Catherine A Chapin, Thomas M Burn, Tamir Diamond, Kathleen M Loomes, Estella M Alonso, Edward M Behrens
A distinct phenotype of pediatric acute liver failure (PALF) has been identified, labeled activated T-cell hepatitis. These patients, previously included within the indeterminate group, have evidence of systemic immune activation and liver biopsy specimens with dense infiltration of CD8+ T-cells. We aimed to evaluate the peripheral blood T-cell phenotype in PALF patients with activated T-cell hepatitis compared to indeterminate cause. PALF patients with unknown etiology age 1-17 years were prospectively enrolled between 2017-2020...
2023: PloS One
Shunichiro Nakao, Hiroshi Ito, Yusuke Katayama, Tetsuhisa Kitamura, Tomoya Hirose, Jotaro Tachino, Hiroshi Ogura, Jun Oda
The purpose of this study was to describe the characteristics of published international literature using the Japan Trauma Data Bank (JTDB). We undertook a scoping review of studies using data from JTDB. We carried out a systematic search of the following databases on November 21, 2022, using search terms that covers trauma registries in Japan: MEDLINE, Web of Science, CINAHL, and Cochrane Library. Two authors independently abstracted the data. We included all original articles written in English. We identified 166 studies from the 456 included articles...
2023: Acute Medicine & Surgery
Koichi Miyata, Emelia V Bainto, Xiaoying Sun, Sonia Jain, Kirsten B Dummer, Jane C Burns, Adriana H Tremoulet
OBJECTIVE: Children with Kawasaki disease (KD) and an initial echocardiogram that demonstrates coronary artery aneurysms (CAAs, Z score ≥2.5) are at high risk for severe cardiovascular complications. We sought to determine if primary adjunctive infliximab treatment at a dose of either 5 or 10 mg/kg, compared with intravenous immunoglobulin (IVIG) alone, is associated with a greater likelihood of CAA regression in patients with KD with CAA at the time of diagnosis. DESIGN AND SETTING: Single-centre observational study...
May 31, 2023: Archives of Disease in Childhood
João Francisco de Castro Silveira, Ana Paula Sehn, Luiza da Silva, Anelise Reis Gaya, Rodrigo Antunes Lima, Ryan Donald Burns, Lars Bo Andersen, Jane Dagmar Pollo Renner, Cézane Priscila Reuter
OBJECTIVE: The present study aims to verify the odds of remaining with the clustering of 3 or more, 4 or more, and 5 or more risk factors across a 2-year time span. METHODS: Observational longitudinal study that included 358 children and adolescents (10.96 ± 2.28 years of age at baseline). Cardiorespiratory fitness, glucose, systolic blood pressure, total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, and waist circumference were assessed...
June 2023: Journal of Diabetes and Metabolic Disorders
Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D'Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Daniëlle van Keulen, Taco Kuijpers, Henriette Moll, Irene Papatheodorou, Stephane Paulus, Marko Pokorn, Andrew J Pollard, Irene Rivero-Calle, Pablo Rojo, Fatou Secka, Luregn J Schlapbach, Adriana H Tremoulet, Maria Tsolia, Effua Usuf, Michiel Van Der Flier, Ulrich Von Both, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Lachlan J M Coin, Aubrey Cunnington, Jane C Burns, Victoria Wright, Federico Martinon-Torres, Jethro A Herberg, Jesus Rodriguez Manzano, Myrsini Kaforou, Michael Levin
OBJECTIVE: To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease (KD), bacterial infections and viral infections. STUDY DESIGN: Children presenting with MIS-C to participating hospitals in the United Kingdom and the European Union between April 2020-April 2021 were prospectively recruited. Whole blood RNA Sequencing was performed, contrasting the transcriptomes of children with MIS-C (n=38) to those from children with KD (n=136), definite bacterial (DB; n=188) and viral infections (DV; n=138)...
May 31, 2023: Journal of the Pediatric Infectious Diseases Society
Jill G Azok, Katherine A O'Donnell, Michele E Long, Helen C Wang, Travis Crook, Mark I Pogemiller, Hasina Momotaz, Abena B Knight, Rebekah A Burns, Virginia A Harrison, Suzanne M Schmidt, Elizabeth R Van Opstal, Adam R Weinstein
No abstract text is available yet for this article.
May 27, 2023: Journal of Pediatrics
Noémie Lacombe, Maryelle Hey, Verena Hofmann, Céline Pagnotta, Myriam Squillaci
BACKGROUND: Current data show an increase in stress among youth since the COVID-19 pandemic, raising the question of the measures to be put in place to limit it. AIM: The aim of this study is to measure the prevalence of burnout and the different risk and protective factors of burnout among students and to compare the mean scores obtained with those collected in a similar sample in 2014. METHOD: Perceived health, school burnout, and the different risk and protective factors among students were measured by self-reported questionnaires among a sample of 184 students (11-13 years old)...
April 30, 2023: Children
Matthew J Mahoney, Ruegba Bekibele, Sydney L Notermann, Thomas G Reuter, Emily C Borman-Shoap
Conjunctivitis is a common pediatric problem and is broadly divided into infectious and non-infectious etiologies. Bacterial conjunctivitis makes up the majority of cases in children and often presents with purulent discharge and mattering of the eyelids. Treatment is supportive with an individual approach to antibiotic use in uncomplicated cases since it may shorten symptom duration, but is not without risks. Viral conjunctivitis is the other infectious cause and is primarily caused by adenovirus, with a burning, gritty feeling and watery discharge...
April 29, 2023: Children
O A Olawoye, C P Isamah, I O Obadan, S A Ademola, R O Aderibigbe, A I Michael, A O Iyun, O M Oluwatosin
The coronavirus disease and the subsequent pandemic that followed drastically changed human civilization with disruptive effects on health and overall wellbeing of mankind. This disruptive effect has been shown to include changes in epidemiology of burn injuries. This study therefore aimed to determine the impact of COVID-19 on acute burn presentation at the University College Hospital, Ibadan. This was a retrospective study carried out between April 1st 2019 and March 31st 2021. The period was divided into two: April 1st 2019 to March 31st 2020 and April 1st 2020 to March 31st 2021...
May 26, 2023: Journal of Burn Care & Research: Official Publication of the American Burn Association
Lina Sophie Toft Lernevall, Asgjerd Litleré Moi, Eva Gjengedal, Pia Dreyer
PURPOSE: When a burn injured child is discharged from hospital to its home, the responsibility for the after-care treatment is transferred to the parent(s). A knowledge gap exists concerning how parents experience caring for a burn-injured child at home after discharge. The aim is to gain an in-depth understanding of parents' lived experience of living with and caring for their burn-injured child in a home setting. METHODS: Twenty-four parents of burn-injured children treated at a Norwegian burn centre were interviewed 74 to 195 days after the burn accident (June 2017 to November 2018)...
December 2023: International Journal of Qualitative Studies on Health and Well-being
Jasjit K Dillon, Aparna Bhat, Christopher Barnes, Barclay Stewart, Andrea B Burke
Establishing a secure airway is critical in the acute phase of facial burns. This case report involving a 9-month-old infant with facial burns describes two techniques of securing an oral airway - trans-alveolar wiring and the application of an intermaxillary fixation (IMF) screw. The use of an IMF screw was more reliable than trans-alveolar wiring, as it allowed a secure airway through the patient's hospitalization, which involved 7 additional surgical interventions including 5 separate facial skin grafts over a 3-month period...
May 26, 2023: Journal of Burn Care & Research: Official Publication of the American Burn Association
Norah R Janosy, Emily M DeBoer, Jeremy D Prager, Jo Vogeli, Todd Wine, Abbie O Beacham
OBJECTIVES: Burnout among healthcare workers is a public health crisis. Burnout is associated with elevated cynicism, emotional exhaustion, and low job satisfaction. Methods to combat burnout have been challenging to identify. Based on positive experiences of pediatric aerodigestive team members, we hypothesized that social support in multidisciplinary aerodigestive teams moderates the effects of burnout on job satisfaction. METHODS: Using a survey of the Aerodigestive Society, members of Aerodigestive teams (N = 119) completed demographics, the Maslach Burnout Inventory, and measures of job satisfaction, emotional, and instrumental social support...
May 19, 2023: International Journal of Pediatric Otorhinolaryngology
Andrew S Oh, Steve G Schauer, Kathleen Adelgais, John L Fletcher, Fritz Karrer
BACKGROUND: The wars in Afghanistan and Iraq produced thousands of pediatric casualties, utilizing substantial military medical resources. We sought to describe characteristics of pediatric casualties that underwent operative intervention in Iraq and Afghanistan. METHODS: This is a retrospective analysis of pediatric casualties treated by US Forces in the Department of Defense Trauma Registry (DoDTR) with at least one operative intervention during their course. We report descriptive, inferential statistics, and multivariable modeling to assess associations for receiving an operative intervention and survival...
May 23, 2023: Journal of Trauma and Acute Care Surgery
Katelyn V Chiang, Erica H Anstey, Steven A Abrams, Cria G Perrine
BACKGROUND: Guidance for preparing powdered infant formula (PIF) helps to ensure it meets the nutritional needs of infants and is safe to consume. Among safety concerns is Cronobacter sakazakii contamination which can lead to serious infections and death. PIF preparation guidance varies; there is a lack of consensus on whether there is a need to boil water to inactivate potential Cronobacter and for how long to let the water cool before reconstitution. We sought to quantify the burden of burn injuries among infants related to water heating for PIF preparation...
2023: Frontiers in Pediatrics
Samantha Jane Wala, Kelli Patterson, Steven Scoville, Shruthi Srinivas, Dana Noffsinger, Renata Fabia, Rajan K Thakkar, Dana M Schwartz
BACKGROUND: Thermal injury has a significant impact on disability and morbidity in pediatric patients. Challenges in caring for pediatric burn patients include limited donor sites for large total body surface area (TBSA) burn as well as optimization of wound management for long term growth and cosmesis. ReCell® technology produces autologous skin cell suspensions from minimal donor split-thickness skin samples, allowing for expanded coverage using minimal donor skin. Most literature on outcomes reports on adult patients...
2023: International Journal of Burns and Trauma
James S Leung, Sarah Foohey, Rebekah Burns, Ilana Bank, Joe Nemeth, Elizabeth Sanseau, Marc Auerbach
BACKGROUND: Simulation provides consistent opportunities for residents to practice high-stakes, low-frequency events such as pediatric resuscitations. To increase standardization across North American residency programs, the Emergency Medicine Resident Simulation Curriculum for Pediatrics (EM ReSCu Peds) was developed. However, access to high-quality simulation/pediatric expertise is not uniform. As the concurrent COVID-19 pandemic necessitated new virtual simulation methods, we adapted the Virtual Resus Room (VRR) to teach EM ReSCu Peds...
June 2023: AEM Education and Training
Katrina M Morgan, Elissa Abou-Khalil, Stephen Strotmeyer, Ward M Richardson, Barbara A Gaines, Christine M Leeper
IMPORTANCE: Optimal hemostatic resuscitation in pediatric trauma is not well defined. OBJECTIVE: To assess the association of prehospital blood transfusion (PHT) with outcomes in injured children. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study of the Pennsylvania Trauma Systems Foundation database included children aged 0 to 17 years old who received a PHT or emergency department blood transfusion (EDT) from January 2009 and December 2019...
May 22, 2023: JAMA Pediatrics
Nicholas B Dimenstein, Caitlin E Crumm, Eve Champaloux, Rebekah Burns
BACKGROUND: The differential diagnosis for pediatric neck pain is broad and includes benign and life-threatening entities. The neck is a complex structure with many compartments. Rare disease processes exist that can mimic more serious conditions, such as meningitis. CASE REPORT: We present a case of a teenager with several days of severe pain underneath her left jaw, limiting the motion of her neck. After laboratory and imaging evaluation, the patient was found to have an infected Thornwaldt cyst and was subsequently admitted for IV antibiotic treatment...
March 8, 2023: Journal of Emergency Medicine
Harsita Patel, Amalia Sintou, Rasheda A Chowdhury, Stephen Rothery, Alma Octavia Iacob, Sanjay Prasad, Peter P Rainer, Federico Martinón-Torres, Vanessa Sancho-Shimizu, Chisato Shimizu, Kirsten Dummer, Adriana H Tremoulet, Jane C Burns, Susanne Sattler, Michael Levin
IMPORTANCE: Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. Understanding the role of autoantibodies in these conditions is essential for guiding MIS-C management and vaccination strategies in children. OBJECTIVE: To investigate the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic study included children with acute MIS-C or acute vaccine myocarditis, adults with myocarditis or inflammatory cardiomyopathy, healthy children prior to the COVID-19 pandemic, and healthy COVID-19 vaccinated adults...
May 1, 2023: JAMA Network Open
Burak Özkan, Burak Ergün Tatar, Süleyman Savran, Abbas Albayati, Cagri Ahmet Uysal
Volar finger contractures can be challenging for plastic surgeons. The dorsal metacarpal artery perforator (DMCAP) flap is frequently used to cover bones, tendons, and neurovascular structures in the dorsum of the hand after trauma and burns as an alternative to grafts and free flaps. We aimed to report volar finger defect reconstruction with expanded DMCAP flap. A 9-year-old male patient applied to our clinic with the complaint of inability to open the second finger of the left hand after an electrical burn that caused proximal and distal interphalangeal joints flexion contractures...
May 18, 2023: Microsurgery
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