the second and third trimester-specific changes are well described, the first trimester is less well characterized. We therefore wanted to facilitate early detection of abnormalities by generating first trimester reference values for 29 common analytes...
July 25, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
Hongyan Zhang, Qianyu Huo, Lunhui Huang, You Cheng, Yunde Liu, Huijing Bao
Ovarian cancer cases with low CA125 concentration are problematic and increase the high false negative results ratio during routine physical examination testing. Unfortunately, patients without early discovery have very low survival rates. In our study, we investigated the possible role of differential leukocyte counts and the neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer patients to identify an additional discriminative marker to avoid missing diagnoses in normal physical examinations. One hundred seventy-three patients with epithelial ovarian cancer and 70 healthy controls were involved in our study...
2019: BioMed Research International
Xiaoqian Tuo, Lanbo Zhao, Qi Wang, Lu Han, Yiran Wang, Sijia Ma, Xue Feng, Qing Li, Chao Sun, Qing Wang, Guizhi Shi, Huilian Hou, Guanjun Zhang, Qiling Li
The aim of this study is to examine the immunocytochemical expression of p53, Ki-67, and CA125 in endometrial brush samples for endometrial cancer. Forty-four patients were recruited with liquid-based cytology preparations during a 5-month period. Both the histological and cytological samples were assessed by histology based on hematoxylin and eosin (H&E), and the expression of p53, CA125, and Ki-67 in endometrial cells was examined by immunocytochemistry. The percentage and intensity of endometrial cells were scored on a scale of 0-3...
2019: Frontiers in Oncology
Yuki Yamada, Ryuji Kawaguchi, Kana Iwai, Emiko Niiro, Sachiko Morioka, Yasuhito Tanase, Hiroshi Kobayashi
A high pre-treatment plasma D-dimer level was recently identified as a poor prognostic factor in several malignancies. The aim of this study was to evaluate the prognostic significance of plasma D-dimer levels in epithelial ovarian cancer (EOC). Data of 199 patients were retrospectively analysed. The relationships between pre-treatment D-dimer levels and other clinical parameters and prognosis were evaluated. Univariate analysis identified age, pre-treatment plasma D-dimer level, massive ascites, residual tumours, pre-treatment CA125 level, histological type, and FIGO stage as predictors of overall survival...
July 23, 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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