Lauren E Mazur, Katelyn M Even, Conrad Krawiec
Children with neurodevelopmental disorders are at risk for burn injury, but the clinical outcomes, particularly mortality, are unknown in this patient population in the United States (U.S.). The main objectives of this study are to evaluate (1) subject characteristics; (2) burn injury type; (3) clinical care provided; and (4) mortality in children with autism spectrum disorder (ASD), hypothesizing that this patient population has similar mortality and critical care management requirements when compared to children without ASD...
April 12, 2024: Journal of Autism and Developmental Disorders
Maxime D Cuijpers, Martin G A Baartmans, Koen F M Joosten, Karolijn Dulfer, Paul P M van Zuijlen, Johannes C F Ket, Anouk Pijpe
OBJECTIVE: To evaluate the efficacy of therapeutic interventions on pediatric burn patients' height, weight, body composition, and muscle strength. METHODS: A systematic literature search was conducted in PubMed, Embase, and Web of Science up to March 2021. Eligible interventional studies reported metrics on the height, weight, body composition, or muscle strength of pediatric burn patients in a peer-reviewed journal. Meta-analyses were performed if ≥ 2 trials of clinical homogeneity reported on an outcome measure at the same time point post-burn...
March 11, 2024: Burns
Marshall Thibedeau, Joel Fish, Charis Kelly, Julia Wenskus, Jennifer Zuccaro, Eduardo Gus
Recent evidence has demonstrated that silver has anti-inflammatory properties that are independent from the known antimicrobial ones. In our current model of care, non-adherent, non-silver dressings are applied for acute presentations of pediatric partial thickness burn injuries. The wounds are re-assessed after the progression phase (48-72 hours after injury) and silver dressings are applied. However, when logistical obstacles prevent re-assessment within the 48-72-hour window, nanocrystalline silver-based dressings are applied on presentation...
April 5, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
Sai Krishna Bhogadi, Khaled El-Qawaqzeh, Christina Colosimo, Hamidreza Hosseinpour, Louis J Magnotti, Audrey L Spencer, Tanya Anand, Michael Ditillo, Qaidar Alizai, Adam Nelson, Bellal Joseph
INTRODUCTION: There is a paucity of large-scale data on the factors that suggest an impending or underlying extremity pediatric acute compartment syndrome (ACS). In addition, literature regarding the timing of operative fixation and the risk of ACS is mixed. We aimed to describe the factors associated with pediatric ACS. METHODS: Analysis of 2017-2019 Trauma Quality Improvement Program. We included patients aged <18 y diagnosed with upper extremity (UE) and lower extremity (LE) fractures...
April 2, 2024: Journal of Surgical Research
Namita Kalra, Rishi Tyagi, Amit Khatri, Khadeeja Kulood, Puja Sabherwal
BACKGROUND: Benign migratory glossitis or geographic tongue is a chronic recurring inflammatory condition of the oral cavity. With its ephemeral characteristics, there has been reported literature showing its association with the administration of certain drugs including angiogenesis inhibitors. The antiangiogenic drugs act by selectively inhibiting the vascular endothelial growth factor (VEGF) signaling. It has been widely used as an adjunct and a maintenance agent for the treatment of various cancers...
January 2024: International Journal of Clinical Pediatric Dentistry
Moreen W Njoroge, Bashar Hassan, Atharva M Bhagwat, Jordan Gornitsky, Matthew J Heron, Howard D Wang, Christopher D Lopez, Robin Yang, Richard J Redett
BACKGROUND: Tissue expansion has been widely used to reconstruct soft tissue defects following burn injuries in pediatric patients, allowing for satisfactory cosmetic and functional outcomes. Factors impacting the success of tissue expander (TE)-based reconstruction in these patients are poorly understood. Herein, we aim to determine the risk factors for postoperative complications following TE-based reconstruction in pediatric burn patients. METHODS: A retrospective review of pediatric patients who underwent TE placement for burn reconstruction from 2006 to 2019 was performed...
April 1, 2024: Annals of Plastic Surgery
Da Yeon Choi, Nayeon Shin, Sohyeon Park, Doo Hee Han, Kihong Park, Moo Kyun Park
OBJECTIVE: Increasing evidence suggests a link between middle ear inflammation and the development of diesel exhaust particles (DEPs). Chronic middle ear inflammation can lead to bone damage and remodeling. This study aimed to explore the impact of DEPs on the expression of interleukin (IL)-6 and RANKL under conditions of middle ear inflammation. METHODS: DEPs were collected by burning fuel in a diesel engine at the Gwangju Institute of Science and Technology. Human middle ear epithelial cells were cultured to 70-80% confluence in culture plates and then treated with DEPs at concentrations of 0, 5, 10, 20, 40, and 80 μg/mL for 24 h...
March 29, 2024: International Journal of Pediatric Otorhinolaryngology
Ivan Baljošević, Aleksandar Perić, Aleksandar Sovtić, Slaviša Antić
Congenital laryngeal cysts are rare lesions that may occur in newborns, characterized by symptoms of respiratory obstruction and severe dyspnea. The aim of this study was to indicate optimal surgical treatment of congenital laryngeal cysts in newborns. We present a case series of five neonates treated for congenital laryngeal cysts during the 2011-2017 period at our pediatric tertiary care hospital. Patient age ranged from one day to 14 days. All patients had unilateral cysts. After surgical excision, burning of the walls of the cysts was performed by a CO2 laser...
August 2023: Acta Clinica Croatica
Martim Santos, Ana Ferraz, Maria Garcia, M Graça Pereira
Pediatric burn injuries are a critical medical condition that triggers a series of ongoing multifactorial stressors that affect both children and their families. To inform healthcare research and clinical practice, this study aimed to understand and describe the perceptions and experiences of the parents of burn-injured children during hospital stay. Forty-six parents (thirty-eight mothers) of forty-six children (eighteen girls) with a mean age of 2.28 years ( SD = 1.52) answered ten open-ended questions. This qualitative study was conducted in a referral hospital in the northern region of Portugal...
March 8, 2024: Healthcare (Basel, Switzerland)
Cristian Locci, Elena Chicconi, Roberto Antonucci
Bromelain is a complex natural mixture of sulfhydryl-containing proteolytic enzymes that can be extracted from the stem or fruit of the pineapple. This compound is considered a safe nutraceutical, has been used to treat various health problems, and is also popular as a health-promoting dietary supplement. There is continued interest in bromelain due to its remarkable therapeutic properties. The mechanism of action of bromelain appears to extend beyond its proteolytic activity as a digestive enzyme, encompassing a range of effects (mucolytic, anti-inflammatory, anticoagulant, and antiedematous effects)...
March 21, 2024: Children
Maximilian Dölling, Martin Herrmann, Michael Boettcher
This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in pediatric surgery. Focusing on NET formation, functions, and implications, this study highlights their dual impact in infection control and contribution to tissue damage after surgery. It covers the role of NET formation in a range of pediatric conditions including immunothrombosis, formation of peritoneal adhesions, appendicitis, burns, gallstones, tumors, and necrotizing enterocolitis (NEC). The results underscore the significance of NETs in fighting infections and their association with complications like sepsis and delayed wound healing...
March 1, 2024: Children
Kari Bjornard, Allison Close, Karen Burns, Josuah Chavez, Eric J Chow, Lillian R Meacham
Treatment for childhood solid tumors may lead to an increased risk for gonadal dysfunction/infertility. Discussion of risk should occur at diagnosis, any changes in therapy, and during survivorship. Gonadotoxic therapies were abstracted from 32 Children's Oncology Group (COG) phase III, frontline solid tumor protocols, in use from 2000 to 2022. Risk for gonadal dysfunction/infertility was assessed based on gonadotoxic therapies, sex, and pubertal status and assigned as minimal, significant, and high following the Oncofertility Consortium Pediatric Initiative Network (PIN) risk stratification...
March 26, 2024: Pediatric Blood & Cancer
Jingchun Zhao, Kai Shi, Nan Zhang, Xinxin Chen, Jiaao Yu
BACKGROUND: Pediatric burn patients are an essential part of burn populations. However, there is limited publicly available data on the epidemiological impact of COVID-19 on pediatric burns in China. OBJECTIVE: In this paper, pediatric burn patients admitted to the Department of Burn Surgery of the First Hospital of Jilin University before and during COVID-19 were retrospectively investigated to determine the impact of COVID-19 on pediatric burn inpatients. METHODS: The information of inpatients from July 2017 to December 2019 (pre-COVID-19 group) and from January 2020 to June 2022 (COVID-19 group) in the Department of Burn Surgery at the First Hospital of Jilin University was retrospectively investigated...
March 19, 2024: Journal of Tissue Viability
Demet Kahramanlar, Sare Gülfem Özlü, Pervin Demirci, Elif Emel Erten, Emrah Şenel, Umut Selda Bayrakçi
BACKGROUND: Acute kidney injury (AKI) is a common and important complication of burn injury. Although there are numerous adult studies, data regarding AKI in pediatric burn patients are scarce. Here, we aimed to evaluate the frequency, clinical features, and prognosis of AKI among pediatric burn injury patients. METHODS: This is a retrospective cohort study. Patients aged between 1 month and 18 years who had been followed up between the years 2011 and 2017 were included, and patients with previous kidney disease were excluded...
March 22, 2024: Pediatric Nephrology
Aisha H Frazier, Alexis A Topjian, Ron W Reeder, Ryan W Morgan, Ericka L Fink, Deborah Franzon, Kathryn Graham, Monica L Harding, Peter M Mourani, Vinay M Nadkarni, Heather A Wolfe, Tageldin Ahmed, Michael J Bell, Candice Burns, Joseph A Carcillo, Todd C Carpenter, J Wesley Diddle, Myke Federman, Stuart H Friess, Mark Hall, David A Hehir, Christopher M Horvat, Leanna L Huard, Tensing Maa, Kathleen L Meert, Maryam Y Naim, Daniel Notterman, Murray M Pollack, Carleen Schneiter, Matthew P Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Andrew R Yates, Robert M Sutton, Robert A Berg
RATIONALE: Adult and pediatric studies provide conflicting data whether post-cardiac arrest hypoxemia, hyperoxemia, hypercapnia and/or hypocapnia are associated with worse outcomes. OBJECTIVES: Determine if post-arrest hypoxemia or post-arrest hyperoxemia are associated with lower rates of survival to hospital discharge compared to post-arrest normoxemia, and if post-arrest hypocapnia or hypercapnia are associated with lower rates of survival compared to post-arrest normocapnia...
March 20, 2024: Annals of the American Thoracic Society
Asad Khan, Yasir S Siddiqui, Mohd Baqar Abbas, Mazhar Abbas, Julfiqar Mohd, Mohd Hadi Aziz
The primary objective of this study was to juxtapose the union rate and incidence of complications in paediatric patients presenting early (≤ 7 days) following injury with children presenting later (> 7 days) with femoral neck fractures. This critical appraisal evaluated 15 patients according to their timing of presentation and surgery from the initial day of injury (Group A: operated ≤ 7 days or Group B: > 7 days of injury). Patients with traumatic femoral neck fractures with Delbet 1 to 4 subtypes who were skeletally immature (age ≤ 16 years) were included in the study...
2024: International Journal of Burns and Trauma
Vincenzo Mancini, Martina Borellini, Paolo Belardi, Maria Carolina Colucci, Emanuel Yuda Kadinde, Christina Mwibuka, Donald Maziku, Pasquale Parisi, Anteo Di Napoli
BACKGROUND: Despite pediatric acute illnesses being leading causes of death and disability among children, acute and critical care services are not universally available in low-middle income countries, such as Tanzania, even if in this country significant progress has been made in child survival, over the last 20 years. In these countries, the hospital emergency departments may represent the only or the main point of access to health-care services. Thus, the hospitalization rates may reflect both the health system organization and the patients' health status...
March 18, 2024: Italian Journal of Pediatrics
Conor J Loy, Venice Servellita, Alicia Sotomayor-Gonzalez, Andrew Bliss, Joan Lenz, Emma Belcher, Will Suslovic, Jenny Nguyen, Meagan E Williams, Miriam Oseguera, Michael A Gardiner, Jong-Ha Choi, Hui-Mien Hsiao, Hao Wang, Jihoon Kim, Chisato Shimizu, Adriana Tremoulet, Meghan Delaney, Roberta L DeBiasi, Christina A Rostad, Jane C Burns, Charles Y Chiu, Iwijn De Vlaminck
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, including Kawasaki disease (KD), Multisystem Inflammatory Syndrome in Children (MIS-C), viral infections and bacterial infections...
March 8, 2024: medRxiv
Martini Nafiza, Almasri Imad-Addin, Almouallem Mohamad Moamen, Khaled Raghad, Hamdar Hussein, Nahle Ali Alakbar, Mahmod Jaber
INTRODUCTION: Accidental ingestion of caustic agents poses a significant concern in pediatric emergency departments globally. It is a growing public health concern in low-to-middle income countries, which often lack comprehensive data reporting. This study examines high doses of corticosteroid treatment outcomes of caustic ingestion injuries in Syrian pediatric patients, addressing clinical features, and associated variables. METHODS AND MATERIALS: A retrospective observational study was conducted at University Pediatric Hospital from January 2016 to January 2019...
2024: SAGE Open Medicine
Dorothy Bbaale, Christoph Mohr, Judith Lindert, Nikki Allorto, Tresor Mabanza, Jean Bosco Katabogama, Shobha Chamania, Richard Elrod, Michael Boettcher, Julia Elrod
INTRODUCTION: The current standard management of full-thickness or deep dermal burns is early tangential excision and skin grafting. A conservative approach to deep burns without the option of skin grafting results in delayed wound healing, possibly leading to wound infection and is associated with hypertrophic scarring and increased morbidity and mortality. The aim of this study was to improve the understanding of the management and availability to perform skin grafting for burns on the African continent...
February 28, 2024: Burns
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