Ola Gutzeit, Gal Bachar, Roee Iluz, Alaa Arraf, Keren Nebenzahl-Sharona, Maya Nasatzky, Zeev Weiner, Ron Beloosesky, Ofer Fainaru
OBJECTIVES: Perinatal hypoxia causes premature activation and initiation of growth in dormant follicles, leading to diminished ovarian reserve. An indirect mechanism such as the release of stress-related hormones, may influence ovarian follicle recruitment under hypoxic conditions. We wanted to determine whether hypoxic ovarian damage results from increased follicle growth and "burnout" or from increased apoptosis, and whether this damage is age-dependent. DESIGN: Animal study Participants/Materials, Setting, Methods: Using adult 6-week-old (n=8) and one-day-old newborn (n=20) ICR (CD-1) female mice, ovarian follicular counts were conducted on H&E-stained sections...
April 3, 2024: Gynecologic and Obstetric Investigation