Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D'Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Daniëlle van Keulen, Taco Kuijpers, Henriette Moll, Irene Papatheodorou, Stephane Paulus, Marko Pokorn, Andrew J Pollard, Irene Rivero-Calle, Pablo Rojo, Fatou Secka, Luregn J Schlapbach, Adriana H Tremoulet, Maria Tsolia, Effua Usuf, Michiel Van Der Flier, Ulrich Von Both, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Lachlan J M Coin, Aubrey Cunnington, Jane C Burns, Victoria Wright, Federico Martinon-Torres, Jethro A Herberg, Jesus Rodriguez Manzano, Myrsini Kaforou, Michael Levin
OBJECTIVE: To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease (KD), bacterial infections and viral infections. STUDY DESIGN: Children presenting with MIS-C to participating hospitals in the United Kingdom and the European Union between April 2020-April 2021 were prospectively recruited. Whole blood RNA Sequencing was performed, contrasting the transcriptomes of children with MIS-C (n=38) to those from children with KD (n=136), definite bacterial (DB; n=188) and viral infections (DV; n=138)...
May 31, 2023: Journal of the Pediatric Infectious Diseases Society