Hortência Ribeiro Liberato, Jéssica Bezerra Maciel, Antonio Wlisses da Silva, Ana Eloysa Freitas da Silva, Luana San O Brito, Jacilene Silva, Francisco S H Da Silva, Arnaldo S Bezerra, Maria Kueirislene Amâncio Ferreira, Marcia Machado Marinho, Gabrielle Silva Marinho, Otília Deusdênia Loiola Pessoa, Paulo Goberlânio de Barros Silva, Andrelina Noronha Coelho-de-Souza, Maria Izabel Florindo Guedes, Andreia Ferreira de Castro Gomes, Jane Eire Silva Alencar de Menezes, Helcio Silva Dos Santos
This study carried out to investigate the anti-inflammatory and antinociceptive effect of tropane alkaloid (EB7) isolated from E. bezerrae. It evaluated the toxicity and possible involvement of ion channels in the antinociceptive effect of EB7, as well as its anti-inflammatory effect in adult zebrafish (Zfa). Docking studies with EB7 and COX-1 and 2 were also performed. The tested doses of EB7 (4, 20 and 40 mg/kg) did not show any toxic effect on Zfa during the 96h of analysis (LD50 > 40 mg/kg). They did not produce any alteration in the locomotor behavior of the animals...
May 22, 2024: Chemistry & Biodiversity