Asmaa S Mohamed, Dina S Abdel-Fattah, Ghada A Abdel-Aleem, Thanaa F El-Sheikh, Manal M Elbatch
Parkinson's disease (PD) is a chronic and ongoing neurological condition. Unfortunately, as the dopaminergic terminals continue to deteriorate, the effectiveness of anti-Parkinson therapy decreases. This study aimed to examine the effects of BM-MSCs-derived exosomes in rats induced with Parkinson's disease. The goal was to determine their potential for neurogenic repair and functional restoration. Forty male albino rats were divided into four groups: control (group I), PD (group II), PD-L-Dopa (group III), and PD-exosome (group IV)...
March 26, 2023: Molecular and Cellular Biochemistry
Bryan A Killinger, Gabriela Mercado, Solji Choi, Tyler Tittle, Yaping Chu, Patrik Brundin, Jeffrey H Kordower
Synucleinopathies are neurodegenerative diseases characterized by pathological inclusions called "Lewy pathology" (LP) that consist of aggregated alpha-synuclein predominantly phosphorylated at serine 129 (PSER129). Despite the importance for understanding disease, little is known about the endogenous function of PSER129 or why it accumulates in the diseased brain. Here we conducted several observational studies using a sensitive tyramide signal amplification (TSA) technique to determine PSER129 distribution and function in the non-diseased mammalian brain...
March 25, 2023: NPJ Parkinson's Disease
Anna Masato, Nicoletta Plotegher, Francesca Terrin, Michele Sandre, Gaia Faustini, Andrea Thor, Stephen Adams, Giulia Berti, Susanna Cogo, Federica De Lazzari, Camilla Maria Fontana, Paul Anthony Martinez, Randy Strong, Rina Bandopadhyay, Marco Bisaglia, Arianna Bellucci, Elisa Greggio, Luisa Dalla Valle, Daniela Boassa, Luigi Bubacco
Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal neuron degeneration in Parkinson's disease (PD). Several studies in experimental models and postmortem PD patients underlined increasing levels of the dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is highly reactive towards proteins. DOPAL has been shown to covalently modify the presynaptic protein αSynuclein (αSyn), whose misfolding and aggregation represent a major trait of PD pathology, triggering αSyn oligomerization in dopaminergic neurons...
March 25, 2023: NPJ Parkinson's Disease
Celia Painous, Yaroslau Compta
No abstract text is available yet for this article.
March 8, 2023: Parkinsonism & related Disorders
Gordon Duffley, Aniko Szabo, Barbara J Lutz, Emily C Mahoney-Rafferty, Christopher W Hess, Adolfo Ramirez-Zamora, Pamela Zeilman, Kelly D Foote, Shannon Chiu, Michael H Pourfar, Clarisse Goas Cnp, Jennifer L Wood, Ihtsham U Haq, Mustafa S Siddiqui, Mitra Afshari, Melissa Heiry, Jennifer Choi, Monica Volz, Jill L Ostrem, Marta San Luciano, Nicki Niemann, Andrew Billnitzer, Daniel Savitt, Arjun Tarakad, Joohi Jimenez-Shahed, Camila C Aquino, Michael S Okun, Christopher R Butson
INTRODUCTION: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), but its efficacy is tied to DBS programming, which is often time consuming and burdensome for patients, caregivers, and clinicians. Our aim is to test whether the Mobile Application for PD DBS (MAP DBS), a clinical decision support system, can improve programming. METHODS: We conducted an open-label, 1:1 randomized, controlled, multicenter clinical trial comparing six months of SOC standard of care (SOC) to six months of MAP DBS-aided programming...
March 16, 2023: Parkinsonism & related Disorders
I O Ishola, I O Awogbindin, T G Olubodun-Obadun, A E Olajiga, O O Adeyemi
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. Epidemiological reports showed a significant association between environmental toxicants-induced gut dysbiosis and PD. Neuroinflammation, mitochondrial dysfunction and decreased cerebral blood flow are hallmarks of PD. This study sought to evaluate the protective ability of vinpocetine (VIN), a neuroprotectant, on rotenone (ROT) (mitochondrial complex I inhibitor) induced PD in rats. Sixty male Sprague Dawley rats were randomly divided into six groups (n=10) and treated orally as follows; group 1: vehicle (10ml/kg); group 2: rotenone (10mg/kg) + vehicle; group 3-5: vinpocetine (5, 10 or 20mg/kg) + rotenone (10mg/kg), respectively, or group 6: vinpocetine 20mg/kg before behavioural assay for motor symptoms (fore-limb hanging test and open field test) and non-motor symptoms (working memory and learning capabilities in Y-maze/Morris water maze tasks, anxiety in hole board test and gut motility with intestinal transit time)...
March 23, 2023: Neurotoxicology
Sara Khosropoor, Mohaddeseh Sadat Alavi, Leila Etemad, Ali Roohbakhsh
BACKGROUND: Cannabidiol (CBD) is one of the main phytocannabinoids found in Cannabis sativa. In contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors CB1 and CB2, thereby it does not induce significant psychoactive effects. However, CBD may interact with other receptors, including peroxisome proliferator-activated receptor gamma (PPARγ). CBD is a PPARγ agonist and changes its expression. There is considerable evidence that CBD's effects are mediated by its interaction with PPARγ...
March 15, 2023: Phytomedicine
Kun Liang, Ren-Peng Li, Yuan Gao, Chong Liu, Qiao Wang, Dong-Mei Gao, Hui-Min Wang, Liang-Ying Zou, Xin Zhang, Chun-Lei Han, Jian-Guo Zhang, Fan-Gang Meng
BACKGROUND: Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non-motor symptoms. However, there are differences in the improvement of patients' emotional symptoms and cognitive function. OBJECTIVE: To investigate the impact of active contact location and the volume of tissue activated (VTA) on patients' emotional symptoms and cognitive function in STN-DBS in PD. METHODS: A total of 185 PD patients were included in this study...
March 25, 2023: CNS Neuroscience & Therapeutics
Yogeshachar Chithra, Gourav Dey, Vivek Ghose, Vivek Chandramohan, Niya Gowthami, V Vasudev, M M Srinivas Bharath
Mitochondrial dysfunction and oxidative stress are critical to neurodegeneration in Parkinson's disease (PD). Mitochondrial dysfunction in PD entails inhibition of the mitochondrial complex I (CI) in the dopaminergic neurons of substantia nigra. The events contributing to CI inhibition and downstream pathways are not completely elucidated. We conducted proteomic analysis in a dopaminergic neuronal cell line exposed individually to neurotoxic CI inhibitors: rotenone (Rot), paraquat (Pq) and 1-methyl-4-phenylpyridinium (MPP+ )...
March 25, 2023: Neurochemical Research
Erika da Cruz Guedes, Adolfo Garcia Erustes, Anderson H F F Leão, César Alves Carneiro, Vanessa C Abílio, Antonio W Zuardi, Jaime Eduardo C Hallak, José Alexandre Crippa, Claudia Bincoletto, Soraya S Smaili, Patrícia Reckziegel, Gustavo J S Pereira
Progressive neurodegenerative disorders such as Parkinson Disease (PD) lack curative or long-term treatments. At the same time, the increase of the worldwide elderly population and, consequently, the extension in the prevalence of age-related diseases have promoted research interest in neurodegenerative disorders. Caenorhabditis elegans is a free-living nematode widely used as an animal model in studies of human diseases. Here we evaluated cannabidiol (CBD) as a possible neuroprotective compound in PD using the C...
March 25, 2023: Neurochemical Research
Andrea Gardoni, Elisabetta Sarasso, Federica Agosta, Massimo Filippi, Davide Corbetta
BACKGROUND: People with Parkinson's disease (PD) often complain about handwriting difficulties. Currently, there is no consensus on the rehabilitative treatment and outcome measures for handwriting rehabilitation in PD. OBJECTIVES: This study aims to investigate evidence on handwriting rehabilitation in people with PD, examining characteristics of interventions and outcomes. METHODS: A scoping review was conducted according to Arksey and O'Malley's framework and PRISMA-ScR List...
March 25, 2023: Neurological Sciences
Cécilia Ostertag, Muriel Visani, Thierry Urruty, Marie Beurton-Aimar
PURPOSE: Monitoring and predicting the cognitive state of subjects with neurodegenerative disorders is crucial to provide appropriate treatment as soon as possible. In this work, we present a machine learning approach using multimodal data (brain MRI and clinical) from two early medical visits, to predict the longer-term cognitive decline of patients. Using transfer learning, our model can be successfully transferred from one neurodegenerative disease (Alzheimer's) to another (Parkinson's)...
March 25, 2023: International Journal of Computer Assisted Radiology and Surgery
Martin Regensburger, Chi Wang Ip, Zacharias Kohl, Christoph Schrader, Peter P Urban, Jan Kassubek, Wolfgang H Jost
Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are major strategies to reduce levodopa degradation and thus to increase and prolong its effect in striatal dopaminergic neurotransmission in Parkinson's disease patients. While selegiline/rasagiline and tolcapone/entacapone have been available on the market for more than one decade, safinamide and opicapone have been approved in 2015 and 2016, respectively. Meanwhile, comprehensive data from several post-authorization studies have described the use and specific characteristics of the individual substances in clinical practice under real-life conditions...
March 24, 2023: Journal of Neural Transmission
Guilherme Pasetto Fadanni, Anderson Henrique França Figueiredo Leão, Natalli Granzotto, Aline Guimarães Pereira, Auderlan Mendonça de Gois, Pâmela Andressa Ramborger Anjos, Áurea Elizabeth Linder, José Ronaldo Santos, Regina Helena Silva, Geison Souza Izídio
OBJECTIVE AND METHODS: We investigated the locomotor, emotional, physiological, and neurobiological effects induced by low-dose reserpine repeated treatment (0.1 mg/kg; 14 injections) in males from the Lewis (LEW), Spontaneously Hypertensive Rats (SHR), and SHR.LEW-(D4Rat76-D4Mgh11) (SLA16) isogenic rat strains, which have different genetic backgrounds on chromosome 4. Behavioral responses in the catalepsy, open-field, and oral movements' tests were coupled with blood pressure, body weight, and striatal tyrosine hydroxylase (TH) level assessments to establish neurobiological comparisons between reserpine-induced impairments and genetic backgrounds RESULTS: Results revealed the SHR strain was more sensitive in the catalepsy test and exhibited higher TH immunoreactivity in the dorsal striatum...
March 24, 2023: Psychopharmacology
Fátima Cereja, Mariana Alves, Joaquim J Ferreira, Daniel Caldeira
The association of Parkinson's Disease (PD) with atrial fibrillation (AF) is not well established and previous studies' results were heterogeneous. This review aimed to evaluate if patients with PD are at increased risk of having AF. MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science, were searched from inception May 2021. Two reviewers independently selected observational studies with data allowing to estimate the risk of atrial fibrillation in PD patients compared with no-PD controls...
March 25, 2023: Journal of Thrombosis and Thrombolysis
Jarson Pedro da Costa Pereira, Andressa Caroline Burgos Gomes, José Reginaldo Alves de Queiroz Júnior, Taís Galdêncio do Nascimento, Marcella Campos Lima da Luz, Mellina Neyla de Lima Albuquerque, Poliana Coelho Cabral
BACKGROUND AND AIMS: Currently, the impact of nutritional status in Parkinson's disease over the cardiovascular risk is poorly understood. Thus, this study aimed to evaluate dynapenic abdominal obesity and its influence in anthropometric parameters of cardiovascular risk in older patients with Parkinson's disease. METHODS: This is a cross-sectional study involving outpatients diagnosed with Parkinson's disease in two treatment centers in northeast of Brazil. We included patients who aged 60 years and older...
April 2023: Clinical Nutrition ESPEN
Tianmi Yang, Yi Xiao, Yangfan Cheng, Jingxuan Huang, Qianqian Wei, Chunyu Li, Huifang Shang
BACKGROUND: Biological ageing is one of the principal risk factors for neurodegenerative diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as measured by the epigenetic clock, is closely associated with many age-related diseases. METHODS: We searched the PubMed and Web of Science databases to identify eligible studies reporting epigenetic clocks in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)...
March 24, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
Vibeke Wagner, Mikkel Sneftrup Knudsen, Derek John Curtis, Christian Gunge Riberholt
The EXOPULSE Mollii is designed to reduce spasticity through low-current electrical stimulation of major muscle groups. The effect on severe cerebellar ataxia has not been investigated. This case describes the use of the EXOPULSE Mollii in an adult male with severe cerebellar ataxia 4 months after cardiac arrest and ischaemic stroke. The patient used the suit in 15 of 19 possible sessions (78.9%). He improved in the sit-to-stand test, arm function test and 10 m walking test. He described improved visual focus, ability to speak and swallow...
March 24, 2023: BMJ Case Reports
Jialu Mo, Jiao Hu, Xianglin Cheng
High mobility group box 1 (HMGB1) is a ubiquitous and highly conserved non-histone DNA-binding protein with different biological functions according to its subcellular localization. It is widely believed that HMGB1, which is released into the extracellular space, plays a key role in the inflammatory response. In recent years, numerous studies have shown that the development of various neurological diseases such as epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), cerebrovascular disease and traumatic brain injury (TBI) are inextricably linked to inflammation...
March 22, 2023: Biomedicine & Pharmacotherapy
Sena Boncuk Ulaş, Yeşim Güzey Aras, Sezen Irmak Gözükara, Türkan Acar, Bilgehan Atılgan Acar
INTRODUCTION: Idiopathic Parkinson's Disease is a chronic, progressive, neurodegenerative disease that affects the substantia nigra pars compacta and dopaminergic neurons in the brain stem. Since zonulin and claudin-5 are involved in intestinal and brain endothelial permeability and it is hypothesized that the brain-gut axis is relevant in IPD, the aim of our study is to evaluate whether the relationship between Zonulin and Claudin-5 levels and Parkinson's Disease patients. METHODS: A total of 139 patients, including 34 mild, 33 moderate, 39 severe stage patients and 33 healthy controls were included...
March 17, 2023: Parkinsonism & related Disorders
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