Saman Saedi, Mohammad Reza Jafarzadeh Shirazi, Ali Niazi, Ahmad Tahmasebi, Esmaeil Ebrahimie
Cadmium (Cd) is a toxic metal, which seems to be crucial during the prepubertal period. Cd can destroy the structural integrity of the blood-brain barrier (BBB) and enters into the brain. Although the brain is susceptible to neurotoxicity induced by Cd, the effects of Cd on the brain, particularly hypothalamic transcriptome, are still relatively poorly understood. Therefore, we investigated the molecular effects of Cd exposure on the hypothalamus by profiling the transcriptomic response of the hypothalamus to high dose of Cd (25 mg/kg bw/day cadmium chloride (CdCl2 )) during the prepubertal period in Sprague-Dawley female rats...
January 13, 2021: Chemico-biological Interactions
Amanda L Penko, Nicole M Zimmerman, Michael Crawford, Susan M Linder, Jay L Alberts
OBJECTIVE: To determine the impact of aerobic exercise on maximal and submaximal cardiopulmonary responses and predictors of change in individuals with Parkinson's disease (PD). DESIGN: Single-center, parallel-group, rater-blind study. SETTING: Research laboratory PARTICIPANTS: Individual's with mild to moderate PD (N=100) INTERVENTION: Participants were enrolled in a trial evaluating the impact of cycling on PD and randomized to either voluntary exercise (VE), forced exercise (FE), or a no exercise, control group...
January 13, 2021: Archives of Physical Medicine and Rehabilitation
Federico Micheli, Matteo Vissani, Guido Pecchioli, Federica Terenzi, Silvia Ramat, Alberto Mazzoni
BACKGROUND: Impulsive-compulsive behaviors are common in Parkinson's disease (PD) patients. However, the basal ganglia dysfunctions associated with high impulsivity have not been fully characterized. The objective of this study was to identify the features associated with impulsive-compulsive behaviors in single neurons of the subthalamic nucleus (STN). METHODS: We compared temporal and spectral features of 412 subthalamic neurons from 12 PD patients with impulsive-compulsive behaviors and 330 neurons from 12 PD patients without...
January 16, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
Gulay Kenangil, Mehmet Demir, Esma Tur, Fusun Domac
BACKGROUND: Basal ganglia are connected to dorsal prefrontal and orbitofrontal structures, which have an important role in emotional experience. Alexithymia is defined as the inability to recognize and verbalize emotions. There is little known about alexithymia and cognitive dysfunction and its relationship with depression. In this study, we examined the relation of alexithymia with cognition and depression in non-demented patients with Parkinson's disease (PD). MATERIALS AND METHODS: Fort-two consecutive non-demented patients PD and 40 healthy controls were enrolled in the study...
January 16, 2021: Acta Neurologica Belgica
J Thaddeus Coin, Jeffery M Vance
OBJECTIVE: The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552]. METHODS: Clinical observations and analysis of video-recorded eye movements were used before and after gabapentin. RESULTS: Gabapentin relieved vertigo of all three treated patients with EA4, particularly during activities that typically would induce vertiginous symptoms...
January 16, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
Deepak Sachan, Amit Yadav, Dinesh Yadav
No abstract text is available yet for this article.
January 15, 2021: Indian Pediatrics
Aida Arroyo, José A Periáñez, Marcos Ríos-Lago, Genny Lubrini, Jorge Andreo, Julián Benito-León, Elan D Louis, Juan Pablo Romero
INTRODUCTION: Bradyphrenia is a key cognitive feature in Parkinson's disease (PD). There is no consensus on whether information processing speed is impaired or not beyond motor performance. OBJECTIVE: This study aims to explore which perceptual, motor, or cognitive components of information processing are involved in the slowdown affecting cognitive performance. METHODS: The study included 48 patients with PD (age: 63, 3 ± 8, 18; HY I-III; UPDRS 15,46 ± 7,76) and 53 healthy controls (age: 60,09 ± 12,83)...
January 15, 2021: Brain and Behavior
Anna Siegert, Marija Rankovic, Filippo Favretto, Tina Ukmar-Godec, Timo Strohäker, Stefan Becker, Markus Zweckstetter
In Parkinson's disease with dementia, up to 50 % of patients develop a high number of tau-containing neurofibrillary tangles. Tau-based pathologies may thus act synergistically with the α-synuclein pathology to confer a worse prognosis. A better understanding of the relationship between the two distinct pathologies is therefore required. Liquid-liquid phase separation (LLPS) of proteins has recently been shown to be important for protein aggregation involved in amyotrophic lateral sclerosis, whereas tau phase separation has been linked to Alzheimer's disease...
January 15, 2021: Protein Science
Konstantinos Kyritsis, Petter Fagerberg, Ioannis Ioakimidis, K Ray Chaudhuri, Heinz Reichmann, Lisa Klingelhoefer, Anastasios Delopoulos
Parkinson's disease (PD) is a neurodegenerative disorder with both motor and non-motor symptoms. Despite the progressive nature of PD, early diagnosis, tracking the disease's natural history and measuring the drug response are factors that play a major role in determining the quality of life of the affected individual. Apart from the common motor symptoms, i.e., tremor at rest, rigidity and bradykinesia, studies suggest that PD is associated with disturbances in eating behavior and energy intake. Specifically, PD is associated with drug-induced impulsive eating disorders such as binge eating, appetite-related non-motor issues such as weight loss and/or gain as well as dysphagia-factors that correlate with difficulties in completing day-to-day eating-related tasks...
January 15, 2021: Scientific Reports
Sathyanarayanan Ranganayaki, Neema Jamshidi, Mohamad Aiyaz, Santhosh-Kumar Rashmi, Narayanappa Gayathri, Pulleri Kandi Harsha, Balasundaram Padmanabhan, Muchukunte Mukunda Srinivas Bharath
Mitochondrial dysfunction and neurodegeneration underlie movement disorders such as Parkinson's disease, Huntington's disease and Manganism among others. As a corollary, inhibition of mitochondrial complex I (CI) and complex II (CII) by toxins 1-methyl-4-phenylpyridinium (MPP+ ) and 3-nitropropionic acid (3-NPA) respectively, induced degenerative changes noted in such neurodegenerative diseases. We aimed to unravel the down-stream pathways associated with CII inhibition and compared with CI inhibition and the Manganese (Mn) neurotoxicity...
January 15, 2021: Scientific Reports
Mohammed Homaida, Avinash Kumar Kanodia, Neil Young, Wai Meng Yu
No abstract text is available yet for this article.
January 15, 2021: BMJ Case Reports
Shohei Nomura, Mitsuru Kashiwagi, Takuya Tanabe, Chizu Oba, Kumiko Yanagi, Tadashi Kaname, Nobuhiko Okamoto, Akira Ashida
BACKGROUND: Rapid-onset dystonia-parkinsonism (RDP) is a disease characterized by an abrupt onset of dystonia accompanied by signs of parkinsonism and prominent bulbar symptoms. CASE REPORT: We describe a case of a female patient, born after normal delivery, but diagnosed with mild intellectual disability at age 7. She presented with an abrupt onset of upper limb dystonia and bradykinesia without tremor in parkinsonism, as well as dysarthria and dysphagia caused by prominent bulbar symptoms, at age 9...
January 12, 2021: Brain & Development
Eva Griesser, Hannah Wyatt, Sara Ten Have, Birgit Stierstorfer, Martin Lenter, Angus I Lamond
Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens. In combination with formalin-fixed and paraffin-embedded (FFPE) tissue it provides a powerful tool for retrospective and clinically relevant studies of tissue proteins in a healthy and diseased context. We first optimized the protocol for efficient LCM analysis of FFPE tissue specimens. The use of SDS containing extraction buffer in combination with the single-pot solid-phase-enhanced sample preparation (SP3) digest method gave the best results regarding protein yield and protein/peptide identifications...
May 2020: Molecular & Cellular Proteomics: MCP
Özge Karayel, Francesca Tonelli, Sebastian Virreira Winter, Phillip E Geyer, Ying Fan, Esther M Sammler, Dario R Alessi, Martin Steger, Matthias Mann
Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to quantify pRab10 levels for drug target engagement or patient stratification. To meet this challenge, we developed an high accuracy and sensitivity targeted mass spectrometry (MS)-based assay for determining Rab10-Thr73 phosphorylation stoichiometry in human samples...
September 2020: Molecular & Cellular Proteomics: MCP
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Linnea Ransom, Janneca Ames, Gloria Shen, Christopher B Lietz, Zhenze Jiang, Anthony J O'Donoghue, Charisse Winston, Tsuneya Ikezu, Robert A Rissman, Shauna Yuan, Vivian Hook
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and related tauopathies. Extracellular vesicles, specifically exosomes, have recently been demonstrated to participate in mediating Tau propagation in brain. Exosomes produced by human induced pluripotent stem cell (iPSC)-derived neurons expressing mutant Tau (mTau), containing the P301L and V337M Tau mutations of FTDP-17, possess the ability to propagate p-Tau pathology after injection into mouse brain...
June 2020: Molecular & Cellular Proteomics: MCP
Li-Sheng Hou, Dong Zhang, Feng Ge, Hai-Feng Li, Tian-Jun Gao
BACKGROUND: Previous research and published literature indicate that some patients with spinal diseases who underwent percutaneous transforaminal endoscopic decompression (PTED) still suffer some discomfort in the early recovery stage in the form of pain, stiffness, and swelling. These are usually considered minor residual symptoms or normal postoperative phenomenon (NPF) in the clinic, occur frequently, and are acknowledged by surgeons worldwide. To the best of our knowledge, we report the first case of a patient who had an osteoporotic vertebral fracture (OVF) misdiagnosed as NPF after she underwent PTED as a result of lumbar disc herniation (LDH)...
January 15, 2021: BMC Musculoskeletal Disorders
Laura Marsal-García, Aintzane Urbizu, Laura Arnaldo, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Jordi Gascón-Bayarri, Ramón Reñé, Ramiro Álvarez, Katrin Beyer
Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene ( SNCA ) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, and SNCA112, in 45 LBD and control temporal cortex samples and in the blood of 72 DLB, 59 PD, and 54 control subjects. The results revealed overexpression of SNCAtv1 and SNCA112 in DLB, and SNCAtv2 in PD temporal cortices...
January 13, 2021: International Journal of Molecular Sciences
Shiro Horisawa, Atsushi Fukui, Hayato Yamahata, Yukiko Tanaka, Atsushi Kuwano, Oji Momosaki, Mutsumi Iijima, Magi Nanke, Takakazu Kawamata, Takaomi Taira
OBJECTIVE: Neurosurgical ablation is an effective treatment for medically refractory motor symptoms of Parkinson's disease (PD). A limited number of studies have reported the effect of ablation of the pallidothalamic tract for PD. In this study, the authors evaluated the safety and efficacy of unilateral pallidothalamic tractotomy for akinetic-rigid (AR)-PD. METHODS: Fourteen AR-PD patients, who were enrolled in this prospective open-label study, underwent unilateral pallidothalamic tractotomy...
January 15, 2021: Journal of Neurosurgery
Zach Dwyer, Chris Rudyk, Kyle Farmer, Sheryl Beauchamp, Pragya Shail, Alexa Derksen, Teresa Fortin, Katelyn Ventura, Carlos Torres, Kiara Ayoub, Shawn Hayley
The primary motor symptoms of Parkinson's disease (PD) result from the degeneration of dopamine-producing neurons of the substantia nigra pars compacta (SNc), and often, the loss is asymmetrical, resulting in unilateral tremor presentation. Notably, age is the primary risk factor for PD, and it is likely that the disease ultimately stems from the impact of environmental factors, which interact with the aging process. Recent research has focused on the role of microglia and pro-oxidative responses in dopaminergic neuronal death...
November 26, 2020: Neurobiology of Aging
Arnaud Delval, Nacim Betrouni, Céline Tard, David Devos, Kathy Dujardin, Luc Defebvre, Jordan Labidi, Caroline Moreau
OBJECTIVE: Although a number of clinical factors have been linked to falls in Parkinson's disease (PD), the diagnostic value of gait parameters remains subject to debate. The objective of this retrospective study was to determine to what extent the combination of gait parameters with clinical characteristics can distinguish between fallers and non-fallers. METHODS: Using a video motion system, we recorded gait in 174 patients with PD. The patients' clinical characteristics (including motor status, cognitive status, disease duration, dopaminergic treatment and any history of falls or freezing of gait) were noted...
December 19, 2020: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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