Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Andrew T Lenis, Karissa Whiting, Vignesh Ravichandran, Jacob E Tallman, Syed M Alam, Carissa E Chu, Manual De Jesus Escano, Emily Bochner, Andrew Katims, Peter A Reisz, Hong Truong, Timothy N Clinton, Leon Telis, Shawn Dason, Victor McPherson, Min Yuen Teo, Samuel Funt, David Aggen, Alvin C Goh, Timothy F Donahue, Eugene K Cha, S Machele Donat, Harry W Herr, Guido Dalbagni, Nikolaus Schultz, Michael F Berger, Dean F Bajorin, Jonathan E Rosenberg, Bernard H Bochner, Irina Ostrovnaya, Hikmat Al-Ahmadie, David B Solit, Gopa Iyer, Eugene J Pietzak
PURPOSE: Patients with residual invasive bladder cancer after neoadjuvant chemotherapy (NAC) and radical cystectomy have a poor prognosis. Data on adjuvant therapy for these patients are conflicting. We sought to evaluate the natural history and genomic landscape of chemotherapy-resistant bladder cancer to inform patient management and clinical trials. METHODS: Data were collected on patients with clinically localized muscle-invasive urothelial bladder cancer treated with NAC and cystectomy at our institution between May 15, 2001, and August 15, 2019, and completed four cycles of gemcitabine and cisplatin NAC, excluding those treated with adjuvant therapies...
April 2024: JCO Precision Oncology
#2
JOURNAL ARTICLE
Tongyi Li, Liangliang Geng, Yunjiao Yang, Guannan Liu, Haichen Li, Cong Long, Qiu Chen
BACKGROUND: The etiology of diabetic kidney disease is complex, and the role of lipoproteins and their lipid components in the development of the disease cannot be ignored. However, phospholipids are an essential component, and no Mendelian randomization studies have yet been conducted to examine potential causal associations between phospholipids and diabetic kidney disease. METHODS: Relevant exposure and outcome datasets were obtained through the GWAS public database...
2024: PloS One
#3
JOURNAL ARTICLE
Hojjat Asadollahpour Nanaei, Zeinab Amiri Ghanatsaman, Mohammad Ali Farahvashi, Seyedeh Fatemeh Mousavi, Mohammad Hossein Banabazi, Masood Asadi Fozi
Understanding how evolutionary factors related to climate adaptation and human selection have influenced the genetic architecture of domesticated animals is of great interest in biology. In the current study, by using 304 whole genomes from different geographical regions (including Europe, north Africa, Southwest Asia, east Asia, west Africa, south Asia, east Africa, Australia and Turkey), We evaluate global sheep population dynamics in terms of genetic variation and population structure. We further conducted comparative population analysis to study the genetic underpinnings of climate adaption to local environments and also morphological traits...
May 1, 2024: Tropical Animal Health and Production
#4
JOURNAL ARTICLE
Gbolahan Bamgbose, Guillaume Bordet, Niraj Lodhi, Alexei Tulin
PARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks, particularly H4K20me1. We found that H4K20me1 plays a critical role in facilitating PARP-1 binding and the regulation of PARP-1-dependent loci during both development and heat shock stress. Here, we report that the sole H4K20 mono-methylase, pr-set7 , and parp-1 Drosophila mutants undergo developmental arrest...
May 1, 2024: ELife
#5
EDITORIAL
Agnieszka Latosinska, Justyna Siwy, Harald Mischak
No abstract text is available yet for this article.
June 1, 2024: Journal of Hypertension
#6
JOURNAL ARTICLE
Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
As the genome encodes the information crucial for cell growth, a sizeable genomic deficiency often causes a significant decrease in growth fitness. Whether and how the decreased growth fitness caused by genome reduction could be compensated by evolution was investigated here. Experimental evolution with an Escherichia coli strain carrying a reduced genome was conducted in multiple lineages for approximately 1000 generations. The growth rate, which largely declined due to genome reduction, was considerably recovered, associated with the improved carrying capacity...
May 1, 2024: ELife
#7
JOURNAL ARTICLE
Youlan Chen, Lixiao Hao, Jun Cong, Jianmei Ji, Yancheng Dai, Li Xu, Biao Gong
BACKGROUND AND AIMS: Mounting evidence highlights a strong association between chronic pancreatitis (CP) and type 2 diabetes (T2D), although the exact mechanism of interaction remains unclear. This study aimed to investigate the crosstalk genes and pathogenesis between CP and T2D. METHODS: Transcriptomic gene expression profiles of CP and T2D were extracted from Gene Expression Omnibus, respectively, and the common differentially expressed genes (DEGs) were subsequently identified...
May 2024: Health Science Reports
#8
REVIEW
Laura Fontana, Silvia M Sirchia, Chiara Pesenti, Giovanni Maria Colpi, Monica R Miozzo
Recent advancements in reproductive medicine have guided novel strategies for addressing male infertility, particularly in cases of non-obstructive azoospermia (NOA). Two prominent invasive interventions, namely testicular sperm extraction (TESE) and microdissection TESE (micro-TESE), have emerged as key techniques to retrieve gametes for assisted reproduction technologies (ART). Both heterogeneity and complexity of NOA pose a multifaceted challenge to clinicians, as the invasiveness of these procedures and their unpredictable success underscore the need for more precise guidance...
2024: Frontiers in Endocrinology
#9
JOURNAL ARTICLE
Dan Yu, Yan Luo, Rong Guo, Fang Ma, Yunyun Chang, Jianhong Dang
BACKGROUND: The cell endocrine pathway is a critical physiological process composed of the endoplasmic reticulum, Golgi apparatus and associated vesicles. Loss of enzymes or proteins can cause dysfunction of endoplasmic reticulum and Golgi apparatus and affect secretion pathways leading to a variety of human diseases, including cancer. METHODS: The single-cell RNA sequencing and single nucleotide variant principal component analysis data of ovarian cancer were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) datasets...
May 2024: Journal of Gene Medicine
#10
Filippo Pinto E Vairo, Jennifer L Kemppainen, Carolyn R Rohrer Vitek, Denise A Whalen, Kayla J Kolbert, Kaitlin J Sikkink, Sarah A Kroc, Teresa Kruisselbrink, Gabrielle F Shupe, Alyssa K Knudson, Elizabeth M Burke, Elle C Loftus, Lorelei A Bandel, Carri A Prochnow, Lindsay A Mulvihill, Brittany Thomas, Dale M Gable, Courtney B Graddy, Giovanna G Moreno Garzon, Idara U Ekpoh, Eva M Carmona Porquera, Fernando C Fervenza, Marie C Hogan, Mireille El Ters, Kenneth J Warrington, John M Davis, Matthew J Koster, Amir B Orandi, Matthew L Basiaga, Adrian Vella, Seema Kumar, Ana L Creo, Aida N Lteif, Siobhan T Pittock, Peter J Tebben, Ejigayehu G Abate, Avni Y Joshi, Elizabeth H Ristagno, Mrinal S Patnaik, Lisa A Schimmenti, Radhika Dhamija, Sonia M Sabrowsky, Klaas J Wierenga, Mira T Keddis, Niloy Jewel J Samadder, Richard J Presutti, Steven I Robinson, Michael C Stephens, Lewis R Roberts, William A Faubion, Sherilyn W Driscoll, Lily C Wong-Kisiel, Duygu Selcen, Eoin P Flanagan, Vijay K Ramanan, Lauren M Jackson, Michelle L Mauermann, Victor E Ortega, Sarah A Anderson, Stacy L Aoudia, Eric W Klee, Tammy M McAllister, Konstantinos N Lazaridis
No abstract text is available yet for this article.
April 30, 2024: Journal of Translational Medicine
#11
JOURNAL ARTICLE
Ziyi Sun, Zhangjun Yun, Jianguo Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang, Xingjiang Xiong, Kuiwu Yao
BACKGROUND: Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies. This study aimed to identify potential therapeutic targets for coronary heart disease (CHD) and myocardial infarction (MI) by investigating the causal relationship between plasma proteins and these conditions. METHODS: A two-sample Mendelian randomization (MR) study was performed to evaluate more than 1600 plasma proteins for their causal associations with CHD and MI...
April 30, 2024: Journal of Translational Medicine
#12
REVIEW
Yoona Seo, Jiho Rhim, Jong Heon Kim
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression. The molecular mechanistic interplay between miRNAs and their regulatory factors, RNA-binding proteins (RBPs) and exoribonucleases, has been revealed to play a critical role in tumorigenesis. Moreover, recent studies have shown that the proliferation of hepatocellular carcinoma (HCC)-causing hepatitis C virus (HCV) is also characterized by close crosstalk of a multitude of host RBPs and exoribonucleases with miR-122 and its RNA genome, suggesting the importance of the mechanistic interplay among these factors during the proliferation of HCV...
May 1, 2024: Experimental & Molecular Medicine
#13
JOURNAL ARTICLE
Sachiko Hasebe, Kota Maekawa, Yukiko Shishido-Hara, Kazuo Nakamichi, Nobuaki Funata, Makio Takahashi
A middle-aged man with progressive multifocal leukoencephalopathy (PML) in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier on haemodialysis presented with mild dysarthria and ataxia. Brain MRI revealed asymmetric T2 -hyperintense lesions in the cerebral white matter, cerebellum and brainstem. A small amount of JC virus (JCV) genome in cerebrospinal fluid was detected by PCR and cerebellar biopsy demonstrated JCV-DNA presence. Pathological findings showed demyelinating lesions and glial cells with mildly enlarged nuclei, accompanied by T-lymphocytes, neutrophils and plasma cell infiltration...
April 30, 2024: BMJ Case Reports
#14
JOURNAL ARTICLE
Chiao-Hsu Ke, Pan-Yun Lai, Feng-Yang Hsu, Po-Ren Hsueh, Ming-Tang Chiou, Chao-Nan Lin
Actinobacillus pleuropneumoniae infection causes a high mortality rate in porcine animals. Antimicrobial resistance poses global threats to public health. The current study aimed to determine the antimicrobial susceptibilities and probe the resistome of A. pleuropneumoniae in Taiwan. Herein, 133 isolates were retrospectively collected; upon initial screening, 38 samples were subjected to next-generation sequencing (NGS). Over the period 2017-2022, the lowest frequencies of resistant isolates were found for ceftiofur, cephalexin, cephalothin, and enrofloxacin, while the highest frequencies of resistant isolates were found for oxytetracycline, streptomycin, doxycycline, ampicillin, amoxicillin, kanamycin, and florfenicol...
December 2024: Veterinary Quarterly
#15
JOURNAL ARTICLE
Navidreza Shayan, Negin Ghiyasimoghaddam, Hanieh Alsadat Mirkatuli, Mohammadhasan Baghbani, Zahra Ranjbarzadhagh, Nooshin Mohtasham
Cancer stem cells (CSCs) play a crucial role in tumor relapse, proliferation, invasion, and drug resistance in head and neck squamous cell carcinoma (HNSCC). This narrative review aims to synthesize data from articles published between 2019 and 2023 on biomarkers for detecting CSCs in HNSCC and changes in molecular pathways, genetics, epigenetics, and non-coding RNAs (ncRNAs) in CSCs relevant to precision medicine approaches in HNSCC management. The search encompassed 41 in vitro studies and 22 clinical studies...
April 28, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
#16
REVIEW
Kirti S Prabhu, Shilpa Kuttikrishnan, Nuha Ahamad, Ummu Habeeba, Zahwa Mariyam, Muhammad Suleman, Ajaz A Bhat, Shahab Uddin
Cancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it can cause genetic mutations that contribute to the initiation and progression of cancer. On the other hand, the DNA damage response system, which involves the phosphorylation of the histone variant H2AX (γH2AX), is crucial in preserving genomic integrity by signaling and facilitating the repair of DNA double-strand breaks...
April 29, 2024: Biomedicine & Pharmacotherapy
#17
JOURNAL ARTICLE
Ling Li, Jie Ma, Shuzhen Shen
OBJECTIVE: This study aims to elucidate the significance of HOX11 gene expression in acute leukemia, offering insights for readers unfamiliar with this gene's role. METHODS: We utilized qRT-PCR to examine HOX11 expression in 76 patients, categorizing them into high and low expression groups based on specific thresholds established for this study. Real-time quantitative polymerase chain reaction (qRT-PCR) was performed at the time of diagnosis and on day 28, associated with the analysis of the correlation of HOX11 gene expression with clinical outcomes and prognosis...
April 26, 2024: Alternative Therapies in Health and Medicine
#18
JOURNAL ARTICLE
Xiaojing Shen, Xiaolin Zhu, Hairong Liu, Rongtao Yuan, Qingyuan Guo, Peng Zhao
Growing evidence has increasingly suggested a potential linkage between the oral microbiome and various diseases, including pancreatic ductal adenocarcinoma (PDAC). However, the utilization of gene-level information derived from the oral microbiome for diagnosing PDAC remains unexplored. In this study, we sought to investigate the novel potential of leveraging genomic signatures associated with antibiotic resistance genes (ARGs) within the oral microbiome for the diagnosis of PDAC. By conducting an analysis of oral microbiome samples obtained from PDAC patients, we successfully identified specific ARGs that displayed distinct sequence abundance profiles correlated with the presence of PDAC...
2024: PloS One
#19
JOURNAL ARTICLE
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanisms remain elusive. Using a well-defined drug-gene pair, we identified an enhancer region for dihydropyrimidine dehydrogenase (DPD, DPYD gene) expression that is relevant to the metabolism of the anti-cancer drug 5-fluorouracil (5-FU). Using reporter systems, CRISPR genome-edited cell models, and human liver specimens, we demonstrated in vitro and vivo that genotype status for the common germline variant (rs4294451; 27% global minor allele frequency) located within this novel enhancer controls DPYD transcription and alters resistance to 5-FU...
April 30, 2024: ELife
#20
JOURNAL ARTICLE
Yue Wu, Kai-Yuan Min, Jiang-Feng Liu, Wan-Feng Liang, Ye-Hong Yang, Gang Hu, Jun-Tao Yang
Objective To screen out the biomarkers linked to prognosis of breast invasive carcinoma based on the analysis of transcriptome data by random forest (RF),extreme gradient boosting (XGBoost),light gradient boosting machine (LightGBM),and categorical boosting (CatBoost). Methods We obtained the expression data of breast invasive carcinoma from The Cancer Genome Atlas and employed DESeq2, t -test,and Cox univariate analysis to identify the differentially expressed protein-coding genes associated with survival prognosis in human breast invasive carcinoma samples...
April 2024: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
