Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J Mondesir, Dong-Gi Mun, Andrew Zale Ding, Isabelle M A Lombaert, Rob P Coppes, Chitra Priya Emperumal, Akhilesh Pandey, Jeffery R Janus, Nagarajan Kannan
The salivary gland (SG) is an essential organ that secretes saliva, which supports versatile oral function throughout life, and is maintained by elusive epithelial stem and progenitor cells (SGSPC). Unfortunately, aging, drugs, autoimmune disorders, and cancer treatments can lead to salivary dysfunction and associated health consequences. Despite many ongoing therapeutic efforts to mediate those conditions, investigating human SGSPC is challenging due to lack of standardized tissue collection, limited tissue access, and inadequate purification methods...
February 27, 2024: bioRxiv