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Morbidity and mortality

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https://read.qxmd.com/read/31707754/sub-acute-more-than-chronic-hyponatremia-is-associated-with-serious-falls-and-hip-fractures
#1
Simran K Bhandari, Annette L Adams, Bonnie H Li, Connie M Rhee, Shirin Sundar, Holly Krasa, Kim N Danforth, Michael H Kanter, Kamyar Kalantar-Zadeh, Steven J Jacobsen, John J Sim
BACKGROUND: Falls and hip fractures among older people are associated with high morbidity and mortality. Hyponatremia may be a risk for falls/hip fractures, but the effect of hyponatremia duration is not well understood. AIMS: We sought to evaluate individuals with periods of sub-acute and chronic hyponatremia on subsequent risk for serious falls and/or hip fractures. METHODS: Retrospective cohort study in the period 1/1/1998-6/14/2016 within an integrated health system of individuals aged ≥55 years with ≥2 outpatient serum sodium measurements...
November 10, 2019: Internal Medicine Journal
https://read.qxmd.com/read/31707594/the-plasma-metabolome-as-a-predictor-of-biological-aging-in-humans
#2
Lawrence C Johnson, Keli Parker, Brandon F Aguirre, Travis G Nemkov, Angelo D'Alessandro, Sarah A Johnson, Douglas R Seals, Christopher R Martens
Chronological age is an important predictor of morbidity and mortality; however, it is unable to account for heterogeneity in the decline of physiological function and health with advancing age. Several attempts have been made to instead define a "biological age" using multiple physiological parameters in order to account for variation in the trajectory of human aging; however, these methods require technical expertise and are likely too time-intensive and costly to be implemented into clinical practice...
November 9, 2019: GeroScience
https://read.qxmd.com/read/31707559/acute-vascular-insufficiency-of-intestine-incidence-highest-in-summer-outcomes-worst-in-winter
#3
Asad Jehangir, Rashmi Dhital, Anam Qureshi, Eugene P York
BACKGROUND: The incidence of acute vascular insufficiency of intestine (AVII) is on the rise in the USA and is associated with significant morbidity and mortality. Seasonal variations have been observed in the onset of several gastrointestinal diseases. It is thus far unknown whether the incidence, in-hospital mortality rates, and length of hospital stay (LOS) of AVII vary in different seasons. AIMS: The aims of this study were to study the seasonal variations in the (1) incidence, (2) in-hospital mortality, and (3) LOS of AVII in the USA...
November 9, 2019: International Journal of Colorectal Disease
https://read.qxmd.com/read/31707504/cardiovascular-consequences-of-obstructive-sleep-apnea
#4
REVIEW
Brynn K Dredla, Pablo R Castillo
PURPOSE OF REVIEW: To review the clinical evidence for a relationship between obstructive sleep apnea and hypertension, arrhythmias, coronary artery disease, and congestive heart failure. RECENT FINDINGS: Current data show that obstructive sleep apnea is a risk for cardiovascular disease. Studies have linked untreated moderate to severe obstructive sleep apnea to hypertension, cardiac arrhythmias, coronary artery disease, and congestive heart failure. However, uncertainty regarding benefits of treatment of obstructive sleep apnea to reduce the risk of cardiovascular disease still exists...
November 9, 2019: Current Cardiology Reports
https://read.qxmd.com/read/31707415/scrotal-abscess-as-the-first-symptom-of-fatal-necrotizing-pancreatitis
#5
Nikica Sutalo, Vedran Dragisic, Josip Miskovic, Martina Soljic
Acute necrotizing pancreatitis represents a severe form of acute pancreatitis, characterized by pancreatic collections and necrosis of the pancreas and surrounding tissues. It is associated with higher rates of morbidity and mortality. Scrotal swelling is a rare complication of acute necrotizing pancreatitis due to the extension of pancreatic necrotic masses involving the inguinal canal and scrotum. We report a case of scrotal swelling as the first sign of unrecognized severe necrotizing pancreatitis with a fatal outcome...
November 2019: Saudi Medical Journal
https://read.qxmd.com/read/31707400/alisol-b-23-acetate-ameliorates-lipopolysaccharide-induced-cardiac-dysfunction-by-suppressing-toll-like-receptor-4-tlr4-nadph-oxidase-2-nox2-signaling-pathway
#6
BinYan Wang, Liang Chen, LingHao Dai, WenMing Fang, Hui Wang
BACKGROUND Cardiac dysfunction during endotoxemia is a major cause of cardiovascular disease with high morbidity and mortality. Alisol B 23-acetate (AB23A) is a triterpenoid extracted from the Rhizoma Alismatis, a kind of traditional Chinese medicine, exhibits anti-inflammatory activity on endotoxemia. This investigation aimed to uncover the protective effects of AB23A against sepsis-induced cardiac dysfunction. MATERIAL AND METHODS Adult male C57BL/6 mice received lipopolysaccharide (LPS) (20 mg/kg intravenous) stimulation, with or without pre-treatment of AB23A (10 mg/kg, 20 mg/kg, or 40 mg/kg)...
November 10, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/31707389/hybrid-ventricular-tachycardia-ablation-after-failed-percutaneous-endocardial-and-epicardial-ablation
#7
Danielle M Haanschoten, Ahmet Adiyaman, Jaap Jan J Smit, Peter Paul H M Delnoy, Anand R Ramdat Misier, Fabiano Porta, Robert P H Storm van Leeuwen, Arif Elvan
INTRODUCTION: Recurrent ventricular tachycardia (VT) after percutaneous ablation is associated with a high morbidity and mortality. We assessed the feasibility of open chest extracorporeal circulation (ECC)-supported 3D multielectrode mapping and targeted VT substrate ablation in patients with previously failed percutaneous endocardial and epicardial VT ablations. METHODS: In patients with previously failed percutaneous endocardial and epicardial VT ablations and a high risk of hemodynamic collapse during the procedure, open chest ECC-supported mapping and ablation were performed in a hybrid EP lab setting...
November 8, 2019: Cardiology
https://read.qxmd.com/read/31707376/sotalol-as-an-effective-adjunct-therapy-in-the-management-of-supraventricular-tachycardia-induced-fetal-hydrops-fetalis
#8
M Refaat, J El Dick, M Sabra, F Bitar, C Tayeh, M Arabi
Sustained fetal supraventricular tachycardia (SVT) complicated by hydrops fetalis carries a significant risk of morbidity and mortality. While there is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis, there exists significant nonrandomized experience with a number of antiarrhythmic agents that has founded the basis for management. Furthermore, recently published meta-analyses and ongoing multicenter prospective studies have aimed to bridge the gap in the literature...
November 5, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/31707201/epidemiology-and-genetic-variability-of-respiratory-syncytial-virus-in-portugal-2014-2018
#9
Emma Sáez-López, Paula Cristóvão, Inês Costa, Pedro Pechirra, Patrícia Conde, Raquel Guiomar
INTRODUCTION: Respiratory syncytial virus (RSV) is associated with substantial morbidity and mortality since it is a predominant viral agent causing respiratory tract infections in infants, young children and the elderly. Considering the availability of the RSV vaccines in the coming years, molecular understanding in RSV is necessary. OBJECTIVE: The objective of the present study was to describe RSV epidemiology and genotype variability in Portugal during the 2014/15-2017/18 period...
October 10, 2019: Journal of Clinical Virology
https://read.qxmd.com/read/31706832/in-hospital-30-day-mortality-for-older-patients-with-pancreatic-cancer-undergoing-pancreaticoduodenectomy
#10
Walid L Shaib, Katerina Zakka, Farhan N Hoodbhoy, Astrid Belalcazar, Sungjin Kim, Kenneth Cardona, Maria C Russell, Shishir K Maithel, Juan M Sarmiento, Christina Wu, Mehmet Akce, Olatunji B Alese, Bassel F El-Rayes
OBJECTIVE: Surgical resection remains the only potentially curative therapy for pancreatic ductal adenocarcinoma (PDAC). There is paucity of literature about morbidity and mortality in older patients with PDAC undergoing pancreaticoduodenectomy. This retrospective analysis evaluates the in-hospital 30-day mortality of this population utilizing the Nationwide Inpatient Sample (NIS) database. SUBJECTS AND METHODS: All US patients hospitalized for pancreaticoduodenectomy (Whipple procedure) were included...
November 6, 2019: Journal of Geriatric Oncology
https://read.qxmd.com/read/31706809/summary-of-the-vaccines-and-related-biological-products-advisory-committee-meeting-held-to-consider-evaluation-of-vaccine-candidates-for-the-prevention-of-respiratory-syncytial-virus-disease-in-rsv-na%C3%A3-ve-infants
#11
Sarah K Browne, Judy A Beeler, Jeffrey N Roberts
Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed preventive vaccine. Clinical trials conducted in the 1960s evaluating a formalin-inactivated RSV vaccine (FI-RSV) in RSV-naïve infants resulted in observations of enhanced respiratory disease (ERD) following subsequent natural RSV infection in vaccinees. In these studies, infants immunized with FI-RSV had higher rates of severe RSV disease compared with controls...
November 6, 2019: Vaccine
https://read.qxmd.com/read/31706807/albuminuria-and-other-target-organ-damage-in-chinese-patients-with-hypertension-and-diabetes-a-data-analysis-based-on-the-attend-study
#12
Qian Ren, Changsheng Ma, Jiguang Wang, Xiaohui Guo, Linong Ji
AIMS: The relationship between albuminuria and left ventricular hypertrophy (LVH) was well characterized in hypertension (HTN), but not in diabetes. Moreover, most studies have described the correlation between albuminuria and cardiovascular mortality, but not cardiovascular diseases (CVD) morbidity. This study aimed to explore the relationship between albuminuria and LVH, CVD morbidity in patients with HTN, diabetes mellitus (DM) or HTN + DM. METHODS: Conducted a data analysis based on the demographic, medical history and laboratory data of 2504 patients from the ATTEND study, a national registry study on HTN and DM in Chinese outpatients...
November 5, 2019: Journal of Diabetes and its Complications
https://read.qxmd.com/read/31706732/suboptimal-lipid-levels-in-clinical-practice-among-portuguese-adults-with-dyslipidemia-under-lipid-lowering-therapy-data-from-the-disgen-lipid-study
#13
Pedro Marques da Silva, Carlos Aguiar, João Morais
INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. METHODS: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months...
November 6, 2019: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://read.qxmd.com/read/31706640/selective-apoptosis-inducing-activity-of-synthetic-hydrocarbon-stapled-sos1-helix-with-d-amino-acids-in-h358-cancer-cells-expressing-kras-g12c
#14
Li-Li Xu, Cui-Cui Li, Lu-Yan An, Zhen Dai, Xiao-Yi Chen, Qi-Dong You, Chi Hu, Bin Di
Lung cancer is one of the most malignant tumors with the highest morbidity and mortality. Most of them are non-small cell lung cancer (NSCLC). KRASG12C gene mutation is an important driving factor for NSCLC. However, the development of high-affinity inhibitors targeting KRASG12C mutants remains a daunting challenge. Here, we report the design and development of a series of hydrocarbon-stapled peptides containing d-amino acids to mimic the alpha helix of SOS1. D-hydrocarbon-stapled peptides maintain good alpha helix structure and bind to KRASG12C with high affinity...
November 2, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/31706285/pattern-of-renal-amyloidosis-in-south-africa
#15
Muhammed Hassen, William Bates, Mohammed Rafique Moosa
BACKGROUND: Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) infected patients and is also an important cause of renal amyloid; there are however no reports of renal amyloidosis in South Africa in the HIV era. METHODS: This was a retrospective record review of cases of amyloidosis diagnosed on renal biopsies at our tertiary referral hospital between January 1985 and December 2016...
November 9, 2019: BMC Nephrology
https://read.qxmd.com/read/31706283/optimal-treatment-for-elderly-patients-with-resectable-proximal-gastric-carcinoma-a-real-world-study-based-on-national-cancer-database
#16
Xuefei Wang, Junjie Zhao, Mark Fairweather, Tingsong Yang, Yihong Sun, Jiping Wang
BACKGROUND: High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks and survival benefits of different strategies treated in this group. METHODS: Octogenarians (≥80 years) with resectable proximal gastric carcinoma who were recommended for surgery were identified from National Cancer Database during 2004-2013...
November 9, 2019: BMC Cancer
https://read.qxmd.com/read/31706253/tobacco-use-and-the-interplay-of-internalizing-externalizing-and-substance-use-problems-a-latent-class-analysis-of-data-from-the-population-assessment-of-tobacco-and-health-study
#17
Ollie Ganz, Rajiv N Rimal, Amanda L Johnson, Amy M Cohn, Kimberly Horn, Cristine D Delnevo, Andrea C Villanti
BACKGROUND: Cigarette smoking is disproportionately high among adults with two or more psychiatric disorders (psychiatric comorbidities), yet research on non-cigarette tobacco use among this population is scant. Additionally, most studies on tobacco use this among this population rely on psychiatric diagnoses rather than individual symptoms, potentially excluding individuals with symptom-specific issues that increase their risk for tobacco use but do not meet the criteria for diagnosis...
October 28, 2019: Drug and Alcohol Dependence
https://read.qxmd.com/read/31706158/rapid-and-sustained-improvement-in-treatment-refractory-depression-through-use-of-acute-intravenous-ketamine-and-concurrent-transdermal-selegiline-a-case-series
#18
Brett Y Lu, James R Agapoff, Daniel J Olson, Steven R Williams, Adam Roller, Deborah Goebert
BACKGROUND: Treatment resistant depression is a significant source of morbidity and mortality. For patients having failed or unable to undergo the electroconvulsive therapy procedure few effective alternative treatments exist. METHODS: A case series is presented where six patients with treatment resistant depression failing both electroconvulsive therapy and oral antidepressants are concomitantly treated with short course intravenous ketamine and longer term selegiline transdermal system...
October 31, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/31706076/atherosclerotic-calcification-in-major-vessel-beds-in-chronic-obstructive-pulmonary-disease-the-rotterdam-study
#19
Lies Lahousse, Daniel Bos, Sara R A Wijnant, Maryam Kavousi, Bruno H Stricker, Aad van der Lugt, Meike W Vernooij, Guy G Brusselle
BACKGROUND AND AIMS: COPD is associated with an increased risk of cardiovascular morbidity and mortality, potentially by mechanisms of atherosclerosis. Insight into location-specific vulnerability to atherosclerosis in COPD, including intracranial arteries, is lacking. We aimed to investigate the relation between COPD and atherosclerosis in multiple vessel beds within a large population-based cohort study. METHODS: From 2003 to 2006, a random sample of 2187 elderly participants (mean age, 69...
October 24, 2019: Atherosclerosis
https://read.qxmd.com/read/31706075/correlates-of-nonmedical-use-of-prescription-opioids-among-a-cohort-of-adolescents-in-ontario-canada
#20
Maryam Kebbe, Hugues Sampasa-Kanyinga, Hayley A Hamilton, Ian Colman, Jean-Philippe Chaput
INTRODUCTION: Mortality and morbidity rates related to prescription opioid analgesics have been rising in North America and may be a gateway to the nonmedical use of prescription opioids (NUPO). The purpose of this study was to explore correlates of NUPO in the adolescent population given the scarce literature in this area. METHODS: Cross-sectional data from 10,163 middle- and high-school students (15.1 ± 1.8 years old; 57.0% female; 55.6% White ethnic background) in Ontario were derived from the 2017 Ontario Student Drug Use and Health Survey...
November 1, 2019: Journal of Psychiatric Research
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