Edo Richard, Bastiaan R Bloem
No abstract text is available yet for this article.
November 23, 2022: Journal of Parkinson's Disease
Herma Lennaerts-Kats, Anne Ebenau, Silvia Kanters, Bastiaan R Bloem, Kris C P Vissers, Bauke W Dijkstra, Marjan J Meinders, Marieke M Groot
BACKGROUND: Parkinson's disease (PD) is an increasingly prevalent and progressive degenerative disease. Palliative care for PD should be integrated into the routine care for people with PD. However, PD health care professionals typically lack knowledge of palliative care, highlighting the necessity of educational programs in this field. OBJECTIVE: To determine the effectiveness of a multidisciplinary blended learning program for health care professionals specialized in PD in the Netherlands...
November 19, 2022: Journal of Parkinson's Disease
Eleanor Mitchell, Harneek Chohan, Jonathan P Bestwick, Alastair J Noyce
BACKGROUND: A substantial body of research has examined the relationship between alcohol consumption and risk of Parkinson's disease (PD). OBJECTIVE: To provide an updated systematic review and meta-analysis of observational studies examining the relationship between alcohol consumption and risk of PD. METHODS: Eligible studies comparing PD risk in ever vs. never alcohol drinkers were sourced from six databases. Outcomes were pooled using standard meta-analysis techniques...
November 25, 2022: Journal of Parkinson's Disease
Negin Badihian, Lauren M Jackson, Bryan T Klassen, Anhar Hassan, Phillip A Low, Wolfgang Singer, Elizabeth A Coon
The course of patients with multiple system atrophy (MSA) who undergo deep brain stimulation (DBS) is unclear. In a retrospective review of 1,496 patients with MSA evaluated at our institutions from 1998-2021, 12 patients underwent DBS; 9 had a diagnosis of Parkinson's disease at the time of surgery. Nine patients reported initial improvement in at least one symptom and 7 experienced overall worsening following DBS. All patients had at least one red flag sign or symptom suggesting atypical parkinsonism prior to surgery...
November 21, 2022: Journal of Parkinson's Disease
Keren Zhang, Kimberly C Paul, Jonathan P Jacobs, Hsiang-Chin Lori Chou, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Jeff M Bronstein, Adrienne M Keener, Beate Ritz
BACKGROUND: Increasing evidence connects the gut microbiome to Parkinson's disease (PD) etiology, but little is known about microbial contributions to PD progression and its clinical features. OBJECTIVE: We aim to explore the association between the gut microbiome with PD, and the microbial association with PD-specific clinical features. METHODS: In a community-based case-control study of 96 PD patients and 74 controls, microbiome data were obtained from 16 S rRNA gene sequencing of fecal samples, and analyzed for microbial diversity, taxa abundance, and predicted functional pathways that differed in PD patients and controls, and their association with PD-specific features (disease duration, motor subtypes, L-DOPA daily dose, and motor function)...
November 22, 2022: Journal of Parkinson's Disease
Mohan Zhao, Na Wang, Yaoting Guo, Jingwen Li, Yue Yin, Yan Dong, Jiabin Zhu, Chao Peng, Tingting Xu, Jinsong Liu
Orphan nuclear receptor Nurr1 plays important roles in the progression of various diseases, including Parkinson's disease, neuroinflammation, Alzheimer's disease, and multiple sclerosis. It can recognize DNA as a monomer or heterodimer with retinoid X receptor α (RXRα). But the molecular mechanism of its transcriptional activity regulation is still largely unknown. Here we obtained a crystal structure of monomer Nurr1 (DNA- and ligand-binding domains, DBD and LBD) bound to NGFI-B response element...
December 6, 2022: Proceedings of the National Academy of Sciences of the United States of America
Priya Pallavi, Neeti Jariwala, Niravkumar Patel, Manasi Kanetkar, Shraddha Diwan, Uttama Lahiri
Fear of Fall (FoF) is often associated with postural and gait abnormalities leading to decreased mobility in individuals with Parkinson's Disease (PD). The variability in knee flexion (postural index) during heel-strike and toe-off events while walking can be related to one's FoF. Depending on the progression of the disease, gait abnormality can be manifested as start/turn/stop hesitation, etc. adversely affecting one's cadence along with an inability to transfer weight from one leg to the other. Also, task demands can have implications on one's gait and posture...
November 28, 2022: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Hasan Nadeem, Bo Zhou, Dana Goldman, John Romley
INTRODUCTION: Previous observational studies assessing β2-agonist/-antagonist use on PD risk have yielded conflicting results. We evaluated the relationship between β2-agonist use and the incidence of Parkinson's disease in patients with chronic lung disease. METHODS: We performed a retrospective cohort analysis on a 20% random sample abstracted from a traditional (fee-for-service) Medicare program in the United States. Inclusion criteria were individuals over 65 years old diagnosed with asthma, COPD, and/or bronchiectasis who were enrolled in a prescription drug (standalone Part D) plan over 2007-2010 and alive through 2014...
2022: PloS One
Alberto J Espay, Michael S Okun
No abstract text is available yet for this article.
November 28, 2022: JAMA Neurology
Seyed-Mohammad Fereshtehnejad, Philip A Saleh, Lais M Oliveira, Neha Patel, Suvorit Bhowmick, Gerard Saranza, Lorraine V Kalia
BACKGROUND: Hereditary spastic paraplegia (HSP) is a rare genetic disorder associated with mutations in > 80 loci designated SPG (SPastic parapleGia). The phenotypic spectrum of HSP can extend to include other neurologic features, including movement disorders. Our aim was to investigate genotype-phenotype associations in HSP with a focus on movement disorders. METHODS: We performed a systematic review and individual participant data (IPD)-level meta-analysis by retrieving publications from Medline/EMBASE/Web of Science on HSP with a SPG genotype...
November 28, 2022: Neurological Sciences
David Payares-Garcia, Jorge Mateu, Wiebke Schick
Magnetic resonance imaging (MRI) plays an increasingly important role in the diagnosis and prognosis of neurodegenerative diseases. One field of extensive clinical use of MRI is the accurate and automated classification of degenerative disorders. Most of current classification studies either do not mirror medical practice where patients may exhibit early stages of the disease, comorbidities, or atypical variants, or they are not able to produce probabilistic predictions nor account for uncertainty. Also, the spatial heterogeneity of the brain alterations caused by neurodegenerative processes is not usually considered, despite the spatial configuration of the neuronal loss is a characteristic hallmark for each disorder...
November 28, 2022: Statistics in Medicine
A A Pilipovich, O V Vorob'eva
OBJECTIVE: To evaluate the main symptoms of the upper gastrointestinal dysfunction (salivation and swallowing disorders) and to determine their impact on the quality of life for patients with PD of stages I-III, as well as the possibility of their correction by dopamine receptor agonists. MATERIAL AND METHODS: 252 patients (128 women and 124 men, 42-80 years old) with PD of stages I-III were examined using: UPDRS items «salivation», «swallowing» and «anorexia», scale of daily activity (Schwab and England ADL scale), questionnaire quality of life (PDQ-39), measurement of saliva amount, BMI, MMSE scale; 53 patients were treated with piribedil during 6 months...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
A Matas-García, A Téllez, S Fernández, E Salgado, P Castro
INTRODUCTION: Disulfiram-induced-encephalopathy is a rare complication that has been well described in adults. Although it usually occurs in acute intoxication with high doses of disulfiram, late onset encephalopathy has also been reported. Some authors propose the inhibition of dopamine beta-hydroxylase mediated by toxic metabolites of disulfiram as the main responsible, but the exact mechanism remains unclear. The aim of this report was to describe the clinical and neuroimaging findings in an unusual case of acute encephalitis due to disulfiram toxicity associated to chronic intranasal consume...
December 1, 2022: Revista de Neurologia
Ernesto Yagüe, He Sun, Yunhui Hu
Traditional Chinese medicine (TCM) has used herbal remedies for more than 2,000 years. The use of complimentary therapies has increased dramatically during the last years, especially in the West, and the incorporation and modernization of TCM in current medical practice is gaining momentum. We reflect on the main bottlenecks in the modernization of arcane Chinese herbal medicine: lack of standardization, safety concerns and poor quality of clinical trials, as well as the ways these are being overcome. Progress in these areas will facilitate the implementation of an efficacy approach, in which only successful clinical trials lead to the molecular characterization of active compounds and their mechanism of action...
2022: Frontiers in Neuroscience
Yajun Yang, Yi Wang, Ce Wang, Xinjuan Xu, Cai Liu, Xintao Huang
Parkinson's disease (PD) is a common neurodegenerative disease, and there is still a lack of effective diagnostic and treatment methods. This study aimed to search for hub genes that might serve as diagnostic or therapeutic targets for PD. All the analysis was performed in R software. The expression profile data of PD (number: GSE7621) was acquired from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) associated with PD were screened by the "Limma" package of the R software...
2022: Frontiers in Neuroscience
Genevieve Hayes, Joana Pinto, Sierra N Sparks, Congxiyu Wang, Sana Suri, Daniel P Bulte
Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is compromised. An increasing body of research suggests that VSMCs have remarkable plasticity and their pathophysiology may play a key role in the complex process of neurodegeneration. Furthermore, extrinsic risk factors, including environmental conditions and traumatic events can impact vascular function through changes in VSMC morphology...
2022: Frontiers in Neuroscience
Camryn R Rohringer, Isabella J Sewell, Shikha Gandhi, Jonah Isen, Benjamin Davidson, Melissa McSweeney, Walter Swardfager, Nadia Scantlebury, Richard H Swartz, Clement Hamani, Peter Giacobbe, Sean M Nestor, Yana Yunusova, Benjamin Lam, Michael L Schwartz, Nir Lipsman, Agessandro Abrahao, Jennifer S Rabin
Tremor is a debilitating symptom that can lead to functional impairment. Pharmacotherapy is often successful, but up to 50% of patients are resistant to medications or cannot tolerate side effects. Thalamotomy to the ventral intermediate nucleus of the thalamus is a surgical intervention for refractory tremor. Thalamotomy surgeries include radiofrequency and incisionless procedures, such as Gamma Knife radiosurgery and magnetic resonance-guided focused ultrasound. Cognitive changes following thalamotomy have been inconsistently reported across studies...
2022: Brain communications
Sipei Pan, Hongming Wei, Shushu Yuan, Yu Kong, Huiqun Yang, Yuhe Zhang, Xiaorui Cui, Weian Chen, Jiaming Liu, Yang Zhang
Recent evidence demonstrated that functional bacteria were involved in the regulation of Parkinson's disease (PD). However, the mechanism of probiotics in improving PD was unclear. Here the antioxidant effect and the mechanism of probiotics Pediococcus pentosaceus (PP) on PD were studied by regulating the gut-brain axis. In this study, male C57BL/6J mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneally to establish a PD model and were then treated with PP for 4 weeks...
2022: Frontiers in Cellular and Infection Microbiology
Shao Yin, Fengya Zhu
BACKGROUND: Parkinson's disease (PD)-related constipation may affects both disease occurrence and disease progression. Probiotics, as a potential therapeutic intervention, have attracted the attention of researchers, but the evidence of their efficacy and safety has not been systematically reviewed. AIM: A systematic review and meta-analysis of randomized controlled trials of probiotics in the treatment of PD constipation was conducted to determine the efficacy and safety of probiotics in the treatment of PD constipation...
2022: Frontiers in Cellular and Infection Microbiology
Peter A LeWitt, Fabrizio Stocchi, David Arkadir, Yoseph Caraco, Liat Adar, Itay Perlstein, Ryan Case, Nir Giladi
BACKGROUND: While treatment with levodopa remains the cornerstone of Parkinson's disease (PD) management, chronic oral therapy is often associated with the development of motor complications, that correlate to fluctuating levodopa plasma concentrations, limiting its clinical utility. Continuous infusion is considered to be the optimal delivery route for treating PD patients with motor fluctuations, but current infusion systems require invasive surgery. Subcutaneous infusion of (SC) levodopa has the potential to provide a better tolerated and more convenient route of continuous levodopa delivery...
2022: Frontiers in Neurology
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