A Ortiz, F Troya, J de Vera, E Vázquez
Progressive Supranuclear Palsy (PSP), also known as Steele-Richardson-Olszewski syndrome, is a rare neurodegenerative disease characterized by a variety of motor and neuro-ophthalmological symptoms. We present the case of a 73-year-old male patient with a history of type 2 diabetes and high blood pressure, who consulted for gait disorders, tremors in the extremities, and difficulty controlling conjugate gaze. During physical examination, findings consistent with PSP were noted, including hypomimia, muscle rigidity, and abnormal movements...
May 18, 2024: Archivos de la Sociedad Española de Oftalmología
Yash Wardhan, Sukriti Vishwas, Arumugam Porselvi, Sachin Kumar Singh, Violina Kakoty
Parkinsons disease (PD) is a chronic fast growing neurodegenerative disorder of Central Nervous System (CNS) characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and formation of Lewy bodies (LBs) which causes dopamine deficiency within basal ganglia leading to motor and non-motor manifestation. According to reports, many factors are responsible for pathogenesis of PD which includes environmental factors, genetic factors, and aging factors. Whereas death of dopaminergic neurons is also caused by oxidative stress, neuroinflammation, and autophagy disorder...
May 18, 2024: Behavioural Brain Research
Meijie Ye, Qianqian Ji, Qi Liu, Yue Xu, Enxiang Tao, Yiqiang Zhan
BACKGROUND: Previous studies have suggested a connection between impaired olfactory function and an increased risk of rapid eye movement sleep behavior disorder (RBD) in individuals diagnosed with Parkinson's disease (PD). However, there is a gap in knowledge regarding the potential impact of olfactory dysfunction on the long-term patterns of sleep disorders among early PD patients. METHODS: Data from the Parkinson's Progression Markers Initiative program included 589 participants with assessments of sleep disorders using the Epworth Sleepiness Scale (ESS) and RBD Screening Questionnaire (RBDSQ)...
May 20, 2024: Neuroepidemiology
Weidong Cai, Christina B Young, Rui Yuan, Byeongwook Lee, Sephira Ryman, Jeehyun Kim, Laurice Yang, Taylor F Levine, Victor W Henderson, Kathleen L Poston, Vinod Menon
Speech impediments are a prominent yet understudied symptom of Parkinson's disease (PD). While the subthalamic nucleus (STN) is an established clinical target for treating motor symptoms, these interventions can lead to further worsening of speech. The interplay between dopaminergic medication, STN circuitry, and their downstream effects on speech in PD is not yet fully understood. Here, we investigate the effect of dopaminergic medication on STN circuitry and probe its association with speech and cognitive functions in PD patients...
May 28, 2024: Proceedings of the National Academy of Sciences of the United States of America
Jiajun Wu, Meiting Mao, Jie Yang, Kexin Li, Pengxin Deng, Jing Zhong, Xiaoai Wu, Yan Cheng
Nuclear imaging of aggregated α-synuclein pathology is an urgent clinical need for Parkinson's disease, yet promising tracers for brain α-synuclein aggregates are still rare. In this work, a class of compact benzothiazole derivatives was synthesized and evaluated for α-synuclein aggregates. Among them, azobenzothiazoles exhibited specific and selective detection of α-synuclein aggregates under physiological conditions. Fluoro-pegylated azobenzothiazole NN-F further demonstrated high-affinity binding to α-synuclein aggregates and efficient 18 F-radiolabeling via nucleophilic displacement of a tosyl precursor...
May 20, 2024: Organic & Biomolecular Chemistry
Arnas Petrauskas, Daniel L Fortunati, Arvind Reddy Kandi, Sai Shruti Pothapragada, Khushboo Agrawal, Amanjot Singh, Joern Huelsmeier, Jens Hillebrand, Georgia Brown, Dhananjay Chaturvedi, Jongbo Lee, Chunghun Lim, Georg Auburger, K VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
Ataxin-2 (ATXN2) is a gene implicated in spinocerebellar ataxia type II (SCA2), amyotrophic lateral sclerosis (ALS) and Parkinsonism. The encoded protein is a therapeutic target for ALS and related conditions. ATXN2 (or Atx2 in insects) can function in translational activation, translational repression, mRNA stability and in the assembly of mRNP-granules, a process mediated by intrinsically disordered regions (IDRs). Previous work has shown that the LSm (Like-Sm) domain of Atx2, which can help stimulate mRNA translation, antagonizes mRNP-granule assembly...
May 20, 2024: PLoS Genetics
Ningcun Xu, Chen Wang, Liang Peng, Xiao-Hu Zhou, Jingyao Chen, Zhi Cheng, Zeng-Guang Hou
Freezing of gait (FOG) leads to an increased risk of falls and limited mobility in individuals with Parkinson's disease (PD). However, existing research ignores the fine-grained quantitative assessment of FOG severity. This paper provides a double-hurdle model that uses typical spatiotemporal gait features to quantify the FOG severity in patients with PD. Moreover, a novel multi-output random forest algorithm is used as one hurdle of the double-hurdle model, further enhancing the model's performance. We conduct six experiments on a public PD gait database...
May 20, 2024: IEEE Transactions on Bio-medical Engineering
Pingfei Jin, Yong Li, Yao Li
To conduct a meta-analysis investigating the relationship between the chromosome 9 open reading frame 72 ( C9orf72 ) GGGGCC (G4C2) and neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We searched the EMBASE, PubMed, Web of Science, and Cochrane databases. Twenty-seven case-control studies were included, comprising 7202 AD, 5856 PD, 644 MSA, 439 PSP, and 477 CBD cases...
May 20, 2024: Journal of Neurogenetics
Lene Clausen, Justyna Okarmus, Vasileios Voutsinos, Morten Meyer, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that arises from the loss of dopaminergic neurons in the substantia nigra and is mainly characterized by progressive loss of motor function. Monogenic familial PD is associated with highly penetrant variants in specific genes, notably the PRKN gene, where homozygous or compound heterozygous loss-of-function variants predominate. PRKN encodes Parkin, an E3 ubiquitin-protein ligase important for protein ubiquitination and mitophagy of damaged mitochondria...
May 20, 2024: Cellular and Molecular Life Sciences: CMLS
Lei Hanzhou, X U Guixing, Wei Zepeng, Zhao Ling, Liang Fanrong
OBJECTIVE: To present a bibliometric analysis of global scientific publications on the nondrug and nonsedative hypnotic treatment of insomnia with regard to influential institutions, publications, countries, research hotspots, trends, and frontiers. METHODS: A literature review was conducted by searching the Web of Science Core Collection (WoSCC) and China National Knowledge Infrastructure (CNKI) databases to identify all publications related to the nondrug and nonsedative hypnotic treatment of insomnia from 2000 to 2021...
June 2024: Journal of Traditional Chinese Medicine
Fengjuan Jiao, Lingyan Meng, Kang Du, Xuezhi Li
Parkinson's disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in neurons. As one of the major intracellular degradation pathways, the autophagy-lysosome pathway plays an important role in eliminating these proteins. Accumulating evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance of α-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson's disease...
January 1, 2025: Neural Regeneration Research
Hanki Kim, Bum Jun Kim, Seungyon Koh, Hyo Jin Cho, Xuelian Jin, Byung Gon Kim, Jun Young Choi
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields, including neurology and neuroscience. High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern, which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke, Alzheimer's disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, epilepsy, and traumatic brain injury...
January 1, 2025: Neural Regeneration Research
Yujie Yang, Xinyi Li, Jiaying Lu, Jingjie Ge, Mingjia Chen, Ruixin Yao, Mei Tian, Jian Wang, Fengtao Liu, Chuantao Zuo
Nowadays, presynaptic dopaminergic positron emission tomography, which assesses deficiencies in dopamine synthesis, storage, and transport, is widely utilized for early diagnosis and differential diagnosis of parkinsonism. This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism. We conducted a thorough literature search using reputable databases such as PubMed and Web of Science...
January 1, 2025: Neural Regeneration Research
Stiven Roytman, Rebecca Paalanen, Giulia Carli, Uros Marusic, Prabesh Kanel, Teus van Laar, Nico I Bohnen
Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population. Posture and gait control does not happen automatically, as previously believed, but rather requires continuous involvement of central nervous mechanisms. To effectively exert control over the body, the brain must integrate multiple streams of sensory information, including visual, vestibular, and somatosensory signals...
January 1, 2025: Neural Regeneration Research
Raquel Moreno-Loshuertos, Patricio Fernández-Silva
Over the last decades, the evidence accumulated about the existence of respiratory supercomplexes (SCs) has changed our understanding of the mitochondrial electron transport chain organization, giving rise to the proposal of the "plasticity model." This model postulates the coexistence of different proportions of SCs and complexes depending on the tissue or the cellular metabolic status. The dynamic nature of the assembly in SCs would allow cells to optimize the use of available fuels and the efficiency of electron transfer, minimizing reactive oxygen species generation and favoring the ability of cells to adapt to environmental changes...
May 3, 2024: Journal of Visualized Experiments: JoVE
(no author information available yet)
Chai, Z., Zheng, P., Zheng, J. (2021) Mechanism of ARPP21 antagonistic intron miR-128 on neurological function repair after stroke. Annals of Clinical and Translational Neurology, 8: 1408-1421. The above article, published online on 28 May 2021 in Wiley Online Library (, has been retracted by agreement between the journal Editor-in-Chief Ahmet Hoke and Wiley Periodicals LLC on behalf of the American Neurological Association. The retraction has been agreed following a report by a third party who found that images in Figure 6 of the above article had been published previously in the following articles by other authors: Zhao et al...
May 20, 2024: Annals of Clinical and Translational Neurology
Giuseppe Arena, Zied Landoulsi, Dajana Grossmann, Thomas Payne, Armelle Vitali, Sylvie Delcambre, Alexandre Baron, Paul Antony, Ibrahim Boussaad, Dheeraj Reddy Bobbili, Ashwin Ashok Kumar Sreelatha, Lukas Pavelka, Nico J Diederich, Christine Klein, Philip Seibler, Enrico Glaab, Thomas Foltynie, Oliver Bandmann, Manu Sharma, Rejko Krüger, Patrick May, Anne Grünewald
OBJECTIVE: The aim of our study is to better understand the genetic architecture and pathological mechanisms underlying neurodegeneration in idiopathic Parkinson's disease (iPD). We hypothesized that a fraction of iPD patients may harbor a combination of common variants in nuclear-encoded mitochondrial genes ultimately resulting in neurodegeneration. METHODS: We used mitochondria-specific polygenic risk scores (mitoPRSs) and created pathway-specific mitoPRSs using genotype data from different iPD case-control datasets worldwide, including the Luxembourg Parkinson's Study (412 iPD patients and 576 healthy controls) and COURAGE-PD cohorts (7,270 iPD cases and 6,819 healthy controls)...
May 20, 2024: Annals of Neurology
Emmi K Saarinen, Tomi Kuusimäki, Kari Lindholm, Kalle Niemi, Emma A Honkanen, Tommi Noponen, Marko Seppänen, Toni Ihalainen, Kirsi Murtomäki, Tuomas Mertsalmi, Elina Jaakkola, Elina Myller, Mikael Eklund, Simo Nuuttila, Reeta Levo, Kallol Ray Chaudhuri, Angelo Antonini, Tero Vahlberg, Marko Lehtonen, Juho Joutsa, Filip Scheperjans, Valtteri Kaasinen
OBJECTIVE: This study was undertaken to investigate the effects of dietary caffeine intake on striatal dopamine function and clinical symptoms in Parkinson disease in a cross-sectional and longitudinal setting. METHODS: One hundred sixty-three early Parkinson disease patients and 40 healthy controls were investigated with [123 I]FP-CIT single photon emission computed tomography, and striatal dopamine transporter binding was evaluated in association with the level of daily coffee consumption and clinical measures...
May 20, 2024: Annals of Neurology
Valentina Tedeschi, Silvia Sapienza, Raffaella Ciancio, Lorella Maria Teresa Canzoniero, Anna Pannaccione, Agnese Secondo
Besides controlling several organellar functions, lysosomal channels also guide the catabolic "self-eating" process named autophagy, which is mainly involved in protein and organelle quality control. Neuronal cells are particularly sensitive to the rate of autophagic flux either under physiological conditions or during the degenerative process. Accordingly, neurodegeneration occurring in Parkinson's (PD), Alzheimer's (AD), and Huntington's Diseases (HD), and Amyotrophic Lateral Sclerosis (ALS) as well as Lysosomal Storage Diseases (LSD) is partially due to defective autophagy and accumulation of toxic aggregates...
May 17, 2024: Current Neuropharmacology
Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Shivendra Kumar, Sunam Saha, Ashwani Sharma
Neurological disorders present a formidable challenge in healthcare, necessitating the continuous exploration of innovative therapeutic avenues. This review delves into the burgeoning field of natural diterpenoid derivatives and their promising role in addressing neurological disorders. Derived from natural sources, these compounds exhibit a diverse range of pharmacological properties, positioning them as potential agents for treating conditions such as Alzheimer's and Parkinson's disease. The review highlights recent advancements, shedding light on the multifaceted mechanisms through which diterpenoid derivatives exert their effects, from antiinflammatory to neuroprotective actions...
May 17, 2024: Current Pharmaceutical Biotechnology
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